Frontiers in reproductive health最新文献

{"title":"Editorial: Intersection of adolescent sexual, reproductive, and mental health in Sub-Saharan Africa.","authors":"Negussie Boti Sidamo, Sultan Hussen Hebo, Stephen O Chukwudeh, Zacharie Tsala Dimbuene","doi":"10.3389/frph.2025.1614317","DOIUrl":"10.3389/frph.2025.1614317","url":null,"abstract":"","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1614317"},"PeriodicalIF":2.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV disclosure in the social networks of adolescents with HIV in Cape Town, South Africa.","authors":"Marta I Mulawa, Frances Hung, Nicole J Phillips, Mark F Austin, Richard Barfield, Hui-Jie Lee, Heather J Zar, Dan J Stein, Jacqueline Hoare","doi":"10.3389/frph.2025.1545039","DOIUrl":"10.3389/frph.2025.1545039","url":null,"abstract":"<p><strong>Background: </strong>Little is known about HIV status disclosure within the social networks of adolescents with perinatally-acquired HIV (APHIV) in sub-Saharan Africa, where HIV prevalence is high and stigma surrounding HIV is pervasive. This study employed egocentric network analysis to characterize HIV disclosure in the social networks of APHIV in Cape Town South Africa. Associations between HIV disclosure and characteristics of APHIV (egos), their relationship to network members (alters), and features of the social network, including ego's network size and alter's centrality within the network, were also examined.</p><p><strong>Methods: </strong>Network data were collected from 58 APHIV (mean age 14.3 years; 52% female) using a customized touchscreen-based assessment, providing data on 349 ego-alter relationships. Associations with HIV disclosure within the ego-alter pairs were evaluated by adjusted odds ratios (AOR) from multivariable logistic regression with generalized estimating equations, clustering by ego.</p><p><strong>Results: </strong>Among all ego-alter pairs identified, 36.4% (127/349) were disclosed to by egos. Odds of disclosure did not differ based on the ego's gender or viral suppression. Odds of disclosure were significantly higher when alters were presumed by the ego to have HIV [AOR 6.26; 95% confidence interval (CI): 2.36-16.58, <i>p</i> < 0.001], were more trusted by the ego (AOR 2.84; 95% CI: 1.14-7.06, <i>p</i> = 0.03), or were older than the ego (1-year difference AOR 1.04; 95% CI: 1.02-1.07, <i>p</i> < 0.001). Increasing alter's centrality by 0.01 was associated with an increased odds of disclosure (AOR 1.02; 95% CI: 1.002-1.03, <i>p</i> = 0.03), though overall network size was not associated with increased odds of disclosure. The effect of the ego's emotional support network size on disclosure, however, depended on the type of ego-alter relationship.</p><p><strong>Conclusions: </strong>HIV status disclosure was low in the social networks of APHIV. Our study found that disclosure was not influenced by network size, gender, or viral suppression but rather by factors related to interpersonal trust and shared experience, such as perceived HIV status of alters, network-level centrality and emotional support network size. The study further highlights the benefits and future potential of using social network data collection and analysis methods to better understand HIV disclosure among adolescents.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1545039"},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a 12-week obesity intervention on menopausal symptoms and psychological well-being across menopause stages: a cross-sectional analysis.","authors":"Rupal Kumar, Moattar Raza Rizvi, Waqas Sami","doi":"10.3389/frph.2025.1524790","DOIUrl":"10.3389/frph.2025.1524790","url":null,"abstract":"<p><strong>Introduction: </strong>Menopause poses unique physical and psychological challenges, especially for obese women, impacting quality of life across menopausal stages. This study evaluates a 12-week obesity educator program on body composition, menopausal symptoms, and psychological well-being among pre-, peri-, and post-menopausal obese women in Delhi NCR, India.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted with 291 obese women (97 per menopausal stage) assessing anthropometric measures, menopausal symptoms via the Menopause Rating Scale (MRS), and psychological well-being using the Well-being Questionnaire (W-BQ12). Data were analyzed using paired t-tests, ANCOVA, Pearson's correlation, and regression analysis.</p><p><strong>Results: </strong>The intervention led to significant weight reduction across all groups (3.8-4.5 kg, <i>p</i> < 0.001), waist circumference decreases (5.7-6.5 cm, <i>p</i> < 0.001), and HbA1c reductions by 0.4% (<i>p</i> < 0.001). Regression analysis identified waist-to-hip ratio and hemoglobin as predictors of somato-vegetative and psychological symptoms (<i>R</i> ² = 0.15, <i>p</i> < 0.05). MRS scores showed the most improvement in perimenopausal women.