Frontiers in reproductive health最新文献

{"title":"Exploring drivers and prevention strategies for sexual violence among adolescent girls and young women in Kicukiro, Rwanda.","authors":"Wongani Patricia Kawonga, Sam M Livingstone, Augustine Ndaimani, Jean Pierre Sibomana, Tsion Yohannes Waka, Maxwell Mhlanga, Andrew Mclellan","doi":"10.3389/frph.2025.1420947","DOIUrl":"10.3389/frph.2025.1420947","url":null,"abstract":"<p><strong>Introduction: </strong>Sexual violence against adolescent girls and young women (AGYW) is a pervasive issue globally, with particularly high prevalence in sub-Saharan Africa. This study explores the drivers and prevention strategies for sexual violence among AGYW in Kicukiro, Rwanda.</p><p><strong>Methods: </strong>A descriptive exploratory design guided by the socioecological model and feminist standpoint theory was employed. In-depth interviews were conducted with 13 AGYW participating in a mentorship program and 5 male community members. Data was analyzed using thematic analysis to identify key drivers and potential prevention strategies.</p><p><strong>Results: </strong>Four themes emerged: (1) empowering mentorship programs, (2) tiered drivers of sexual violence, (3) optimizing violence-mitigating resources, and (4) interference with judicial processes. Key drivers of sexual violence included substance use, transactional sexual relationships, inadequate family protection, entrenched gender stereotypes, and limited legal literacy.</p><p><strong>Conclusion: </strong>Findings underscore the need for multifaceted interventions that address systemic and cultural barriers, strengthen legal frameworks, and expand community-based programs. Addressing sexual violence requires a holistic approach, integrating empowerment initiatives, robust community engagement, and legal reforms to create safer environments for AGYW. The mentorship program's success suggests scalability across other settings.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1420947"},"PeriodicalIF":2.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs.","authors":"Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu","doi":"10.3389/frph.2025.1561341","DOIUrl":"https://doi.org/10.3389/frph.2025.1561341","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frph.2024.1473354.].</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1561341"},"PeriodicalIF":2.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs.","authors":"Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu","doi":"10.3389/frph.2025.1560111","DOIUrl":"https://doi.org/10.3389/frph.2025.1560111","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frph.2024.1473354.].</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1560111"},"PeriodicalIF":2.3,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing factors influencing adolescent sexual debut in Nigeria: a multi-cluster survival analysis approach.","authors":"Fabio Mathias Correa, Peter Enesi Omaku, Joseph Odunayo Braimah","doi":"10.3389/frph.2025.1475421","DOIUrl":"10.3389/frph.2025.1475421","url":null,"abstract":"<p><strong>Introduction: </strong>Early sexual debut is an area of concern in Nigeria with implications for reproductive health.</p><p><strong>Methods: </strong>This study addresses this by proposing a more effective survival model-one that incorporates both independent and identically distributed (IID) and Besag intrinsically conditional auto-regressive (ICAR) random effect priors, using a generalised additive model that accounts for both individual and spatial influences on age at first sex. We analyse data from the 2018 Nigerian NDHS survey and compare our model with existing models: a model without the cluster frailty effect, a model that ignores the Besag ICAR and includes the IID, and a model that ignores the IID and includes only the Besag ICAR.</p><p><strong>Results: </strong>Our approach, which combines independent and spatial random effects, outperforms others based on statistical criteria (Deviation Information Criterion and the Widely Applicable Information Criterion).</p><p><strong>Discussion: </strong>As shown in this study, the proposed model effectively captures the complexity of age at first sex. In addition, visualisations reveal significant geographic and social clusters with high rates of early sexual debut in Nigeria. These findings highlight the importance of considering multi-level clustering to better understand and promote healthy sexual behaviour among young Nigerians through targeted interventions.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1475421"},"PeriodicalIF":2.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tryptophan as a biomarker of pregnancy-related immune expression and modulation: an integrative review.","authors":"Stephanie Prescott, Natasa Billeci, Melissa Gotcher, Sapna Patel, Addison Almon, Hailey Morgan, Danielle Abukhalaf, Maureen Groer","doi":"10.3389/frph.2024.1453714","DOIUrl":"10.3389/frph.2024.1453714","url":null,"abstract":"<p><strong>Background: </strong>Degradation pathways of Tryptophan (TRP) are implicated in a spectrum of physiological adaptations and outcomes associated with pregnancy. The immunomodulatory role of TRP and its metabolites through the indoleamine 2,3-dioxygenase (IDO) pathway is particularly relevant to pregnancy due to its potential influence on maternal and fetal immune tolerance and the mother's health.</p><p><strong>Methods: </strong>A targeted literature search was conducted via PubMed, Web of Science, and Embase, focusing on maternal serum TRP levels in pregnancy. We included original human subject research on maternal serum TRP, published in English within the last five years. We included 16 quality studies with direct measurement of TRP in pregnancy including ten prospective cohorts, four case-control studies, and two cross-sectional studies.