Frontiers in reproductive health最新文献

{"title":"Preconception care utilization and pregnancy outcomes among postpartum women at Komfo Anokye Teaching Hospital, Ghana.","authors":"Timothy Kwabena Adjei, Opei Kwafo Adarkwa, Evans Ansu-Yeboah, Esmond Ofori, Bernard Arhin, Augustine Tawiah, Charles Mawunyo Senaya, Seth Amponsah Tabi, Amponsah Peprah, Edward Tieru Dassah, Atta Owusu Bempah","doi":"10.3389/frph.2025.1509737","DOIUrl":"https://doi.org/10.3389/frph.2025.1509737","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal and perinatal morbidities are alarming in Sub-Saharan Africa. However, most of these can be prevented through appropriate care and interventions including preconception care (PCC). There is paucity of data on the effect of PCC on pregnancy outcomes in Ghana. This study sought to determine the association between PCC utilization and late pregnancy outcomes among postpartum women at Komfo Anokye Teaching Hospital (KATH). The study also assessed factors associated with its utilization.</p><p><strong>Method: </strong>A total of 336 postpartum women from an unmatched 1:2 case-control study, were interviewed. Women with late adverse pregnancy outcomes (APO) in the index pregnancy constituted the case group while those with no APO made up the control group. For every case who gave consent, two consecutive controls were recruited until the sample size was attained. Categorical variables were compared using Chi-square (<i>χ</i>2) or Fisher's exact test as appropriate, while continuous variables were compared using student t-tests. Multivariable logistic regression analysis was performed to estimate the odds ratios and the association between PCC utilization and pregnancy outcomes as well as factors associated with PCC utilization.</p><p><strong>Results: </strong>A total of 112 cases and 224 controls were analyzed with comparable mean ages (Cases-30.2 ± 5.97 vrs Controls-30.5 ± 5.89 years, <i>p</i> = 0.45). PCC utilization rates were significantly lower among women who suffered late APO (14.3%) than those who did not (25.0%) <i>p</i> = 0.0241. PCC utilization was protective of late APO (OR-0.582) but not statistically significant (95% CI, 0.256-1.324; <i>p</i> = 0.197). Factors associated with PCC uptake included pregnancy intention (OR- 22.781; 95% CI, 7.883-65.837; <i>p</i> = 0.001), knowledge of PCC (OR- 56.4; 95% CI, 16.105-197.517; <i>p</i> = 0.001) and pre-existing medical condition (OR-3.976; 95% CI, 1.009-15.677, <i>p</i> = 0.049).</p><p><strong>Conclusion: </strong>PCC utilization rates are low among postpartum women. Women who utilized PCC were twice less likely to suffer any late APO outcome compared to those who did not, though this was not statistically significant. Knowledge of PCC, pregnancy intention, and the presence of pre-existing medical conditions are factors associated with PCC utilization. These findings underscore the need for enhanced PCC education and targeted interventions to improve its utilization, particularly among women at high risk of APO.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1509737"},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial consequences and early life factors impact on the occurrence of childhood sexual assault among secondary school students in Southern Ethiopia: unmatched case-control study.","authors":"Dagne Deresa Dinagde, Habtamu Wana Wada, Shambel Negesa, Bekam Dibaba Degefa, Gemeda Wakgari Kitil, Gizu Tola Feyisa","doi":"10.3389/frph.2024.1369245","DOIUrl":"https://doi.org/10.3389/frph.2024.1369245","url":null,"abstract":"<p><strong>Background: </strong>Child sexual assault is a violation of fundamental human rights that leads to various negative consequences, including psychological and physical problems. While it is the least reported and addressed form of violence against schoolgirls in Ethiopia, it is a public health issue that affects millions of people globally each year. Thus, this study aims to provide information on the early life factors impact on the occurrence of childhood sexual assault among secondary school students.</p><p><strong>Methods: </strong>An institution unmatched case-control study was conducted in Arba Minch Zuria district among high school female students attending regular education from March 20, 2023 to May 20, 2023. The data were collected using structured, pretested self-administered questionnaire in all school in Arba Minch Zuria Woreda. Reports of schoolgirls being sexually assaulted were first obtained from the district police office. According to these reports, there were seventy-five (75) cases where the girls were attending or had attended the mentioned high school. In addition, female control students were randomly selected from non-case students. Odds ratio with 95% CI was used as a measure of association, and variables with a <i>p</i>-value of ≤0.05 were considered to be statistically significant.