Frontiers in bioscience (Elite edition)最新文献

{"title":"Ferritin Iron Responsive Elements (IREs) mRNA Interacts with eIF4G and Activates <i>In Vitro</i> Translation.","authors":"Mateen A Khan","doi":"10.31083/j.fbe1403017","DOIUrl":"https://doi.org/10.31083/j.fbe1403017","url":null,"abstract":"<p><strong>Background: </strong>Eukaryotic initiation factor (eIF) 4G plays an important role in assembling the initiation complex required for ribosome binding to mRNA and promote translation. Translation of ferritin IRE mRNAs is regulated by iron through iron responsive elements (IREs) and iron regulatory protein (IRP). The noncoding IRE stem-loop (30-nt) structure control synthesis of proteins in iron trafficking, cell cycling, and nervous system function. High cellular iron concentrations promote IRE RNA binding to ribosome and initiation factors, and allow synthesis of ferritin.</p><p><strong>Methods: </strong><i>In vitro</i> translation assay was performed in depleted wheat germ lysate with supplementation of initiation factors. Fluorescence spectroscopy was used to characterize eIF4F/IRE binding.</p><p><strong>Results: </strong>Eukaryotic initiation factor eIF4G increases the translation of ferritin through binding to stem loop structure of iron responsive elements mRNA in the 5'-untranslated region. Our translation experiment demonstrated that exogenous addition of eIF4G selectively enhanced the translation of ferritin IRE RNA in depleted WG lysate. However, eIF4G facilitates capped IRE RNA translation significantly higher than uncapped IRE RNA translation. Addition of iron with eIF4G to depleted WG lysate significantly enhanced translation for both IRE mRNA (capped and uncapped), confirming the contribution of eIF4G and iron as a potent enhancer of ferritin IRE mRNA translation. Fluorescence data revealed that ferritin IRE strongly interacts to eIF4G (<i>Kd</i> = 63 nM), but not eIF4E. Further equilibrium studies showed that iron enhanced (~4-fold) the ferritin IRE binding to eIF4G. The equilibrium binding effects of iron on ferritin IRE RNA/eIFs interaction and the temperature dependence of this reaction were measured and compared. The <i>Kd</i> values for the IRE binding to eIF4G ranging from 18.2 nM to 63.0 nM as temperature elevated from 5 °C to 25 °C, while the presence of iron showed much stronger affinity over the same range of temperatures. Thermodynamic parameter revealed that IRE RNA binds to eIF4G with ΔH = -42.6 ± 3.3 kJ. mole-1, ΔS = -11.5 ± 0.4 J. mole-1K-1, and ΔG = -39.2 ± 2.7 kJ. mole-1, respectively. Furthermore, addition of iron significantly changed the values of thermodynamic parameters, favoring stable complex formation, thus favoring efficient protein synthesis. This study first time demonstrate the participation of eIF4G in ferritin IRE mRNA translation.</p><p><strong>Conclusions: </strong>eIF4G specifically interacts with ferritin IRE RNA and promotes eIF4G-dependent translation.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 3","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33470137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does a Diet Rich in the Bacterium <i>Rhodopirellula rubra</i> Improve <i>Daphnia magna</i> Performance?","authors":"Maria Marinho,&nbsp;Gustavo Jesus,&nbsp;Luís Spencer,&nbsp;José Catita,&nbsp;Olga M Lage,&nbsp;Sara C Antunes","doi":"10.31083/j.fbe1403016","DOIUrl":"https://doi.org/10.31083/j.fbe1403016","url":null,"abstract":"<p><strong>Background: </strong>In the wild various organisms contribute to daphnids diet. This study, intendeds to evaluate the potential of the concentration of <i>Rhodopirellula rubra</i> as a single or supplementary food source for <i>Daphnia magna</i>.</p><p><strong>Methods: </strong>Feeding assays were performed according to standard guidelines for chronic assays (21 days), and life-history parameters and several biomarkers (protein content, oxidative stress, energetic reserves and pigments) were measured. Five food regimens were conducted with 20 individual replicates (A - <i>R. subcapitata</i>; 0.2 - suspension of <i>R. rubra</i> at 0.2 arbitrary units (AU); 0.4 - suspension of <i>R. rubra</i> at 0.4 AU; 0.2+A - suspension of <i>R. rubra</i> at 0.2+alga; 0.2+A-suspension of <i>R. rubra</i> at 0.4 AU + alga). Additionally, the effects of three diets (A, 0.2, and 0.2+A) on the longevity of <i>D. magna</i> were assessed.