</p><p><strong>Results: </strong>TRP levels are reduced both pre- and postnatally in women with depressive symptoms, but not during pregnancy, though the TRP/Kynurenine pathway is disturbed during pregnancy in women with depressive symptoms, women with prolonged labor, women with gestational hypertension, and in adverse outcomes of pregnancy including prematurity and growth restriction.</p><p><strong>Conclusion: </strong>TRP and its metabolites hold promise as biomarkers for various pregnancy-related outcomes. Future research should aim to clarify the mechanisms by which TRP metabolism influences maternal and fetal health outcomes.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1453714"},"PeriodicalIF":2.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2023.","authors":"Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen","doi":"10.3389/frph.2024.1439461","DOIUrl":"10.3389/frph.2024.1439461","url":null,"abstract":"<p><strong>Background: </strong>In Vietnam, PrEP was introduced in 2017 and scaled up from 2019. Private sector engagement (PSE) in PrEP service delivery was deployed as a strategy from the start to increase PrEP access. We assessed the effectiveness of this approach to inform ongoing efforts to accelerate epidemic control by 2030.</p><p><strong>Methods: </strong>We implemented a process evaluation with longitudinal design using retrospective programmatic data collected and uploaded onto a secure online system (HMED) from 23 public and 17 private PrEP clinics in Hanoi, Ho Chi Minh City (HCMC), and Dong Nai. We measured the effectiveness of PrEP service delivery by PrEP initiation/reinitiation, uptake, persistence, discontinuation, and HIV seroconversion. We used the Kaplan-Meier time-to-event approach to estimate PrEP persistence and mixed-effects logistic regression analysis to assess factors associated with the PrEP persistence.</p><p><strong>Results: </strong>From October 2017 to September 2023, 29,944 individuals initiated PrEP, and among these, 79.3% started PrEP at a private sector clinic while 20.7% initiated in a public sector clinic. The median duration of PrEP use persistence at private clinics was significantly longer than that at public clinics (268 days vs. 148 days, respectively). Mixed-effects logistic regression analysis results indicated a significant statistical association between PrEP persistence for at least three months and initiating PrEP at a private clinic [adjusted odds ratio [aOR] = 4.28; 95% confidence interval [CI]: 2.96-6.19], opting for TelePrEP (aOR = 3.42; 95% CI: 2.12-5.53), or being 20 years of age or older (aOR = 1.86; 95% CI: 1.62-2.13). HIV seroconversion was significantly lower among PrEP users at private clinics compared to public clinics (0.03 vs. 0.13 per 100 person-years, respectively; <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Offering choice in PrEP service delivery options is essential to increase access and uptake. Private-sector PrEP providers play a pivotal role in increasing PrEP uptake and coverage in Vietnam, and will be critical to delivery of new long-acting options.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1439461"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generational trends in education and marriage norms in rural India: evidence from the Pune Maternal Nutrition Study.","authors":"Akanksha A Marphatia, Jonathan C K Wells, Alice M Reid, Marios Poullas, Aboli Bhalerao, Pallavi Yajnik, Chittaranjan S Yajnik","doi":"10.3389/frph.2024.1329806","DOIUrl":"10.3389/frph.2024.1329806","url":null,"abstract":"<p><strong>Introduction: </strong>Globally in 2024, 1 in 5 women aged 20-24 years worldwide had been married before the age of 18 years. One reason for this persistent prevalence of underage marriage may be the slow change in social norms relating to education levels and women's marriage age. However, we know little about how norms change, and whether they vary by socio-demographic characteristics. We aimed to investigate changes in social norms across generations in rural Maharashtra, India.</p><p><strong>Methods: </strong>To understand the status quo, we identified education levels and marriage ages typical of contemporary young adults in rural Maharashtra using the National Family Health Survey. To see if norms have shifted across generations, we analysed data on education and marriage age in 659 parent-adolescent dyads from the Pune Maternal Nutrition Study (PMNS) in rural Maharashtra. To ascertain if norms might shift in the future, we investigated adolescents' aspirations for their future hypothetical children's education and marriage, and classified adolescents as wanting (a) their children to decide themselves, (b) more education and later marriage age, or (c) the status quo. We assessed whether these aspirations differed by socio-demographic characteristics.</p><p><strong>Results: </strong>Compared to the status quo and PMNS adults, PMNS adolescents had substantially more education, and girls were marrying slightly later. About 70% of the adolescents wanted their children to themselves decide their schooling. The remainder of both sexes wanted their children to have the same education as them (15 years). Only 10% of adolescent girls and 14% of boys wanted their child to decide their own marriage age. Most adolescents wanted a later marriage age for their children than their own experience. Lower educated and early married girls aspired for greater education for their children. More educated boys aspired for later marriage for their children.