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Acquired cytomegaly–Description of three cases 获得性细胞肿大--三个病例的描述
Global pediatrics Pub Date : 2024-05-01 DOI: 10.1016/j.gpeds.2024.100176
Patrycja Kałużna , Ewa Maria Łuczkowska , Ksenia Mazur , Beata Łoniewska
{"title":"Acquired cytomegaly–Description of three cases","authors":"Patrycja Kałużna ,&nbsp;Ewa Maria Łuczkowska ,&nbsp;Ksenia Mazur ,&nbsp;Beata Łoniewska","doi":"10.1016/j.gpeds.2024.100176","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100176","url":null,"abstract":"<div><p>The case reports describe the hospitalization of three extremely premature infants who developed cytomegalovirus (CMV) infection. The most probable source of infection was their mothers' milk. Although the infants were already stable and had survived for several weeks, their health and lives were threatened by the CMV infection. Despite the Polish recommendations for feeding extreme preterm infants with fresh breast milk, we have implemented our own management procedure due to the specific clinical circumstances. We test the breast milk of a seropositive mother for CMV early on and then provide the infant with pasteurized milk from 8 days of age until the test results are available or up to 34 postmenstrual age if CMV presence is confirmed. This procedure ensures the health and safety of the infants while providing them with necessary nutrients. We also outline the treatment of premature infants, potential complications during therapy, and monitoring treatment effects. We describe milk pasteurization techniques and the differences in composition due to the processes used. The paper provides also a summary of practices for feeding extremely premature infants with milk from seropositive mothers in other countries.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000447/pdfft?md5=f2eeaf7e3ba517bb349b2fcfc2924257&pid=1-s2.0-S2667009724000447-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140843558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental health distress and associated factors among HIV- positive adolescents attending ART Clinics in Nigeria 尼日利亚接受抗逆转录病毒疗法(ART)治疗的艾滋病阳性青少年的心理健康问题及相关因素
Global pediatrics Pub Date : 2024-04-27 DOI: 10.1016/j.gpeds.2024.100180
Adebayo Akadri , Akinmade Adepoju , Olabisi Bamidele , Temitayo Oluwole , Kolawole Sodeinde , Olumide Abiodun
{"title":"Mental health distress and associated factors among HIV- positive adolescents attending ART Clinics in Nigeria","authors":"Adebayo Akadri ,&nbsp;Akinmade Adepoju ,&nbsp;Olabisi Bamidele ,&nbsp;Temitayo Oluwole ,&nbsp;Kolawole Sodeinde ,&nbsp;Olumide Abiodun","doi":"10.1016/j.gpeds.2024.100180","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100180","url":null,"abstract":"<div><h3>Background</h3><p>Mental health disorders may have a negative influence on health outcomes in patients with HIV; however, these conditions are under-diagnosed among adolescents living with HIV. This study aimed to assess the prevalence of mental health distress and associated factors among adolescents living with HIV attending Antiretroviral Therapy clinics in Nigeria.</p></div><div><h3>Methods</h3><p>This was a cross-sectional study of 212 HIV-infected adolescents attending routine HIV clinic visits across five high patient-density clinics in southwestern Nigeria. Mental health distress was assessed using the General Health Questionnaire-12 (GHQ-12) and data was analyzed using IBM-SPSS Statistics for Windows version 22.0 (IBM Corp., Armonk, NY, USA).</p></div><div><h3>Results</h3><p>The prevalence of mental health distress among participants was 34.9 %. On bivariate analysis, respondents who consumed alcohol sometimes had significantly higher mental health scores than those who never took alcohol (<em>t</em>-test 2.738; <em>P</em> = 0.007). There were no significant differences in the mean mental health scores of respondents with regards to social factors (smoking, experience of rape, disability status, mode of payment for health services, and number of living companions) and clinical factors (duration of diagnosis and treatment of HIV, the type of HAART regimen, and whether there had been a change in regimen). On multivariate analysis no social or clinical factor was found to be independently associated with mental health distress.</p></div><div><h3>Conclusions</h3><p>The prevalence of mental health distress among adolescents living with HIV in southwestern Nigeria is high. Respondents who consumed alcohol had significantly higher mental health scores than those who never took alcohol. Future studies should explore psychosocial stressors that could be determinants of mental health distress among adolescents living with HIV in Nigeria.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000484/pdfft?md5=6a17df51bd076faa608e1754a1bfa643&pid=1-s2.0-S2667009724000484-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital glucose-galactose malabsorption: A case report about cause and consequence, not exactly in this order 先天性葡萄糖-半乳糖吸收不良:一份关于前因后果的病例报告,顺序并不完全如此