</p><p><strong>Results: </strong>Multivariate logistic regression analysis was used to identify significant factors. Accordingly factors such as had consumed alcohol (AOR = 4.0, 95CI: 1.68-9.70), living with non-biological parents (AOR = 7.49, 95CI: 2.72-13.65) and living alone (AOR = 4.6, 95CI: 1.49-14.41), being street food vendors (AOR = 4.5, 95CI: 1.48-13.70) and visiting library at improper time (AOR = 5.0, 95CI: 1.87-13.47) were significantly associated with childhood sexual assault.</p><p><strong>Conclusion: </strong>Had consumed alcohol, living with non-biological parents and alone, being street food vendors and improper library time were identified as significant determinants of child sexual assault (CSA) among students included in this study. Thus, high schools and families with children should collaborate to develop a plan to reduce sexual abuse that violates children rights. Families should oversee their children to help prevent substance use during their school years. Additionally, parents should remain close to their children, as distancing can lead to exposure to risky relationships.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"6 ","pages":"1369245"},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of the live biotherapeutic LACTIN-V (<i>Lactobacillus crispatus</i> CTV-05) among young women at high risk of HIV acquisition in South Africa: data from the phase 2 placebo-controlled trial.","authors":"A Hemmerling, V Govender, K Dong, M Dong, Sooseela Pillay, T Ndung'u, A Bhoola, J Moodley, G Casillas, L Lagenaur, C M Mitchell, D S Kwon, C R Cohen","doi":"10.3389/frph.2025.1544458","DOIUrl":"https://doi.org/10.3389/frph.2025.1544458","url":null,"abstract":"<p><strong>Introduction: </strong>Live biotherapeutic products (LBPs) containing <i>Lactobacillus crispatus</i> may optimize the vaginal microbiota, reduce genital inflammation, and protect against HIV acquisition. Determining acceptability of LBPs among African women at high risk of HIV is essential to guide product development.</p><p><strong>Methods: </strong>The phase 2 double-blind randomized placebo-controlled trial recruited young sexually active cis-women with vaginal dysbiosis from a community-based research clinic. Following antibiotics (oral metronidazole), participants were randomized (2:1) to receive 11 doses of LACTIN-V (2 × 10⁹ L<i>. crispatus</i> CTV-05) or placebo over 4 weeks. A questionnaire assessed product acceptability.</p><p><strong>Results: </strong>Forty-five young Black South African women were randomized to LACTIN-V (<i>N</i> = 32) or placebo (<i>N</i> = 13). Forty-two (93.3%) had an active sexual partner. Adherence was high with 36 participants (80.0%) completing all 11 doses. Of the 43 participants who completed the acceptability questionnaire, 38 (88.4%) were satisfied using the vaginal applicator and 41 (95.5%) confirmed ease of use. For 14 (32.5%) participants, product use without the partner knowing was important. Thirty-one (72.1%) participants felt that partner approval for product use was not important. On Likert scales of 0-10 (lowest to highest), agreement with positive product attributes (effective, comfortable, easy to use) scored at means of  ≥6.7. Negative product attributes (dosing, leakage, vaginal dryness, partner's disapproval) were rated less important with lower mean scores ≤3.2. Overall, 75% of participants would use the product again, with no significant difference between study arms.</p><p><strong>Conclusions: </strong>Young South African women at high risk of HIV found the LACTIN-V study product highly acceptable and easy to use.</p><p><strong>Clinical trial registration: </strong>[clinicaltrials.gov], identifier [NCT05022212].</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1544458"},"PeriodicalIF":2.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices regarding contraception amongst community pharmacy staff: a cross-sectional study in Nigeria.","authors":"Obi Peter Adigwe, Godspower Onavbavba","doi":"10.3389/frph.2025.1488707","DOIUrl":"10.3389/frph.2025.1488707","url":null,"abstract":"<p><strong>Introduction: </strong>Lack of access to effective contraception methods can lead to an increased prevalence of unintended pregnancies, as well as possible deleterious health consequences. Community pharmacies represent the most accessible gateway for population medicines' and healthcare needs. Regarding contraceptives, they have also been identified as a platform for the provision of additional services, such as complementary counselling. This study aimed at assessing the knowledge, attitudes, and practices of community pharmacy staff towards contraception.