Frontiers in sleep最新文献

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Implementing TeleSleep at Veterans Healthcare Administration: an organizational case study of adaptation and sustainment. 在退伍军人医疗保健管理局实施远程睡眠:关于适应和维持的组织案例研究。
Frontiers in sleep Pub Date : 2024-09-10 DOI: 10.3389/frsle.2024.1444689
Jeffrey K Belkora, Jill Reichert, Katherine Williams, Mary A Whooley, Talayeh Rezayat, Stacy Sorensen, Priyanka Chilakamarri, Elizabeth Sanders, Andrea Maas, Alexander Gomez, Philip Kurien, Liza Ashbrook, Jacque Thomas, Kathleen F Sarmiento
{"title":"Implementing TeleSleep at Veterans Healthcare Administration: an organizational case study of adaptation and sustainment.","authors":"Jeffrey K Belkora, Jill Reichert, Katherine Williams, Mary A Whooley, Talayeh Rezayat, Stacy Sorensen, Priyanka Chilakamarri, Elizabeth Sanders, Andrea Maas, Alexander Gomez, Philip Kurien, Liza Ashbrook, Jacque Thomas, Kathleen F Sarmiento","doi":"10.3389/frsle.2024.1444689","DOIUrl":"10.3389/frsle.2024.1444689","url":null,"abstract":"<p><p>Veteran access to sleep medicine is of paramount importance to the Veterans Health Administration (VA). To increase access, VA has created community referral policies and programs, as well as telehealth programs. In 2017, the Office of Rural Health (ORH) funded a TeleSleep initiative focused on reaching rural Veterans with unmet sleep needs. ORH provided 3-6 years of funding to help 19 hubs support 98 spoke sites serving rural Veterans. As ORH funding concluded, each hub identified its path to sustainment. This case study follows one TeleSleep hub in VA's western geographic region as it transitioned from ORH funding sustainment as a regional Sleep Clinical Resource Hub. This case study describes the real-world process of adaptation in care delivery strategies. One key area of adaptation revolved around whether to deliver care via the patient's home facility or the provider's home facility. In early 2021, the TeleSleep team implemented an innovative provider transfer model, where temporary reinforcements from the TeleSleep hub increased the workforce capacity of spoke sites, similar to the concept of locum tenens. In this provider transfer model, TeleSleep clinicians scheduled, documented, and billed for each encounter at the Veteran's home facility. Positioning TeleSleep clinicians as local providers facilitated communication and referrals and promoted continuity and quality of care for Veterans in their home facility. This provider transfer model reduced the administrative burden of providers and schedulers and supported patient-side-only documentation of care. While this mirrors current locum tenens practice, transferring providers did not fit VA's financial model as implemented by the western region's Sleep Clinical Resource Hub. Therefore, in December 2021, VA aligned TeleSleep with VA's preferred practice of patient rather than provider transfers. In the patient transfer model, providers schedule and document in both the provider and patient electronic health records, and bill in the provider's facility. However, reflecting on this period of innovation, TeleSleep team members concluded that the provider transfer model could improve patient safety and care coordination while reducing the administrative burden of frontline clinicians. Further research and development are needed to align the provider transfer model with VA's financial model.</p>","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Insights in sleep-related movement disorders and parasomnias 社论:对睡眠相关运动障碍和寄生虫病的见解
Frontiers in sleep Pub Date : 2024-08-08 DOI: 10.3389/frsle.2024.1461464
Ambra Stefani, John Winkelman
{"title":"Editorial: Insights in sleep-related movement disorders and parasomnias","authors":"Ambra Stefani, John Winkelman","doi":"10.3389/frsle.2024.1461464","DOIUrl":"https://doi.org/10.3389/frsle.2024.1461464","url":null,"abstract":"","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141927322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insomnia severity and daytime sleepiness in caregivers of advanced age 高龄护理人员的失眠严重程度和白天嗜睡情况
Frontiers in sleep Pub Date : 2024-07-11 DOI: 10.3389/frsle.2024.1404684