</p><p><strong>Results: </strong>The five diets showed a different C, N, and carotenoids composition, with an increase in the mixed diets. The results confirmed that the mixed diets improved <i>D. magna</i> life-history parameters. A decrease in glycogen, and the increase of haemoglobin, protein, and gluthione-S-transferase (GST) were observed. Furthermore, <i>D. magna</i> fed with bacterial single diets, presented worsen life history parameters and a decrease in the protein content. An induction of oxidative stress response (increased catalase and GST), and a significant decrease in lipid peroxidation and an accumulation of glycogen and carotenoids were observed. Overall, an increase in the amount of <i>R. rubra</i> provided to <i>D. magna</i>, from 0.2 AU to 0.4 AU, negatively impacted daphnid performance. No significant effects on <i>Daphnia</i> longevity (a 110-day assay) were observed among the three diets tested. However, a significant survival percentage and fertility (cumulative offspring is more than twice) was observed when <i>D. magna</i> was fed with the mixed diet.</p><p><strong>Conclusions: </strong>Results demonstrated that different diets provided a nutritional diversified food to the daphnids that induced differences in <i>D. magna</i> performance. The mixed diets proved to be beneficial (with increase in offspring) on <i>D. magna</i> performance, independently of the bacterial concentration tested. When in single diet, bacterial concentration is not nutritionally sufficient to raise <i>D. magna</i> even when in increased concentration.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 3","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33470136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specificity of <i>Rhodococcus opacus</i> 1CP cells' responses to benzoate and 3-chlorobenzoate.","authors":"Elena V Emelyanova,&nbsp;Inna P Solyanikova","doi":"10.31083/j.fbe1402015","DOIUrl":"https://doi.org/10.31083/j.fbe1402015","url":null,"abstract":"<p><strong>Background: </strong>Halogenated aromatic compounds are more resistant to microbial degradation than non-halogenated aromatic compounds. Microbial degradation of sodium benzoate in the presence of sodium 3-chlorobenzoate is of interest. The ability to degrade aromatic compounds is largely determined by the substrate specificity of the first enzyme that initiates degradation, namely, benzoate 1,2-dioxygenase for benzoate degradation, and 3-chlorobenzoate 1,2-dioxygenase for 3-chlorobenzoate degradation. In this study, the perspective of immobilized cells of <i>Rhodococcus opacus</i> 1CP actinobacterium for degradation of benzoate and 3-chlorobenzoate was explored.</p><p><strong>Methods: </strong>The biosensor approach (a membrane microbial sensor based on immobilized cells of <i>Rhodococcus opacus</i> 1CP and the Clark-type oxygen electrode as a transducer) was applied to evaluate the actinobacterial cells' responses to benzoate and 3-chlorobenzoate in the absence of both enzymes, benzoate 1,2-dioxygenase and 3-chlorobenzoate 1,2-dioxygenase, or in the presence of one of the said enzymes.</p><p><strong>Results: </strong>Data obtained show that 1CP actinobacterium possessed a constitutive system for the transport of benzoate and 3-chlorobenzoate into culture cells. The affinity of the transport system for benzoate was higher than that for 3-chlorobenzoate. Moreover, adaptation to one substrate did not preclude the use of the second substrate. Probably, porins facilitated the penetration of benzoate and 3-chlorobenzoate into 1CP cells. Analyzing <i>V vs</i>. <i>S</i> dependencies, negative cooperativity was found, when benzoate 1,2-dioxygenase bound substrate (3-chlorobenzoate), while positive cooperativity was determined at benzoate binding. The observed difference could be associated with the presence of at least two systems of 3-chlorobenzoate transport into actinobacterial cells and allosteric interaction of active sites of benzoate 1,2-dioxygenase in the presence of 3-chlorobenzoate.