Frontiers in sleep最新文献

{"title":"No association between obstructive sleep apnea and restless legs syndrome: results from a large hospital-based cross-sectional study.","authors":"Erik Vevatne Øverland, August Waaraas, Ragnhild S Lundetræ, Sverre Lehmann, Ingvild W Saxvig, Bjørn Bjorvatn","doi":"10.3389/frsle.2025.1632662","DOIUrl":"10.3389/frsle.2025.1632662","url":null,"abstract":"<p><strong>Introduction: </strong>Some studies have indicated a possible association between obstructive sleep apnea (OSA) and restless legs syndrome (RLS). Our aim was to explore this association in a large sample of patients referred to a hospital for suspected OSA.</p><p><strong>Methods: </strong>The sample included 8,852 patients referred to Haukeland University Hospital with suspicion of OSA between 2011 and 2022. OSA was diagnosed and categorized using standard respiratory polygraphy. Prior to the sleep study the patients completed an extensive questionnaire, including questions to determine if they had RLS. Pearson chi-square tests were used to examine RLS in relation to the presence and severity of OSA. Two separate logistic regression analyses were conducted. The first with moderate-severe OSA as the dependent variable and RLS as predictor, the second with RLS as the dependent variable and OSA severity as predictor. Both were adjusted for sex, age, marital status, alcohol consumption, daily smoking, caffeine after 17:00, and body mass index ≥30.</p><p><strong>Results: </strong>In total, 24.0% fulfilled the criteria for RLS, whereas moderate-severe OSA (apnea-hypopnea-index ≥15) occurred in 38.1% of the patients. The proportion of patients with RLS did not differ depending on OSA severity. Furthermore, there was no association between RLS and OSA in either chi-square or logistic regression analyses.</p><p><strong>Conclusion: </strong>The present study did not show increased prevalence of RLS in patients with OSA compared to patients without OSA. Furthermore, we found no increase in prevalence of RLS with increasing OSA severity. This suggests that these two sleep disorders are independent of each other.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1632662"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a scale for measuring orthosomnia: the Bergen Orthosomnia Scale (BOS).","authors":"Bodil V Guldbrandsen, Kelly Baron, Øystein Vedaa, Bjørn Bjorvatn, Ståle Pallesen","doi":"10.3389/frsle.2025.1640355","DOIUrl":"10.3389/frsle.2025.1640355","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to extend the knowledge about orthosomnia, that is, excessive preoccupation with sleep, by developing a scale for its assessment.</p><p><strong>Methods: </strong>In Study 1, an initial item pool was presented to 34 sleep experts for assessment using the Delphi method. In Study 2, relevant items were administered to 994 survey respondents (mean age = 42 years, <i>SD</i> = 13.2) for exploratory and confirmatory factor analysis. Two factors were retained, reflecting \"interference\" and \"rigidity,\" each comprising six items. In Study 3, the scale was validated against multiple validated instruments reflecting sleep-related behaviors and perceptions, the five-factor personality traits, the dark triad personality traits, measures of obsessive-compulsive disorder (OCD) and health anxiety, as well as demographic variables, in a new sample (<i>n</i> = 473, mean age = 41 years, <i>SD</i> = 12.8).</p><p><strong>Results: </strong>The two-factor model demonstrated acceptable fit (root mean square of approximation = 0.07, comparative fit index = 0.96, Tucker-Lewis Index = 0.95) with Cronbach's alphas of 0.87 and 0.88, and 3-week test-retest reliability of 0.74 and 0.82, respectively. Both orthosomnia factors correlated positively with sleep effort, dysfunctional beliefs and attitudes about sleep, narcissism, perfectionism, OCD, and health anxiety. The interference factor correlated positively with insomnia, neuroticism, psychopathy, and Machiavellianism and negatively with conscientiousness. The rigidity factor correlated positively with conscientiousness.</p><p><strong>Conclusion: </strong>The new scale for assessing orthosomnia possesses good psychometric properties and provides clinicians and researchers with an instrument for further investigating this new sleep construct.