Frontiers in sleep最新文献

{"title":"Memory retention following acoustic stimulation in slow-wave sleep: a meta-analytic review of replicability and measurement quality","authors":"Tylor J. Harlow, Matthew Jané, H. Read, J. J. Chrobak","doi":"10.3389/frsle.2023.1082253","DOIUrl":"https://doi.org/10.3389/frsle.2023.1082253","url":null,"abstract":"The role of slow oscillations and spindles during sleep on memory retention has become an area of great interest in the recent decade. Accordingly, there are multiple studies that examine the efficacy of acoustic stimulation during sleep to facilitate slow oscillations and associated memory retention. Here, we run meta-analyses on a current set of 14 studies that use audible noise-burst sound stimulation to modulate overnight retention of word pairs (kS = 12 studies, kES = 14 effect sizes, n = 206 subjects). Our meta-analyses demonstrate a steady, yearly decline in effect size that accounts for 91.8% of the heterogeneity between studies. We find that the predicted effect on memory retention in 2013 favored the acoustic stimulation condition at dδ = 0.99 (95% CI [0.49, 1.49]), while the predicted effect in 2021 declined to a moderate and significant effect favoring no acoustic stimulation at dδ = −0.39 (95% CI [−0.73, −0.05]). Our meta-regression model finds no coded study-level characteristics could account for the decline in effect sizes over time other than the publication date alone. Using available data, we estimate that 34% of subjects are not actually blind to the acoustic stimulation condition due to hearing acoustic stimulation during sleep. In addition, we find that the test-retest reliability of memory retention scores is nearly zero (ρd = 0.01, 95% CI [−0.18, 0.21]), and through simulation demonstrate the impact this has on statistical power and observed effect sizes. Based on our analyses, we discuss the need for larger sample sizes, true placebo controls, age range restrictions, open-data sharing, and improvements in the reliability of memory retention tasks.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88590741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the Better Nights, Better Days for Children with Neurodevelopmental Disorders program for large scale implementation","authors":"Alzena Ilie, M. Orr, S. Weiss, I. Smith, G. Reid, A. Hanlon-Dearman, Cary A. Brown, E. Constantin, R. Godbout, S. Shea, O. Ipsiroglu, P. Corkum","doi":"10.3389/frsle.2023.1158983","DOIUrl":"https://doi.org/10.3389/frsle.2023.1158983","url":null,"abstract":"Objective Pediatric insomnia is one of the most commonly reported disorders, especially in children with neurodevelopmental disorders. Better Nights, Better Days for Children with Neurodevelopmental Disorders (BNBD-NDD) is a transdiagnostic, self-guided, eHealth behavioral sleep intervention developed for parents of children with NDDs ages 4–12 years with insomnia. After usability testing, a randomized controlled trial (RCT) was conducted to evaluate the effectiveness of the BNBD-NDD program. By interviewing RCT participants after their outcome measures were collected, we sought to determine the barriers and facilitators that affect the reach, effectiveness, adoption, implementation, and maintenance of the BNBD-NDD intervention, as well as to assess whether barriers and facilitators differ across levels of engagement with the program and NDD groups. Method Twenty parents who had been randomized to the treatment condition of the RCT participated in this study. These parents participated in virtual semi-structured qualitative interviews about their experiences with the BNBD-NDD program. Rapid analysis was used, in which one researcher facilitated the interview, and another simultaneously coded the interview using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Results Overall, more facilitators than barriers were identified for Reach, Effectiveness, Implementation, and Maintenance, whereas for Adoption more barriers emerged. Participants who were engaged reported more facilitators about the BNBD-NDD program design and behavior change, while unengaged participants mentioned needing more support to help facilitate their use of the program. Lastly, parents of children with ASD reported more facilitators and more barriers than did parents of children with ADHD. Conclusion With this feedback from participants, we can optimize BNBD-NDD for large-scale implementation, by modifying the program to better support parents, helping them implement the strategies effectively at home, and increasing the accessibility of this evidence-based treatment.