Global advances in integrative medicine and health最新文献

筛选
英文 中文
In Vitro and in Silico Analysis of α -Amylase Inhibitory Activity of Ethanolic Extract of Adhatoda vasica Leaves. Adhatoda vasica 叶乙醇提取物的 α - 淀粉酶抑制活性的体外和硅学分析
Global advances in integrative medicine and health Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241270621
Chandrajeet K Yadav, Sandhya Kc, Shankar Thapa
{"title":"In Vitro and in Silico Analysis of α -Amylase Inhibitory Activity of Ethanolic Extract of <i>Adhatoda vasica</i> Leaves.","authors":"Chandrajeet K Yadav, Sandhya Kc, Shankar Thapa","doi":"10.1177/27536130241270621","DOIUrl":"10.1177/27536130241270621","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic individuals have a higher probability of suffering from illness and death due to small blood vessel-related problems such as retinopathy, neuropathy, nephropathy, and stroke than other complications. There are many synthetic anti-diabetic agents available, but these can be expensive and have undesirable pathological effects. The enzyme α-amylase (hydrolase), catalyzes the hydrolysis of starch to maltose and glucose via the cleavage of α-1,4-glucosidic linkages. Diabetes mellitus patients may benefit from a therapeutic strategy that involves slowing the hydrolysis of starch by inhibiting the activity of α-amylase. Thus, looking for cost-effective, natural, and safe antidiabetic agents is essential. This study aims to screen phytoconstituents and evaluate the in-vitro and in-silico α-amylase inhibitory activity of the ethanolic extract of <i>Adhatoda vasica</i> leaves.</p><p><strong>Methods: </strong>The extraction of <i>Adhatoda vasica</i> leaves was performed using ethanol via the Soxhlet extraction process. Different concentrations (100 μg/mL to 1000 μg/mL) of ethanolic extract, Acarbose, and Sitagliptin, were prepared and evaluated for α-amylase inhibitory activity using the spectrophotometric method. Molecular docking (AutodockVina 1.2.0) and toxicity profiling (SToPToX web server) studies were performed.</p><p><strong>Results: </strong>The ethanolic extract of <i>Adhatoda vasica</i> leaves showed the highest percentage inhibition against α-amylase (56.763 ± 0.0035) at a concentration of 1000 μg/mL. The in-silico study supported this inhibitory activity. Vasicoline (<b>C5</b>) and Quercetin (<b>C9</b>), the active constitute of <i>Adhatoda vasica</i>, showed the best binding energies of -8.3 and -8.0 Kcal/mol, respectively against α-amylase enzyme (PDBID: 4W93). A toxicity study revealed the safety profile of the plant extract.</p><p><strong>Conclusion: </strong>It was concluded that <i>Adhatoda vasica</i> leaves possess some bioactive compounds that are responsible for controlling blood glucose levels, and their identification, purification, and isolation may lead to the development of new therapeutic agents with fewer side effects than the available drugs.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241270621"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview and Feasibility of a Novel Transdisciplinary Integrative Approach to High Impact Chronic Pain in Vermont. 佛蒙特州新型跨学科慢性疼痛综合治疗方法概述及可行性。
Global advances in integrative medicine and health Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241271643
Joshua Plavin, Jerry Landau, Gail L Rose, Erika Ziller, Sarah Nowak, Heather Finley, Laurel Audy, Jon Porter
{"title":"Overview and Feasibility of a Novel Transdisciplinary Integrative Approach to High Impact Chronic Pain in Vermont.","authors":"Joshua Plavin, Jerry Landau, Gail L Rose, Erika Ziller, Sarah Nowak, Heather Finley, Laurel Audy, Jon Porter","doi":"10.1177/27536130241271643","DOIUrl":"10.1177/27536130241271643","url":null,"abstract":"<p><strong>Background/objective: </strong>Pain is one of the most common chronic conditions in the US, estimated to affect 20.9% of the population (51.6 million people). We evaluated the Partners Aligned in Transformative Healing (PATH) program at University Medical Center's Comprehensive Pain Program clinic. Feasibility, initial clinical and financial results were assessed to inform payers' support for PATH, an integrative transdisciplinary program within a bundled payment format.