Lucy A. Webster, Talha Ali, Jody Sharninghausen, Alexandra M. Hajduk, Thomas Gill, Brienne Miner
{"title":"Insomnia severity and daytime sleepiness in caregivers of advanced age","authors":"Lucy A. Webster, Talha Ali, Jody Sharninghausen, Alexandra M. Hajduk, Thomas Gill, Brienne Miner","doi":"10.3389/frsle.2024.1404684","DOIUrl":"https://doi.org/10.3389/frsle.2024.1404684","url":null,"abstract":"Aging-related changes and caregiver burden may increase the risk for sleep disturbances among older caregivers, yet few studies have examined the prevalence of insomnia and daytime sleepiness in this group. We examined the relationship of caregiver status with insomnia and daytime sleepiness among persons of advanced age (>75 years of age).Cross-sectional.Community.Yale Precipitating Events Project participants (n=383, mean age 84.4 years, 67% female, 12% African American, 25% caregivers).Caregivers were persons who reported caring for another person in the past week or caring for/helping a friend or relative >4 times in the past month. We examined the correlates of caregiver status, including demographic (age, sex, race/ethnicity, education, marital status), psychosocial (living alone, Medicaid eligibility, depressive symptoms, social support, hours volunteered), and physical (obesity, chronic conditions, medication use, self-rated health status, physical activity, functional disability, cognitive impairment) factors. We used the Insomnia Severity Index (ISI) to establish insomnia severity (ISI score 0–28) or clinically significant insomnia symptoms (ISI ≥8). We used the Epworth Sleepiness Scale to establish daytime sleepiness (ESS score 0–24) or hypersomnia (ESS ≥10). In nonparametric multivariable regression analyses, we examined the relationship of caregiver status with insomnia or daytime sleepiness.Compared to non-caregivers, caregivers were younger, more educated, less likely to be Medicaid eligible and had lower rates of depression, obesity, poor self-rated health, low physical activity, functional disability, and cognitive impairment. Mean ISI and ESS scores were in the normal range and similar among non-caregivers and caregivers (ISI scores of 6.9±5.6 and 6.9±5.4, and ESS scores of 6.4±4.7 and 6.1±4.3, in non-caregivers and caregivers, respectively). Multivariable-adjusted models demonstrated no significant differences in ISI and ESS scores between non-caregivers and caregivers (regression coefficients for ISI and ESS scores of −0.01 [95% CI = −1.58, 1.21] and −0.10 [−1.05, 1.21], respectively).When compared to older non-caregivers, older caregivers had more advantageous demographic, psychosocial, and physical profiles and had similar levels of insomnia and daytime sleepiness on standardized questionnaires. Future research is needed to elucidate contextual factors (e.g., caregiving intensity and care partner disease) that may increase the risk of sleep disturbances among caregivers of advanced age.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a telehealth cognitive behavioral therapy for improving sleep and nightmares in children aged 6–17 远程保健认知行为疗法对改善 6-17 岁儿童睡眠和噩梦的疗效
Frontiers in sleep Pub Date : 2024-07-11 DOI: 10.3389/frsle.2024.1401023
L. Cromer, Sarah Beth Bell, Lauren E. Prince, Nicholas Hollman, Elissar El Sabbagh, Tara R. Buck
{"title":"Efficacy of a telehealth cognitive behavioral therapy for improving sleep and nightmares in children aged 6–17","authors":"L. Cromer, Sarah Beth Bell, Lauren E. Prince, Nicholas Hollman, Elissar El Sabbagh, Tara R. Buck","doi":"10.3389/frsle.2024.1401023","DOIUrl":"https://doi.org/10.3389/frsle.2024.1401023","url":null,"abstract":"This study examined the efficacy of a five-module cognitive behavioral therapy for nightmares in children (CBT-NC) and improving sleep.Forty-six youth aged 6–17 years with sleep problems and at least weekly chronic and distressing nightmares were randomized to treatment (n = 23) or waiting list (n = 23) using a block four randomized design. Among participants, 65% (n = 30) were White, 4% (n = 2) were Black/African American, 2% (n = 1) were Asian American, 13% (n = 6) were Native