Frontiers in reproductive health最新文献

{"title":"Factors influencing sexual behaviors among youths in Myanmar: the results from the Myanmar demographic and health survey 2015-16.","authors":"Yoon Shwe Yee Hlaing, Pallop Siewchaisakul, Sineenart Chautrakarn","doi":"10.3389/frph.2025.1626266","DOIUrl":"10.3389/frph.2025.1626266","url":null,"abstract":"<p><strong>Background: </strong>Youths in Myanmar face heightened risks for adverse sexual health outcomes such as unintended pregnancies and sexually transmitted infections (STIs), including HIV/AIDS. Despite the increasing youth population in Myanmar, nationally representative data on factors influencing their sexual behaviors are limited. This study aimed to investigate the factors associated with sexual behaviors among youths in Myanmar.</p><p><strong>Methods: </strong>This study used data from the Myanmar Demographic Health Survey 2015-16 to analyze a sample of 4,645 youths aged 15-24. Descriptive statistics were used to investigate sociodemographic factors, HIV/STI and contraceptive knowledge, and sexual behaviors. Multivariable logistic regression was used to identify factors associated with sexual behaviors. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) were presented. Statistical significance was determined at a <i>p</i>-value of <0.05.</p><p><strong>Results: </strong>Among sexually active youths (<i>n</i> = 1,366), 47.0% reported having their first sex at or before the age of 18, 54.0% were currently using contraception, and only 8.1% of males had paid for sex. Higher education levels, middle, richer, and richest wealth, as well as moderate and high contraception knowledge, were all protective against early sexual initiation. Females and currently married youths were more likely to use contraception, while regional disparities persisted, with youths from hilly, coastal, and plains regions less likely to use contraceptives than those from the delta and lowlands. Married males were less likely to pay for sex. Male youths with moderate or high contraception knowledge reported higher risk of paying for sex.</p><p><strong>Conclusion: </strong>According to this study, gender, education level, wealth status, marital status, region, and contraceptive knowledge all have a significant impact on sexual behaviors among Myanmar youths. Early sexual initiation and low contraceptive use are common, especially among young people with low education and socioeconomic status. Targeted, inclusive, and culturally sensitive sexual and reproductive health education and services are urgently needed to address knowledge gaps and promote safer behaviors among Myanmar's youth.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1626266"},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping menstrual health and hygiene progress in US schools: a systematic policy review and comparison across states.","authors":"April M Ballard, Emily Wallace, Pranitha Kaza, Shannon Self-Brown, Matthew C Freeman, Bethany A Caruso","doi":"10.3389/frph.2025.1589772","DOIUrl":"10.3389/frph.2025.1589772","url":null,"abstract":"<p><strong>Introduction: </strong>Menstrual health and hygiene (MHH) policy initiatives have emerged as a key strategy to improve adolescent MHH, particularly through the expansion of state-level legislation aimed at increasing access to menstrual materials in K-12 schools in the United States (US). However, limited research has evaluated the implementation or effectiveness of these policies, and efforts to rigorously track and characterize existing policies remain limited. This study systematically reviewed and characterized state-level policies concerning menstrual material access in K-12 schools.</p><p><strong>Methods: </strong>We conducted a comprehensive search of all 50 US state government websites and legal databases to identify relevant legislation. Using MHH domains covered by the indicators recommended by the Global MHH Monitoring Group, we characterized policies. We also estimated policy reach by state and overall using National Center for Education Statistics enrollment data.</p><p><strong>Results: </strong>We found that 32 (64%) US states have enacted policies since 2017, which have the potential to improve MHH for approximately nine million, or 34%, of K-12 students. Most policies lack comprehensive coverage of essential MHH domains, including only three of the seven MHH domains on average.</p><p><strong>Discussion: </strong>These findings highlight the need for more rigorous research to evaluate the effectiveness of different policies and identify the best strategies for implementation.