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90937193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythms in pediatric craniopharyngioma","authors":"Dana Kamara, S. Crowley, V. Crabtree, Donna Hancock, Yimei Li, H. Darji, J. Semko, M. Wise, T. Merchant, B. Mandrell","doi":"10.3389/frsle.2023.1153144","DOIUrl":"https://doi.org/10.3389/frsle.2023.1153144","url":null,"abstract":"Introduction Craniopharyngioma is a brain tumor arising in the region of the hypothalamic-pituitary axis. Children and adolescents with craniopharyngioma have high survival rates, but often experience significant morbidity, including high rates of sleep disorders. Vulnerabilities to circadian disruption are present in this population, but little is known about circadian health. Methods We present exploratory circadian findings from a prospective trial at a single center. Data presented here are from the baseline timepoint. Fifty-three patients between the ages of 7 and 20 years provided salivary melatonin samples, following surgical resection and prior to completion of proton therapy, when indicated. We estimated dim light melatonin onset (DLMO) and collected additional sleep data from actigraphy, overnight polysomnography, and the multiple sleep latency test. Results Almost half of participants did not have a valid DLMO estimate during the sampling window, with most being above the threshold at the first sample timepoint. Those with greater disease severity variables (greater hypothalamic involvement and the presence of diabetes insipidus) were significantly more likely to have missed DLMO. For those with valid estimates, DLMO timing correlated with BMI and other sleep variables, including mean sleep latency values on the MSLT. Discussion These findings suggest that a subset of those with pediatric craniopharyngioma may experience a phase advance and that this may relate to poorer prognostic indicators. Furthermore, circadian timing correlates with other sleep and health factors. Further research with earlier sampling is needed to better understand circadian rhythms in pediatric craniopharyngioma and associations with other health and disease variables.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of the hypnodensity approach to scoring sleep for polysomnography and home sleep testing","authors":"P. Anderer, M. Ross, A. Cerny, R. Vasko, E. Shaw, P. Fonseca","doi":"10.3389/frsle.2023.1163477","DOIUrl":"https://doi.org/10.3389/frsle.2023.1163477","url":null,"abstract":"Human experts scoring sleep according to the American Academy of Sleep Medicine (AASM) rules are forced to select, for every 30-second epoch, one out of five stages, even if the characteristics of the neurological signals are ambiguous, a very common occurrence in clinical studies. Moreover, experts cannot score sleep in studies where these signals have not been recorded, such as in home sleep apnea testing (HSAT). In this topic review we describe how artificial intelligence can provide consistent and reliable scoring of sleep stages based on neurological signals recorded in polysomnography (PSG) and on cardiorespiratory signals recorded in HSAT. We also show how estimates of sleep stage probabilities, usually displayed as hypnodensity graph, can be used to quantify sleep stage ambiguity and stability. As an example of the application of hypnodensity in the characterization of sleep disordered breathing (SDB), we compared 49 patients with sleep apnea to healthy controls and revealed a severity-depending increase in ambiguity and decrease in stability during non-rapid eye movement (NREM) sleep. Moreover, using autoscoring of cardiorespiratory signals, we show how HSAT-derived apnea-hypopnea index and hypoxic burden are well correlated with the PSG indices in 80 patients, showing how using this technology can truly enable HSATs as alternatives to PSG to diagnose SDB.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80294177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of dendritic spines in the amygdala following sleep deprivation","authors":"L. Rexrode, Matthew Tennin, Jobi Babu, Caleb Young, R. Bollavarapu, Lamiorkor Ameley Lawson, J. Valeri, H. Pantazopoulos, B. Gisabella","doi":"10.3389/frsle.2023.1145203","DOIUrl":"https://doi.org/10.3389/frsle.2023.1145203","url":null,"abstract":"The amygdala is a hub of emotional circuits involved in the regulation of cognitive and emotional behaviors and its critically involved in emotional reactivity, stress regulation, and fear memory. Growing evidence suggests that the amygdala plays a key role in the consolidation of emotional memories during sleep. Neuroimaging studies demonstrated that the amygdala is selectively and highly activated during rapid eye movement sleep (REM) and sleep deprivation induces emotional instability and dysregulation of the emotional learning process. Regulation of dendritic spines during sleep represents a morphological correlate of memory consolidation. Several studies indicate that dendritic spines are remodeled during sleep, with evidence for broad synaptic downscaling and selective synaptic upscaling in several cortical areas and the hippocampus. Currently, there is a lack of information regarding the regulation of dendritic spines in the amygdala during sleep. In the present work, we investigated the effect of 5 h of sleep deprivation on dendritic spines in the mouse amygdala. Our data demonstrate that sleep deprivation results in differential dendritic spine changes depending on both the amygdala subregions and the morphological subtypes of dendritic spines. We observed decreased density of mushroom spines in the basolateral amygdala of sleep deprived mice, together with increased neck length and decreased surface area and volume. In contrast, we observed greater densities of stubby spines in sleep deprived mice in the central amygdala, indicating that downscaling selectively occurs in this spine type. Greater neck diameters for thin spines in the lateral and basolateral nuclei of sleep deprived mice, and decreases in surface area and volume for mushroom spines in the basolateral amygdala compared to increases in the cental amygdala provide further support for spine type-selective synaptic downscaling in these areas during sleep. Our findings suggest that sleep promotes synaptic upscaling of mushroom spines in the basolateral amygdala, and downscaling of selective spine types in the lateral and central amygdala. In addition, we observed decreased density of phosphorylated cofilin immunoreactive and growth hormone immunoreactive cells in the amygdala of sleep deprived mice, providing further support for upscaling of dendritic spines during sleep. Overall, our findings point to region- and spine type-specific changes in dendritic spines during sleep in the amygdala, which may contribute to consolidation of emotional memories during sleep.