Frontiers in bioscience (Elite edition)最新文献_第10页

G82S RAGE polymorphism is associated with Alzheimer's disease. G82S RAGE多态性与阿尔茨海默病相关

Frontiers in bioscience (Elite edition) Pub Date : 2020-03-01 DOI: 10.2741/E864

Rani Cathrine Chellappa, Palaniswamy Rani

引用次数: 3

Deregulation of cell growth and apoptosis in UV-induced melanomagenesis. 紫外线诱导的黑色素瘤形成中细胞生长和凋亡的调控。

Frontiers in bioscience (Elite edition) Pub Date : 2020-03-01 DOI: 10.2741/E868

Allal Ouhtit, Ishita Gupta, Rajiv L Gaur, Augusta Fernando, Amira O Abd El-Azim, Ali Eid

{"title":"Deregulation of cell growth and apoptosis in UV-induced melanomagenesis.","authors":"Allal Ouhtit, Ishita Gupta, Rajiv L Gaur, Augusta Fernando, Amira O Abd El-Azim, Ali Eid","doi":"10.2741/E868","DOIUrl":"https://doi.org/10.2741/E868","url":null,"abstract":"We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to elucidate further the coordinated molecular mechanisms occurring during early UVB exposure. Our results showed that melanocytes expressed p16 only at a high UVB dose, with undetectable p53. The Bax/Bcl2 ratio increased at higher dose, indicating that the cells had selected apoptosis program. In the wt-p16 melanoma cells, while low UVB dose upregulated p16, the high dose suppressed it, and further abrogated Cdk6 but not Cdk4. Interestingly, while induction of mutant-p16 increased Cdk4, cdk6 and pRb proteins, UVB exposure did not affect this increase. More interestingly, p16 mutant cells increased their resistance to apoptosis at high UVB-dose, associated with decreased Bax and increased Bcl2 expression. Thus, mutant-p16 appears to dictate a deregulation of cell cycle and increased resistance to apoptosis in melanoma cells. Together, the data indicate a deregulation of p16INK4/Rb pathway as an early event in UVB-induced melanomagenesis.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of human milk oligosaccharides (HMOs) on gastrointestinal health. 人乳低聚糖(HMOs)对胃肠道健康的影响。

Frontiers in bioscience (Elite edition) Pub Date : 2020-03-01 DOI: 10.2741/E866

Maurizio Salamone, Veronica Di Nardo

引用次数: 4

Wilson's disease: A new perspective review on its genetics, diagnosis and treatment. 肝豆状核变性:遗传学、诊断和治疗的新进展。

Frontiers in bioscience (Elite edition) Pub Date : 2019-06-01 DOI: 10.2741/E854

Luca Saba, Anurag Tiwari, Mainak Biswas, Suneet Kumar Gupta, Elisa Godia-Cuadrado, Amrita Chaturvedi, Monika Turk, Harman S Suri, Sandro Orru, J Miguel Sanches, Carlo Carcassi, Rui Tato Marinho, Christopher Kwaku Asare, Narendra N Khanna, Madhusudhan B K, Jasjit S Suri

{"title":"Wilson's disease: A new perspective review on its genetics, diagnosis and treatment.","authors":"Luca Saba, Anurag Tiwari, Mainak Biswas, Suneet Kumar Gupta, Elisa Godia-Cuadrado, Amrita Chaturvedi, Monika Turk, Harman S Suri, Sandro Orru, J Miguel Sanches, Carlo Carcassi, Rui Tato Marinho, Christopher Kwaku Asare, Narendra N Khanna, Madhusudhan B K, Jasjit S Suri","doi":"10.2741/E854","DOIUrl":"https://doi.org/10.2741/E854","url":null,"abstract":"Wilson's disease (WD) is an autosomal recessive disorder which is caused by poor excretion of copper in mammalian cells. In this review, various issues such as effective characterization of ATP7B genes, scope of gene network topology in genetic analysis, pattern recognition using different computing approaches and fusion possibilities in imaging and genetic dataset are discussed vividly. We categorized this study into three major sections: (A) WD genetics, (B) diagnosis guidelines and (3) treatment possibilities. We addressed the scope of advanced mathematical modelling paradigms for understanding common genetic sequences and dominating WD imaging biomarkers. We have also discussed current state-of-the-art software models for genetic sequencing. Further, we hypothesized that involvement of machine and deep learning techniques in the context of WD genetics and image processing for precise classification of WD. These computing procedures signify changing roles of various data transformation techniques with respect to supervised and unsupervised learning models.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37278967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Epithelial-to-mesenchymal transition: Event and core associates in bladder cancer. 上皮到间质转化:膀胱癌的事件和核心关联。

Frontiers in bioscience (Elite edition) Pub Date : 2019-06-01 DOI: 10.2741/E853

Minal Garg, Rinni Singh

引用次数: 16

Identification of salt-tolerant cowpea genotypes using ISSR markers and proteome analysis. 利用ISSR标记和蛋白质组学分析鉴定耐盐豇豆基因型。

Frontiers in bioscience (Elite edition) Pub Date : 2019-06-01 DOI: 10.2741/E852

Madhavan Lysal Mini, Mohan Sathya, Musthafa Mohamed Essa, Abdullah M Al-Sadi, Kesavan Swaminathan Jayachandran, Muthuswamy Anusuyadevi

