Frontiers in bioscience (Elite edition)最新文献

{"title":"<i>Medicago sativa</i> L. Root Exudation of Phenolic Compounds and Effect of Flavonoids on Phenanthrene Degradation by Two Rhizobacteria.","authors":"Dmitry Kuzyanov, Leonid Panchenko, Natalia Pozdnyakova, Anna Muratova","doi":"10.31083/FBE25779","DOIUrl":"https://doi.org/10.31083/FBE25779","url":null,"abstract":"<p><strong>Background: </strong>Plant-microbial degradation of organic pollutants occurs in the rhizosphere under the influence of plant root exudates. Similarities in chemical structure to polycyclic aromatic hydrocarbons (PAHs), phenolic compounds and flavonoids released with exudates can determine the ability of rhizosphere microorganisms to degrade hazardous aromatic pollutants.</p><p><strong>Methods: </strong>Here, we analyzed phenolic compounds in the root exudates of alfalfa (<i>Medicago sativa</i> L.) grown in quartz sand uncontaminated and phenanthrene-contaminated quartz sand, a model PAH pollutant, under axenic conditions. The effect of six flavonoids (naringenin, rutin, morin, quercetin, apigenin, and luteolin) on phenanthrene degradation by two PAH-degrading bacteria, <i>Ensifer meliloti</i> P221 and <i>Mycolicibacterium gilvum</i> PAM1, previously isolated from the rhizosphere of alfalfa was also investigated. Ultraviolet (UV)-vis spectroscopy and high-performance liquid chromatography (HPLC) were applied to assay flavonoid and phenanthrene content in cultivation media.</p><p><strong>Results: </strong>The quantitative and qualitative characteristics of the root-exuded phenolic compounds changed under the influence of phenanthrene. The impact of the flavonoids on PAH biodegradation varied from neutral or even inhibitory to stimulatory. The same flavonoid (quercetin) had opposite effects on the growth of the two bacteria and on phenanthrene degradation. The effect of the flavonoids on bacterial growth did not depend on the presence of PAHs. Using naringenin as an example, we showed that increased PAH degradations could not accompany bacterial growth promotion by any flavonoid. Except for rutin, all flavonoids were subject to bacterial degradation. Inoculation of alfalfa with the competent rhizobacterium <i>Ensifer meliloti</i> increased the contents phenolic compounds in the plant root exudate, promoted qualitative changes in their profile, and increased the rhizodegradation of phenanthrene from 6% and 22% to 57% and 34% at initial phenanthrene concentrations of 50 and 100 mg/L respectively.</p><p><strong>Conclusion: </strong>Our data suggest a the role for plant flavonoids in the rhizome-mediated degradation of PAHs. The microbe-induced qualitative and quantitative changes in root exudation illustrate the induction of PAH-mediated catabolic activity in the rhizosphere.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"25779"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Postbiotic-Based Orodispersible Film to Prevent Dysbiosis in the Oral Cavity.","authors":"Mariana B Rebelo, Cláudia S Oliveira, Freni K Tavaria","doi":"10.31083/FBE26987","DOIUrl":"https://doi.org/10.31083/FBE26987","url":null,"abstract":"<p><strong>Background: </strong>Oral diseases affect over three billion peopleand are among the most commonly observed infections worldwide. Recent studies have shown that controlling the ecology of the oralome is more effective in reducing the risk of caries than the complete removal of both harmful and beneficial microorganisms. This work aimed to develop a strategy for preventing dysbiosis in the oral cavity by applying a postbiotic-based orodispersible film.</p><p><strong>Methods: </strong><i>Lactiplantibacillus plantarum</i> 226V and <i>Lacticaseibacillus paracasei</i> L26 were cultured in De Man-Rogosa-Sharpe (MRS) broth for 48 hours, followed by centrifugation and filtration. Then, the resultant postbiotics were then subjected to various dilutions (10% (v/v), 20% (v/v), 40% (v/v), 60% (v/v) and 100% (v/v)) and co-incubated with <i>Streptococcus mutans.</i> Antimicrobial efficacy, minimal inhibitory concentration, the time required to inhibit <i>S. mutans</i> growth, and antibiofilm properties of the postbiotics were assessed. Subsequently, an orodispersible film comprising polymers and plasticizers, namely Xanthan gum, maltodextrin, and glycerol, was developed as a vehicle for postbiotic delivery. Formulation optimization, physical property evaluation, and cytotoxicity against the TR146 human oral cell line (TR146 cell line) were conducted.</p><p><strong>Results: </strong>Postbiotics demonstrated antimicrobial and antibiofilm activity against <i>S. mutans</i> following 24-hour co-incubation. The minimal inhibitory concentration for combined postbiotics administration was 20% (v/v). Remarkably, 79.6 ± 8.15% inhibition of biofilm formation was achieved using 100% (v/v) of the postbiotic derived from <i>L. plantarum</i> 226V. Incorporating postbiotics did not compromise the dissolution time of orodispersible films, all exceeding 20 minutes. Furthermore, solubility improved following postbiotic addition, facilitating ease of handling. Importantly, postbiotic-impregnated orodispersible films were non-cytotoxic when exposed to the TR146 cell line.