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82747591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doctor-diagnosed sleep disorders in the United States: Prevalence and impact of tobacco smoke exposure and vitamin D deficiency. A population-based study","authors":"P. Kum-Nji, Samuel A. Taylor, Bah Tanwi","doi":"10.3389/frsle.2023.1113946","DOIUrl":"https://doi.org/10.3389/frsle.2023.1113946","url":null,"abstract":"Background and purpose: We determined the prevalence of physician-diagnosed sleep disorder and its association with tobacco smoke exposure and vitamin D deficiency. Methods The National Health and Nutrition Examination Survey (NHANES) of 2011–2012 data base was used for the study. Subjects were asked two questions: “Ever told your doctor you had trouble sleeping?” and “Ever told by doctor have sleep disorder?” The answer “yes” to the second question indicated presence of a doctor-diagnosed sleep disorder (DSD) and “no” indicated its absence. Tobacco smoke exposure was defined by serum cotinine levels while vitamin D levels were measured by serum 25(OH) D. Eight selected variables included in the analyses were BMI, age, gender, smoking exposure, vitamin D levels, income, insurance, and race. Univariate and multivariate analyses were conducted to determine if tobacco smoke exposure and Vitamin D were each predictive of DSD. Results Of 5,470 subjected aged 16 to 80+ years about 9% had doctor-diagnosed sleep disorder (DSD). In a multiple regression analysis, active tobacco smoking was predictive of DSD (OR 1.92; 95% CI = 1.38–2.69), while passive smoke exposure was not, even after controlling for all the other significant variables (OR 0.93; 95% CI = 0.57–1.52). The other variables significantly associated with DSD were by order of importance BMI (P < 0.001), Age (P < 0.001) and race (P ≤ 0.001). Vitamin D deficiency was not predictive of DSD. Conclusion The prevalence of physician-diagnosed DSD was about 9%. Active smoking but not passive smoking as defined by cotinine levels was significantly associated with DSD. Vitamin D was not predictive of DSD. Future studies are therefore needed to demonstrate whether smoking cessation could help reduce DSD.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77920134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and diagnosis of pediatric obstructive sleep apnea—An update","authors":"Taylor B. Teplitzky, Audrey J. Zauher, A. Isaiah","doi":"10.3389/frsle.2023.1127784","DOIUrl":"https://doi.org/10.3389/frsle.2023.1127784","url":null,"abstract":"Purpose Formal overnight polysomnography (PSG) is required to diagnose obstructive sleep apnea (OSA) in children with sleep disordered breathing (SDB). Most clinical guidelines do not recommend home-based tests for pediatric OSA. However, PSG is limited by feasibility, cost, availability, patient discomfort, and resource utilization. Additionally, the role of PSG in evaluating disease impact may need to be revised. There is a strong need for alternative testing that can stratify the need for PSG and improve the time to diagnosis of OSA. This narrative review aims to evaluate and discuss innovative approaches to pediatric SDB diagnosis. Findings Methods to evaluate pediatric SDB outside of PSG include validated questionnaires, single-channel recordings, incorporation of telehealth, home sleep apnea testing (HSAT), and predictive biomarkers. Despite the promise, no individual metric has been found suitable to replace standard PSG. In addition, their use in combination to diagnose OSA diagnosis still needs to be defined. Summary When combined with adjunct assessments, HSAT advancements may accurately evaluate SDB in children and thus minimize the need for overnight in-laboratory PSG. Further studies are required to confirm diagnostic validity vis-à-vis PSG as a reference standard.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85043990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of non-completion of sleep apnea testing during pregnancy","authors":"K. Antony, A. L. Rice, Sakshi Bajaj, Abigail M. Wiedmer, N. Jacobson, Julia Nick, Allison Eichmann, A. K. Stanic, M. Bazalakova","doi":"10.3389/frsle.2023.1144213","DOIUrl":"https://doi.org/10.3389/frsle.2023.1144213","url":null,"abstract":"Study objectives Completion of testing during pregnancy for those who screen positive for obstructive sleep apnea (OSA) is imperative for the diagnosis and treatment of OSA, as the latter may reduce the risk of developing hypertensive disorders of pregnancy. To identify potential barriers, we assessed predictors of non-completion of sleep apnea testing by people identified to be at high risk of OSA by screening during