</p><p><strong>Conclusion: </strong>The obesity educator program effectively improved body composition, glycemic control, and well-being across menopausal stages, highlighting the value of personalized interventions for menopausal health management.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1524790"},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital tracking of girls exposed to community led alternative rites of passage to prevent female genital mutilation/cutting, and child, early and forced marriages in Kenya: a longitudinal study.","authors":"David Kawai, Bernard Mbogo, Yvonne Opanga, Samuel Muhula, Tammary C Esho, Hilke Conradi, Viola J Rutto, Denge Lugayo, Dennis J Matanda","doi":"10.3389/frph.2025.1445504","DOIUrl":"10.3389/frph.2025.1445504","url":null,"abstract":"<p><strong>Introduction: </strong>Female genital mutilation/cutting (FGM/C) and child marriage (CEFM) are harmful practices that are a human rights violation. For decades, many interventions have been implemented to end these practices. One such intervention is the Alternative Rite of Passage (ARP), which allows girls to go through a meaningful rite of passage without the cut. The ARPs have come under scrutiny due to a lack of data to show how effective ARPs have been. This study aimed to establish the effect of the Community-Led Alternative Rite of Passage (CL-ARP) model on incidences of FGM/C, CEFM and keeping girls and young women in school.</p><p><strong>Methods: </strong>The study adopted a longitudinal design where girls and young women were enrolled into the CL-ARP programme and later followed up for over three years to assess the effectiveness of the CL-ARP model in preventing incidences of FGM/C, CEFM and keeping girls in school. A total of 2,647 girls aged 10-23 years who resided in Kajiado County were recruited and followed up post-exposure to CL-ARP. Data analysis involved conducting descriptive and logistic regression analyses.</p><p><strong>Results: </strong>The CL-ARP programme kept 98% of girls free of FGM/C, 99% free of CEFM and 98% kept in school. 41 cases of FGM/C, 12 cases of CEFM and 48 cases of school dropouts were reported three years post-exposure. Girls who underwent FGM/C had been kept free of FGM/C for an average of 39.5 months, those who experienced CEFM had been kept free of CEFM for an average of 40.2 months, and those who dropped out of school had been kept in school for an average of 38.5 months. Girls and young women who experienced instances of threats/violence were more likely to experience FGM/C, CEFM and drop out of school than those who had not.</p><p><strong>Conclusions: </strong>The CL-ARP programme was successful in keeping the majority of girls and young women free of FGM/C and CEFM, and retained in school post-enrollment. Reported cases of FGM/C, CEFM and school dropouts underline the importance of considering other contextual factors such as gender-based violence that may continue to put girls and young women at risk despite embracing CL-ARP.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1445504"},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review of social norms interventions to reduce violence and improve SRHR outcomes among adolescents and young people in sub-Saharan Africa.","authors":"Luciana Leite, Rachel Yates, Gaia Chiti Strigelli, Jenny Yi-Chen Han, Jenny Chen-Charles, Maria Rotaru, Elona Toska","doi":"10.3389/frph.2025.1592696","DOIUrl":"10.3389/frph.2025.1592696","url":null,"abstract":"<p><strong>Introduction: </strong>Despite growing interest, guidance to inform effective social norms interventions that improve adolescents and young people's sexual and reproductive health and rights (SRHR) is needed.</p><p><strong>Methods: </strong>We conducted a scoping review of experimental and quasi-experimental studies of social norms interventions in sub-Saharan Africa. Single and multi-component interventions that included a social norms component and assessed impacts on SRHR outcomes among 10- to 24-year-old adolescents and young people were included. We mapped interventions across eight programmatic strategies and six SRHR outcomes, drawing programmatic insights.</p><p><strong>Results: </strong><i>N</i> = 40 interventions from 12 countries reported effectiveness on intimate partner and non-partner sexual, physical and emotional violence (<i>N</i> = 14), child marriage (<i>N</i> = 6), sexual risk behaviours (<i>N</i> = 20), contraception and family planning (<i>N</i> = 23), prevention and treatment of HIV and other sexually transmitted infections (<i>N</i> = 17), and early pregnancy (<i>N</i> = 10). Intervention strategies included life skills approaches (<i>N</i> = 23), community dialogues (<i>N</i> = 14), school-based SRHR programming (<i>N</i> = 10), parenting programmes (<i>N</i> = 8), training of healthcare professionals on youth-friendly services (<i>N</i> = 7), media or digital-based approaches (<i>N</i> = 7), interventions with community leaders (<i>N</i> = 5), and rights-based advocacy (<i>N</i> = 2). Norms interventions can improve multiple SRHR outcomes, including reducing gender-based and intimate partner violence and child marriage, increasing HIV testing, and contraceptive use. Effective programmes were often implemented in combined interventions, and included life skills, community conversations, mass media and digital programmes with norms components.