</p><p><strong>Methods: </strong>Participants completed a multi-week program including integrative therapies, with empirically validated assessment surveys administered at the beginning and end of the program. Insurance claims data were analyzed 12 months pre- and post-program. Statistical significance of pre-post differences was assessed by paired T-tests with <i>P</i> < 0.05.</p><p><strong>Results: </strong>Between June 2019 and August 2022, 170 individuals enrolled in PATH, 151 (88.8%) completed the program, and 121 participants completed outcome surveys. Participants were predominately White, non-Hispanic (98%), female (76%), with an average age of 49.8. All participant-reported clinical outcomes (PROs) showed statistically significant improvement from baseline to final assessment, and some but not all were clinically significant. PEG subscale of average pain interference, enjoyment of life, and interference with general activity each decreased. The T-scores for the following domains of PROMIS-29 decreased: Pain interference; fatigue; sleep disturbance; anxiety, and depression. The PROMIS-29 domains of overall physical function and social roles and activities mean T-scores increased. Per Member Per Month (PMPM) total cost of care decreased by $462 (18%). Emergency room utilization for all diagnoses decreased by 457 visits/1000 patients (65%), and for pain-related diagnoses by 194 visits/1000 patients (67%) during the observation period.</p><p><strong>Conclusions: </strong>Results suggest that the PATH Program is a feasible and acceptable model that shows initial effectiveness relative to short-term patient-reported clinical outcomes and shows signs of durability in both utilization and financial outcomes at 1 year. The results support continued study including a multi-site RCT.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241271643"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Qualitative Insights Regarding the Use of Tai Chi for Pain Management Among Adults With HIV. 关于在艾滋病病毒感染者中使用太极拳控制疼痛的定性分析。
Global advances in integrative medicine and health Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241277561
Eugene M Dunne, Christina Mitchell, Georgiana McTigue, Rochelle K Rosen, Gloria Y Yeh, Michael P Carey
{"title":"Qualitative Insights Regarding the Use of Tai Chi for Pain Management Among Adults With HIV.","authors":"Eugene M Dunne, Christina Mitchell, Georgiana McTigue, Rochelle K Rosen, Gloria Y Yeh, Michael P Carey","doi":"10.1177/27536130241277561","DOIUrl":"10.1177/27536130241277561","url":null,"abstract":"<p><strong>Background: </strong>Approximately one-half of all adults with HIV experience chronic pain. Needed are nonpharmacological approaches to improve pain management in this population.</p><p><strong>Methods: </strong>For this study, we conducted in-depth qualitative interviews (n = 20) with thirteen adults with HIV and 7 HIV care providers regarding their perceptions of Tai Chi for chronic pain management. The interviews were audio recorded, transcribed, double-coded, and analyzed using applied thematic analysis.</p><p><strong>Results: </strong>HIV patients had limited prior exposure to Tai Chi and had not previously considered this practice for pain management. However, after viewing a brief video demonstration of Tai Chi, patients recognized potential benefits, including relaxation, stress reduction, and pain lessening. Patients were surprised by the gentle nature of Tai Chi and expressed enthusiasm to learn more about Tai Chi. HIV healthcare providers similarly had limited knowledge of Tai Chi for pain management. HIV care providers shared several helpful insights on the potential implementation of Tai Chi with this population.</p><p><strong>Conclusions: </strong>Adults with HIV and healthcare providers were optimistic that Tai Chi would reduce stress and ease chronic pain. These data suggest that Tai Chi would be of interest to HIV patients and care providers as a novel pain management strategy.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241277561"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Randomized Controlled Trial of a Culturally Adapted, Community-Based, Remotely Delivered Mindfulness Program for Latinx Patients With Breast Cancer is Acceptable and Feasible While Reducing Anxiety. 针对拉美裔乳腺癌患者的文化适应性、基于社区的远程传递正念计划的随机对照试验在减轻焦虑的同时是可接受和可行的。
