Frontiers in reproductive health最新文献

{"title":"Reproductive health problem among youths and associated factors in Dilla town, southern Ethiopia.","authors":"Seblewongel Gebretsadik Sertsewold, Getachew Assefa Zenebe, Amanuel Yosef Gebrekidan","doi":"10.3389/frph.2025.1519024","DOIUrl":"https://doi.org/10.3389/frph.2025.1519024","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescents are defined by the World Health Organization as people aged 10-19, youth 15-24, and young people 10-24. Youth are a demographic that experiences life-threatening physical, emotional, mental, and social changes. Most young individuals are therefore more vulnerable to reproductive health problems than adults for a number of reasons.</p><p><strong>Methods: </strong>A community-based cross-sectional study was done in Dilla town between January and March 2024 with 536 youths. A survey of houses with young people was followed by the use of a systematic sampling technique. Data was gathered using pretested and structured questionnaires. Coded and entered into EPI INFO version 7 after being verified for completeness, it was then exported to SPSS version 22 for analysis. Both multivariate and bivariate logistic regression were performed. Variables with a <i>p</i>-value <0.2 in bi-variable logistic regression were moved to multivariable logistic regression, and variables with a <i>p</i>-value of <0.05 in multivariable logistic regression were considered statistically significant.</p><p><strong>Result: </strong>A total of 493 youths participated in this study, with a response rate of 92%. Among them, 271 (55%) of them were under the age group of 21-25 years old, 225 (45.6%) were females, and 214 (43.4%) were protestants. In addition, 287 (58.2%) said that they are ashamed to discuss sexual issues, and a few respondents, 158 (32%), had multiple sexual partners. Most of the respondents (92.1%, 87.4%, 100%, and 72.6%) reported that they had no history of khat chewing, cigarette smoking, shisha smoking, or drinking alcohol, respectively. The overall youth reproductive health problem in Dilla town is 66.1% (95% CI: 62.5-70.4). Being in the age category 21-25 (AOR: 8.52; 95% CI: 4.61-15.76), employed (AOR: 2.12; 95% CI: 1.09-4.13), ashamed to discuss sexual issues (AOR: 6.66; 95% CI: 3.79-11.71), having multiple sexual partners (AOR: 2.01; 95% CI: 1.08-3.73), not using condoms (AOR: 4.05; 95% CI: 2.31-7.11), health facility inconvenience (AOR: 3.2; 95% CI: 1.85-5.55), and drinking alcohol (AOR: 2.28; 95% CI: 1.29-3.99) were found to be significantly associated with youth reproductive health problems.</p><p><strong>Conclusion and recommendation: </strong>Healthcare facilities should provide comprehensive, age-appropriate, and accurate sexual education as part of specialized reproductive health services for youth that prioritize privacy and nonjudgmental treatment. In addition, screening and early detection of RH problems and engaging in community outreach programs are some of the recommended activities.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1519024"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Inequities and disparities in reproductive health: HIV and STIs.","authors":"Mat Lowe, Choolwe Jacobs, Ruth Oladele","doi":"10.3389/frph.2025.1595001","DOIUrl":"https://doi.org/10.3389/frph.2025.1595001","url":null,"abstract":"","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1595001"},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of the research on anti-Müllerian hormone and polycystic ovary syndrome: current status, hotspots, and trends.","authors":"Bingqing Ran, Cai Liu, Yajun He, Lizhu Ma, Fang Wang","doi":"10.3389/frph.2025.1519249","DOIUrl":"https://doi.org/10.3389/frph.2025.1519249","url":null,"abstract":"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age. Over the past 30 years, significant efforts have been devoted to exploring its various pathogenic mechanisms, physiological and pathological characteristics, and biomarkers. Among these, Anti-Müllerian Hormone (AMH), as a biomarker for PCOS, is a significant biomarker for diagnosing, treating, and monitoring. However, the individual key information extracted from numerous studies is difficult to apply in clinical practice. Therefore, this article employs bibliometric analysis to summarize the current state of knowledge and offer future perspectives.</p><p><strong>Methods: </strong>The Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection database has been identified as the material source for obtaining articles related to AMH and PCOS. Software such as Origin, Microsoft Excel, Pajek, VOSviewer, and CiteSpace were used for bibliometric analysis and statistical assessment, evaluating countries, institutions, journals, references, and authors, as well as for constructing visual knowledge network maps.