American or Pacific Islander, and 15% (n = 7) were multiracial. Fifty percent of participants (n = 23) were cisgender girls, 35% were cisgender boys (n = 16), 7% were transgender boys (n = 3), and 9% were gender non-binary (n = 4). The baseline nightmare persistence ranged from 6 months to 13.5 years. The treatment adapted exposure, relaxation, and rescription therapy for trauma-related nightmares in adults and added elements of cognitive behavioral therapy for insomnia in children. Psychoeducation included topics of sleep and nightmares, relaxation, anxiety management, and sleep hygiene; the youth were guided through nightmare exposure and rescription.There was a statistically significant improvement in the number of nights with awakening (Cohen's d = 1.08), the number of weekly nightmares (Cohen's d = 0.82), and nightmare distress (Cohen's d = 1.05) for the treatment group compared to the wait-list group. Parent-reported youth sleep improved for the entire group from pretreatment to posttreatment (p < 0.001) but did not reach statistical significance for between-subjects analyses of the treatment group compared to the wait-list group (p = 0.05). Between-subjects analyses saw improvement for the treatment group compared to the wait-list group on internalizing and externalizing problems and suicidal thoughts and behaviors.This study supports the efficacy of CBT-NC for improving sleep maintenance, nightmare frequency and distress, and other mental health difficulties in youth. Preliminary evidence of possibly improving suicidal thinking and behavior is also presented.https://clinicaltrials.gov/study/NCT05588739, identifier: NCT05588739.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revitalizing CPAP adherence: lessons from THN study in patients with hypoglossal nerve stimulators 重振 CPAP 的依从性:从舌下神经刺激器患者的 THN 研究中汲取的经验教训
Frontiers in sleep Pub Date : 2024-07-05 DOI: 10.3389/frsle.2024.1380373
G. Mwenge, J. Bousata, Daniel Rodenstein
{"title":"Revitalizing CPAP adherence: lessons from THN study in patients with hypoglossal nerve stimulators","authors":"G. Mwenge, J. Bousata, Daniel Rodenstein","doi":"10.3389/frsle.2024.1380373","DOIUrl":"https://doi.org/10.3389/frsle.2024.1380373","url":null,"abstract":"This retrospective study aimed to address acceptance and long-term adherence to Continuous Positive Airway Pressure (CPAP) treatment among non-responder patients to ImThera THN system who initially declined this therapy.We employed a structured outpatient approach to communicate THN study results, categorize initial CPAP nonadherence reasons, and encourage CPAP trials through tailored appointments. Recorded follow-ups addressed individual concerns, providing medical guidance and acknowledging person-specific challenges. Adherence data were collected using CPAP hour meters at predetermined intervals, following Belgium's social security stipulations.Between July 2014 and October 2016, eleven participants, including one woman, with prior CPAP experience (average 2 months) were enrolled. Initial non-adherence was linked to ENT or psychological factors. Ten patients agreed to CPAP trials, where interventions included changing CPAP brand, pressure adjustments, mask changes, and additional measures like cognitive-behavioral therapy and nasal spray. After 1 year, mean adherence was 6.3 ± 2 h/day, and average CPAP usage duration was 8.67 ± 2.13 years. As of November 2023, eight out of eleven patients were still actively using CPAPIn this investigation, we challenged the concept of CPAP non-adherence, highlighting evolving adherence and the significance of continuous monitoring and personalized interventions. Our findings underscore ongoing patient education, multidisciplinary support, and dynamic intervention adaptation for enhanced adherence in challenging patient populations. The results provide insights applicable to non-adherent patients with obstructive sleep apnea, emphasizing the importance of individualized care and sustained engagement for improved CPAP acceptance.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From macro to micro: slow-wave sleep and its pivotal health implications 从宏观到微观:慢波睡眠及其对健康的关键影响