</p><p><strong>Conclusions: </strong>These findings underscore the potential of orodispersible films loaded with postbiotics as a promising potential intervention for oral dysbiosis.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"26987"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of Nitrogen Cycle Microorganisms to Multifactorial Global Changes in Soil Ecosystems.","authors":"Marina Sidorenko","doi":"10.31083/FBE23082","DOIUrl":"https://doi.org/10.31083/FBE23082","url":null,"abstract":"<p><strong>Background: </strong>Climate change affects life on Earth. Meanwhile, microorganisms (unlike plants and animals) are usually not considered when studying climate change, particularly due to the impact of climatic fluctuation on them. A substantial variety of microbes and their responses to changing environmental conditions make determining their role in the ecosystem functioning very difficult. Nevertheless, microorganisms support the existence of all life forms on the planet. It is also important to know how microorganisms affect climate change and how this subsequently then affects microorganisms. Previous research demonstrates the leading role and importance of microorganisms in studying the biological aspects of climate change. Thus, this paper aimed to examine the correlation between nitrogen cycle microorganisms and climate change.</p><p><strong>Methods: </strong>The nitrogen cycle microorganism (NCM) soil formed the primary research object, which, simultaneously, is not associative microflora and belongs to the following groups: amino heterotrophs using organic forms of nitrogen, aminoautotrophs using mineral forms of nitrogen, and diazotrophs fixing nitrogen in the air. The response of NCMs in simultaneously increasing atmospheric CO₂, precipitation, temperature, and nitrogen in an artificially created agricultural soil ecosystem was investigated.</p><p><strong>Results: </strong>The NCM number and their structure responded to these simulated changes. The increased volume of nitrogen significantly changed the NCM structure, which depends on temperature and precipitation. The dominance of NCMs was noted when the temperature and precipitation remained unchanged. However, the number of microorganisms consuming mineral forms of nitrogen increased following a rise in temperature and a reduction in precipitation. Further, the proportion of microorganisms consuming organic forms of nitrogen increased following a decrease in temperature and increased precipitation. Total NCMs reduced significantly when the CO2 increased; this decrease was most pronounced with increased precipitation. Changes in the group composition of the community are associated with an increase in the nitrification process, with no changes in total NCMs.</p><p><strong>Conclusions: </strong>These results illustrate that the ever-increasing concentration of CO₂ in the atmosphere has a direct impact on both Earth's climate and alters the composition and activity of microbial populations.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"23082"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Binding Affinity of Nitrosylcobalamin to Intrinsic Factor as a Predictive Model for Cobalamin Binding Protein Interactions: A Comparative Study with Hydroxocobalamin.","authors":"Annette M Sysel, Joseph A Bauer","doi":"10.31083/FBE26810","DOIUrl":"https://doi.org/10.31083/FBE26810","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic factor (IF) is a glycoprotein crucial for cobalamin (vitamin B₁₂) absorption in the human body. This study aimed to evaluate the binding affinity of nitrosylcobalamin (NO-Cbl), a cobalamin analog, to recombinant human IF derived from plants, using hydroxocobalamin (OH-Cbl) as a comparative standard.</p><p><strong>Methods: </strong>Surface plasmon resonance (SPR) was employed to assess the kinetic parameters of NO-Cbl and OH-Cbl interactions with plant- derived IF across various concentrations.</p><p><strong>Results: </strong>SPR analysis demonstrated that NO-Cbl and OH-Cbl exhibited high binding affinities to IF, with equilibrium dissociation constant (<i>K</i>_D) values in the picomolar range. OH-Cbl showed a slightly stronger binding affinity (<i>K</i>_D = 4.79 × 10^-11 M) than NO-Cbl (<i>K</i>_D = 8.58 × 10^-11 M). Despite NO-Cbl and OH-Cbl both being bound to IF, differences in binding affinity and stability were observed, particularly at higher concentrations.