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1640355"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Novel technologies in the diagnosis and management of sleep-disordered breathing, volume II.","authors":"Ding Zou, Henri Korkalainen","doi":"10.3389/frsle.2025.1696478","DOIUrl":"10.3389/frsle.2025.1696478","url":null,"abstract":"","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1696478"},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Insomnia Severity Index among South African first responders: evidence from classical test theory, Rasch, and Mokken analyses.","authors":"Tyrone B Pretorius, Anita Padmanabhanunni","doi":"10.3389/frsle.2025.1635434","DOIUrl":"10.3389/frsle.2025.1635434","url":null,"abstract":"<p><strong>Background: </strong>Sleep is essential for physical health and psychological wellbeing, and insomnia is strongly associated with mental health difficulties, including depression, anxiety, and fatigue. Among first responders, the prevalence of insomnia is particularly high due to chronic exposure to stress, trauma, and irregular work hours.</p><p><strong>Aim: </strong>As part of a broader study focusing on the mental health of first responders in South Africa, the current study examined the psychometric properties of the Insomnia Severity Index from three different psychometric perspectives: classical test theory, Rasch analysis and Mokken scale analysis.</p><p><strong>Methods: </strong>Participants were first responders (<i>n</i> = 429) in the Western Cape province of South Africa and they included police officers (n = 309) and paramedics (n = 120). They completed the Insomnia Severity Index (ISI), the Patient Health Questionnaire-9, the Generalized Anxiety Disorder-7, and the Chalder Fatigue Questionnaire.</p><p><strong>Results: </strong>The three psychometric paradigms converged to confirm that the ISI measures a unidimensional scale. Furthermore, all three paradigms provided evidence for the construct validity of the ISI. In addition, classical test theory indices provided evidence for convergent and discriminant validity. Lastly, the correlations between insomnia as measured by the ISI and depression, anxiety, and fatigue provided evidence for concurrent validity.</p><p><strong>Conclusion: </strong>These findings affirm that the ISI is a stable and sound tool for assessing insomnia severity within the first responder population. The absence of measurement bias across gender and professional roles also enhances the practical utility of the ISI, as it ensures equitable assessment across subgroups within the first responder workforce. The ISI emerges from this study as a valuable resource for clinicians, researchers, and occupational health professionals working with South African first responders.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1635434"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and estrous-specific effects of paradoxical sleep deprivation: neurobehavioral changes and hippocampal neuroinflammation.","authors":"Laura K Olsen, Krysten A Jones, Raquel J Moore, Hunter McCubbins, Frances S Curtner, Birendra Sharma, Candice N Hatcher-Solis","doi":"10.3389/frsle.2025.1611192","DOIUrl":"10.3389/frsle.2025.1611192","url":null,"abstract":"<p><p>With millions suffering from sleep disorders in today's society, a better understanding of sleep disruption related to cognitive outcomes is urgently needed. To that end, a preclinical investigation into the effects of paradoxical sleep deprivation (PSD) on neurobehavioral outcomes and associated hippocampal neuroinflammation was conducted in male and female rats. Due to epidemiological identification of sex differences in many aspects of sleep disorders, sex and estrous-cycle stage factors were investigated. Sprague-Dawley rats underwent 120 h of PSD using a modified multiple-platform \"flowerpot\" method. At 96 h of PSD, animals were trained on neurobehavioral Novel Object Recognition (NOR) and Passive Avoidance Task (PAT) paradigms. Before NOR/PAT testing, at 120 h PSD, the Elevated Zero Maze (EZM) was used to assess anxiolytic-like behavior. PSD-impaired PAT performance among males and females. In males after PSD, anxiolytic-like and locomotor behavior was increased, and NOR performance was impaired. Based on estrous cycle stages determined by cytological analysis of daily wet smears, females were found to exhibit estrous-specific differences across all neurobehavioral paradigms, with increased anxiolytic-like behavior and impaired PAT performance only among PSD females in estrus. Immunohistochemical analysis of the hippocampus after 120 h of PSD found microgliosis, but not astrogliosis, in the CA1/2 of males and females in estrus. This study contributes to a better understanding of the sex- and estrous-specific differences in sleep disruption-induced neurobehavioral outcomes and associated hippocampal inflammation. Further research is needed to investigate the molecular mechanisms underlying the interaction between estrous cycle, hippocampal microgliosis, and sleep-disrupted cognitive outcomes.