Frontiers in sleep Pub Date : 2024-07-02 DOI: 10.3389/frsle.2024.1322995
Toru Ishii, P. Taweesedt, Christina F. Chick, Ruth O'Hara, Makoto Kawai
{"title":"From macro to micro: slow-wave sleep and its pivotal health implications","authors":"Toru Ishii, P. Taweesedt, Christina F. Chick, Ruth O'Hara, Makoto Kawai","doi":"10.3389/frsle.2024.1322995","DOIUrl":"https://doi.org/10.3389/frsle.2024.1322995","url":null,"abstract":"Research on slow-wave sleep (SWS) began almost a century ago, not long after the discovery of electroencephalography. From maintaining homeostasis to memory function, the pivotal role of SWS in health has been established. The elucidation of its mechanisms and functions is directly related to the fundamental question of why people sleep. This comprehensive review first summarizes the basic science of SWS from anatomical and physiological aspects. It describes the fundamental mechanisms and functions of SWS, including hormonal regulation, developmental changes in SWS across the lifespan, and associations between SWS and optimal physical, psychological, and cognitive functions. Next, the relationship between SWS and physical and mental disorders, for which increasing knowledge has accumulated in recent years, is discussed from both research and clinical perspectives. Conditions such as memory impairment, sleep-disordered breathing, neurodevelopmental disorders, and various psychiatric disorders are of concern. The relationship between SWS and the glymphatic system, which is responsible for waste clearance in the brain, has also been explored, highlighting the potential neuroprotective role of SWS. Finally, we discuss the future direction of the field regarding whether interventions in SWS can improve health. We also address the problem of the inconsistent definitions of SWS, slow-wave activity, and slow oscillations. This review emphasizes the importance of discussing SWS from both macro- and microarchitectural perspectives and highlights its potential clinical and research impacts. By reviewing these aspects, we aim to contribute to a deeper understanding of SWS and the future development of this research field.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Māori perspectives on sleep and aging 毛利人对睡眠和衰老的看法
Frontiers in sleep Pub Date : 2024-06-05 DOI: 10.3389/frsle.2024.1410856
Rosemary Gibson, Hannah Lowe, Erina Korohina, Anna Rolleston
{"title":"Māori perspectives on sleep and aging","authors":"Rosemary Gibson, Hannah Lowe, Erina Korohina, Anna Rolleston","doi":"10.3389/frsle.2024.1410856","DOIUrl":"https://doi.org/10.3389/frsle.2024.1410856","url":null,"abstract":"Sleep is vital for health in older adulthood. Ethnic disparities have been noted with regards to sleep health. However, culturally appropriate approaches to sleep as a broader social experience are lacking.Here, sleep-related group interviews were conducted in the form of hui (group meetings and discussions) with eleven participants of a health service intervention for older Māori (the Indigenous people of New Zealand) and their whānau (extended family). Notes were collated and analyzed thematically.Four key themes were constructed that represent the key conversations and ideas. These concerned the conceptualizing of sleep—including appreciation for its somatic role but also the spiritual properties of sleep states; the changing obligations around sleep and wake—including individual and communal time use and changing cultural and familial obligations with advancing age; and the barriers and facilitators for supporting sleep—including the social and spiritual nature of communal sleeping, the schedules and sleep of others, as well as holistic and environmental methods for relaxation. Findings demonstrate the multifaceted nature of sleep and aging among Māori. Culturally relevant interpretations of sleep practices and disturbances were offered and are beyond typical Western models which are predominantly medicalized.This work aids the understanding and representation of sleep as a social and cultural perspective within the New Zealand context. This provides foundations for future participatory research to design culturally appropriate approaches to assessing and supporting sleep health in forms that are meaningful for aging well across cultures.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141382914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of spectral sleep scoring with polysomnography using forehead EEG device 使用前额脑电图设备验证多导睡眠监测仪的频谱睡眠评分法