</p><p><strong>Conclusion: </strong>Variations in IF binding between NO-Cbl and OH-Cbl may be attributed to the saturation of binding sites or recognition issues specific to plant-derived IF. This study underscores the potential of NO-Cbl as a targeted therapeutic agent capable of leveraging natural cobalamin uptake pathways. These results also highlight the suitability of using recombinant plant-derived IF as a model for predicting the biological activity of cobalamin analogs despite the nuanced differences from native human IF.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"26810"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel Dressings as Insulin Delivery Systems for Diabetic Wounds.","authors":"Agnieszka Kłapcia, Patrycja Domalik-Pyzik","doi":"10.31083/FBE26446","DOIUrl":"https://doi.org/10.31083/FBE26446","url":null,"abstract":"<p><p>Diabetic wounds are one of the most common and challenging complications of diabetes. Similar to chronic wounds, diabetic wounds are difficult to treat due to prolonged inflammation, a lack of angiogenesis, abnormal differentiation of new scar tissue, and the occurrence of numerous bacterial infections. Moreover, elevated sugar levels in tissues disrupt the healing process by enhancing inflammatory reactions, disrupting signaling pathways, and leading to the production of abnormal biological structures, which contribute to improper cell differentiation. Traditional dressings, such as bandages, gauze, and semi-occlusive foams, are inadequate for diabetic wounds with high exudation; moreover, frequently changing the dressing can cause secondary irritation. Hence, innovative hydrogel dressings are being developed, which, thanks to their soft polymer matrix, provide an ideal substrate for regenerating tissue. Hydrogels also allow for the introduction and controlled release of growth factors, making them a promising solution for treating diabetic wounds. Recently, researchers have focused on insulin, a hormone secreted by the human body to lower blood sugar levels, due to its interesting characteristics, such as supporting anti-inflammatory and proangiogenic processes and stimulating cell migration and proper proliferation. This review discusses the most important aspects of diabetes and diabetic wounds and traditional and innovative treatment methods, particularly hydrogel dressings used as systems for insulin delivery in response to glucose concentration.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"26446"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhizosphere Microbiome and Functioning in Alternative Rice Cropping Methods: A Critical Review for Rice Sustainability.","authors":"Ejamani Dakshayini, Sengalan Muthuramu, Subramainiyam Maragatham, Rangasamy Anandham, Dananjeyan Balachandar","doi":"10.31083/FBE25926","DOIUrl":"https://doi.org/10.31083/FBE25926","url":null,"abstract":"<p><p>Rice is a staple crop worldwide, providing sustenance to over half the global population. The rice microbiome represents the complex interaction between rice plants and their surrounding microbial communities. Plants host various microorganisms in different regions, including the rhizosphere, surface tissues, such as the rhizoplane and phylloplane, and inner tissues (endosphere). These microorganisms engage in diverse interactions with the plants, ranging from beneficial to neutral or harmful. This rhizosphere microbiome plays a crucial role in improving the resilience and sustainability of rice cultivation. The relationship between the rice plants and their microbial communities is imperative for developing farming practices that maximize yields while minimizing biotic and abiotic stresses. Our examination underscores the diverse functions of rhizosphere microbiota within rice farming systems, particularly in nutrient uptake, drought resilience, pest and disease management, and tolerance to salinity. This review describes the different types of rice cultivation methods farmers use worldwide to improve the efficiency of rice production in various agro-ecological contexts. Moreover, the review details how alternate cropping methods influence the rhizosphere functioning of rice and techniques for managing the microbiome function for rice sustainability.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"25926"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Commensal Bacteria: Next-generation Pro- and Post-biotics for Anticancer Therapy.","authors":"Himal Sapkota, Subrata Dasgupta, Bishnudeo Roy, Ejaj K Pathan","doi":"10.31083/FBE26809","DOIUrl":"https://doi.org/10.31083/FBE26809","url":null,"abstract":"<p><p>Cancer is a common, deadly disease with an unknown etiology. Meanwhile, current therapeutic options possess significant risks. However, probiotic bacteria and their metabolites have been reported to have antiproliferative and apoptotic effects on cancer cells. Therefore, because of their selective specificity and lack of treatment-associated comorbidities, these bacteria and their metabolites could be potential alternatives to conventional chemical and radiation therapies. Given their superior immunomodulatory and anti-cancer