Global pediatrics Pub Date : 2024-04-25 DOI: 10.1016/j.gpeds.2024.100181
Rafaella Mergener , Marcela Rodrigues Nunes , Lívia Polisseni Cotta Nascimento , Victória Feitosa Muniz , Carla Graziadio , Paulo Ricardo Gazzola Zen
{"title":"Congenital glucose-galactose malabsorption: A case report about cause and consequence, not exactly in this order","authors":"Rafaella Mergener ,&nbsp;Marcela Rodrigues Nunes ,&nbsp;Lívia Polisseni Cotta Nascimento ,&nbsp;Victória Feitosa Muniz ,&nbsp;Carla Graziadio ,&nbsp;Paulo Ricardo Gazzola Zen","doi":"10.1016/j.gpeds.2024.100181","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100181","url":null,"abstract":"<div><p>Congenital glucose-galactose malabsorption (CGGM) is a rare metabolic disorder caused by a deficient intestinal sodium-dependent glucose cotransporter (SGLT1) protein. Its failure leads to a lack of absorption of galactose, glucose, and sodium, which remains inside the intestinal lumen. The consequence of that involves, among other things, dehydration and diarrhea on neonatal onset. The basic treatment consists of diet management. A 6-month-old Brazilian infant with CGGM caused by a one base pair deletion on <em>SLC5A1</em>gene, in both alleles, causing a frameshift mutation and, consequently, a deleterious impact on the terminal protein portion is, for the first time, characterized here. Besides the common disease aspects, the child presented Necrotizing Enterocolitis (NEC), a new outcome for his condition. The fact that a non-consanguineous couple could produce a child with a recessive disease is puzzling. However, we were able to correlate all symptoms, including NEC, to the disruption of the protein terminal portion, based on literature review. This article brings a new point of view on disease report; putting together the social aspects, clinical examination, laboratory trials, genetic diagnostic, protein assemble and literature research in order to fulfill the patient history. This process allows us to improve the understanding of the disease mechanism, perform targeted genetic counseling and institute appropriate treatment using an adequate diet through nutritional guidance and surveillance.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000496/pdfft?md5=16562031c5f5037e3799ab18bf531471&pid=1-s2.0-S2667009724000496-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heat waves and pediatric emergency department febrile-related visits 热浪与儿科急诊室发热相关就诊率
Global pediatrics Pub Date : 2024-04-21 DOI: 10.1016/j.gpeds.2024.100178
Miguel Ángel Molina Gutiérrez , Belén Tortajada Hernández , Clara Díez-Picazo Garot , María Camacho Gil , María Bellido Gómez , Ferrán Campillo López
{"title":"Heat waves and pediatric emergency department febrile-related visits","authors":"Miguel Ángel Molina Gutiérrez ,&nbsp;Belén Tortajada Hernández ,&nbsp;Clara Díez-Picazo Garot ,&nbsp;María Camacho Gil ,&nbsp;María Bellido Gómez ,&nbsp;Ferrán Campillo López","doi":"10.1016/j.gpeds.2024.100178","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100178","url":null,"abstract":"<div><h3>Background</h3><p>In recent decades, we have observed an increase in ambient temperature due to the effects of climate change.</p></div><div><h3>Objective</h3><p>In this study, we aimed to determine whether there is a correlation between environmental temperature and urgent consultations of pediatric patients related to febrile processes.</p></div><div><h3>Research design and method</h3><p>We conducted an observational, retrospective, single-center study in the pediatric ED of the Hospital Universitario La Paz, Madrid, Spain. We analyzed visits to the ED for febrile processes during the last heat waves in Madrid.