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1589772"},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria.","authors":"Imran Morhason-Bello, Yusuf Bello, Deborah Oke, Adekunle Daniel, Akinyele Adisa, Adeola Fowotade, Yinan Zheng, Joshua Akinyemi, Isaac Adewole, Miquel A Pavon, Robert Murphy, Lifang Hou, Suzanna C Francis, Deborah Watson-Jones","doi":"10.3389/frph.2025.1570984","DOIUrl":"10.3389/frph.2025.1570984","url":null,"abstract":"<p><strong>Purpose: </strong>To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan.</p><p><strong>Methods: </strong>This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by Anyplex^TM II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, <i>p</i> < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, <i>p</i> < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (<i>p</i> < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58].</p><p><strong>Conclusion: </strong>Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1570984"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and reproductive health service utilization among patients with podoconiosis in Wolaita Zone, South Ethiopia: a multilevel mixed-effect analysis.","authors":"Temesgen Lera Abiso, Amene Abebe Kerbo, Eskinder Wolka Woticha","doi":"10.3389/frph.2025.1562495","DOIUrl":"10.3389/frph.2025.1562495","url":null,"abstract":"<p><strong>Background: </strong>Sexual and reproductive health (SRH) services are essential for promoting the wellbeing of individuals and communities. Achieving universal health coverage is unattainable without ensuring equitable access to SRH services and upholding sexual and reproductive rights. Podoconiosis, a neglected tropical disease and non-filarial form of elephantiasis, is caused by prolonged barefoot exposure to irritant volcanic soils. Although SRH services have been increasingly integrated into primary healthcare systems in Ethiopia, people affected by podoconiosis continue to face substantial barriers in accessing these services due to stigma, mobility limitations, and socioeconomic constraints. In this context, the present study aims to assess the utilization of SRH services and the factors associated with their utilization among patients with podoconiosis in Wolaita Zone, South Ethiopia.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted among 836 patients with podoconiosis in Wolaita Zone from 12 November to 20 December 2024. Multistage sampling was used to select participants, and data were collected through face-to-face interviews. A multilevel logistic regression analysis was performed to identify the factors associated with SRH service utilization. Statistical significance was set at <i>p</i> < 0.05, and adjusted odds ratios (AOR) with 95% confidence intervals (CI) were reported.</p><p><strong>Results: </strong>The study found that 154 respondents (18.4%; 95% CI: 16%, 21%) utilized SRH services within the past 12 months. The factors significantly associated with SRH service utilization included the following: age groups 18-29 years (AOR = 3.57; 95% CI: 1.55-8.25), 30-34 years (AOR = 2.89; 95% CI: 1.30-6.40), and 35-39 years (AOR = 5.06; 95% CI: 2.45-10.45); prior experience with health services (AOR = 2.39; 95% CI: 1.56-4.93); family awareness of podoconiosis etiology (AOR = 3.60; 95% CI: 2.13-6.21); positive attitude toward SRH services (AOR = 5.80; 95% CI: 3.16-10.70); family support (AOR = 2.47; 95% CI: 1.47-4.14); and autonomy in using household financial resources for healthcare (AOR = 2.05; 95% CI: 1.18-3.57).</p><p><strong>Conclusion: </strong>The utilization of SRH services among patients with podoconiosis was found to be low. The significant factors associated with SRH service utilization included the age of respondents, prior experience with health services, family awareness of podoconiosis etiology, family support, autonomy in using household financial resources for healthcare, and positive attitudes toward SRH services.