GMS ophthalmology cases最新文献

{"title":"A case of corneal epithelial downgrowth after penetrating keratoplasty treated by intracameral 5-fluorouracil injection and mitomycin C.","authors":"Noel Hong-Kei Wat, Gillian Denise Ji-Yee Siu, Mei Sze Wu, Lee Wong","doi":"10.3205/oc000268","DOIUrl":"https://doi.org/10.3205/oc000268","url":null,"abstract":"<p><strong>Background: </strong>Corneal epithelial downgrowth is an uncommon, yet potentially sight-threatening complication of intraocular surgery or trauma with poor prognosis. We hereby describe a case of epithelial downgrowth after penetrating keratoplasty which was treated by intracameral 5-fluorouracil injection.</p><p><strong>Case description: </strong>In 2019, penetrating keratoplasty was performed for a 69-year-old man with pseudophakic bullous keratopathy. Six months after penetrating keratoplasty, an endothelial opacity suspicious of epithelial downgrowth was noted. Two treatments of intracameral 5-fluorouracil injection were performed at the eighth and ninth month after penetrating keratoplasty, which allowed the epithelial downgrowth to become quiescent. A repeated penetrating keratoplasty with intracameral application of mitomycin C was subsequently performed without reactivation of the epithelial downgrowth.</p><p><strong>Conclusion: </strong>Intracameral 5-fluorouracil injection is effective in halting disease progression in epithelial downgrowth.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"16 ","pages":"Doc04"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-laser in situ keratomileusis (LASIK) epithelial ingrowth after interface fluid syndrome.","authors":"Emiel Matthys, Isabelle Saelens, Heleen Delbeke","doi":"10.3205/oc000267","DOIUrl":"https://doi.org/10.3205/oc000267","url":null,"abstract":"<p><strong>Objectives: </strong>We present a case of epithelial ingrowth after late onset interface fluid syndrome, a rare complication after laser in situ keratomileusis (LASIK).</p><p><strong>Methods: </strong>This patient presented herself to the emergency department with corneal oedema due to endothelial failure after multiple intraocular surgeries. Anterior segment optical coherence tomography (OCT) showed a fluid filled pocket in the LASIK interface, 20 years after LASIK surgery.</p><p><strong>Results: </strong>As a result, she was diagnosed with late onset interface fluid syndrome which resolved after endothelial transplantation (DMEK). However, 3 months after surgery, epithelial ingrowth in the LASIK interface was noticed. We adopted a conservative approach as there was no progression after 3 weeks.</p><p><strong>Conclusions: </strong>Epithelial ingrowth is a rare complication after DMEK, which might be caused by interface fluid induced flap lifting and further facilitated by intraoperative flap manipulation during graft unfolding.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"16 ","pages":"Doc03"},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic metastatic retinal lymphoma masquerading as granulomatous uveitis.","authors":"Ayşe Yağmur Kanra, Saniye Üke Uzun","doi":"10.3205/oc000266","DOIUrl":"https://doi.org/10.3205/oc000266","url":null,"abstract":"<p><strong>Objective: </strong>To highlight the importance of considering systemic metastatic retinal lymphoma (SMRL) in the differential diagnosis of atypical uveitis and to emphasize the need for a comprehensive diagnostic and treatment approach for optimal patient outcomes.</p><p><strong>Methods: </strong>Medical records and imaging of the patient were retrospectively reviewed.</p><p><strong>Results: </strong>A 61-year-old man presented with blurred vision, initially diagnosed as granulomatous uveitis following cataract surgery. Further ocular examination revealed optic nerve infiltration and retinal white infiltrates, prompting additional systemic evaluation. Imaging and biopsy confirmed a diagnosis of primary adrenal non-Hodgkin lymphoma with ocular involvement. The patient underwent R-CHOP chemotherapy and autologous stem cell transplantation during the COVID-19 pandemic, achieving systemic remission. However, due to pandemic-related logistical challenges, he declined further ocular treatment. At 1.5-year follow-up, his final visual acuity was 20/25 in the right eye and 20/125 in the left eye, with persistent cystoid macular edema in the left eye.</p><p><strong>Conclusion: </strong>This case underscores the importance of recognizing SMRL as a potential cause of atypical uveitis, particularly in the presence of optic nerve and retinal infiltrates. It highlights the need for early diagnosis and a multidisciplinary approach, integrating systemic and ocular management to improve patient outcomes.