</p></div><div><h3>Results</h3><p>Between 2018 and 2022, seven heat waves were recorded in Madrid. A total of 3967 patients with fever as the main reason for consultation attended during this period. In two of the seven heat waves analyzed, febrile-related visits were higher during the heat alert. The first occurred between 6/11/2022 and 6/16/2022, with 345 febrile-related ED visits, 25.4% more than the previous days and 19.7% more than the following days. During this heat wave, we observed a positive correlation between the maximum temperature recorded and the number of visits to the ED for febrile processes (Rs=0.552; <em>p</em> = 0.018). During the heat wave between 09/07/2022 and 17/07/2022, 362 febrile-related ED visits were 3.1% more than the previous days and 24.9% more than the following days.</p></div><div><h3>Conclusion</h3><p>During recent heat waves in our city, we registered an increase in febrile-related visits compared with non-heat alert periods.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000460/pdfft?md5=d20af6c505ad42f08aaa9ca8dec18390&pid=1-s2.0-S2667009724000460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-post implementation study of chronic diuretic clinical practice guideline for bronchopulmonary dysplasia in preterm infants 早产儿支气管肺发育不良慢性利尿剂临床实践指南》实施前和实施后研究
Global pediatrics Pub Date : 2024-04-20 DOI: 10.1016/j.gpeds.2024.100177
Brittany M. Thompson , Anna Wanzenberg , Kimberly Van , Sreekanth Viswanathan
{"title":"Pre-post implementation study of chronic diuretic clinical practice guideline for bronchopulmonary dysplasia in preterm infants","authors":"Brittany M. Thompson ,&nbsp;Anna Wanzenberg ,&nbsp;Kimberly Van ,&nbsp;Sreekanth Viswanathan","doi":"10.1016/j.gpeds.2024.100177","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100177","url":null,"abstract":"<div><h3>Background</h3><p>Chronic diuretics are frequently used (off-label) in preterm infants to manage evolving or established bronchopulmonary dysplasia (BPD). Chronic diuretic use, however, is limited by tolerance with no long-term safety and efficacy data, leading to wide variation in its use in preterm infants.</p></div><div><h3>Objective</h3><p>To determine the impact of the chronic diuretic clinical practice guideline (CPG) on the patterns of diuretic use, severity of BPD, and hospital length of stay (LOS) in preterm infants born less than 32 weeks gestation.</p></div><div><h3>Methods</h3><p>Single-center retrospective pre-post CPG cohort study in a level IV neonatal intensive care unit. Chronic diuretic CPG was implemented in November 2021 and the data was collected one year before (Pre-CPG) and one year after (Post-CPG).</p></div><div><h3>Results</h3><p>In total, 73 infants (39 Pre-CPG, and 34 Post-CPG) were identified. There were no significant differences in patient characteristics at birth or in the use and duration of respiratory support between the two groups. Compared to Pre-CPG, the frequency of thiazide diuretic use was not decreased in Post-CPG (30.8 vs. 20.6 %, <em>p</em> = 0. 42), but the duration of use was significantly reduced (35 vs. 6 days, <em>p</em> = 0.01). Both frequency (20.5 vs. 2.9 %) and duration (28.5 vs. 4 days) of spironolactone were reduced in the Post-CPG (<em>p</em> &lt; 0.05). Furosemide exposure (69.2 vs. 41.2 %, <em>p</em> = 0.02) and total doses [3.0 (0.0–8.0) vs. 0.0 (0.0–2.3), <em>p</em> = 0.003] were also significantly reduced in the Post-CPG. The incidence of any BPD at 36 weeks and LOS were similar between groups, while the incidence of moderate/severe BPD and home oxygen use were decreased in the Post-CPG.</p></div><div><h3>Conclusions</h3><p>Chronic diuretic CPG was associated with a reduction in diuretic exposure in preterm infants</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000459/pdfft?md5=b7f962ad2e6ffeb299c50b4b400e604a&pid=1-s2.0-S2667009724000459-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum regarding missing Declaration of Competing Interest Statements in Previously Published Articles 关于以前发表的文章中缺少竞争利益声明的勘误
Global pediatrics Pub Date : 2024-04-16 DOI: 10.1016/j.gpeds.2024.100175
{"title":"Erratum regarding missing Declaration of Competing Interest Statements in Previously Published Articles","authors":"","doi":"10.1016/j.gpeds.2024.100175","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100175","url":null,"abstract":"","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000435/pdfft?md5=2111501d5c211f8c512ae0ce6e1ffef7&pid=1-s2.0-S2667009724000435-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life in a cohort of Kenyan children with cerebral palsy 肯尼亚一组脑瘫儿童的生活质量
Global pediatrics Pub Date : 2024-04-16 DOI: 10.1016/j.gpeds.2024.100172
Pauline Samia , Melissa Tirkha , Amina-Inaara Kassam , Richard Muindi , Wahu Gitaka , Susan Wamithi , James Orwa , Eugene Were , Michael Shevell