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1562495"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of dual protection use based on information-motivation-behavior skill model among female university students: a cross-sectional study.","authors":"Banti Negero Feyisa, Gurmesa Tura Debelew, Zewdie Birhanu Koricha","doi":"10.3389/frph.2025.1407854","DOIUrl":"10.3389/frph.2025.1407854","url":null,"abstract":"<p><strong>Background: </strong>The burden of sexually transmitted infections and unintended pregnancy remain a major health problem disproportionately affecting young woman in sub Saharan Africa. While there is a growing interest in promoting dual protection as a means of simultaneously preventing both HIV/STIs and unwanted pregnancy, little is known about patterns and predictors of dual protection use based on theoretical models for designing targeted interventions to promote dual protection for youth. This study aimed to examine predictors of dual protection use based on the information-motivation-behavioral skills model among female university students in Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 1,020 female students at Mattu University between April and June 2023. Data were collected using a self-administered questionnaire and analyzed using SPSS version 24. Bivariate and multivariate analyses were conducted using structural equation modeling with AMOS program to examine predictors of dual-protection use.</p><p><strong>Results: </strong>Of the 1,020 participants, 396 (38.8%) had ever had sexual intercourse, 370 (93.4%) of whom were sexually active in the last 12 months. Of these, only 76 (20.5%) used dual protection at last sex in the past 6 months. Multivariate analysis indicated that dual-protection use was directly and strongly predicted by motivation (<i>β</i> = 0.29, <i>P</i> < 0.001) and behavioral skills (<i>β</i> = 0.27, <i>P</i> < 0.001), whereas it was weakly predicted by information (<i>β</i> = 0.04, <i>P</i> < 0.05), while the information had a strong effect (<i>β</i> = 0.27, <i>p</i> < .001) on behavioral skills to indirectly influence dual protection use.</p><p><strong>Conclusion: </strong>These findings support the key roles of motivation and behavioral skills in directly predicting dual protection use, while information can also influence behavioral skills to indirectly affect dual protection use, suggesting the importance of incorporating all elements of the IMB model constructs in designing targeted intervention to promote dual protection behaviors for youth.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1407854"},"PeriodicalIF":2.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12391127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing menstrual hygiene knowledge, attitudes, and practices among adolescent girls in African rural schools: scoping review.","authors":"Mosotho Zenia Tshivule, Molatelo Melitah Rasweswe, Tebogo Maria Mothiba, Mamare Adelaide Bopape","doi":"10.3389/frph.2025.1553101","DOIUrl":"10.3389/frph.2025.1553101","url":null,"abstract":"<p><p>Menstrual hygiene management (MHM) is a critical component of adolescent health and well-being, particularly in rural African schools where cultural, economic, and infrastructural challenges persist. This scoping review followed the steps proposed by Arksey and O'Malley to explore the factors influencing menstrual hygiene knowledge, attitudes, and practices among adolescent girls in rural African settings. The review systematically analysed literature conducted in diverse African rural public schools. Findings reveal that many adolescent school girls lack comprehensive knowledge about menstruation, due to unreliable or insufficient sources of menstrual hygiene management information and unpreparedness for menarche. Furthermore, their menstrual hygiene practices are shaped by various sociocultural and religious influences. There is also resource limitation, related to availability and cost of menstrual hygiene management supplies, and water, sanitation, and hygiene (WASH) infrastructure in rural schools. These challenges have a significant impact on school attendance, academic performance, and the overall quality of life for adolescent girls. The review practice. It emphasizes the importance of multi-sectoral approaches in supporting adolescent girls in rural African schools and advocates for further research to address persistent knowledge and practice gaps. There is also a need for integrated interventions, including menstrual health education, improved WASH infrastructure, and the provision of affordable menstrual products. Addressing these factors holistically can enhance menstrual hygiene management, reduce stigma, and promote gender equality in education.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1553101"},"PeriodicalIF":2.