pregnancy. We hypothesized that non-completion of sleep apnea testing would be predicted by insurance status and obstetric factors, such as gestational age at time of testing. Methods We performed a retrospective analysis of the first 500 people in our sleep pregnancy database which includes both pregnant and preconception patients who screened positive for OSA; those screened preconception were excluded. Multivariable Poisson regression was used to determine which factors were independently associated with non-completion. Results Of 445 referred, 214 (48.1%) completed sleep apnea testing. Factors associated with non-completion of testing on univariate analysis included referral in the third trimester, higher parity, one or more living children, history of preterm birth, history of preeclampsia, type 2 diabetes mellitus, non-partnered status, race, and payor. Symptoms of loud snoring or witnessed apneas were associated with increased incidence of sleep apnea testing completion. Multivariable Poisson regression demonstrated that having public insurance predicted non-completion of sleep apnea testing during pregnancy. Conclusion In this small study, public insurance was an independent predictor of non-completion of sleep apnea testing during pregnancy. These findings aid efforts to improve patient completion of sleep apnea testing during pregnancy.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"58 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72417462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in mandibular advancement splint therapy for obstructive sleep apnoea","authors":"A. Mohammadieh, B. Tong, P. de Chazal, P. Cistulli","doi":"10.3389/frsle.2023.1144327","DOIUrl":"https://doi.org/10.3389/frsle.2023.1144327","url":null,"abstract":"Mandibular advancement splint (MAS) therapy emerged as an effective therapy for obstructive sleep apnoea (OSA) in the mid 1990s, and is now the leading treatment alternative for OSA. Since its inception, the field has seen a suite of revisions and advances in relation to design and customisation, fabrication, titration methods, response prediction models and the integration of data collection technology. This paper reviews these current and emerging innovations in MAS therapy and their impact upon sleep apnoea management.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87582355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based therapy for insomnia alleviates insomnia, depression, and cognitive arousal in treatment-resistant insomnia: A single-arm telemedicine trial","authors":"D. Kalmbach, P. Cheng, J. Ong, A. Reffi, D. Fresco, C. Fellman-Couture, Melissa K. Ruprich, Zain Sultan, C. Sagong, C. Drake","doi":"10.3389/frsle.2023.1072752","DOIUrl":"https://doi.org/10.3389/frsle.2023.1072752","url":null,"abstract":"Objectives Cognitive-behavioral therapy and pharmacotherapy are effective insomnia treatments, yet half of patients do not remit. Emerging evidence indicates refractory cognitive arousal is associated with poor insomnia treatment outcomes, giving rise to the concept that therapeutic approaches directly aimed at reducing cognitive arousal may benefit patients with a history of inadequate response to intervention. This proof-of-concept study examined the effects of mindfulness-based therapy for insomnia (MBTI) delivered individually via telemedicine on insomnia, depression, and cognitive arousal in patients with treatment-resistant insomnia. Methods A single-arm trial wherein 19 patients whose insomnia did not remit with prior psychotherapy and/or pharmacotherapy received a course of MBTI as second-stage therapy, which included eight weekly 1-h sessions in an individual format via telemedicine video. Study outcomes included the 15-item version of the five-facet mindfulness questionnaire (FFMQ-15), insomnia severity index (ISI), Patient Health Questionnaire-9 to assess depression (PHQ-9), and three cognitive arousal indices: pre-sleep arousal scale's cognitive factor, perseverative thinking questionnaire, and the daytime insomnia symptom response scale. Results Patients reported increased mindfulness from pretreatment to posttreatment (FFMQ-15: 52.95 ± 8.30 to 57.47 ± 9.82, p = 0.008). Patients also reported large reductions in ISI (16.42 ± 3.95 to 8.37 ± 4.19, p < 0.001, Cohen's dz = 1.73; 57.9% remission), PHQ-9 (6.42 ± 3.47 to 3.32 ± 2.93, p = 0.001, Cohen's dz = 0.93), and all cognitive arousal indices (Cohen's dzs = 0.82–1.30) at posttreatment. Six months later, ISI scores and cognitive arousal levels remained significantly lower than pretreatment, although effect sizes decreased for ISI (Cohen's dz = 1.11) and cognitive arousal (Cohen's dzs = 0.63–0.68). Antidepressant effects were no longer significant at follow-up. Conclusion Treatment-resistant insomnia patients are engaged in MBTI, which produces large acute reductions in insomnia, depression, and cognitive arousal. MBTI effects on insomnia and cognitive arousal were moderate to large 6 months after treatment. These findings support the concept and feasibility of MBTI for treatment-resistant patients along with indication that longer-term strategies are needed to help maintain acute treatment gains. Clinical trial registration ClinicalTrials.gov, identifier NCT03724305.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85854011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}