Global pediatrics最新文献

{"title":"Impact of surgical treatment on neonatal management in extremely low birth weight infants: Single-center retrospective study","authors":"Seiichiro Inoue,&nbsp;Yuki Muta,&nbsp;Yuta Takeuchi,&nbsp;Kohei Kawaguchi,&nbsp;Akio Odaka","doi":"10.1016/j.gpeds.2024.100240","DOIUrl":"10.1016/j.gpeds.2024.100240","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have examined the details of extremely low birth weight (ELBW) infants (i.e., infants with a birth weight &lt; 1000 g) on neonatal intensive care units (NICUs) who require surgical treatment. Therefore, we analyzed mortality, morbidity, and clinical variables in ELBW infants who received surgical treatments at our center from 2009 to 2022.</div></div><div><h3>Methods</h3><div>All ELBW infants were included who received surgical treatment at our NICU from January 2009 to December 2022. We compared data from infants treated in the early (2009–2015) and late (2016–2022) periods and investigated trends in mortality, morbidity, and clinical variables.</div></div><div><h3>Results</h3><div>A total of 678 ELBW infants were admitted and cared at our neonatal center and 56 ELBW infants were received surgical treatment. The number of patients who received surgical treatment increased in the late period (10.4 % (36/345)) compared to the early period (6.33 % (20/316)) (early vs late period: <em>p</em> = 0.0398). The indications for surgery were expanded in late period compared to early periods. In the late period, the survival rate was higher (63.5 vs 75.0 %: early vs late period). No statistical difference was observed between the early and late period in the duration of the NICU stay. However, the duration of NICU stay in died patients were shorter compared to the survived patients (median (lower -upper quartiles):196.5 (166.75–261.25 vs 75.0 (49.0–183.5): early vs late period). The total number of surgical treatments which each patient received were higher in survived cases (median (lower -upper quartiles): 2.0 (2.0–4.0) vs 1.0 (1.0–2.0): survived vs died cases: <em>p</em> = 0.013).</div></div><div><h3>Conclusions</h3><div>Recent advances in NICU care have expanded the indications for surgical treatment in ELBW infants. Survival rates appear to have improved. In more recent years, patients have increasingly undergone multi-step surgical treatment, which we consider to be a result of the improved the systemic status of infants in perioperative period.</div></div><div><h3>Level of evidence</h3><div>3</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"11 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turkish Neonatal Society position paper for stem cell therapy in neonates","authors":"Merih Cetinkaya ,&nbsp;Esin Koc ,&nbsp;Betul Acunas ,&nbsp;Mete Akisu ,&nbsp;Saadet Arsan ,&nbsp;Fuat Emre Canpolat ,&nbsp;Dilek Dilli ,&nbsp;Zeynep Ince ,&nbsp;Nilgun Koksal ,&nbsp;Abdullah Kumral ,&nbsp;Eren Ozek ,&nbsp;Hasan Ozkan ,&nbsp;Ayse Korkmaz Toygar ,&nbsp;Sule Yigit ,&nbsp;Aysegul Zenciroglu ,&nbsp;Mehmet Vural","doi":"10.1016/j.gpeds.2024.100239","DOIUrl":"10.1016/j.gpeds.2024.100239","url":null,"abstract":"<div><div>Stem cell (SC) therapy has been proposed as a promising therapeutic modality in neonatology, especially for prevention and/or treatment of several interactable diseases such as bronchopulmonary dysplasia, intraventricular hemorrhage, hypoxic-ischemic encephalopathy and others. However, there are several uncertainities in terms of indications, timing, dosage, and safety of SC therapy for routine clinical use in neonates. Herein, a group of Turkish Neonatal Society members evaluated the systematic reviews, meta-analyses, clinical and experimental studies and also case-reports in the literature about the usage of SC therapy in neonatal diseases.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"11 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143094179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right side Bochdalek's hernia with right herniated thoracic renal ectopia: A case report and review of literature","authors":"Osias Tilahun Merga,&nbsp;Nebiyou Simegnew Bayleyegn","doi":"10.1016/j.gpeds.2024.100238","DOIUrl":"10.1016/j.gpeds.2024.100238","url":null,"abstract":"<div><h3>Introduction and importance</h3><div>Congenital diaphragmatic hernia is an uncommon defect of the diaphragm that can cause the abdominal contents to herniate into the chest cavity, putting the newborn at risk for complications with the heart and lungs. The spectrum of congenital diaphragmatic hernia disease can include acute respiratory failure that manifests as neonatal death, as well as asymptomatic problems that are not detected during the neonatal era.</div></div><div><h3>Case presentation</h3><div>A 6 kilogram, 4-month-old baby had been breathing rapidly for two weeks. According to the mother, he has also had breastfeeding interruption, dry intermittent cough, and high-grade intermittent fever. Meanwhile, the patient was diagnosed with severe acute malnutrition, severe pneumonia, and a congenital diaphragmatic hernia complicated with Intrathoracic ectopic kidney. He was admitted to pediatric ward and managed with intravenous antibiotics, intranasal oxygen and Formula-75 for two weeks.</div></div><div><h3>Clinical discussion</h3><div>Congenital diaphragmatic hernia is a rare kind of congenital surgical problem. The diaphragm fails to close during embryonic development, leading to intrathoracic abdominal viscera herniation, as well as variable degrees of pulmonary hypoplasia, pulmonary hypertension, and heart failure at birth. Intrathoracic ectopic kidneys are exceptionally rare. They represent only &lt;5 % of renal ectopia. The prognosis for early presenters in high-income nations has improved because of advancements in newborn care; nevertheless, in Africa, the situation is still dire.