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory mediators and the RAGE pathway in placental tissues of pregnancies complicated by severe preeclampsia.","authors":"Neelima Chandra, Thomas D Kimble, Kathleen R Heim, Sharon M Anderson, Andrew P Wong, Andrea R Thurman, Gustavo F Doncel","doi":"10.3389/frph.2025.1587699","DOIUrl":"10.3389/frph.2025.1587699","url":null,"abstract":"<p><strong>Introduction: </strong>Preeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Studies using placental tissue from either vaginal or cesarean deliveries are confined to semiquantitative analysis using subjective scoring methods and generally involve a small sample size.</p><p><strong>Methods: </strong>In this study, we have quantified the expression of inflammatory mediators by immunohistochemical image analysis of archived placental tissues obtained from cesarean delivery of preeclamptic, chorioamnionitic, and normal pregnancies.</p><p><strong>Results: </strong>Among the inflammatory mediators, we found a significant elevation in the expression of receptors of advanced glycation end products (RAGE) and two of its damage-associated molecular pattern proteins (DAMPs) and ligands, the high mobility group box protein HMGB1 and the calcium binding protein S100, in preeclamptic tissues as compared to normal placentas. In addition, we observed a significant increase in the master pro-inflammatory transcription factor, nuclear factor kappa B p65 subunit (NFκB), as well as non-significant increases in cyclooxygenase 2 (COX-2) and interleukin 8 (IL-8) in the PE group.</p><p><strong>Conclusion: </strong>This study provides insight into the relationship of tissue inflammatory mediators with severe preeclampsia and the RAGE associated signaling complex, suggesting a pathogenic role for this pathway which has clinical implications for the understanding, diagnosis, and potential novel therapeutic approaches to the syndrome.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1587699"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of eight antenatal care contacts among mothers who give birth in Shebel Berenta district, East Gojjam zone, northeast Ethiopia, 2024.","authors":"Nigusie Abebaw, Yezbalem Negesse, Asnake Begashw, Dagnachew Amare, Genet Tsegaw, Dessalew Meshesha, Kefale Geto","doi":"10.3389/frph.2025.1531380","DOIUrl":"10.3389/frph.2025.1531380","url":null,"abstract":"<p><strong>Introduction: </strong>Antenatal care refers to the medical attention provided by skilled healthcare professionals to pregnant women to ensure optimal health outcomes for both the mother and fetus throughout pregnancy. In Ethiopia, there is limited evidence regarding the completion of eight antenatal care contacts and the factors associated with it. Therefore, the aim of this study was to assess the prevalence and associated factors of completing eight antenatal care contacts among mothers in Shebel Berenta Woreda.</p><p><strong>Method: </strong>A community-based cross-sectional study was employed. A stratified sampling technique was employed to select the sample. Data were exported from Kobo Toolbox software to SPSS version 27 for analysis. Bivariable and multivariable logistic regression analyses were used to assess associations between the outcome and independent variables, with statistical significance determined at a <i>p</i>-value of <0.05.</p><p><strong>Result: </strong>This study showed that the prevalence of eight or more antenatal care contacts was 9.6% [95% confidence interval (CI): 7.4-12.3]. In this study, good knowledge of ANC [adjusted odds ratio (AOR) = 2.402; 95% CI: 1.115-5.175], media exposure (AOR = 2.47; 95% CI: 1.15-5.306), time of early initiation for first ANC contact (AOR = 5.46; 95% CI: 2.837-10.51), women's governmental occupation (AOR = 3.745; 95% CI: 1.364-10.28), two to four pregnancies (AOR = 3.524; 95% CI: 1.696-7.32), and family size less than five (AOR = 3.005; 95% CI: 1.461-6.179) were significantly associated with the outcome variable.</p><p><strong>Conclusion: </strong>The study indicates that the prevalence of eight or more antenatal care contacts was low. Time of initiation for first ANC contact, women's occupational status, knowledge of antenatal care, family size, number of pregnancies, and media exposure were significantly associated with the outcome variable.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1531380"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal hormone therapy and exercise on psychosocial well-being and stress in menopausal women.","authors":"Ming Jun Kuck, Eef Hogervorst","doi":"10.3389/frph.2025.1582406","DOIUrl":"10.3389/frph.2025.1582406","url":null,"abstract":"<p><strong>Introduction: </strong>Menopausal hormone therapy (MHT) is widely used to alleviate menopausal symptoms, but concerns regarding its risks have led many women to seek alternative treatments, such as physical activity, mindfulness, and yoga. While research suggests that these non-pharmaceutical interventions may improve quality of life (QoL), their efficacy remains debated. This study investigates the independent and interactive effects of MHT and exercise on psychosocial QoL and perceived stress in menopausal women.