</p><p><strong>Methods: </strong>A cross-sectional study was undertaken in the Federal Capital Territory, Nigeria. Data were collected from 315 community pharmacy staff using self-administered questionnaires. The participants' knowledge and attitude scores were categorised using Bloom's cut-off point. Analyses were undertaken using Statistical Package for Social Sciences. The data were analysed using frequency distribution, chi-square, and linear regression at a 5% level of significance.</p><p><strong>Results: </strong>Male participants in the study (165/315, 52.4%) were slightly higher than the female respondents (150/315, 47.6%), and about two-thirds of the study cohort were pharmacists (200/315, 63.5%). The majority of the participants (183/315, 58.1%) had poor knowledge of contraceptive use. A quarter of them (81/315, 25.7%) reported moderate attitudes. Almost all the participants (279/298, 93.6%) indicated recommending contraceptives for married adults, and a significant proportion of them (136/292, 45.5%) were opposed to recommending contraceptives for unmarried adolescents. Study respondents' professional role was also identified as a significant influence on their knowledge of contraceptives and contraception (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Findings from this study revealed poor knowledge and negative attitudes of community pharmacy staff towards contraception. Government and relevant stakeholders can build on these novel findings to reform pertinent contextual policies and practices. This can significantly improve access to contraceptives amongst the populace, and consequently reduce unintended pregnancies alongside possible health and societal implications.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1488707"},"PeriodicalIF":2.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The integration of artificial intelligence in assisted reproduction: a comprehensive review.","authors":"Pragati Kakkar, Shruti Gupta, Kasmiria Ioanna Paschopoulou, Ilias Paschopoulos, Ioannis Paschopoulos, Vassiliki Siafaka, Orestis Tsonis","doi":"10.3389/frph.2025.1520919","DOIUrl":"10.3389/frph.2025.1520919","url":null,"abstract":"<p><p>Artificial Intelligence (AI) has emerged as a transformative force in healthcare, with its integration into assisted reproduction technologies representing a notable milestone. The utilization of AI in assisted reproduction is rooted in the persistent challenge of optimizing outcomes. Despite years of progress, success rates in assisted reproductive techniques remain a concern. The current landscape of AI applications demonstrates significant potential to revolutionize various facets of assisted reproduction, including stimulation protocol optimization, embryo formation prediction, oocyte and sperm selection, and live birth prediction from embryos. AI's capacity for precise image-based analysis, leveraging convolutional neural networks, stands out as a promising avenue. Personalized treatment plans and enhanced diagnostic accuracy are central themes explored in this review. AI-driven healthcare products demonstrate the potential for real-time, adaptive health programs, fostering improved communication between patients and healthcare teams. Continuous learning systems to address challenges associated with biased training data and the time required for accurate decision-making capabilities to develop is imperative. Challenges and ethical considerations in AI-assisted conception as evident when taking into consideration issues such as the lack of legislation regulating AI in healthcare, a fact that emphasizes the need for transparency and equity in the development and implementation of AI technologies. The regulatory framework, both in the UK and globally, is making efforts to balance innovation with patient safety. This paper delves into the revolutionary impact of Artificial Intelligence (AI) in the realm of assisted reproduction technologies (ART). As AI continues to evolve, its application in the field of reproductive medicine holds great promise for improving success rates, personalized treatments, and overall efficiency. This comprehensive review explores the current state of AI in assisted reproduction, its potential benefits, challenges, and ethical considerations.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1520919"},"PeriodicalIF":2.