{"title":"Quality of life in a cohort of Kenyan children with cerebral palsy","authors":"Pauline Samia ,&nbsp;Melissa Tirkha ,&nbsp;Amina-Inaara Kassam ,&nbsp;Richard Muindi ,&nbsp;Wahu Gitaka ,&nbsp;Susan Wamithi ,&nbsp;James Orwa ,&nbsp;Eugene Were ,&nbsp;Michael Shevell","doi":"10.1016/j.gpeds.2024.100172","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100172","url":null,"abstract":"<div><h3>Aim</h3><p>The objective of the study was to evaluate the quality of life in Kenyan children (age 4–18 years) with cerebral palsy (CP).</p></div><div><h3>Methods</h3><p>A cross-sectional descriptive study was conducted. Children with CP were recruited from the pediatric clinics at the Aga Khan hospital Nairobi (AKUHN). Parent proxy-reports using CPQoL-child and CPQoL-adolescents were obtained. Clinical and demographic data were compiled from medical records and parent interviews. A Likert scale was utilized to determine QoL across several domains.</p></div><div><h3>Results</h3><p>One hundred and fourteen child–parent dyads with CP were recruited. The median age of study participants was 8 years (IQR 3–13 years), with males being the majority (57.02 %). Parent proxy-reports using CPQoL-child scale were obtained for <em>n</em> = 93 and CPQoL-adolescents for <em>n</em> = 21 respondents. Parents in both groups reported low domain QoL scores pertaining to function, family health and rehabilitation service accessibility.</p></div><div><h3>Interpretation</h3><p>Stigma, accessibility to services, therapies and schooling, particularly for children with severe functional limitations, remains a concern. Caregivers would benefit from awareness campaigns of available supports and from local community respite programs. Where national support systems exist, there are critical inefficiencies in service delivery to target population.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400040X/pdfft?md5=0b8694f132d35a40953f4121726d572a&pid=1-s2.0-S266700972400040X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commonly used medications for respiratory and cardiovascular support in neonates: Evidence, knowledge gaps, and future perspectives 新生儿呼吸和心血管支持的常用药物:证据、知识差距和未来展望
Global pediatrics Pub Date : 2024-04-07 DOI: 10.1016/j.gpeds.2024.100171
Eleni Agakidou , Angeliki Kontou , Ilias Chatziioannidis , William Chotas , Kosmas Sarafidis
{"title":"Commonly used medications for respiratory and cardiovascular support in neonates: Evidence, knowledge gaps, and future perspectives","authors":"Eleni Agakidou ,&nbsp;Angeliki Kontou ,&nbsp;Ilias Chatziioannidis ,&nbsp;William Chotas ,&nbsp;Kosmas Sarafidis","doi":"10.1016/j.gpeds.2024.100171","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100171","url":null,"abstract":"<div><p>Critically ill neonates admitted to neonatal intensive care units require specialized pharmacological treatment due to various medical conditions. However, despite the decades of clinical use of some pharmacological agents, there are still significant knowledge gaps surrounding their everyday use. The wide variability of drugs used in neonates, and how they are used in different settings worldwide, precisely reflects this fact. A major factor contributing to this variability is the lack of adequate studies regarding the effectiveness and safety of medications administered to neonates, especially in those born preterm. This is mainly due to inherent difficulties in performing pharmacokinetic, pharmacodynamic, and clinical studies in this age group. In this review, we discuss the existing data on medications most commonly used in the respiratory and cardiovascular care of the sick neonate. Knowledge gaps and future perspectives are highlighted, as well.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000393/pdfft?md5=10593f1dd7460890ebba1b8d438e96c6&pid=1-s2.0-S2667009724000393-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140554424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral corneal perforation due to vitamin A deficiency in a child with seizures 一名癫痫患儿因缺乏维生素 A 导致双侧角膜穿孔
Global pediatrics Pub Date : 2024-04-03 DOI: 10.1016/j.gpeds.2024.100170
Maiah Zarrabi , Giovanni A. Campagna , Xander Parisky , Irwin Weiss , Simon Sheung Man Fung