</p><p><strong>Discussion: </strong>Integrating gender-transformative approaches such as reflections on gender roles and inequalities, youth sexuality, and gendered power relations, and engaging with reference groups were key to the success of programmes. Effective approaches delivered SRHR information alongside reflections on social norms, and combined participatory methods with a structured curriculum guiding activities led by trained facilitators. Most interventions focused on changing social expectations and awareness, but few reported clear diffusion strategies to ensure the spread of the new norms and behaviours for the expected change. Key evidence gaps identified include integrating implementation research to inform the scale-up and sustainability of effective social norms interventions. Social norms interventions that effectively address the needs of high-risk adolescents and young people are needed.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1592696"},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"One's life becomes even more miserable when we hear all those hurtful words\". A mixed methods systematic review of disrespect and abuse in abortion care.","authors":"Meghana Munnangi, Priya Shreedhar, Regina Gilyan, Hedda Lippus, Dabney P Evans, Lauren Maxwell","doi":"10.3389/frph.2025.1561707","DOIUrl":"10.3389/frph.2025.1561707","url":null,"abstract":"<p><strong>Background: </strong>Disrespect and abuse during facility-based abortion and postabortion care (PAC) manifests in various forms, including disrespect, abuse (physical, verbal, and sexual), stigma, discrimination, failure to meet standards of care, neglect, breaches in privacy and confidentiality, misinformation or a lack of information, mistreatment or undignified care, and the presence of protestors. The objective of this mixed methods systematic review was to describe the various forms of disrespect and abuse that women face based on their personal experiences during facility-based abortion care or PAC.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search in Embase, Medline, and PubMed using Medical Subject Headings (MeSH) and text-based terms targeting disrespect and abuse in facility-based abortion care. The initial search was conducted in 2019, followed by an updated search in 2023. Thirty-eight studies conducted in 20 countries met the inclusion criteria and were included in this review.</p><p><strong>Results: </strong>The most frequently observed form of disrespect and abuse, identified in 33 studies, was the failure to meet care standards in providing quality abortion care or PAC, particularly in terms of offering adequate and accurate information to women before, during and after the procedures which was identified in 21 studies. Additionally, stigma was reported in 22 studies, disrespect in 19 studies, discrimination in 10 studies, and verbal, physical and sexual abuse, as well as humiliation and condescension, each in 9 studies. The presence and impact of abortion protestors were also looked at in 8 studies.</p><p><strong>Conclusions: </strong>Our results indicate the need for multi-level strategies to transform healthcare providers' perceptions and attitudes towards women seeking abortion care and other actions at the individual, institutional, and policy levels to provide quality, respectful abortion care and PAC. This systematic measurement of disrespect and abuse in facility-based abortion care and PAC can help understand the distribution of experiences across different groups.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1561707"},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to sexual and reproductive health communication in Southwest Ethiopia: perspectives of parents, youths, and teachers.","authors":"Abraham Tamirat Gizaw, Sualiha Abdulkader Muktar, Yohannes Addisu Wondimagegene, Mengistu Abayneh, Belay Zeleke Sefere, Kasahun Girma Tareke, Abebayehu N Yilma","doi":"10.3389/frph.2025.1444603","DOIUrl":"10.3389/frph.2025.1444603","url":null,"abstract":"<p><strong>Background: </strong>Youths throughout the world face considerable challenges related to their sexual and reproductive health (SRH). In Ethiopia, the adolescent and youth groups account for nearly half the population. Parents play a vital role in SRH communication. Parents' communication with their children regarding SRH is considered an important part of adolescent development, as this contributes to optimizing safe SRH. Therefore, this study aimed to explore barriers to SRH communication from the perspectives of parents, youths, and teachers in Southwest Ethiopia.