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of late first antenatal care initiation in western Ethiopia: findings from a multi-centered cross-sectional study.","authors":"Atitegeb Alebachew Amsalu, Alemayehu Worku Yalew, Awgichew Kifle Zemlak","doi":"10.3389/frph.2025.1551706","DOIUrl":"10.3389/frph.2025.1551706","url":null,"abstract":"<p><strong>Background: </strong>Late initiation of antenatal care (ANC) continues to be a significant public health issue in sub-Saharan African countries, including Ethiopia. However, despite the high prevalence of late ANC initiation in Ethiopia, only a few studies have been conducted, particularly in developing regions, such as Bebishangul-Gumez. Therefore, this study aims to assess the prevalence of late initiation of the first ANC and associated factors among pregnant women in Western Ethiopia, 2023.</p><p><strong>Methods: </strong>A facility-based cross-sectional study was conducted in Western Ethiopia from March 28, 2023 to April 30, 2023. We employed a systematic random sampling technique to select 427 participants. Data were collected using an electronic capture technique with open data kit (ODK), then, transported to XLS and exported to Stata version 17 software for analyses. Bivariate analysis was performed at significance level of <i>p</i>-value < 0.25 to select candidate variables for multivariable analysis. In the final model, factors with a <i>p</i>-value ≤ 0.05 were considered significantly associated with late initiation of ANC.</p><p><strong>Results: </strong>A total of 414 pregnant women participated, yielding a response rate of 96.9%. The prevalence of late first ANC booking in this study was 56.8% (95% CI: 51.9, 61.5). Multivariable analysis revealed that being a housewives (AOR = 2.09, 95% CI 1.09, 4.01), having education status below secondary school (AOR = 3.5, 95% CI: 1.9, 6.1), having an unplanned pregnancy (AOR = 3.01, 95% CI 1.31, 6.90), lack of advise on when to start ANC (AOR = 1.74, 95% CI (1.09, 2.79), and attending ANC at hospital reduce the odds of late initiation of ANC (AOR = 0.41, 95% CI, 0.23, 0.72) were factors significantly associated with the late initiation of ANC.</p><p><strong>Conclusion: </strong>The prevalence of late initiation of ANC was found to be high in the study area. Educational status below secondary school, unplanned pregnancy, lack of advice on when to start ANC, housewives and attending ANC at hospital were factors found to be significantly associated with the late initiation of ANC. Therefore, policies should be developed to increase support for female education, maintain women's empowerment initiatives through economic changes, expand family planning programs to decrease unplanned pregnancies, and increase awareness in the early initiation of ANC.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1551706"},"PeriodicalIF":2.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a survey on reproductive health behaviors to reduce exposure to endocrine-disrupting chemicals in Koreans.","authors":"Hye Jin Kim, Sung Hae Kim, So Young Choi, Gisoo Shin","doi":"10.3389/frph.2025.1519896","DOIUrl":"10.3389/frph.2025.1519896","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, issues related to climate change and endocrine-disrupting chemicals have come to the forefront. In particular, the pursuit of convenience has led to increased exposure to endocrine-disrupting chemicals in daily life, posing threats to reproductive health, including infertility and cancer. Therefore, this study aims to develop a questionnaire to assess the reproductive health behaviors of Koreans for reducing exposure to endocrine-disrupting chemicals, and to verify its reliability and validity.</p><p><strong>Materials and method: </strong>This methodological study involved 288 adult men and women in South Korea and conducted item analysis, exploratory factor analysis, and confirmatory factor analysis.</p><p><strong>Results: </strong>The developed survey questionnaire consists of four factors and 19 detailed items related to reproductive health behaviors and reproductive health promotion behaviors through the main exposure routes of endocrine-disrupting chemicals: food, respiratory pathways, and skin absorption.</p><p><strong>Conclusion: </strong>Based on the results of this study, it is hoped that research on reproductive health behaviors aimed at reducing EDC exposure will expand, considering various environments such as national and ethnic differences.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1519896"},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Feasibility of mail-based biospecimen collection in an online preconception cohort study.","authors":"Martha R Koenig, Amelia K Wesselink, Andrea S Kuriyama, Alina Chaiyasarikul, Elizabeth E Hatch, Lauren A Wise","doi":"10.3389/frph.2025.1582697","DOIUrl":"https://doi.org/10.3389/frph.2025.1582697","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frph.2022.1052231.].</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1582697"},"PeriodicalIF":2.