</p><p><strong>Conclusions: </strong>The membrane microbial sensor based on immobilized <i>Rhodococcus opacus</i> 1CP cells could be useful as a perspective tool for comparative evaluation of enzymes of complex structure such as benzoate- and 3-chlorobenzoate 1,2-dioxygenase.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> evaluation of Kedo-S and RaCe rotary files compared to hand files in preparing the root canals of primary molar teeth.","authors":"Maryam Tofangchiha,&nbsp;Anita Ebrahimi,&nbsp;Mamak Adel,&nbsp;Fatemeh Kermani,&nbsp;Navid Mohammadi,&nbsp;Rodolfo Reda,&nbsp;Luca Testarelli","doi":"10.31083/j.fbe1402014","DOIUrl":"https://doi.org/10.31083/j.fbe1402014","url":null,"abstract":"<p><strong>Background and aims: </strong>Considering the advantages of rotary files in instrumenting the root canals of permanent teeth and a lack of adequate data on the use of these systems in primary teeth, the present study aimed to evaluate two rotary files and compare them with hand files in the cleaning efficacy of the root canals of primary molar teeth.</p><p><strong>Materials and methods: </strong>In the present study, three groups of teeth were prepared with Kedo-S paediatric rotary file system, RaCe (reamer with alternating cutting edges), and hand files (n = 40). The groups were evaluated under a stereomicroscope concerning the cleaning efficacy of the files after cleaning the teeth in the apical, middle, and coronal thirds. The data were analyzed with SPSS 24 (IBM Corporation, USA, 2016) using Fisher's exact test and chi-squared test; statistical significance was set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>There were no significant differences in the apical and middle thirds between the different study groups. However, there were significant differences in the coronal third between the hand file and Kedo-S (<i>p</i> = 0.016) and RaCe and Kedo-S (<i>p</i> = 0.001) groups.</p><p><strong>Conclusions: </strong>The present study showed that Kedo-S files were more effective than RaCe and hand files in the coronal area than the hand and RaCe files.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of green silver nanoparticles synthesized from the red seaweeds <i>Halymenia porphyriformis</i> and <i>Solieria robusta</i> against oral pathogenic bacteria by using microscopic technique.","authors":"Khadija Dilawaiz Khan,&nbsp;Uzma Hanif,&nbsp;Iram Liaqat,&nbsp;Shabnum Shaheen,&nbsp;Umer Farooq Awan,&nbsp;Saiqa Ishtiaq,&nbsp;Leonel Pereira,&nbsp;Saraj Bahadur,&nbsp;Marriam Dilawaiz Khan","doi":"10.31083/j.fbe1402013","DOIUrl":"https://doi.org/10.31083/j.fbe1402013","url":null,"abstract":"<p><p>Aqueous extracts of two red seaweeds <i>Halymenia porphyriformis</i> and <i>Solieria robusta</i> were used to synthesize green silver nanoparticles. These biogenic nanoparticles were tested against four strains of oral pathogenic bacteria which cause tooth decay or cavities. <i>Staphylococcus aureus</i> (MT416445), <i>Streptococcus viridans</i> (MT416448), <i>Lactobacillus acidophilus</i> (MT416447) and <i>Lactobacillus brevis</i> (MT416446) were used. Characterization of AgNPs was done by UV-Visible spectroscopy, SEM, XRD and FTIR. XRD analysis revealed the crystalline nature of the particles. The size analysis by XRD of the green AgNPs by <i>H. porphyriformis</i> indicated it had smaller particles, 15.23 nm, when compared to AgNPs by <i>S. robusta</i> (17 nm). Both green synthesized silver nanoparticles showed moderate antibacterial activity against all strains of bacteria, except <i>L. acidophilus</i>. Both particles showed their maximum zone of inhibition against <i>L. acidophilus</i> at a lower concentration of 50 and 100 μg. However, it was concluded that silver nanoparticles of <i>H. porphyriformis</i> are more effective than that of <i>S. robusta</i> due to their smaller size.