Frontiers in sleep Pub Date : 2024-05-10 DOI: 10.3389/frsle.2024.1349537
Julie A. Onton, Katherine C. Simon, Allison B. Morehouse, Alessandra E Shuster, Jing Zhang, Andres Pena, S. Mednick
{"title":"Validation of spectral sleep scoring with polysomnography using forehead EEG device","authors":"Julie A. Onton, Katherine C. Simon, Allison B. Morehouse, Alessandra E Shuster, Jing Zhang, Andres Pena, S. Mednick","doi":"10.3389/frsle.2024.1349537","DOIUrl":"https://doi.org/10.3389/frsle.2024.1349537","url":null,"abstract":"Visual scoring of sleep electroencephalography (EEG) has long been considered the gold standard for sleep staging. However, it has several drawbacks, including high cost, time-intensiveness, vulnerability to human variability, discomfort to patients, lack of visualization to validate the hypnogram, and no acknowledgment of differences between delta and slow oscillation deep sleep. This report highlights a spectral scoring approach that addresses all these shortcomings of visual scoring. Past algorithms have used spectral information to help classify traditional visual stages. The current method used the clearly visible spectral patterns to develop new spectral stages, which are similar to but not the same as visual stages. Importantly, spectral scoring delivers both a hypnogram and a whole-night spectrogram, which can be visually inspected to ensure accurate scoring.This study compared traditional visual scoring of 32-channel polysomnography with forehead-only spectral scoring from an EEG patch worn concurrently. The PSG was visually scored by trained technicians and the forehead patch was scored spectrally. Because non-rapid eye movement (NREM) stage divisions in spectral scoring are not based on visual NREM stages, the agreements are not expected to be as high as other automated sleep scoring algorithms. Rather, they are a guide to understanding spectral stages as they relate to the more widely understood visual stages and to emphasize reasons for the differences.The results showed that visual REM was highly recognized as spectral REM (89%). Visual wake was only scored as spectral Wake 47% of the time, partly because of excessive visual scoring of wake during Light and REM sleep. The majority of spectral Light (predominance of spindle power) was scored as N2 (74%), while less N2 was scored as Light (65%), mostly because of incorrect visual staging of Lo Deep sleep due to high-pass filtering. N3 was scored as both Hi Deep (13 Hz power, 42%) and Lo Deep (0–1 Hz power, 39%), constituting a total of 81% of N3.The results show that spectral scoring better identifies clinically relevant physiology at a substantially lower cost and in a more reproducible fashion than visual scoring, supporting further work exploring its use in clinical and research settings.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders 血液代谢物对失眠和昼夜节律睡眠觉醒障碍的因果效应研究
Frontiers in sleep Pub Date : 2024-05-03 DOI: 10.3389/frsle.2024.1333154
Zheng Lv, Liyuan Huang, Yongfu Song, Yuejiao Lan, Shizhuo Sun, Yongji Wang, Yinan Ding, Xiaodan Lu
{"title":"Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders","authors":"Zheng Lv, Liyuan Huang, Yongfu Song, Yuejiao Lan, Shizhuo Sun, Yongji Wang, Yinan Ding, Xiaodan Lu","doi":"10.3389/frsle.2024.1333154","DOIUrl":"https://doi.org/10.3389/frsle.2024.1333154","url":null,"abstract":"Insomnia (IS) and circadian rhythm sleep-wake disorders (CRSWD) are complex disorders with limited and unsatisfactory treatment options that can even cause some side effects. By analyzing blood metabolites to reveal underlying biological processes, studies of sleep and the complex interactions between its influencing factors can be elucidated. Therefore, we hope to bring new hope for the treatment