</div></div><div><h3>Conclusion</h3><div>Congenital diaphragmatic hernias with Intrathoracic ectopic kidneys are exceptionally rare. Compared to congenital diaphragmatic hernias linked to other abnormalities or syndromes, isolated congenital diaphragmatic hernias have a higher survival rate.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"11 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143094178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbances in hospitalized children: Comparison between acute admission and regular care units","authors":"Pia Burger ,&nbsp;Lindsay M.H. Steur ,&nbsp;Jorinde A.W. Polderman ,&nbsp;Reinoud J.B.J. Gemke","doi":"10.1016/j.gpeds.2024.100237","DOIUrl":"10.1016/j.gpeds.2024.100237","url":null,"abstract":"<div><h3>Introduction</h3><div>Hospitalization adversely affects children's sleep, primary due to disease-, staff-, psychosocial- and environment-related factors. Clustering discontinuity in Acute Admission Units (AAU's) appears to enhance efficiency in clinical care. However, sleep may be more affected in a pediatric AAU as compared to regular care units (RCUs).</div></div><div><h3>Methods</h3><div>In children of 1–12 years of age admitted to the AAU or RCUs, we used actigraphy to observe sleep, assessing Total Sleep Time (TST), Sleep Onset Latency (SOL), Wake After Sleep Onset (WASO), sleep efficiency, and awakenings. Subjective sleep quality was evaluated with PROMIS questionnaires. Sleep disturbances due to disease-, staff-, patient-, environment-, treatment-related factors were examined and compared between wards.</div></div><div><h3>Results</h3><div>Significant differences were observed between the AAU and RCUs in terms of specialty type and admission reasons: surgical patients and exacerbations of chronic diseases were more often admitted to RCUs. No significant differences were found between AAU and RCUs regarding TST (497 (92) (mean (SD)) vs 476 (96)), and WASO (113 (74) in both the AAU and RCU's). There was a trend towards more staff-related disturbances in the AAU (67 % vs 56 % <em>p</em> = 0.07, specifically regarding waking (32 % vs 22 %, <em>p</em> = 0.07). In all wards, sleep disturbances were reported by approximately 93 % of the patients.</div></div><div><h3>Conclusion</h3><div>Despite the concentration of clinical discontinuity to enhance efficiency of care in a novel pediatric AAU, no differences with regards to sleep (disturbances) were observed in comparison to the RCUs. Yet substantial sleep disturbances in both settings indicate the need for targeted interventions to improve inpatient sleep.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"11 ","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follow-up of the preterm NICU graduates","authors":"Sinan Uslu ,&nbsp;Ersin Ulu","doi":"10.1016/j.gpeds.2024.100236","DOIUrl":"10.1016/j.gpeds.2024.100236","url":null,"abstract":"<div><div>The care and follow-up of premature babies after they graduate from neonatal intensive care units (NICU) are essential for maintaining quality of life and maximizing well-being. Ensuring the standardization of this complex multi-disciplinary process and creating individualized care plans is one of the areas that clinicians find most difficult to solve. In this review article, recommendations including somatic growth, vaccination, respiratory system, visual, auditory, surgical, metabolic, and other system follow-up of preterm babies, starting from preparation for discharge and post-discharge from NICU, are discussed in the context of the literature.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"10 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum Regarding Previously Published Articles","authors":"","doi":"10.1016/j.gpeds.2024.100231","DOIUrl":"10.1016/j.gpeds.2024.100231","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"10 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The validity of lateral neck X-Ray for the diagnosis of retropharyngeal infection in pediatric patients","authors":"Yehonatan Adler ,&nbsp;Shani Blushtein-Levin ,&nbsp;Eli Somekh ,&nbsp;Yoram Ben-Yehuda ,&nbsp;Haim Bibi ,&nbsp;Nathan Peled ,&nbsp;Michael Wolf","doi":"10.1016/j.gpeds.2024.100235","DOIUrl":"10.1016/j.gpeds.2024.100235","url":null,"abstract":"<div><h3>Aim</h3><div>To examine the validity of lateral neck x ray (LNXR) for the diagnosis of retropharyngeal infection (RPI) in emergency room (ER) settings. Effectiveness of conservative treatment with IV antibiotics for RPI was also examined.</div></div><div><h3>Methods</h3><div>A retrospective analysis of patients diagnosed with RPI at a university-affiliated primary care center, between the years 2012–2022. Pre-vertebral space diameter at C2 level on LNXR was compared to a control group as well as before and after treatment. A sensitivity analysis was performed.</div></div><div><h3>Results</h3><div>44 and 20 patients were included in the study and control group, respectively. Median pre-vertebral thickness was significantly different between the groups (14.9 mm [IQR: 12.5, 18.4] vs. 4.1 mm [3.6, 5], <em>p</em> &lt; 0.001). Sensitivity and specificity of LNXR combined with clinical presentation for RPI diagnosis were 87 % and 74 %, respectively. Median pre-vertebral space diameter before and after treatment declined significantly (14.3 mm [12.3, 18.1] vs. 7.2 mm [4.6, 9.6], <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>LNXR is a good and valid modality for the diagnosis of RPI, in conjunction with clinical presentation in ER setting. IV antibiotics are efficient for most children with RPI. Neck CT and surgical intervention should be reserved for select patients.