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"16 ","pages":"Doc02"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging observation of torpedo maculopathy.","authors":"Hongtao Duan, Meng Dong, Shiyong Xie, Tongmei Zhang, Bin Wu, Yuezhong Zheng","doi":"10.3205/oc000265","DOIUrl":"https://doi.org/10.3205/oc000265","url":null,"abstract":"<p><p>An 18-year-old male was discovered with an oval, 1PD-sized, well-defined lesion on the inferonasal fovea of the right eye. Multimodal imaging was carried out. The lesion was diagnosed as torpedo maculopathy (TM). Most TM patients have no visual symptoms, are often detected during routine examination, and are generally stable.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"16 ","pages":"Doc01"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A macular horseshoe tear following posterior vitreous detachment and longstanding branch retinal vein occlusion.","authors":"Konstantina Manoli, Jared Ching","doi":"10.3205/oc000264","DOIUrl":"10.3205/oc000264","url":null,"abstract":"<p><strong>Objective: </strong>We present a case of a macular horseshoe tear that demonstrated signs of progression over time that was therefore deemed sight threatening. There are no reports that provide a definitive means to treat such a rare pathology.</p><p><strong>Methods: </strong>Spectral domain optical coherence tomography (SD-OCT) scans were used to monitor subretinal fluid at each follow up. Once confirmation of the accumulation of subretinal fluid was made, vitrectomy surgery including amputation of the horseshoe tear flap, short acting gas tamponade and face down positioning were utilized.</p><p><strong>Results and conclusion: </strong>Macular horseshoe tears can be treated with a vitrectomy approach akin to retinal detachment repair without the need for retinopexy.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc16"},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue fever maculopathy: case report and brief review.","authors":"Aluisio Rosa Gameiro Filho, Willian Gabriel Odorcik, Matheus Henrique Rocha Garcia, Marcelo Brillinger Novello, Daniella Socci da Costa","doi":"10.3205/oc000263","DOIUrl":"10.3205/oc000263","url":null,"abstract":"<p><p>A 45-year-old woman with a 7-day history of fever and nausea sought assistance at the emergency department complaining of blurred vision in her right eye. She was recently diagnosed with dengue fever. Fundus showed a discrete well-circumscribed, round yellow-orange lesion localized in the foveal region, retinal hemorrhages, macular oedema, soft exudates, and adjacent perivasculitis in the affected eye. Spectral domain optical coherence tomography (OCT) was compatible with dengue maculopathy. She was closely followed, with complete improvement after 1 week. The increasing incidence of dengue makes essential for the ophthalmologist to recognize this rare condition.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc15"},"PeriodicalIF":0.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of contralateral Athens and decentered individualized sphero-cylindrical (DISC) protocols for keratoconus management.","authors":"Igor Knezović, Nina Jovanović, Sara Djurić","doi":"10.3205/oc000261","DOIUrl":"10.3205/oc000261","url":null,"abstract":"<p><strong>Purpose: </strong>To present the results of two different surgical procedures, decentered individualized sphero-cylindrical protocol (DISC protocol) and Athens protocol, performed on a 34-year-old patient after being diagnosed with keratoconus in both eyes.</p><p><strong>Observation: </strong>The patient's left eye was subjected to the Athens protocol (phototherapeutic keratectomy (PTK) + partial topo-guided photorefractive keratectomy (TG-PRK) + corneal cross-linking (CXL)). In contrast, the patient's right eye was subjected to the DISC protocol (PTK + DISC excimer ablation + CXL). After administration of topical anesthetic, the patient was subjected to PTK of the central 7 mm optical zone with 50 µm depth of epithelial ablation. After excimer laser ablation in both eyes, riboflavin 0.1% solution was applied topically every 2 minutes for 20 minutes. This was followed by five cycles of 5-minute-long irradiation (for 25 minutes) using a UVA 370 nm at 3.0 mW/cm² CXL (CSO VEGA CMB X Linker, Florence, Italy) application. 36 months postoperative uncorrected visual acuity (UCVA) of the left eye remained the same as preoperatively, while the best corrected visual acuity (BCVA) was -3.5 Dsph=20/30. In the right eye, UCVA and BCVA were both 20/22. Results of Fourier's analysis of the right eye imply a 52% decrease in corneal irregularity, while in the left eye, corneal irregularity decreased by 12.8%. Values of spheric aberration in Zernike analysis 36 months postoperatively showed a lower increase in Athens protocol than DISC protocol. The index of vertical asymmetry and the index of surface variance showed lower values in both procedures during the whole postoperative period, while the index of height decentration showed a more significant decline in Athens protocol 36 months postoperatively.