of these diseases through blood metabolites.Investigating the causal link between blood metabolites and IS and CRSWD.A genome-wide association study (GWAS) for 486 metabolites was used as the exposure, whereas two different GWAS datasets for sleep disorders were the outcome, and all datasets were obtained from publicly available databases. We employed the standard inverse variance weighting (IVW) method for causal analysis, supported by the MR-Egger method, weighted median (WM) method, and MR-PRESSO method for sensitivity analysis to mitigate the impact of pleiotropy. Genetic correlation between IS, CRSWD, and blood metabolites was explored through linkage disequilibrium analysis (LDSC), while Multivariable MR analysis (MVMR) elucidated whether these metabolites exhibit a direct association with IS and CRSWD. Further, we conducted metabolic pathway analysis to identify the specific metabolites driving these relationships.Employing meticulous MVMR analysis, we have identified specific metabolites that independently influence IS, including 2-hydroxypalmitate (OR 2.95, 95%CI 1.05–8.31 P = 0.040), X-11786-Methylcysteine (OR = 0.25, 95%CI 0.08–0.76 P = 0.014), and salicylate (OR 0.89, 95%CI 0.83–0.95 P = 9 × 10–4). In the context of CRSWD, our findings reveal direct associations with metabolites such as carnitine (OR 0.02, 95%CI: 0.00–0.20, P = 0.002), levulinate (OR 0.06, 95%CI: 0.01–0.64, P = 0.020), p-cresol sulfate (OR 0.25, 95% CI: 0.09–0.67, P = 0.006), and X-14208-Phenylalanylserine (OR 0.36, 95% CI: 0.16–0.81, P = 0.014). These discoveries contribute to a nuanced understanding of the distinct metabolic signatures underlying IS and CRSWD.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141017405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleepy and popular? The association between popularity, sleep duration, and insomnia in adolescents 爱睡又受欢迎?青少年受欢迎程度、睡眠时间和失眠之间的关系
Frontiers in sleep Pub Date : 2024-05-01 DOI: 10.3389/frsle.2024.1346806
S. Bauducco, Katja Boersma, Michael Gradisar
{"title":"Sleepy and popular? The association between popularity, sleep duration, and insomnia in adolescents","authors":"S. Bauducco, Katja Boersma, Michael Gradisar","doi":"10.3389/frsle.2024.1346806","DOIUrl":"https://doi.org/10.3389/frsle.2024.1346806","url":null,"abstract":"During adolescence, peers gain a central role and with the availability of technology, socializing can occur around the clock. Very few studies have focused on the role of peers in adolescents' sleep using social network analyses. These analyses describe peer relationships and social positions in a defined context (e.g., school) based on friendship nominations. Adolescents who receive many nominations can be defined as “popular,” which has been found to have its costs (i.e., shorter sleep duration) but also benefits (i.e., fewer insomnia symptoms). The aim of this study was to partially replicate and expand previous findings in a large Swedish sample of adolescents.The sample included 1,394 adolescents (46% girls, Mage = 15.3, SD = 0.53, range 14–18) from 16 public schools in middle Sweden. Adolescents reported on their weekly sleep duration, insomnia symptoms, anxiety, depression, alcohol use, demographics, and nominated up to three friends in school. We used R to calculate outgoing nominations and incoming nominations. Linear regressions were used to examine the association between popularity and sleep, controlling for confounding variables (demographics, emotional problems). Finally, we explored sex differences.Controlling for confounders, popular adolescents reported shorter sleep duration (B = −3.00; 95% CI [−5.77, −0.19]), and popular girls reported more insomnia symptoms (B = 0.36; 95% CI [0.04, 0.68]). There were no significant associations found for boys.Popularity was linked to shorter sleep duration (up to −27 min for the most popular teens). Moreover, girls may pay a price for their popularity by experiencing more insomnia symptoms. Sex differences and potential mechanisms should be further explored.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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