</p><p><strong>Methods: </strong>A cross-sectional online survey recruited 272 women aged 40-60 experiencing menopausal symptoms. Participants reported MHT use and engagement in physical activity, mindfulness, or yoga. Psychosocial QoL was assessed using the Menopause-Specific Quality of Life (MenQoL) scale, and perceived stress was measured using PSS-10. Data were analysed using general linear models and partial correlation analyses.</p><p><strong>Results: </strong>MHT use was significantly associated with poorer psychosocial QoL and worse memory complaints. However, physical activity and yoga were linked to lower perceived stress and better psychosocial QoL. In contrast, mindfulness, as a standalone therapy, was associated with higher perceived stress and depression. No significant interaction effects were observed between MHT and exercise.</p><p><strong>Conclusion: </strong>While MHT remains a common treatment for menopausal symptoms, its association with poorer psychosocial QoL and memory issues suggests a need for personalised approaches. Engaging in physical activity and yoga appears to offer greater mental health benefits, whereas mindfulness alone is associated with worse mental health. Future research should explore the mechanisms underlying these relationships and the long-term effects of MHT and exercise, especially in early and surgical menopausal women.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1582406"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of autologous platelet-rich plasma intrauterine perfusion on pregnancy outcomes of frozen-thawed embryo transfer in patients with chronic endometritis.","authors":"Lili Chen, Lan Liu, Huanhuan Guo, Zhenhua Wang","doi":"10.3389/frph.2025.1644445","DOIUrl":"10.3389/frph.2025.1644445","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effect of autologous platelet-rich plasma (PRP) intrauterine perfusion on the clinical outcomes of frozen-thawed embryo transfer in patients with chronic endometritis.</p><p><strong>Methods: </strong>A retrospective continuous cohort of 219 patients diagnosed with chronic endometritis at the Reproductive Medicine Center of Affiliated Hospital of Putian University between January 2020 and December 2022, undergoing their first frozen-thawed embryo transfer cycle, was included. All patients received standardized oral doxycycline treatment after diagnosis. Based on whether they received PRP intrauterine perfusion prior to embryo transfer, patients were divided into an observation group (PRP group, <i>n</i>=103) and a control group (non-PRP group, <i>n</i> = 116). Outcome measures included live birth rate per transfer cycle, clinical pregnancy rate per transfer cycle, and early miscarriage rate per clinical pregnancy.</p><p><strong>Results: </strong>All patients underwent endometrial preparation using a hormone replacement therapy (HRT) protocol. Endometrial thickness on the day before transformation was significantly higher in the PRP group compared to the control group (10.58 ± 1.78 mm vs. 9.79 ± 1.58 mm, <i>P</i> = 0.001). The PRP group exhibited significantly higher clinical pregnancy rate per transfer cycle and live birth rate per transfer cycle than the control group (58.25% vs. 40.52%, <i>P</i> = 0.038; 52.43% vs. 34.48%, <i>P</i> = 0.007). The difference in early miscarriage rate per clinical pregnancy between the PRP group and the control group was not statistically significant (8.33% vs. 14.89%, <i>P</i> = 0.86). The live birth rate per transfer cycle in the single-PRP subgroup was significantly lower than in the multiple-PRP subgroup (44.62% vs. 65.79%, <i>P</i> = 0.038). There were no statistically significant differences in clinical pregnancy rate per transfer cycle or early miscarriage rate per clinical pregnancy between the single-PRP and multiple-PRP subgroups (52.31% vs. 68.42%, <i>P</i> = 0.110; 11.76% vs. 3.85%, <i>P</i> = 0.377).</p><p><strong>Conclusion: </strong>For patients diagnosed with chronic endometritis undergoing their first frozen-thawed blastocyst transfer after standardized antibiotic treatment, adjunctive PRP intrauterine perfusion therapy improves pregnancy outcomes.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1644445"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}