</p><p><strong>Results: </strong>From 1994 to 2024, a total of 1,082 articles were included in the bibliometric analysis of research on AMH and PCOS. The number of publications in this field has consistently increased, with contributions from 70 countries, 1,363 institutions, and 5,144 researchers worldwide. Among them, the United States and China are the two countries with the highest number of publications. Zhejiang University, Monash University, and Peking University rank among the top three institutions exhibiting explosive citation bursts. The author with the highest publication volume is Didier Dewailly. The predictive keywords associated with these articles include \"consensus,\" \"morphology,\" \"criteria,\" \"prevalence,\" and \"Müllerian hormone.\"</p><p><strong>Conclusions: </strong>Through bibliometric analysis, this study has identified the primary research hotspots in the field of AMH and PCOS as follows: (1) Refining the diagnostic criteria for PCOS by using AMH as a biomarker; (2) Exploring the molecular role of AMH in the pathophysiological processes of various PCOS phenotypes and its potential as a therapeutic target; (3) Analyzing the impact of baseline AMH levels on female reproductive health and other biomarkers; (4) Investigating the signalling mechanisms of AMH in PCOS and its role in disease progression.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1519249"},"PeriodicalIF":2.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A homozygous mutation in the <i>SPAG17</i> gene in a case with oligoasthenoteratozoospermic infertility.","authors":"Shruti Sethi, Waseem Andrabi, Kalyan Mitra, Singh Rajender","doi":"10.3389/frph.2025.1554027","DOIUrl":"https://doi.org/10.3389/frph.2025.1554027","url":null,"abstract":"<p><strong>Background: </strong>Defects in sperm size and form, known as teratozoospermia, can adversely impair sperm motility and its ability to fertilize an oocyte. Teratozoospermia has been most often linked with genetic abnormalities with close to 100 genes known.</p><p><strong>Objective: </strong>The primary objective of this study was to investigate the genetic basis of oligoasthenoteratozoospermic infertility in an infertile man.</p><p><strong>Methods: </strong>We performed the whole exome sequencing, followed by <i>in silico</i> filtration of observed genetic variations. Filtered rare variants were assessed for their pathogenic nature on the basis of scores assigned by various in-silico tools and their biological relevance to sperm structural development. The potential pathogenic mutation was validated by Sanger sequencing.</p><p><strong>Results: </strong>Our study identified a homozygous substitution, c.4511A > G, in the <i>SPAG17</i> gene as a potential pathogenic mutation associated with oligoasthenoteratozoospermic infertility in the case under investigation. The mutation resulted in the substitution of asparagine with serine at the 1504^th amino acid position in a protein of 2,223 amino acids. This mutation shows a minor allele frequency of 0.0004671 in the gnomAD database. ACMG classification suggested this mutation to be likely pathogenic.</p><p><strong>Conclusion: </strong>Our study identified a homozygous likely pathogenic mutation (c.4511A > G, Asn1504Ser) in the <i>SPAG17</i> gene that explains oligoasthenoteratozoospermic infertility in the present case.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1554027"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and determinants of abnormal uterine bleeding among reproductive-age women in Kombolcha Rejiopolitan Administrative Town, Northeast Ethiopia: a FIGO-based study (2023).","authors":"Abubeker Seid, Gizachew Abdissa Bulto, Adem Yesuf, Ali Yimer, Hassen Ahmed, Tsegaye Benti Muse","doi":"10.3389/frph.2025.1559105","DOIUrl":"https://doi.org/10.3389/frph.2025.1559105","url":null,"abstract":"<p><strong>Background: </strong>Abnormal uterine bleeding (AUB) is a common reason for women to seek healthcare, affecting their health, quality of life, productivity, and increasing the risk of complications. While menstrual disorders have been studied in Ethiopia, the prevalence and determinants of AUB among reproductive-age women remain poorly understood due to the use of outdated terminology and a lack of standardized approaches, which hinder accurate assessment and comparison with international findings. This study aims to address this gap by assessing the magnitude and determinants of AUB among reproductive-age women in Kombolcha town, Ethiopia, using the 2018 FIGO criteria.