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1611192"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-randomized pre-post pilot study of cooling bed sheets in hot sleeping people.","authors":"Matthew D Weaver, Salim Qadri, Chidera Ejikeme, Stuart F Quan, Charles A Czeisler, Rebecca Robbins","doi":"10.3389/frsle.2025.1587801","DOIUrl":"10.3389/frsle.2025.1587801","url":null,"abstract":"<p><strong>Introduction: </strong>Sleeping hot is a common barrier to good sleep. Characteristics of the sleep environment may impact temperature regulation and sleep. We tested the effectiveness of one brand of bed sheets that advertise cooling properties on sleep and vasomotor symptoms.</p><p><strong>Methods: </strong>Participants were recruited through multiple channels that included potential customers of the intervention sheets and targeted online advertisements. Participants completed a baseline questionnaire, daily electronic diary for 6 weeks, and an end-of-study questionnaire. Assessments included the Pittsburgh Sleep Quality Index and Restorative Sleep Questionnaire. Daily diaries assessed sleep, mood, and perceived temperature during sleep. Within-person responses were compared before and after use of the intervention bed sheets.</p><p><strong>Results: </strong>64 participants provided 2,627 total days of data. The study sample was 89% female, mean age 48 (SD 12). Sixty-nine percent of participants reported improved sleep quality after implementing the intervention. Mean improvement on the Pittsburgh Sleep Quality Index was 1.9 (95% CI 1.3-2.6), from 8.0 (SD 3.0) to 6.1 (SD 2.5) at end-of-study. The proportion of participants reporting trouble sleeping due to feeling too hot was reduced from 82.5 to 39.7%. Reported sleep duration increased 26 min (95% CI 14-38 min), from 6.5 h (SD 1.0) to 7.0 h (SD 0.8). Participants also reported improvements in night sweats, restorative sleep, mood, and alertness.</p><p><strong>Conclusion: </strong>Individuals reported improvements on several dimensions of sleep health, reductions in night sweats, and less sleep disruption due to sleeping too hot after implementing the intervention bed sheets. These findings warrant replication in a randomized, placebo-controlled design.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1587801"},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrated micro choice-based treatment for type 2 diabetes is associated with decreased risk of sleep apnoea, less daytime sleepiness and lower insomnia symptoms. A non-randomized pre - post pilot study.","authors":"Ane Wilhelmsen-Langeland, Karsten Amund Olson, Markus Rød Kjøde, Sigurd William Hystad, Gerd Kvale, Eirik Søfteland","doi":"10.3389/frsle.2025.1639626","DOIUrl":"10.3389/frsle.2025.1639626","url":null,"abstract":"<p><strong>Aims: </strong>Type 2 diabetes and sleep disorders are closely connected. We have evaluated a 4-day concentrated transdiagnostic, micro choice-based and interdisciplinary group treatment for patients with type 2 diabetes, with the aim of improving patient activation. We wanted to explore whether sleep problems would decrease after this intervention.</p><p><strong>Methods: </strong>Patients were assessed pre - post the intervention by Insomnia Severity Index (ISI), Bergen Insomnia Scale (BIS), Epworth Sleepiness Scale (ESS), Berlin Questionnaire (BQ) at baseline, 3-, 6- and 12 months follow-up, to measure symptoms related to insomnia, Obstructive Sleep Apnoea (OSA) and daytime sleepiness. Seventy-five patients with type 2 diabetes were included in our sample.</p><p><strong>Results: </strong>At baseline, 41% and 25% had symptoms of insomnia, as defined by the BIS and ISI, respectively. Another 56% were likely to suffer from OSA using the BQ. At follow-up, the intervention was associated with reduction in symptoms of sleep disorders, and the reduction was still significant at 12 months follow-up.</p><p><strong>Conclusions: </strong>Although the study was not designed to disentangle how much of the improvement was due to sleep education and medication, the outcome still shows the usefulness of the format also in terms of sleep disorders in type 2 diabetes.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1639626"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep factors affecting mental health: mechanics and trigger factors.","authors":"Kathy Sexton-Radek","doi":"10.3389/frsle.2025.1441521","DOIUrl":"10.3389/frsle.2025.1441521","url":null,"abstract":"<p><p>This article explores the concepts in sleep medicine associated with mental health symptoms. A brief overview of key sleep factors is stated, followed by a presentation of empirical research findings on how poor sleep influences mental health conditions. Some specific information on mental health conditions like insomnia, depression, and schizophrenia symptoms are provided. Tables and figures present common sleep conditions associated with mental health conditions. Additionally, a figure by the author proposes a pathway explaining the link between poor sleep quality and mental health conditions.