</p><p><strong>Conclusion and importance: </strong>DISC protocol is a novel approach, with the potential to become a promising strategy for slowing the progression of keratoconus and recovering uncorrected visual abilities.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc13"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe bilateral chorioretinopathy associated with ipilimumab in a patient with metastatic melanoma.","authors":"Víctor Manuel Asensio-Sánchez","doi":"10.3205/oc000262","DOIUrl":"10.3205/oc000262","url":null,"abstract":"<p><strong>Objective: </strong>To report a rare case of severe bilateral chorioretinopathy associated with ipilimumab in a patient with metastatic melanoma, highlighting the ocular toxicities that may arise from immune checkpoint inhibitors.</p><p><strong>Methods: </strong>A 38-year-old woman receiving ipilimumab (3 mg/kg every 3 weeks) for metastatic melanoma presented with painless bilateral vision loss following her third dose. Clinical assessment included visual acuity testing, fundus examination, fluorescein angiography (FA), and optical coherence tomography (OCT) to evaluate retinal changes. The ipilimumab treatment was discontinued, but the patient refused corticosteroid therapy.</p><p><strong>Results: </strong>Fundus examination and OCT revealed bilateral serous retinal detachments with retinal pigment epithelium (RPE) detachment. FA demonstrated multiple pinpoint leakage areas at the RPE level. Over a three-month follow-up period, visual acuity further declined, resulting in total vision loss in one eye and persistent bilateral serous detachments despite cessation of ipilimumab.</p><p><strong>Conclusions: </strong>This case highlights the potential for severe, irreversible vision loss due to ipilimumab-associated chorioretinopathy, underscoring the importance of early ophthalmological assessment and continuous monitoring in patients undergoing immune checkpoint inhibitor therapy. Early recognition and intervention are critical, especially when systemic corticosteroids are not administered.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc14"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive lens exchange with trifocal intraocular lens after radial keratotomy.","authors":"Şefik Can İpek, Seher Köksaldı","doi":"10.3205/oc000259","DOIUrl":"10.3205/oc000259","url":null,"abstract":"<p><strong>Objective: </strong>To report a case with a history of previous radial keratotomy who underwent refractive lens exchange with trifocal intraocular lenses.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 69-year-old man underwent bilateral RK to correct myopia in both eyes elsewhere 40 years ago. He was admitted to our hospital due to progressive deterioration of vision. The uncorrected distance visual acuity in both eyes was 20/40, and the uncorrected near visual acuity (40 cm) was J10. On slit-lamp examination, mild cataract and four radial keratotomy incisions were found. The patient underwent bilateral refractive lens exchange with trifocal intraocular lenses one-week interval. We were unable to obtain the preoperative data or details of the patient's prior surgeries. Calculations were run with the American Society of Cataract and Refractive Surgery calculator using the Barret True K formula. Postoperative follow-up was continued for approximately six months. No perioperative complications were noted.</p><p><strong>Conclusions: </strong>Six months after the surgery, the refractive outcomes for both eyes had stabilized, and no other complications had occurred. The patient was satisfied with the result.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc11"},"PeriodicalIF":0.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed onset Aspergillus niger keratitis post-DALK associated with bandage contact lens: a case report highlighting the importance of vigilant postoperative care and management.","authors":"Dharamveer Singh Choudhary, Nolan Rodrigues, Jeba Shaheen, Sidhya Choudhary, Ajay Dhakad, Bhuvanesh Sukhlal Kalal","doi":"10.3205/oc000260","DOIUrl":"10.3205/oc000260","url":null,"abstract":"<p><p>We present the case of an 18-year-old male who developed a black-colored growth on a bandage contact lens and cornea nine months after undergoing lamellar keratoplasty for advanced keratoconus in his left eye. The growth was identified as Aspergillus niger, which was successfully treated following its removal and microbiological examination.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"15 ","pages":"Doc12"},"PeriodicalIF":0.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}