Global advances in integrative medicine and health Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241274240
Maria Juarez-Reyes, Erica Martinez, Lan Xiao, Lisa Goldman Rosas
{"title":"A Randomized Controlled Trial of a Culturally Adapted, Community-Based, Remotely Delivered Mindfulness Program for Latinx Patients With Breast Cancer is Acceptable and Feasible While Reducing Anxiety.","authors":"Maria Juarez-Reyes, Erica Martinez, Lan Xiao, Lisa Goldman Rosas","doi":"10.1177/27536130241274240","DOIUrl":"10.1177/27536130241274240","url":null,"abstract":"<p><strong>Background/objective: </strong>Few Spanish mindfulness interventions have been evaluated in Latinx patients with cancer. We culturally adapted a mindfulness intervention for Spanish speaking Latinx patients. The objective was to measure feasibility and acceptability as primary outcomes, with changes in anxiety, depression, and sleep as secondary outcomes.</p><p><strong>Method: </strong>Spanish-speaking Latinx patients with breast cancer (n = 31) were randomized, between April 2021 and May 2022 to either intervention or wait-list control groups. The mindfulness intervention consisted of 6-weekly 1.5-hour sessions remotely delivered by a novice facilitator. Cultural adaptations included language, metaphor, goal, concept, trauma informed, and acknowledgement of spirituality. Feasibility was benchmarked as 75% of participants attending their first session, 75% of participants completing 4 of 6 sessions, and scoring ≥ 4 on a 5-point Likert feasability scale measuring ability to implement changes after 6-weeks. Acceptability was measured as scoring ≥ 4 on a 5-point Likert scale measuring usefulness and relevance of the mindfulness intervention for each session. An intention-to-treat, linear mixed model with repeated measures analysis examined changes in anxiety, depression, and sleep at week 6 and 18 (3 months post intervention).</p><p><strong>Results: </strong>All three feasibility benchmarks were met with 75% of first session attendance, 96% of participants completing 4 of 6 sessions, and 94% scoring ≥ 4, on the feasibility scale (Mean (SD) = 4.3 (0.6)). Acceptability scores for both usefulness and relevance questions were ≥ 4 across all 6 sessions. Anxiety was significantly reduced at 3 months (-3.6 (CI -6.9, -0.2), <i>P</i> = .04), but is of unclear clinical significance given the small change. Depression scores declined, but not significantly, and there were no changes in sleep.</p><p><strong>Conclusion: </strong>This culturally adapted, remotely delivered mindfulness intervention using a novice facilitator was acceptable and feasible and demonstrated associated reductions in anxiety amongst Spanish speaking Latinx patients with breast cancer.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID# NCT04834154.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241274240"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Preliminary Integrated Health Care Clinical Competencies for United States Doctor of Chiropractic Programs: A Modified Delphi Consensus Process. 为美国脊骨神经科医生课程开发初步的综合医疗临床能力:改良德尔菲共识程序。
Global advances in integrative medicine and health Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241275944
Clinton J Daniels, Zachary A Cupler, Jason G Napuli, Robert W Walsh, Anna-Marie L Ziegler, Kevin W Meyer, Matthew J Knieper, Sheryl A Walters, Stacie A Salsbury, Robert J Trager, Jordan A Gliedt, Morgan D Young, Kristian R Anderson, Eric J Kirk, Scott A Mooring, Patrick J Battaglia, David J Paris, Amanda G Brown, Justin M Goehl, Cheryl Hawk
