Imran Morhason-Bello, Yusuf Bello, Deborah Oke, Adekunle Daniel, Akinyele Adisa, Adeola Fowotade, Yinan Zheng, Joshua Akinyemi, Isaac Adewole, Miquel A Pavon, Robert Murphy, Lifang Hou, Suzanna C Francis, Deborah Watson-Jones
{"title":"尼日利亚伊巴丹异性恋活跃人群中高危口腔和肛门人乳头瘤病毒感染流行率的性别差异","authors":"Imran Morhason-Bello, Yusuf Bello, Deborah Oke, Adekunle Daniel, Akinyele Adisa, Adeola Fowotade, Yinan Zheng, Joshua Akinyemi, Isaac Adewole, Miquel A Pavon, Robert Murphy, Lifang Hou, Suzanna C Francis, Deborah Watson-Jones","doi":"10.3389/frph.2025.1570984","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan.</p><p><strong>Methods: </strong>This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by Anyplex<sup>TM</sup> II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, <i>p</i> < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, <i>p</i> < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (<i>p</i> < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58].</p><p><strong>Conclusion: </strong>Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.</p>","PeriodicalId":73103,"journal":{"name":"Frontiers in reproductive health","volume":"7 ","pages":"1570984"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399633/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria.\",\"authors\":\"Imran Morhason-Bello, Yusuf Bello, Deborah Oke, Adekunle Daniel, Akinyele Adisa, Adeola Fowotade, Yinan Zheng, Joshua Akinyemi, Isaac Adewole, Miquel A Pavon, Robert Murphy, Lifang Hou, Suzanna C Francis, Deborah Watson-Jones\",\"doi\":\"10.3389/frph.2025.1570984\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan.</p><p><strong>Methods: </strong>This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by Anyplex<sup>TM</sup> II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, <i>p</i> < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, <i>p</i> < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (<i>p</i> < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58].</p><p><strong>Conclusion: </strong>Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.</p>\",\"PeriodicalId\":73103,\"journal\":{\"name\":\"Frontiers in reproductive health\",\"volume\":\"7 \",\"pages\":\"1570984\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399633/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in reproductive health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/frph.2025.1570984\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in reproductive health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/frph.2025.1570984","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
摘要
目的：确定伊巴丹异性恋活跃男性和女性口腔和肛门高危HPV感染患病率的性别差异。方法：这是对伊巴丹尼日利亚人的性行为和HPV感染（SHINI）研究的二次分析，该研究涉及18-45岁的性活跃男性和女性。面对面访谈后，由性别匹配的训练有素的护士从口腔、宫颈、外阴和肛门采集样本。通过AnyplexTM II HPV28检测，口腔或/和肛门部位的高危HPV （hrHPV）是主要结局变量。参与者的人口统计学特征、性行为和社会生活方式被纳入解释变量。使用卡方检验或Fisher精确检验来调查hrHPV的存在与参与者特征之间的关系。在调整潜在混杂因素后，进行多变量逻辑回归来检验参与者性别与每个主要结局之间的关联。结果：共招募女性625人，其中普通人群（FGP）女性310人，女性性工作者（fsw） 315人，男性316人。口腔hrHPV在FGP和fsw中的患病率高于男性（10.5% vs. 14.9% vs. 3.6%, p p p）结论：在异性恋活跃人群中，口腔hrHPV、肛门hrHPV和这两个部位的hrHPV在女性中的患病率高于男性。这些发现强调了制定有针对性的HPV预防策略的重要性，这些策略应考虑到性别特异性风险因素和造成这些差异的潜在生物学基础。
Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria.
Purpose: To determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan.
Methods: This was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18-45 years. After a face-to-face interview, samples were collected from the mouth, cervix, vulva, and anus by a sex-matched trained nurse. High-risk HPV (hrHPV) in oral or/and anal sites were primary outcome variables, profiled by AnyplexTM II HPV28 assay. The participants' demographic characteristics, sexual behaviors, and social lifestyle were included as explanatory variables. The chi-square or Fisher exact test was used to investigate the association between the presence of hrHPV and the participants' characteristics. Multivariable logistic regression was conducted to test the association between the sex of participants and each of the primary outcome after adjusting for potential confounders. Statistical significance was set at p < 0.05.
Results: A total of 625 females including 310 females in general population (FGP) and 315 female sex workers (FSWs) and 316 males were recruited. Oral hrHPV prevalence was higher among FGP and FSWs than among males (10.5% vs. 14.9% vs. 3.6%, p < 0.001), as was anal hrHPV prevalence (39.3% vs. 60.8% vs. 6.7%, p < 0.001). More FGP (7.5%) and FSWs (13.0%) than males (0.9%) had hrHPV at both oral and anal sites (p < 0.001). Males had significantly lower odds of oral hrHPV [adjusted odds ratio (aOR) = 0.43, 95% CI: 0.15-1.24] than FSWs and FGP [aOR = 1.70, 95% CI: 0.62-4.63]. The odds of anal hrHPV was significantly lower among males [aOR = 0.05, 95% CI: 0.03-0.08] compared to FSWs and FGP [aOR = 0.42, 95% CI: 0.30-0.58].
Conclusion: Oral hrHPV, anal hrHPV, and hrHPV at both sites were more prevalent in females than in males in the heterosexually active population. These findings highlight the importance of developing targeted HPV prevention strategies that account for sex-specific risk factors and the potential biological underpinnings contributing to these disparities.
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