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted among 608 reproductive-age women in Kombolcha town from April 20 to May 20, 2023, using systematic random sampling. Data were collected using interviewer-administered structured questionnaires. The data were entered into EPI Data version 4.6 and analyzed using SPSS version 26. All predictor variables with a <i>p</i>-value <0.25 in bivariable analysis were included in multivariable logistic regression. Variables with a <i>p</i>-value <0.05 in the multivariable analysis were considered statistically significant predictors of abnormal uterine bleeding.</p><p><strong>Result: </strong>This study found that 36.5% of 591 reproductive-age women experienced abnormal uterine bleeding (AUB). Several factors were significantly associated with AUB: Women in late reproductive age (41-49 years) had 4.2 times higher odds of experiencing AUB compared to those in mid-reproductive age (AOR = 4.181, 95% CI: 2.199-7.948). Hypertensive women were 3.71 times more likely to experience AUB (AOR = 3.706, 95% CI: 1.106-12.417). Women with a history of abortion had 2.3 times higher odds of AUB (AOR = 2.345, 95% CI: 1.069-5.147). A history of diagnosed anemia and late menarche (≥15 years) were also significantly associated with increased AUB risk (AOR = 2.939, 95% CI: 1.437-6.010; AOR = 3.824, 95% CI: 2.199-7.948).</p><p><strong>Conclusion: </strong>This study highlights the significant burden of AUB, with 36.5% of women affected. Healthcare providers should educate patients about lifestyle changes, treatment options, and when to seek emergency care for AUB to improve health outcomes.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1559105"},"PeriodicalIF":2.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State abortion restrictiveness and prevalence of intimate partner violence and domestic violence among recently birthing black and white individuals.","authors":"Katherine Neff, Stephanie V Hall, Rieham Owda, Andrea Pangori, Kara Zivin, Angela Montoya, Leila McDonnaugh-Eaddy, Yasamin Kusunoki, April M Zeoli, Kamilah Davis-Wilson, Anna Courant, Vanessa K Dalton","doi":"10.3389/frph.2025.1535865","DOIUrl":"https://doi.org/10.3389/frph.2025.1535865","url":null,"abstract":"<p><strong>Objectives: </strong>Intimate partner violence (IPV) and non-intimate domestic violence (DV) during pregnancy may result in poor maternal and infant health outcomes. Whether state-level abortion restrictions, enacted by many states even prior to the 2022 <i>Dobbs v. Jackson Women's Health Organization</i> decision, are associated with IPV/DV remains unknown. This study aimed to investigate the relationship between IPV/DV during pregnancy and abortion restrictions among Black and White birthing people.</p><p><strong>Study design: </strong>We analyzed 2020 data from 36 states participating in the CDC Pregnancy Risk Assessment Monitoring System representing 1,931,458 deliveries of which 1,368,237 deliveries (70.84%) are from Black and White birthing individuals. We divided states into restrictive (<i>N</i> = 17) and less restrictive (<i>N</i> = 19) based on a modified Guttmacher Abortion Policy Hostility Index. We used weighted logistic regression to assess the relationship between state abortion restrictiveness and self-reported IPV/DV.</p><p><strong>Results: </strong>Overall, birthing individuals in restrictive states had higher odds of reporting IPV/DV during pregnancy than those in less restrictive states (aOR: 1.36, 95% CI: 1.15-1.60). Within racial groups, we found that Black birthing individuals in restrictive states had higher odds of reporting IPV/DV than Black birthing individuals in less restrictive states (aOR:1.75, 95% CI: 1.24-2.47). We saw a similar relationship for White birthing individuals (aOR:1.50, 95% CI: 1.17-1.94).</p><p><strong>Discussion: </strong>Even when access to abortion was federally protected, individuals in restrictive states had higher odds of experiencing IPV/DV than those in less restrictive states, particularly among Black individuals. These findings suggest possible detrimental impacts of abortion restrictions and their potential to worsen existing health inequities.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1535865"},"PeriodicalIF":2.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of pregnancy outcomes and safety between cetrorelix and ganirelix in IVF/ICSI antagonist protocols: a retrospective cohort study.","authors":"Xinyue Peng, Xingyu Lv, Penghao Li, Yingxing Li, Yuling Hu, Yi Zhang, Yuan Li","doi":"10.3389/frph.2025.1492441","DOIUrl":"https://doi.org/10.3389/frph.2025.1492441","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the safety, efficacy, and clinical predictors of live birth outcomes between cetrorelix and ganirelix in GnRH antagonist protocols during controlled ovarian stimulation.