{"title":"Development of Preliminary Integrated Health Care Clinical Competencies for United States Doctor of Chiropractic Programs: A Modified Delphi Consensus Process.","authors":"Clinton J Daniels, Zachary A Cupler, Jason G Napuli, Robert W Walsh, Anna-Marie L Ziegler, Kevin W Meyer, Matthew J Knieper, Sheryl A Walters, Stacie A Salsbury, Robert J Trager, Jordan A Gliedt, Morgan D Young, Kristian R Anderson, Eric J Kirk, Scott A Mooring, Patrick J Battaglia, David J Paris, Amanda G Brown, Justin M Goehl, Cheryl Hawk","doi":"10.1177/27536130241275944","DOIUrl":"10.1177/27536130241275944","url":null,"abstract":"<p><strong>Background: </strong>There has been rapid growth of chiropractors pursuing career opportunities in both public and private hospitals and other integrated care settings. Chiropractors that prosper in integrated care settings deliver patient-centered care, focus on the institutional mission, understand and adhere to organizational rules, and are proficient in navigating complex systems. The Council on Chiropractic Education Accreditation Standards do not outline specific meta-competencies for integrated care clinical training.</p><p><strong>Objective: </strong>The purpose of this study was to develop preliminary integrated health care competencies for DC programs to guide the advancement of clinical chiropractic education.</p><p><strong>Methods: </strong>A systematic literature search was performed. Articles were screened for eligibility and extracted in duplicate. Domains and seed statements were generated from this literature, piloted at a conference workshop, and evaluated via a modified Delphi consensus process. Of 42 invited, 36 chiropractors participated as panelists. Public comment period yielded 20 comments, none resulting in substantive changes to the competencies.</p><p><strong>Results: </strong>Of 1718 citations, 23 articles met eligibility criteria. After 2 modified Delphi rounds, consensus was reached on all competency statements. A total of 78 competency statements were agreed upon, which encompassed 4 domains and 11 subdomains. The 4 domains were: 1) Collaboration, (2) Clinical Excellence, (3) Communication, and (4) Systems Administration.</p><p><strong>Conclusion: </strong>We identified 78 preliminary competencies appropriate for preparing DC students and early career chiropractors for clinical practice in integrated healthcare settings. Educational programs may consider these competencies for curricular design and reform to strengthen DC program graduates for integrated practice, advanced training, and employment.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241275944"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of a mHealth Physical Activity Promotion Intervention With Mindful Awareness for Young Adult Cancer Survivors: Design and Methods of Opt2Move Full Factorial Trial. 优化针对年轻成人癌症幸存者的移动医疗体育锻炼促进干预措施:Opt2Move 全因子试验的设计与方法。
Global advances in integrative medicine and health Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241265669
Jean Miki Reading, Payton Solk, Julia Starikovsky, Kristina Hasanaj, Shirlene D Wang, Juned Siddique, Stacy D Sanford, John Salsman, Bruriah Horowitz, Hannah Freeman, Jacqueline Alexander, Christina Sauer, Bonnie Spring, David Victorson, Siobhan M Phillips
{"title":"Optimization of a mHealth Physical Activity Promotion Intervention With Mindful Awareness for Young Adult Cancer Survivors: Design and Methods of Opt2Move Full Factorial Trial.","authors":"Jean Miki Reading, Payton Solk, Julia Starikovsky, Kristina Hasanaj, Shirlene D Wang, Juned Siddique, Stacy D Sanford, John Salsman, Bruriah Horowitz, Hannah Freeman, Jacqueline Alexander, Christina Sauer, Bonnie Spring, David Victorson, Siobhan M Phillips","doi":"10.1177/27536130241265669","DOIUrl":"10.1177/27536130241265669","url":null,"abstract":"<p><strong>Background: </strong>Opt2Move is a theory-guided moderate and vigorous physical activity (MVPA) promotion trial that uses multiphase optimization strategy (MOST) methodology to evaluate the individual and combined effects of four intervention components in a full factorial experiment among young adult cancer survivors (YACS; N = 304). All participants will receive the core mHealth MVPA intervention, which includes a Fitbit and standard self-monitoring Opt2Move smartphone application. YACS will be randomized to one of 16 conditions to receive between zero and four additional components each with two levels (yes v. no): E-Coach, buddy, general mindfulness, and MVPA-specific mindfulness.