{"title":"Bilateral corneal perforation due to vitamin A deficiency in a child with seizures","authors":"Maiah Zarrabi ,&nbsp;Giovanni A. Campagna ,&nbsp;Xander Parisky ,&nbsp;Irwin Weiss ,&nbsp;Simon Sheung Man Fung","doi":"10.1016/j.gpeds.2024.100170","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100170","url":null,"abstract":"<div><p>Dietary vitamin A deficiency is exceptionally rare in resource-rich countries. A well-known consequence of vitamin A deficiency is xeropthalmia, a spectrum which includes pathologic dryness of the conjunctiva and cornea, which can lead to corneal infection, thinning, or perforation, portending a very poor visual prognosis. This case describes a 10-year-old boy with Lennox-Gastaut syndrome and autism who developed malnutrition and deficiencies of multiple micronutrients, including copper, zinc, and an undetectable vitamin A blood level, secondary to dietary restriction for seizure control. After experiencing 3 months of nonspecific symptoms of ocular surface disease including eye dryness, eye redness, and tearing, he developed rapidly progressive keratomalacia and polymicrobial corneal ulcers. Despite treatment with topical antibiotics, he ultimately suffered bilateral corneal perforation requiring full-thickness corneal transplants. This report aims to raise the awareness of potentially debilitating nutrient deficiencies related to restricted diets, which are becoming increasingly common in numerous chronic pediatric conditions including epilepsy. This report also brings attention to the severe, long-term complications that can arise from nutrient deficiencies. Pediatric providers should consider a diagnosis of vitamin A deficiency in any child with a history of a restricted diet and ophthalmological symptoms.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000381/pdfft?md5=df45dd30c99175251d6120b8f1502592&pid=1-s2.0-S2667009724000381-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140349791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early development of infants born prematurely who were conceived through assisted reproductive technologies 通过辅助生殖技术受孕的早产儿的早期发育情况
Global pediatrics Pub Date : 2024-03-24 DOI: 10.1016/j.gpeds.2024.100166
Vesna Pavlović , Aleksandra Stojadinović , Georgios Konstantinidis , Katarina Katić
{"title":"Early development of infants born prematurely who were conceived through assisted reproductive technologies","authors":"Vesna Pavlović ,&nbsp;Aleksandra Stojadinović ,&nbsp;Georgios Konstantinidis ,&nbsp;Katarina Katić","doi":"10.1016/j.gpeds.2024.100166","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100166","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to determine physical and psychomotor development characteristics during the first 24 months of life in prematurely born children conceived with assistive reproductive technologies and to determine specific risk factors for deviation from typical development.</p></div><div><h3>Patients and methods</h3><p>The study included 308 prematurely born children (154 conceived with assistive reproductive technologies – ART group and 154 conceived naturally – NC group) hospitalized at the Institute for the Health Care of Children and Adolescents of Vojvodina in Serbia. The physical and psychomotor development was monitored during the first two years of life.</p></div><div><h3>Results</h3><p>Birth weight was statistically significantly higher in the NC group than in the ART group, and IUGR was more often present in the ART group than in the NC group of newborns. The mean values of body weight, length, and head circumference of children from both groups did not differ statistically significantly at 18 months. At 12 and 18 months, children from the ART group significantly more often had below-average scores on the test for assessment of psychomotor development (corrected GDQ &lt;90) than children from the NC group, but not at 24 months. Logistic regression analysis has shown that at 12 and 18 months, multiple pregnancy is an independent risk factor for lower GDQ.</p></div><div><h3>Conclusion</h3><p>At the age of 12 months, prematurely born children conceived with ART do not differ in physical development from prematurely born children after natural conception. At 12 and 18 months, prematurely born children conceived with ART achieve lower global developmental scores than children conceived naturally, but not at 24 months of age. Multiple pregnancies are an independent risk factor for lower achievement on the test for assessment of psychomotor development in prematurely born children.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"8 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000344/pdfft?md5=4203f97c7d8c5bfffd245f04c8b80506&pid=1-s2.0-S2667009724000344-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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