</p><p><strong>Methods: </strong>A qualitative research approach was used in four schools (two private and two public) in Jimma town. Data collection entailed 16 focused group discussions with parents and youths (15-24 years) and 12 key informant interviews with school directors, unit leaders, and school media coordinators. The interviews were audio-recorded, transcribed, and translated into English. Thematic analysis was conducted using ATLAS_ti software.</p><p><strong>Results: </strong>Participants recognized the crucial role parents play in SRH issues; however, only a few parents were involved in SRH communications, and there were many barriers raised by the participants. Barriers to SRH communications were parental lack of knowledge, cultural and religious beliefs, the effect of social media use, shame and stigma, and parental attitudes towards SRH communication.</p><p><strong>Conclusions: </strong>In summary, addressing barriers to sexual and reproductive health communication between parents and youth is crucial for fostering better health outcomes. Parents should be encouraged to have open discussions with their children from an early age. High schools should implement regular SRH education sessions with healthcare providers, while youth-friendly service clubs should focus on changing attitudes towards SRH communications through social and behavioral changes in communication.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1444603"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multipurpose prevention technologies for the prevention of unintended pregnancy, HIV, and other sexually transmitted infections: regulatory pathways and challenges.","authors":"Logan Donaldson, Robin Schaefer, Sarah Alhakimi, Ruth Akulu, Thesla Palanee-Phillips, Bethany Young Holt, Veronica Miller","doi":"10.3389/frph.2025.1591232","DOIUrl":"10.3389/frph.2025.1591232","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Multipurpose prevention technologies (MPTs) are multi-indication products commonly focusing on the prevention of unintended pregnancy, HIV, and/or other sexually transmitted infections (STIs). MPTs have the potential to simplify product use and service delivery with reduced clinic visits, thus supporting improved product uptake, effective use, and cost-effectiveness. MPTs are complex products that typically include multiple active pharmaceutical ingredients (APIs), with two or more indications, and often use a device to deliver these APIs. These complexities create challenges when seeking regulatory approval. Products with previously approved APIs may be able to rely on bioequivalence (BE) studies, but still face challenges in formulation variation, drug-drug interaction, and fulfilling strict standards. MPTs that use new APIs and devices cannot rely on BE studies for approval and thus face further uncertainty, including clinical trial design for products with multiple indications and outcomes of interest. Efficacious standards of care for HIV prevention and contraception also necessitate active-control designs for registrational clinical trials, thus innovative trial designs may be needed. Compounding these challenges are special regulatory requirements for combination products, in addition to standards applied to individual API and device. Possible approval pathways for combination products exist within the US Food and Drug Administration and other global regulatory authorities, but their complexities and challenges are untested for MPTs. They are highlighted in this article to raise awareness around regulatory pathways for MPTs. In Sub-Saharan Africa, women of reproductive age are the largest percentage of new HIV infections. This, in combination with considerable rates of unintended pregnancy and rising sexually transmitted infection (STI) rates, highlights the need for products that address these complex sexual and reproductive health needs. Multipurpose prevention technologies (MPTs) commonly focus on the prevention of unintended pregnancy, HIV, and/or other STIs in one product. MPTs combine the use of multiple pharmaceutical drugs and often a medical device to address these interrelated challenges. This creates complications in the design of studies for MPTs and in understanding the process of approval from regulatory authorities. Regulatory authorities are responsible for ensuring the safety and effectiveness of health products, and in MPTs this is complicated by targeting the prevention of multiple indications, with differing study designs and challenges, in one product. There are mechanisms in place at some regulatory authorities to evaluate MPTs, but these pathways are untested by product developers and regulatory authorities alike. Some of these pathways are highlighted below. Collaboration between diverse stakeholders like regulators, academics, product developers, and community members is necessary to build consensus on the be","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1591232"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of cervical intraepithelial neoplasia in three members of the same family: a case report.","authors":"M A Vinokurov, A V Minaeva, G V Leshkina, T N Romanyuk, K O Mironov, V G Akimkin","doi":"10.3389/frph.2025.1542480","DOIUrl":"10.3389/frph.2025.1542480","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is the fourth most common cancer and cause of cancer-related death among women globally. Familial cases of cervical cancer highlight the potential role of genetic factors in its development. This study aims to present a clinical case of cervical intraepithelial neoplasia (CIN) affecting a woman and her two daughters.