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1441521"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical association between current depressive symptoms and odds ratio product in US sleep centers.","authors":"Archie Defillo, Massimiliano Grassi, Silvia Daccò, Jennifer L Martin, Veronica Guadagni","doi":"10.3389/frsle.2025.1635704","DOIUrl":"10.3389/frsle.2025.1635704","url":null,"abstract":"<p><strong>Introduction: </strong>The Odds Ratio Product (ORP) is a validated EEG-based measure of sleep depth, more sensitive than traditional metrics. While it has been studied in healthy individuals and those with sleep-wake disorders, its relevance in psychiatric conditions remains unclear. This study examined ORP during sleep and its association with depressive symptoms in a large cohort referred to multiple U.S. sleep centers.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 829 adults (48.85% female; mean age 43.49 ± 13.74 years) enrolled in two multicenter studies. Each participant completed the Patient Health Questionnaire-9 (PHQ-9) and underwent overnight polysomnography (PSG), with ORP calculated from central EEG channels. Mean and standard deviation ORP values were derived for the full night and Wake, stages 1, 2, 3, and REM sleep. Associations between ORP metrics and depression severity (PHQ-9 total and PHQ-9 ≥10) were tested using linear and logistic regressions, adjusting for age and sex. Model fit was assessed with the Akaike Information Criterion (significance level α = 0.05).</p><p><strong>Results: </strong>Fixed-effects models outperformed mixed-effects models. Mean ORP during the full night and light sleep (stages 1 + 2) showed a significant U-shaped association with depression, indicating both high and low ORP values relate to greater depressive burden. In stage 3, higher mean ORP was linearly associated with more severe symptoms. Lower ORP variability across the night also correlated with higher depression scores.</p><p><strong>Conclusions: </strong>ORP shows potential as a non-invasive biomarker for depressive symptoms, with distinct associations depending on sleep depth. Integrating ORP into clinical PSG analyses could improve detection of depression-related sleep patterns.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1635704"},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-neurodegenerative REM parasomnia with immersive dreaming and dream-reality confusion: a case report.","authors":"Nazanin Biabani, Martina Mulas, Carlotta Mutti, Sean Higgins, Katarina Ilic, Joshua Benson, Ana Santic, Valentina Gnoni, Panagis Drakatos, Andrea Romigi, Alexander D Nesbitt, Sharon L Naismith, Carlos H Schenck, David O'Regan, Monica Puligheddu, Ivana Rosenzweig","doi":"10.3389/frsle.2025.1659300","DOIUrl":"10.3389/frsle.2025.1659300","url":null,"abstract":"<p><strong>Background: </strong>REM sleep behavior disorder (RBD) is characterized by loss of normal muscle atonia during REM sleep, often associated with dream enactment behaviors, and is typically a prodromal neurodegenerative condition in middle-aged and older adults. However, emerging case reports and case series suggest that not all RBD presentations follow this trajectory, particularly in younger individuals.</p><p><strong>Case presentation: </strong>A case of 7-year history of vivid, immersive dreaming perceived as continuous with waking life, accompanied by persistent dream-reality confusion, is described. The patient frequently engaged in reality-testing behaviors and reported significant cognitive fatigue. Video-polysomnography confirmed REM sleep without atonia and a concordant dream re-enactment episode. Neuropsychiatric evaluation ruled out dissociative or psychotic disorders, and no evidence of neurodegenerative disease was observed.</p><p><strong>Conclusion: </strong>This presented case illustrates a potentially distinct, non-neurodegenerative REM parasomnia phenotype that underscores the need to expand current parasomnia classifications to better capture the diverse cognitive and metacognitive dimensions of REM sleep disorders. Moreover, potential mechanisms underlying the main features of this case, including immersive dreaming and persistent dream-reality confusion, are discussed in relation to hypothesized dysfunction in melanin-concentrating hormone (MCH) signaling.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"4 ","pages":"1659300"},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}