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"11 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric RSV infection and respiratory coinfections: Is a link related to clinical severity? Single center retrospective study","authors":"Raffaele Falsaperla ,&nbsp;Francesco Gambilonghi ,&nbsp;Daria La Cognata ,&nbsp;Lucia Giovanna Tardino ,&nbsp;Silvia Marino ,&nbsp;Patrizia Grassi ,&nbsp;Grete Francesca Privitera ,&nbsp;Vincenzo Sortino ,&nbsp;Martino Ruggieri","doi":"10.1016/j.gpeds.2024.100233","DOIUrl":"10.1016/j.gpeds.2024.100233","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of the study was to assess whether there was a difference in terms of severity in paediatric patients assessed for respiratory symptoms in paediatric emergency departments between those who tested positive for RSV and those who presented with viral co-infections in addition to RSV. It was also assessed whether there was a difference between the two groups in terms of need for hospitalisation and ventilation.</div></div><div><h3>Methods</h3><div>This is a single center study from October 2022 to February 2023, compared two groups of patients: those infected with RSV and those coinfected with RSV and other viruses. Parameters examined included the severity of illness, as measured by the Clinical Respiratory Score (CRS), the need for and duration of hospitalization, and the need for ventilation via high flow nasal cannula (HFNC).</div></div><div><h3>Results</h3><div>The correlation with disease severity assessed by CRS in the two groups with RSV only and coinfection was not statistically significant (<em>p</em>-value 0.281). The correlation in the two groups between the need for hospitalization (<em>p-value</em> 1) and the need for ventilation (<em>p-value</em> 0.302) was also not significant. No significant correlation was found between the age of patients and CRS (<em>R</em> = −0.26, <em>p</em> = 0.119) and the age of patients and days of hospitalization (<em>R =</em> −0.013, <em>p =</em> 0.938).</div></div><div><h3>Conclusion</h3><div>These findings highlight the importance of careful management of RSV infections in children. Despite the limitations, the lack of significant differences in disease severity indicates the need to explore additional preventive strategies, such as RSV vaccination, to improve the clinical approach.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"10 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Children in jeopardy: Lessons learned from the Middle East Conflict!","authors":"Joseph Haddad","doi":"10.1016/j.gpeds.2024.100234","DOIUrl":"10.1016/j.gpeds.2024.100234","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"10 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation of a unique centrally monitored and operated neonatal transport network in a lower and middle-income country: A first of its kind initiative","authors":"Ranganatha A Devaranavadagi ,&nbsp;Kavya M G ,&nbsp;Netra S Kannur ,&nbsp;Karthik Nagesh N","doi":"10.1016/j.gpeds.2024.100232","DOIUrl":"10.1016/j.gpeds.2024.100232","url":null,"abstract":"<div><h3>Background</h3><div>With the current growth of many neonatal units in the country, good initial stabilization of sick neonates is possible at peripheral centers. However, poor neonatal transport and retrieval facilities are unfortunately leading to higher preventable mortality and morbidity in neonates arriving at a tertiary care center in poor condition.</div></div><div><h3>Objective</h3><div>To bridge the gap between referring hospital and tertiary care, this quality improvement initiative aimed to create a well-organized ‘network transport system’ for the round-the-clock provision of a city-wide retrieval system.</div></div><div><h3>Methods and intervention</h3><div>Various causes linked to adverse events in the transport and retrieval of sick infants were initially assessed through a ‘fishbone analysis’. A step-wise-driven PDSA cycle was performed. It was realized that a well-organized, centrally controlled network of fully equipped neonatal ambulances with trained personnel for delivering neonatal intensive care on wheels was necessary even in a tier-one city like Bengaluru, India. A network transport and retrieval system for the city of Bengaluru was systematically created, involving 10 partner hospitals in the Manipal group. Training of all personnel involved in transport, creating a good infrastructure of state-of-the-art ambulances, transport incubators with ventilators, remote monitoring systems, and the creation of a centralized helpline with 24/7 response. The facility was named Neonatal Care on Wheels (NOW) and was propagated as a NICU on Wheels.</div></div><div><h3>Results</h3><div>This initiative significantly improved the quality of neonatal transport as well as the stabilization of the neonate before transport.</div></div><div><h3>Conclusion</h3><div>This robust network transport has proven to show improvements in the quality of retrieval and survival similar to that seen in Western countries.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"10 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}