</p><p><strong>Case description: </strong>This report describes a familial case involving three patients diagnosed with cervical lesions: (1) Patient A: A 27-year-old woman presented with complaints of postcoital bleeding. She was diagnosed with high-grade squamous intraepithelial lesion (HSIL, CIN3). Radiowave conization of the cervix was performed, and histological examination confirmed the diagnosis of CIN3. (2) Patient B: A 25-year-old woman, the sister of Patient A, also presented with contact bleeding. She was similarly diagnosed with HSIL (CIN3). A radiowave conization procedure was performed successfully, with histopathological analysis confirming the diagnosis. (3) Patient C: A 52-year-old woman, the mother of Patients A and B, was diagnosed with low-grade squamous intraepithelial lesion (LSIL, CIN1) following cytological examination. She declined further diagnostic and therapeutic interventions. Genetic testing for all three patients revealed the presence of risk alleles associated with cervical cancer predisposition (rs10175462, rs1048943, rs4646903) and the absence of protective genotypes.</p><p><strong>Discussion: </strong>Familial cases of CIN are rare and suggest a potential genetic predisposition to the disease. The identification of common genetic polymorphisms underscores the role of hereditary factors in cervical cancer pathogenesis. These findings emphasize the importance of incorporating family history and genetic assessments into screening, diagnosis, and treatment strategies.</p><p><strong>Conclusion: </strong>This case highlights the significant influence of genetic factors in the development of cervical intraepithelial neoplasia. It underscores the need for further research to enhance strategies for early detection, prevention, and management of cervical cancer in individuals with elevated genetic risk.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1542480"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of menopause hormone therapy, exercise, and their combination on bone mineral density and mental wellbeing in menopausal women: a scoping review.","authors":"Olivia Platt, James Bateman, Shagaf Bakour","doi":"10.3389/frph.2025.1542746","DOIUrl":"10.3389/frph.2025.1542746","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis, a condition marked by low bone mineral density (BMD) and structural deterioration, affects more women than men over 50 globally. In women, declining estrogen during the menopause accelerates bone resorption, heightening fracture risk. An association between osteoporosis and depression, frailty fractures and poor quality of life has been identified. Both menopause hormone therapy (MHT) and exercise are shown to improve BMD, with MHT reducing bone resorption and exercise promoting bone formation. This review examines the effectiveness of MHT, exercise, and their combination in managing menopausal osteoporosis.</p><p><strong>Method: </strong>A multifactor scoping review was conducted to address osteoporosis and MHT, osteoporosis and exercise, and osteoporosis and MHT and exercise combined.</p><p><strong>Results: </strong>Initial searches identified 15,158 studies, narrowed to 20 meeting the inclusion criteria. MHT and exercise are effective in preserving BMD in menopausal women. Combined estrogen and progesterone MHT is more effective than estrogen-only, with studies suggesting that MHT prescribed at low doses for longer durations more effectively preserves BMD. Resistance training (RT) completed 2-3 days per week at a moderate-to-high intensity combined with impact activity completed at a minimum of 3 days per week is optimal for improving BMD in menopausal women, while low-impact exercises provide supplemental benefits. Combining MHT with exercise enhances BMD more than either alone.</p><p><strong>Conclusion: </strong>This review highlights that combining MHT and structured exercise is most effective for enhancing BMD in menopausal women. Given certain safety considerations surrounding MHT in some women, exercise remains a cornerstone for the prevention and management of osteoporosis as well as for promoting overall wellness.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1542746"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}