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of prophylactic platelet rich plasma (PRP) following open saphenous vein harvesting in cardiac surgery.","authors":"Federica Jiritano,&nbsp;Raffaele Serra,&nbsp;Antonio Nenna,&nbsp;Antonio Curcillo,&nbsp;Francesco Villella,&nbsp;Francesco Nappi,&nbsp;Camilla Chello,&nbsp;Massimo Chello,&nbsp;Pasquale Mastroroberto,&nbsp;Giuseppe Filiberto Serraino","doi":"10.31083/j.fbe1402012","DOIUrl":"https://doi.org/10.31083/j.fbe1402012","url":null,"abstract":"<p><strong>Background: </strong>Wound infection represents a frequent trouble following open saphenous vein harvesting in cardiac surgery. Platelets' growth factors are crucial for the healing process. Prophylactic platelet rich plasma (PRP) application on leg wound might reduce the incidence of saphenous vein harvest site infections in patients undergoing coronary artery bypass graft surgery (CABG).</p><p><strong>Methods: </strong>Between January 2009 and December 2020, 987 consecutive patients underwent CABG using saphenous vein as conduit graft and were retrospectively divided into two groups. All patients had standard surgical leg wound closure and wound care, but treatment group received adjunctive topical application of PRP (no-PRP and PRP group, respectively). The primary outcome was wound infection.</p><p><strong>Results: </strong>Saphenous vein harvest site infection rate was similar between PRP (3.5%) and No-PRP (5.2%) group, <i>p</i> = 0.215. The ASEPSIS score was lower for the PRP group (PRP: 3.6 ± 9.1 vs. No-PRP: 5.3 ± 11.2; <i>p</i> = 0.014). Performing a subgroup analysis, the diabetic patients (PRP-DM) group had a lower rate of infection than control group (No-PRP DM) (2.6% vs. 7.7%, <i>p</i> = 0.026). PRP-DM patients had an inferior ASEPSIS score (PRP-DM: 2.7 ± 8.3 vs. No PRP-DM: 7.5 ± 13.2, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Topical application of autologous PRP on saphenoug vein harvest site might reduce the rate of surgical site infection, with particular benefit among diabetic patients.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culturomics remains a highly valuable methodology to obtain rare microbial diversity with putative biotechnological potential from two Portuguese salterns.","authors":"Eduarda Almeida,&nbsp;Maria F Carvalho,&nbsp;Olga M Lage","doi":"10.31083/j.fbe1402011","DOIUrl":"https://doi.org/10.31083/j.fbe1402011","url":null,"abstract":"<p><strong>Background: </strong>The high salt concentration is the major factor limiting microbial growth at salterns, along with solar radiation, temperature, and pH. These environmental factors play key roles in the acquisition of unique genetic adaptations for the survival of microorganisms in salterns, which can result in the production of interesting secondary metabolites. The main goal of the present work was to isolate and compare the culturable microbiota from two geographically distant salterns in Portugal and access their biotechnological potential.</p><p><strong>Methods: </strong>Culturomics approaches using different culture media were applied for microbial isolation. All isolates were identified either by 16S rRNA or ITS genes sequencing, and their biotechonological potential was assessed by PCR.</p><p><strong>Results: </strong>Overall, 154 microbial isolates were recovered that were phylogenetically assigned to 45 taxa from 9 different phyla. From these, 26 isolates may represent putative new taxa. The predominant genera obtained were <i>Penicillium</i> (41 isolates, 26.6%), <i>Streptomyces</i> (13 isolates, 8.4%) and <i>Sinomicrobium</i> (11 isolates, 7.1%). Moreover, the polyketide synthase I gene was present in 64 isolates, the nonribosomal peptide synthethase gene in 16 isolates, and both genes in 23 isolates.</p><p><strong>Conclusions: </strong>This study adds up valuable knowledge on the culturable microbiota of Portuguese salterns and on its potential for production of secondary metabolites. In the long run, this study provides a widely diverse microbial collection for future works. Data public repository: All DNA sequences were deposited in the GenBank database at National Centre for Biotechnology Information (NCBI) web platform under accession numbers OK169439-OK169485, OK216020-OK216124, OK287059 and OK326927.