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of three pronuclei incidence and their impact on pregnancy outcomes in women with good prognosis undergoing conventional <i>in vitro</i> fertilization with donor sperm: a retrospective cohort study.","authors":"Jianhua Sun, Xiang Liu, Shengjia Shi, Mingzhao Li","doi":"10.3389/frph.2025.1509710","DOIUrl":"10.3389/frph.2025.1509710","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the influencing factors of three pronuclei (3PN) zygote incidence and their impact on pregnancy outcomes in women with good prognosis undergoing conventional <i>in vitro</i> fertilization with donor sperm (C-IVFD).</p><p><strong>Methods: </strong>This retrospective study included women aged 35 years or younger who underwent the long/ultra-long follicular phase agonist protocol between January 2014 and January 2021. C-IVFD cycles were divided into the 3PN = 0% group (no 3PN zygotes) and the 3PN > 0% group (with 3PN zygotes). Multivariate logistic regression analysis was performed to identify factors influencing 3PN zygote incidence. The primary outcomes were clinical pregnancy, ongoing pregnancy, abortion and live birth rates. The secondary outcomes were cleavage, high-quality embryo, available embryo, implantation and ectopic pregnancy rates.</p><p><strong>Results: </strong>1,250 embryo transfer cycles were included in this study. The peak estradiol (E₂) level on the day of human chorionic gonadotrophin (hCG) administration (OR: 1.16, 95% CI 1.12-1.19, <i>p</i> < 0.001) and the number of retrieved oocytes (OR: 1.08, 95% CI 1.05-1.11, <i>p</i> < 0.001) were independently associated with 3PN incidence. Compared to the 3PN > 0% group, the 3PN = 0% group exhibited significantly higher ongoing pregnancy rates (<i>p</i> = 0.033) and live birth rates (<i>p</i> = 0.009), as well as lower abortion rate (<i>p</i> = 0.026). No significant differences were found between the 3PN = 0% and 3PN > 0% groups in cleavage, high-quality embryo, available embryo, implantation and ectopic pregnancy rates (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The peak E₂ level on hCG administration day and the number of retrieved oocytes were independently associated with 3PN incidence. The incidence of 3PN zygotes has a negative impact on pregnancy outcomes in women with good prognosis undergoing C-IVFD.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1509710"},"PeriodicalIF":2.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First clinical pregnancy and delivery achieved after using a new 3D imaging technology for sperm selection: a case report.","authors":"Yulia Michailov, Shevach Friedler, Bozhena Saar-Ryss","doi":"10.3389/frph.2025.1559684","DOIUrl":"10.3389/frph.2025.1559684","url":null,"abstract":"<p><strong>Objective: </strong>To report a case of a patient who, after experiencing recurrent failed implantations, underwent a novel technological intervention-using the Q300 device-which successfully led to a pregnancy and delivery of a healthy baby.</p><p><strong>Design: </strong>Case report.</p><p><strong>Setting: </strong>Barzilai University Medical Center.</p><p><strong>Patient s: </strong>A 33-year-old woman with primary infertility experienced recurrent implantation failure (RIF), while her 32-year-old male partner was diagnosed with severe oligo-astheno-teratozoospermia (OTA) syndrome.</p><p><strong>Intervention: </strong>Using Q300 device for selection of the morphologically compliant sperm cells for intracytoplasmic sperm injection (ICSI).</p><p><strong>Main outcome measures: </strong>Successful pregnancy and delivery.</p><p><strong>Results: </strong>A unique case of clinical pregnancy and delivery involving a couple facing RIF and severe OTA. In this case, a new technology for sperm selection was used. The semen sample was examined using the Q300 device to choose WHO2021-morphologically compliant sperm cells for micro-injection. The resulting embryos were developed and then frozen. Later, a frozen-thawed embryo transfer was performed during the following natural menstrual cycle, leading to successful pregnancy and delivery.</p><p><strong>Conclusion: </strong>The utilization of this new 3D imaging technology underscores the evolving landscape of reproductive medicine and the potential it holds for transforming outcomes in challenging cases. By documenting such cases, we contribute to the ongoing dialogue to refine assisted reproductive technology (ART) protocols and improve reproductive outcomes for individuals facing similar challenges.</p><p><strong>Trial registration: </strong>NCT06232720 https://clinicaltrials.gov/study/NCT06232720. Date of registration: 15 Feb 2023. Date of enrollment of the first subject: 20 August 2023.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1559684"},"PeriodicalIF":2.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}