Frontiers in bioscience (Elite edition)最新文献_第10页

Yoga and its impact on chronic inflammatory autoimmune arthritis. 瑜伽及其对慢性炎症性自身免疫性关节炎的影响。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/873

Surabhi Gautam, Uma Kumar, Rima Dada

引用次数: 11

Modulation of human ovarian function by melatonin. 褪黑素对人类卵巢功能的调节。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/875

Seema Rai, Hindole Ghosh

引用次数: 14

Therapeutic applications of transdermal microneedles. 透皮微针的治疗应用。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/876

Sumeet Kumar Singla, Arunachalam Muthuraman, Diksha Sahai, Naveen Mangal, Jagadeesh Dhamodharan

引用次数: 0

Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress. 曼氏黄瓜能逆转高脂肪饮食引起的代谢紊乱和氧化应激。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/872

Anthony Tope Olofinnade, Adejoke Yetunde Onaolapo, Azurra Stefanucci, Adriano Mollica, Olugbenga Adekunle Olowe, Olakunle James Onaolapo

引用次数: 6

Wellbeing differences in children with synaesthesia: anxiety and mood regulation. 联觉儿童的健康差异:焦虑和情绪调节。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/878

Julia Simner, Rebecca Smees, Louisa J Rinaldi, Duncan A Carmichael

{"title":"Wellbeing differences in children with synaesthesia: anxiety and mood regulation.","authors":"Julia Simner, Rebecca Smees, Louisa J Rinaldi, Duncan A Carmichael","doi":"10.2741/878","DOIUrl":"https://doi.org/10.2741/878","url":null,"abstract":"Synaesthesia is a neurodevelopmental trait that causes unusual sensory experiences (e.g., perceiving colours when reading letters and numbers). Our paper represents the first evidence that synaesthesia can impact negatively on children's well-being, and that there are likely to be important mental health co-morbidities for children with synaesthesia. We recruited 76 synaesthetes aged 6-10 years who had one of two types of synaesthesia (grapheme-colour synaesthesia and sequence-personality synaesthesia), and compared them to almost one thousand matched non-synaesthete controls. We tested children's wellbeing with two different measures, and found a significant relationship between synaesthesia and affect (i.e., mood), and also between synaesthesia and anxiety. Children with synaesthesia showed evidence suggesting significantly higher rates of Anxiety Disorder, and also displayed a type of mood-moderation in demonstrating fewer extremes of emotion (i.e., significantly fewer negative feelings such as fear, but also significantly fewer positive feelings such as joy). We discuss our results with reference to the emotional moderation of alexithymia (the inability to recognize or describe one's own emotions), and to a set of known links between alexithymia, anxiety, autism and synaesthesia.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"13 1","pages":"195-215"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38584111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Molecular stability of the rabbit and chicken egg yolk immunoglobulins. 兔、鸡蛋黄免疫球蛋白的分子稳定性。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/877

Sonu Gandhi, Saad M Alshehri

{"title":"Molecular stability of the rabbit and chicken egg yolk immunoglobulins.","authors":"Sonu Gandhi, Saad M Alshehri","doi":"10.2741/877","DOIUrl":"https://doi.org/10.2741/877","url":null,"abstract":"Antibodies play a vital role in a variety of applications from diagnostics, imaging, and therapeutics. The stability of antibodies is one of the most important key attributes for its prolonged activity and functionality. Here, we demonstrate a detailed comparative study of the molecular stability of the rabbit immunoglobulin G (IgG) and chicken egg yolk immunoglobulin Y (IgY) at different pH, temperatures, and time points. The molecular stability of IgG and IgY is compared on the basis of its binding activity and conformational changes. The optimum temperature and time were found to be 30 °C, and 37 °C, up to 8 h for both IgY and IgG antibodies. With increasing temperature and time, IgG antibodies were found to be significantly less stable in comparison to IgY antibodies. IgY is almost twenty-fold more stable than IgG at 60° C for up to 8 hours. The extra domain present in the heavy chain of IgY plays a significant role in providing more molecular stability as compared to IgG under the above-mentioned experimental conditions. The results show that, as compared with IgG, the IgY are more stable, are less expensive to make in high yield and exhibit minimal conformational changes and hence are cost effective for use in a diverse array of purposes.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"13 1","pages":"185-194"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38584110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Impact of stress, immunity, and signals from endocrine and nervous system on fascia. 应激、免疫、内分泌和神经系统信号对筋膜的影响。

Frontiers in bioscience (Elite edition) Pub Date : 2021-01-01 DOI: 10.2741/870

Nicola Barsotti, Marco Chiera, Diego Lanaro, Massimo Fioranelli

引用次数: 5

Analysis of genetic diversity in indian natural populations of drosophila ananassae. 印度果蝇自然居群遗传多样性分析。