</p><p><strong>Discussion: </strong>Education norms have changed by a larger magnitude than marriage age norms. Adolescents are already attaining their education aspirations, but aspire for later marriage of their children, more so for their hypothetical sons than daughters. Since senior household members remain influential in marriage decisions, it may take time before adolescents' aspirations for their children become a new norm.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1329806"},"PeriodicalIF":2.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathologic effects of mobile phone radiation exposure on the testes and sperm parameters: a systematic literature review of animal studies.","authors":"Ebrahim Msaye Assefa, Seid Mohammed Abdu","doi":"10.3389/frph.2024.1515166","DOIUrl":"10.3389/frph.2024.1515166","url":null,"abstract":"<p><strong>Introduction: </strong>Male infertility, often attributed to insufficient production of healthy and active sperm, can be exacerbated by electromagnetic radiation emitted from mobile phones, which disrupts normal spermatogenesis and leads to a notable decline in sperm quality. The main targets of mobile phone-induced damage in the testes are Leydig cells, seminiferous tubules, and sperm cells. The aim of this systematic literature review is to identify histopathological changes in the testes due to mobile phone radiation exposure and to examine its effects on sperm parameters in experimental animals.</p><p><strong>Methods: </strong>In this systematic review, an extensive literature search was conducted across databases such as PubMed, ScienceDirect, Hinari, and Google scholar.</p><p><strong>Results: </strong>A total of 752 studies were identified for screening, and 18 studies were deemed eligible for data extraction. Studies have identified histopathological alterations in testicular tissue caused by mobile phone radiation, such as reduced seminiferous tubule diameter, tunica albuginea and germinal epithelial thickness, Leydig cell hypoplasia, and increased intertubular space. Consistent exposure to mobile phone radiation has been shown to significantly reduce sperm count, motility, and viability, while also increasing abnormal sperm morphology in male rats, mice, and rabbits.</p><p><strong>Conclusion: </strong>Animal studies indicate that electromagnetic radiation from mobile phones can negatively impact testicular tissue and sperm parameters, including sperm count, motility, viability, and morphology. As a precaution, preventive measures are recommended to minimize potential risks from mobile phone exposure, and further research is needed to fully understand its effects on human reproductive health.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1515166"},"PeriodicalIF":2.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The impact of metabolic disorders on female reproductive health.","authors":"Lokesh Kumar, Vineet K Maurya, Manasi Kamat","doi":"10.3389/frph.2024.1436451","DOIUrl":"https://doi.org/10.3389/frph.2024.1436451","url":null,"abstract":"","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1436451"},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary dysmenorrhea and its associated factors among female high school students in Nekemte town, East Wallaga Zone, Western Oromia, Ethiopia: a cross-sectional study.","authors":"Bekan Gudata Gindaba, Tesfaye Abera Gudeta, Lemane Dereje Sebu, Ebisa Zerihun Gindaba, Misgana Tesgara Abdisa","doi":"10.3389/frph.2024.1451551","DOIUrl":"10.3389/frph.2024.1451551","url":null,"abstract":"<p><strong>Background: </strong>Primary dysmenorrhea is a common gynecological problem characterized by recurrent, periodical, and <i>cramping pain in the lower abdomen</i> that occurs before or during menstruation, usually without pelvic disease. Its magnitude has not been well studied; some of the associated factors are inconclusive. Therefore, the goal of this study was to fill gaps on the magnitude, and associated factors of primary dysmenorrhea among female high school students in Nekemte town.</p><p><strong>Objectives: </strong>To assess the magnitude of primary dysmenorrhea, its associated factors among high school students in Nekemte town, East Wallaga, Western Oromia, Ethiopia, 2023.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted among high school students in Nekemte town from June 05 to 19, 2023. The calculated total sample size was 534, and data were collected from four governmental high schools and one private high school that were selected by multistage stratified sampling. The collected data were entered into Epi Info version 3.1 and analyzed using SPSS version 25. Binary and multivariable logistic regressions were used to find associations between dependent and independent variables.</p><p><strong>Results: </strong>The magnitude of primary dysmenorrhea was 68.4% (95% CI = 64.3%, 72.0%). Anxiety (AOR = 2.41, 95% CI = 1.31, 4.43), family history of primary dysmenorrhea (AOR = 4.64, 95% CI = 2.74, 7.86), sexual intercourse (AOR = 0.34, 95% CI = 0.21, 0.55), drinking tea <4 cups per day (AOR = 0.38, 95% CI = 0.22, 0.60), and physical activity (AOR = 0.06, 95% CI = 0.03, 0.11) were factors associated with primary dysmenorrhea.</p><p><strong>Conclusion: </strong>The magnitude of primary dysmenorrhea was high among high school students in the study area. Sexual intercourse, physical activity, drinking tea, anxiety, and family history of primary dysmenorrhea were significantly associated with primary dysmenorrhea.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1451551"},"PeriodicalIF":2.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}