{"title":"Identification of salt-tolerant cowpea genotypes using ISSR markers and proteome analysis.","authors":"Madhavan Lysal Mini, Mohan Sathya, Musthafa Mohamed Essa, Abdullah M Al-Sadi, Kesavan Swaminathan Jayachandran, Muthuswamy Anusuyadevi","doi":"10.2741/E852","DOIUrl":"https://doi.org/10.2741/E852","url":null,"abstract":"Soil salinity globally affects the productivity of staple food crops. Therefore, an understanding of the molecular mechanisms that lead to salt tolerance induced by antioxidant mechanisms can assist in the development of salt-tolerant crops. To decipher the molecular fingerprint of salt resistance, in this study, six salt-tolerant cowpea genotypes at the seedling stage were assessed for their antioxidant responses, yield, genetic polymorphism and proteomics under salt stress. Leaves and roots showed distinct tissue-specific responses to salinity, and leaves showed a better protection against salt stress-induced oxidative stress than roots. Inter simple sequence repeat (ISSR) fingerprinting allowed molecular discrimination between salt-tolerant cowpea genotypes. Proteome analysis of cowpea leaves under salt stress revealed up-regulation of ATP synthase, vacuolar ATPase, pentatricopeptide repeat protein, flavanone 3-hydroxylase and outer envelope pore protein. Thus, ISSR and proteome analysis allow the identification of salt-tolerant cowpea cultivars.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37278964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism. 类黄酮曲希蛋白对血压、氧化应激和脂质代谢调节的作用。

Frontiers in bioscience (Elite edition) Pub Date : 2019-01-01 DOI: 10.2741/E851

Boobalan Raja, Dhanasekaran Saranya, Rajendran Prabhu

{"title":"Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.","authors":"Boobalan Raja, Dhanasekaran Saranya, Rajendran Prabhu","doi":"10.2741/E851","DOIUrl":"https://doi.org/10.2741/E851","url":null,"abstract":"The objective of the present study was to investigate the effects of troxerutin (TX) on Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured. TX supplementation throughout the experimental period significantly brings back all the above parameters. Among the three doses (25, 50, and 100 mg/kg) of TX, 100 mg/kg dosage exerts optimum protection against L-Name induced hypertension. These results suggest that TX has enough potential to attenuate hypertension, oxidative stress and dyslipidemia in L-NAME induced hypertensive rats.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36708828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Three-dimensional printing as an educational tool in colorectal surgery. 三维打印技术在结直肠外科教学中的应用。

Frontiers in bioscience (Elite edition) Pub Date : 2019-01-01 DOI: 10.2741/E844

Petros Bangeas, Kostnantinos Drevelegas, Christina Agorastou, Lazaros Tzounis, Aggeliki Chorti, Daniel Paramythiotis, Antonis Michalopoulos, George Tsoulfas, Vassileios N Papadopoulos, Aristomenis Exadaktylos, Jasjit S Suri

{"title":"Three-dimensional printing as an educational tool in colorectal surgery.","authors":"Petros Bangeas, Kostnantinos Drevelegas, Christina Agorastou, Lazaros Tzounis, Aggeliki Chorti, Daniel Paramythiotis, Antonis Michalopoulos, George Tsoulfas, Vassileios N Papadopoulos, Aristomenis Exadaktylos, Jasjit S Suri","doi":"10.2741/E844","DOIUrl":"https://doi.org/10.2741/E844","url":null,"abstract":"3D printing is a rapidly advancing technology which represents a significant technological achievement that could be useful in a variety of biomedical applications. In the field of surgery, 3D printing is envisioned as a significant step in the areas of surgical planning, education and training. The 3D printed models are considered as high quality and efficient educational tools. In this paper A randomized controlled trial was performed to compare the educational role of 3D printed models with that of the conventional MRI films in the training of surgical residents. Statistical analysis revealed that Resident surgeons who studied only the anal fistula printed models, (Group B) achieved a higher overall score in the fistula assessment test (87,2 (82,6-91,6)) compared to resident surgeons (Group A) who studied only MRI images (74,85 (66,8-73,5)). 3D printing technology can lead to improvement in preoperative planning accuracy, followed by efficient optimization of the treatment strategy. It is believed that 3D printing technology could be used in the case of various other surgical applications, thus representing a novel tool for surgical education.","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36709364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Beta₂-adrenergic receptor variants in children and adolescents with bronchial asthma. 支气管哮喘儿童和青少年β -肾上腺素能受体变异

Frontiers in bioscience (Elite edition) Pub Date : 2019-01-01 DOI: 10.2741/E846

Eman A Toraih, Mohammad H Hussein, Ahmed Ibrahim, Nouran B AbdAllah, Eman Mohammad, Ali M Kishk, Manal S Fawzy

引用次数: 13

Antimicrobial activity of Bacillus subtilis silver nanoparticles. 枯草芽孢杆菌纳米银抗菌活性研究。

Frontiers in bioscience (Elite edition) Pub Date : 2019-01-01 DOI: 10.2741/E848

Kannaiyan Muthulakshmi, Chinnaiyan Uma

引用次数: 3