</p><p><strong>Methods: </strong>In this retrospective cohort study conducted at a reproductive medicine center (June 2019-June 2022), 2,365 patients receiving cetrorelix (Group A) and 7,059 patients receiving ganirelix (Group B) were analyzed after 1:3 propensity score matching. Outcomes included LH surge suppression, OHSS incidence, endometrial morphology, embryological parameters, and live birth rates. Multivariate logistic regression identified independent predictors of clinical success.</p><p><strong>Results: </strong>Cetrorelix demonstrated superior LH surge control, with lower incidences of LH ≥10 U/L (4.9% vs. 7.6%, <i>p</i> < 0.001) and LH ratio(trigger day LH Gn day LH) ≥2 (6.1% vs. 9.2%, <i>p</i> < 0.001). Endometrial receptivity was more favorable in Group A, with higher Type A (66.2% vs. 60.1%) and lower Type C morphology (5.3% vs. 6.3%, <i>p</i> < 0.001). Ganirelix showed a higher overall OHSS incidence (1.1% vs. 0.4%, <i>p</i> = 0.01). Live birth rates were comparable (47.2% vs. 49.4%, <i>p</i> = 0.074). Multivariate analysis revealed advanced female age (≥35 years) reduced success (aOR = 0.65, 95% CI 0.57-0.74, <i>p</i> < 0.001), while AMH ≥4 μg/L (aOR = 1.29, 95% CI 1.02-1.64, <i>p</i> = 0.034), and dual embryo transfer (aOR = 1.51, 95% CI 1.38-1.65, <i>p</i> < 0.001) improved outcomes.</p><p><strong>Conclusion: </strong>Cetrorelix and ganirelix demonstrate comparable live birth rates and embryo quality, yet exhibit distinct safety profiles. Cetrorelix provides superior LH surge suppression and reduced OHSS risk, making it preferable for high-risk patients, while ganirelix may serve cases requiring rapid LH control. Cetrorelix offering enhanced endometrial receptivity (66.2% Type A morphology) and safety advantages. These findings support cetrorelix's role in optimizing ART safety without compromising efficacy.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1492441"},"PeriodicalIF":2.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of new population policies on women's reproductive health pattern in Ardabil, Iran: a comparative cross-sectional study.","authors":"Nazila Nejhaddadgar, Afrouz Mardi, Maryam Zare","doi":"10.3389/frph.2025.1520027","DOIUrl":"https://doi.org/10.3389/frph.2025.1520027","url":null,"abstract":"<p><strong>Background: </strong>Family planning helps couples make voluntary, informed, and responsible decisions about having children based on their economic, physical, and psychological capabilities. New population policies have banned family planning services in Iran. This study sought to investigate the impact of these policies on women's reproductive health pattern in Ardabil, Iran.</p><p><strong>Methods: </strong>A comparative cross-sectional study was conducted on 800 eligible women (in two groups of 400, pre/post new policies) attending health centers in Ardabil. Health centers were chosen using a stratified cluster method, and the eligible women were selected through convenience sampling. A researcher-designed questionnaire was used to collect data on demographic characteristics, reproductive health history, and contraceptive use in the past six months. Data were analyzed using SPSS version 24, with Z and Chi2 statistical tests.</p><p><strong>Results: </strong>The majority of women were aged 15-24 (45.25% and 53%), had education levels below a diploma (52.5% and 47%), and were housewives (88.5% and 84.75%). Prior to the policy change, 67.25% of women used modern contraception methods, compared to 31% after. Rates of unwanted pregnancies increased from 28.5% to 49.25%, and the incidence of one abortion rose from 14.25% to 21.75%. These differences were statistically significant (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The ban on family planning services has led to a shift towards traditional contraception methods, an increase in unwanted pregnancies, and unsafe abortions. This highlights the need for health policymakers to implement appropriate interventions.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1520027"},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning applications for human embryo assessment using time-lapse imaging: scoping review.","authors":"Rawan AlSaad, Leen Abusarhan, Nour Odeh, Alaa Abd-Alrazaq, Fadi Choucair, Rachida Zegour, Arfan Ahmed, Sarah Aziz, Javaid Sheikh","doi":"10.3389/frph.2025.1549642","DOIUrl":"https://doi.org/10.3389/frph.2025.1549642","url":null,"abstract":"<p><strong>Background: </strong>The integration of deep learning (DL) and time-lapse imaging technologies offers new possibilities for improving embryo assessment and selection in clinical <i>in vitro</i> Fertilization (IVF).