Frontiers in bioscience (Elite edition) Pub Date : 2020-06-01 DOI: 10.2741/E869

Pranveer Singh, Pankaj Narula, Sarita Azad

{"title":"Analysis of genetic diversity in indian natural populations of drosophila ananassae.","authors":"Pranveer Singh, Pankaj Narula, Sarita Azad","doi":"10.2741/E869","DOIUrl":"https://doi.org/10.2741/E869","url":null,"abstract":"Forty five natural populations of Drosophila ananassae, collected from entire geo-climatic regions of the India were analyzed to determine the distribution of genetic diversity relative to different eco-geographic factors. Quantitative data on the frequencies of three cosmopolitan inversions in the sampled populations were utilized to deduce Nei's gene diversity estimates. Populations were grouped according to the time of collection (years and month); collection-regions like coastal and mainland regions, and collection-seasons. Further, data was subjected to network analysis to detect community structure in the populations and Modularity analysis to quantify the strength in community structure. Gene-diversity statistics revealed the presence of significant variability in the Indian natural populations of D.ananassae. Off all the parameters used to group the populations, geographical attributes seems to have maximum, while the time of collection and seasons have minimum influence on the genetic variability in Indian natural populations of D.ananassae. The results clearly link the association of genetic variability with environmental heterogeneity, elucidating the role of environment specific natural selection. The homogenizing effects could be due to genetic hitchhiking and canalization.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"12 2","pages":"237-253"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37988429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Personality profile of child synaesthetes. 儿童联觉者的人格特征。

Frontiers in bioscience (Elite edition) Pub Date : 2020-03-01 DOI: 10.2741/E865

Louisa J Rinaldi, Rebecca Smees, Duncan A Carmichael, Julia Simner

{"title":"Personality profile of child synaesthetes.","authors":"Louisa J Rinaldi, Rebecca Smees, Duncan A Carmichael, Julia Simner","doi":"10.2741/E865","DOIUrl":"https://doi.org/10.2741/E865","url":null,"abstract":"Previous research into personality and synaesthesia has focused on adult populations and yielded mixed results. One particular challenge has been to distinguish traits associated with synaesthesia, from traits associated with the ways in which synaesthetes were recruited. In the current study we addressed recruitment issues by testing randomly sampled synaesthetes, and we looked particularly at synaesthesia in childhood. Our child synaesthetes were identified by a screening program across 22 primary schools in the South East of England (n = 3387; children aged 6 to 10 years old). This identified two types of synaesthete (grapheme-colour synaesthesia and sequence-personality synaesthesia), and we tested their personalities using both child-report and parent-report measures. We found strong support for synaesthesia being associated with high Openness to Experience, a personality trait linked to intelligence and creativity. Both synaesthesia subtypes showed this feature, supporting previous research in adults (1-3). We additionally found low Extraversion in grapheme-colour synaesthetes and high Conscientiousness in sequence-personality synaesthetes. We discuss our results with reference to earlier recruitment issues, and as to how perceptual differences such as synaesthesia might link to trait-differences in personality.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"12 1","pages":"162-182"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Influence of KCNJ11 gene polymorphism in T2DM of south Indian population. KCNJ11基因多态性对印度南部人群T2DM的影响

Frontiers in bioscience (Elite edition) Pub Date : 2020-03-01 DOI: 10.2741/E867

Rajagopalan Aswathi, Dhasaiya Viji, Prathap Seelan Pricilla Charmine, Rehman Syed Rasheed Akram Husain, Sahul Hameed Noorul Ameen, Shiek Ssj Ahmed, Veerabathiran Ramakrishnan

{"title":"Influence of KCNJ11 gene polymorphism in T2DM of south Indian population.","authors":"Rajagopalan Aswathi, Dhasaiya Viji, Prathap Seelan Pricilla Charmine, Rehman Syed Rasheed Akram Husain, Sahul Hameed Noorul Ameen, Shiek Ssj Ahmed, Veerabathiran Ramakrishnan","doi":"10.2741/E867","DOIUrl":"https://doi.org/10.2741/E867","url":null,"abstract":"Type-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 polymorphism towards an increased risk of T2DM compared to controls with an odds ratio (OR) of 2.52, confidence interval (CI) (0.96-6.64) and p-value 0.046. The functional influence of rs5219 was tested which showed a significant correlation with HbA1c and serum uric acid levels. Although our results confirm rs5219 is a potential contributor to T2DM, several inconclusive results were noticed across the literature. Hence, the meta-analysis was performed by combining the results of case-control study with previous literature to confirm the rs5219 association with T2DM across various populations. Our meta-analysis revealed a significant risk association of rs5219 in T2DM under five genetic models. In summary, our analysis suggests, rs5219 polymorphism plays a significant role in T2DM susceptibility. Further, studies need to be conducted to determine the influence of rs5219 on the other characteristics of T2DM.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"12 2","pages":"199-222"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4