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Major Antioxidant Compounds from the Edible Mushroom <i>Basidiomycetes-X</i> (Echigoshirayukidake).","authors":"Toshio Sakamoto,&nbsp;Zhenshi Li,&nbsp;Ayaka Nishida,&nbsp;Asako Kadokawa,&nbsp;Takayuki Yoshida,&nbsp;Naoki Wada,&nbsp;Seiichi Matsugo,&nbsp;Yutaka Nakamura,&nbsp;Shinji Sato,&nbsp;Tetsuya Konishi","doi":"10.31083/j.fbe1402010","DOIUrl":"https://doi.org/10.31083/j.fbe1402010","url":null,"abstract":"<p><p><i>Basidiomycetes-X</i>, of which Japanese vernacular name is Echigoshirayukidake, is a local speciality mushroom found and cultivated in Japan that has been distributed as a precious cuisine material or as a functional food with medicinal properties. Antioxidant activity-guided isolation of major ingredients in <i>Basidiomycetes-X</i> revealed the presence of ergosterol, <i>trans</i>-10,<i>cis</i>-12-octadecadienoic acid (a conjugated linolenic acid, 10(E),12(Z)-CLA) and 2,3-dihydro-3,5-dihydroxy-6-methyl‑4<i>H</i>‑pyran-4-one (DDMP). Approximately 21% of the 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazino radical (DPPH) scavenging activities in the methanolic extract were related to 10(E),12(Z)-CLA, while approximately 6.2% of the activity was related to ergosterol. DDMP was present in both methanolic and water extracts, and the activity related to DDMP was conspicuously detected in water extracts. Moreover, uridine and adenosine were identified as major components of <i>Basidiomycetes-X</i>. The ingredients identified in <i>Basidiomycetes-X</i> are expected to be involved in biological functions observed in this mushroom, which is an attractive functional food resource.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saliva biotechnology as a diagnostic tool for periodontal diseases: new challenges for clinical practice.","authors":"Gaetano Isola","doi":"10.31083/j.fbe1402009","DOIUrl":"https://doi.org/10.31083/j.fbe1402009","url":null,"abstract":"<p><p>The periodontal apparatus has an essential function for the entire stomatognathic system, especially in dental support and in protecting the biofilm from periodontal pathogenic bacteria. Specifically, interactions with the immune system and the surrounding oral environment make it key in the mechanism of aetiology of periodontitis. In the oral cavity, saliva and crevicular fluid have significant functions including oral hygiene and protection of the oral cavity with specific antibacterial effects, on digestion and as a source of early diagnosis of oral diseases. This editorial aims to analyze current knowledge and new challenges on the benefits of saliva as a diagnostic fluid for the early diagnosis of periodontal disease.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Inflammatory Gut Diseases with Neuroinflammatory and Auditory Disorders.","authors":"Dagmara Kociszewska,&nbsp;Srdjan M Vlajkovic","doi":"10.31083/j.fbe1402008","DOIUrl":"https://doi.org/10.31083/j.fbe1402008","url":null,"abstract":"<p><p>Disorders such as inflammatory bowel disease (IBD) and celiac disease (CeD) result in intestinal hyperpermeability or 'leaky' gut. The increased permeability of the intestinal barrier allows microbial metabolites, toxins, and pathogens to infiltrate the bloodstream and extraintestinal tissues, causing systemic inflammation. Despite differences in aetiology and pathophysiology, IBD and CeD share several extraintestinal manifestations such as neuroinflammation, neurological and psychiatric manifestations, and sensorineural hearing loss (SNHL). This narrative review focuses on the association between intestinal hyperpermeability with the brain and inner ear diseases. We postulate that the microbial metabolites and pathogens released from the gut increase the permeability of natural barriers, such as the blood-brain barrier (BBB) and blood-labyrinth barrier (BLB). The barrier breakdown allows the spreading of inflammatory processes to the brain and inner ear, leading to disease.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"14 2","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40178495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}