</p><p><strong>Objectives: </strong>This scoping review aims to explore the range of deep learning model applications in the evaluation and selection of embryos monitored through time-lapse imaging systems.</p><p><strong>Methods: </strong>A total of 6 electronic databases (Scopus, MEDLINE, EMBASE, ACM Digital Library, IEEE Xplore, and Google Scholar) were searched for peer-reviewed literature published before May 2024. We adhered to the PRISMA guidelines for reporting scoping reviews.</p><p><strong>Results: </strong>Out of the 773 articles reviewed, 77 met the inclusion criteria. Over the past four years, the use of DL in embryo analysis has increased rapidly. The primary applications of DL in the reviewed studies included predicting embryo development and quality (61%, <i>n</i> = 47) and forecasting clinical outcomes, such as pregnancy and implantation (35%, <i>n</i> = 27). The number of embryos involved in the studies exhibited significant variation, with a mean of 10,485 (SD = 35,593) and a range from 20 to 249,635 embryos. A variety of data types have been used, namely images of blastocyst-stage embryos (47%, <i>n</i> = 36), followed by combined images of cleavage and blastocyst stages (23%, <i>n</i> = 18). Most of the studies did not provide maternal age details (82%, <i>n</i> = 63). Convolutional neural networks (CNNs) were the predominant deep learning architecture used, accounting for 81% (<i>n</i> = 62) of the studies. All studies utilized time-lapse video images (100%) as training data, while some also incorporated demographics, clinical and reproductive histories, and IVF cycle parameters. Most studies utilized accuracy as the discriminative measure (58%, <i>n</i> = 45).</p><p><strong>Conclusion: </strong>Our results highlight the diverse applications and potential of deep learning in clinical IVF and suggest directions for future advancements in embryo evaluation and selection techniques.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1549642"},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community PrEP delivery for adolescent girls and young women: insights from the DREAMS PrEP Choice Study in Johannesburg, South Africa.","authors":"Nicolette Prea Naidoo, Nqaba Mthimkulu, Ngcwalisa Jama, Glory Chidumwa, Brison Chabalala, Tafadza Mhakakora, Lauren Parmley, Saiqa Mullick","doi":"10.3389/frph.2025.1474067","DOIUrl":"https://doi.org/10.3389/frph.2025.1474067","url":null,"abstract":"<p><strong>Introduction: </strong>Long-acting pre-exposure prophylaxis (PrEP) methods have the potential to significantly reduce HIV acquisition and increase the uptake and effective use of PrEP among adolescent girls and young women (AGYW). We describe the implementation approach for delivering the PrEP ring and outline provider perspectives related to community-based service delivery.</p><p><strong>Methods: </strong>The DREAMS PrEP Choice Study, a mixed-methods implementation science study delivering PrEP choice to women 18 years and older, was conducted in Johannesburg, South Africa. We extracted quantitative enrollment data from the routine patient management system (REDCap) and collected qualitative data from four focus group discussions with providers. Quantitative data are presented descriptively whilst qualitative data were analyzed using content and thematic analyses.</p><p><strong>Results: </strong>Between October 2023 and April 2024, 657 participants were enrolled and offered PrEP choice. Most (72.1%, <i>n</i> = 474) participants were between 18 and 24 years old and accessed services at education and training institutions (52.1%, <i>n</i> = 342). Furthermore, 68.8% (<i>n</i> = 451) chose oral PrEP at enrollment, 26.6% (<i>n</i> = 175) chose the PrEP ring, and 3.2% (<i>n</i> = 20) selected no method. Most participants accessed services through a mobile truck (<i>n</i> = 365, 55.6%). There was a strong preference for nurse insertion of the ring on site (<i>n</i> = 103, 58.9%). Site setup, privacy, and access to running water, in alignment with national PrEP ring guidelines, were reported as barriers to implementation.</p><p><strong>Conclusion: </strong>As one of the first studies to implement community-based services for PrEP choice, the early results indicate the feasibility of delivering this service with moderate uptake of PrEP by AGYW. Understanding the service delivery conditions required to offer informed choice is important for supporting national scale-up.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1474067"},"PeriodicalIF":2.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}