</p><p><strong>Objective: </strong>The primary aim is to determine the individual and combined effects of the components on MVPA post-intervention (12-weeks) and at 24-week follow-up. The secondary aim is to examine how changes in MVPA are associated with patient-reported outcomes, light-intensity activity, sedentary time, and sleep duration and quality. Potential mediators and moderators of component effects will also be examined.</p><p><strong>Results: </strong>Results will support the selection of a package of intervention components optimized to maximize MVPA to be tested in a randomized controlled trial.</p><p><strong>Conclusion: </strong>Opt2Move represents the first systematic effort to use MOST to design an optimized, scalable mHealth MVPA intervention for YACS and will lead to an improved understanding of how to effectively change YACS' MVPA and ultimately, improve health and disease outcomes.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241265669"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a Menopausal Transition Health Promotion Intervention With Indigenous, Integrative, and Biomedical Health Education: A Community-Based Approach With Urban American Indian/Alaska Native Women. 利用土著、综合和生物医学健康教育制定更年期过渡健康促进干预措施:针对美国印第安/阿拉斯加原住民城市妇女的社区方法。
Global advances in integrative medicine and health Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241268232
Lisa Taylor-Swanson, Jacqueline Kent-Marvick, Sharon Déezbaaˈ Austin, Jessica Ellis, Claudia Charles, Ryan Ward, Leslie Crandall, Saraí Negrete Macias, Camille Moreno, Sara E Simonsen
{"title":"Developing a Menopausal Transition Health Promotion Intervention With Indigenous, Integrative, and Biomedical Health Education: A Community-Based Approach With Urban American Indian/Alaska Native Women.","authors":"Lisa Taylor-Swanson, Jacqueline Kent-Marvick, Sharon Déezbaaˈ Austin, Jessica Ellis, Claudia Charles, Ryan Ward, Leslie Crandall, Saraí Negrete Macias, Camille Moreno, Sara E Simonsen","doi":"10.1177/27536130241268232","DOIUrl":"10.1177/27536130241268232","url":null,"abstract":"<p><strong>Background: </strong>Few studies have examined the menopausal transition in American Indian and Alaska Native (AI/AN) women; these reports indicate they are the most likely group to report bothersome vasomotor symptoms (VMS). Evidence demonstrates VMS may be a biomarker for chronic diseases. Thus, evidence-based interventions to improve VMS and other symptoms and health-screening rates for urban midlife AI/AN women are needed.</p><p><strong>Objective: </strong>The objectives of this community-based project were to form a Community Advisory Board (CAB) with whom to: 1) conduct CAB meetings (similar to a focus group) with midlife AI/AN women to understand their lived health care experiences and needs during the menopausal transition; and 2) obtain guidance in creating a tailored intervention.</p><p><strong>Methods: </strong>Eligible participants indicated they were registered members of American Indian Tribes, self-identified as a woman, aged 35 or older, and were recruited through the Urban Indian Center of Salt Lake and community outreach. Three CAB meetings were conducted via Zoom. A qualitative-descriptive approach was used for analysis, with the aim of staying close to the data to understand AI/AN women's experiences and needs. Transcripts were iteratively coded using content/thematic analysis.</p><p><strong>Results: </strong>Four themes emerged: 1) lack of and desire for information about the menopause transition; 2) barriers to accessing care; 3) matriarchal priorities impacting personal health outcomes; and 4) preferences for Indigenous and integrative medicine as first-line interventions, followed by conventional medicine.</p><p><strong>Conclusions: </strong>Among this sample of urban AI/AN women, there was a great need for and interest in information about menopause, both for themselves and for their daughters and family. Integrative and Indigenous approaches were preferred. Proposed next steps include developing and pilot-testing a nurse-delivered health-education intervention with Indigenous, integrative, and conventional medical content.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241268232"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mechanism of Anti-Viral Activity of a Novel, Hydroponically Selenium-Enriched Garlic Powder (SelenoForce®) Against SARS-CoV-2 Virus. 新型水培富硒大蒜粉(SelenoForce®)对SARS-CoV-2病毒的抗病毒作用机制
Global advances in integrative medicine and health Pub Date : 2024-08-08 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241268100
Muhammed Majeed, Kalyanam Nagabhushanam, Lincy Lawrence, Priji Prakasan, Lakshmi Mundkur
{"title":"The Mechanism of Anti-Viral Activity of a Novel, Hydroponically Selenium-Enriched Garlic Powder (SelenoForce<sup>®</sup>) Against SARS-CoV-2 Virus.","authors":"Muhammed Majeed, Kalyanam Nagabhushanam, Lincy Lawrence, Priji Prakasan, Lakshmi Mundkur","doi":"10.1177/27536130241268100","DOIUrl":"10.1177/27536130241268100","url":null,"abstract":"<p><strong>Abstract: </strong>The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is far from over as new strains are emerging all over the world. Selenium as a micronutrient is important for immunity and also has anti-viral activity.</p><p><strong>Objective: </strong>The study evaluated the activity of a Selenium enriched garlic powder (SeGP or SelenoForce<sup>®</sup>) against SARS-CoV-2 viral replication in vitro and explored its possible mechanism of action.</p><p><strong>Methods: </strong>The anti-SARS-CoV-2 activity assay was carried out in Vero E6 cells in vitro. Human lung carcinoma A549 cells were used to study the antioxidant activity, expression of angiotensin converting enzyme (ACE), transmembrane protease, serine 2 (TMPRSS2) and the activity of proprotein convertase, and furin. Anti-inflammatory activity was evaluated in lipopolysaccharide-activated RAW 264.7 cells.</p><p><strong>Results: </strong>SeGP inhibited the replication of SARS-CoV-2 in Vero E6 cells with an IC<sub>50</sub> of 19.59 μg/ml. It exhibited significant antioxidant activity in vitro with IC<sub>50</sub> value determined as 43.45 μg/ml. The Selenium enriched product inhibited the expression of ACE and TMPRSS2 and also showed inhibition of furin protease activity. In the presence of SeGP, the secretion of nitric oxide, interleukin -6 and TNF-α were reduced in activated RAW 264.7 macrophages.</p><p><strong>Conclusion: </strong>The results of the study suggest that Selenium enriched garlic powder could inhibit SARS-CoV-2 multiplication in vitro, reduce oxidative stress and inflammatory mediators suggesting that it could be developed as an effective supplement or adjunct therapy to combat viral infections.</p>","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241268100"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional Medicine's Contribution to Health Care Access in Burkina Faso. 传统医学对布基纳法索医疗服务的贡献。
Global advances in integrative medicine and health Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241275197
Kampadilemba Ouoba, Wendégoudi Hyacinthe Bonkoungou, Rasmané Semdé
{"title":"Traditional Medicine's Contribution to Health Care Access in Burkina Faso.","authors":"Kampadilemba Ouoba, Wendégoudi Hyacinthe Bonkoungou, Rasmané Semdé","doi":"10.1177/27536130241275197","DOIUrl":"10.1177/27536130241275197","url":null,"abstract":"","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241275197"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11311143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the New Cochrane Column for Global Advances in Integrative Medicine and Health. 介绍 "全球整合医学与健康进展 "新科赫伦专栏。
Global advances in integrative medicine and health Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI: 10.1177/27536130241261160
Gloria Y Yeh, Erik J Groessl, L Susan Wieland
{"title":"Introducing the New Cochrane Column for Global Advances in Integrative Medicine and Health.","authors":"Gloria Y Yeh, Erik J Groessl, L Susan Wieland","doi":"10.1177/27536130241261160","DOIUrl":"https://doi.org/10.1177/27536130241261160","url":null,"abstract":"","PeriodicalId":73159,"journal":{"name":"Global advances in integrative medicine and health","volume":"13 ","pages":"27536130241261160"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信