effects and lack of side effects, commensal bacteria derived from healthy humans are currently used as next-generation probiotics. This review summarizes current findings on these probiotic properties and anti-cancer activities of healthy human commensal bacteria. Additionally, the review focuses on small metabolites, proteins, and enzymes secreted by human commensal bacteria for their therapeutic applications against cancer. Further, utilizing a protein engineering strategy to reduce the toxicity of L-asparaginase, an enzyme-based anti-leukemia drug used for the last forty years, is also discussed. A possible workflow outline for isolating, identifying, screening, and characterizing human commensal bacterial strains for their therapeutic applications in cancer treatment is also proposed. This review emphasizes the need to explore various human commensal bacteria, not just mainstream lactic acid bacteria, for novel cancer therapeutics that provide multiple health benefits.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"26809"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of Plant Breeding Using Data Analytics and Information Technology: Innovations, Applications, and Prospective Directions.","authors":"Mohammad Muzahidur Rahman Bhuiyan, Inshad Rahman Noman, Md Munna Aziz, Md Mizanur Rahaman, Md Rashedul Islam, Mia Md Tofayel Gonee Manik, Kallol Das","doi":"10.31083/FBE27936","DOIUrl":"https://doi.org/10.31083/FBE27936","url":null,"abstract":"<p><p>Our study focused on plant breeding, from traditional methods to the present most advanced genetic and data-driven concepts. Conventional breeding techniques, such as mass selection and cross-breeding, have been instrumental in crop improvement, although they possess inherent limitations in precision and efficiency. Advanced molecular methods allow breeders to improve crops quicker by more accurately targeting specific traits. Data analytics and information technology (IT) are crucial in modern plant breeding, providing tools for data management, analysis, and interpretation of large volumes of data from genomic, phenotypic, and environmental sources. Meanwhile, emerging technologies in machine learning, high-throughput phenotyping, and the Internet of Things (IoT) provide real-time insights into the performance and responses of plants to environmental variables, enabling precision breeding. These tools will allow breeders to select complex traits related to yield, disease resistance, and abiotic stress tolerance more precisely and effectively. Moreover, this data-driven approach will enable breeders to use resources judiciously and make crops resilient, thus contributing to sustainable agriculture. Data analytics integrated into IT will enhance traditional breeding and other key applications in sustainable agriculture, such as crop yield improvement, biofortification, and climate change adaptation. This review aims to highlight the role of interdisciplinary collaboration among breeders, data scientists, and agronomists in absorbing these technologies. Further, this review discusses the future trends that will make plant breeding even more effective with this new wave of artificial intelligence (AI), blockchain, and collaborative platforms, bringing new data transparency, collaboration, and predictability levels. Data and IT-based breeding will greatly contribute to future global food security and sustainable food production. Thus, creating high-performing, resource-efficient crops will be the foundation of a future agricultural vision that balances environmental care. More technological integration in plant breeding is needed for resilient and sustainable food systems to handle the growing population and changing climate challenges.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"27936"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic Composition and Predicted Metabolic Pathway Analyses of the Endometrial and Rectal Microbiota in Dairy Cows Following the Introduction of a Complex Feed Additive.","authors":"Elena A Yildirim, Georgi Yu Laptev, Larisa A Ilina, Ekaterina S Ponomareva, Evgeni A Brazhnik, Tatyana S Smetannikova, Natalia I Novikova, Daria G Turina, Valentina A Filippova, Andrei V Dubrovin, Alisa S Dubrovina, Kseniya A Kalitkina, Irina A Klyuchnikova, Vasiliy A Zaikin, Darren K Griffin, Michael N Romanov","doi":"10.31083/FBE25725","DOIUrl":"https://doi.org/10.31083/FBE25725","url":null,"abstract":"<p><strong>Background: </strong>The microbiome composition in dairy cows (<i>Bos taurus</i>) directly impacts on health and reproductive performance. This study aimed to determine the metagenomic composition and predicted microbial community functions in the endometrium and rectal chyme of cows fed a complex feed additive (CFA). The latter included the <i>Bacillus mucilaginosus</i> 159 strain, a short-chain fatty acid, plus essential oils.</p><p><strong>Methods: </strong>Clinically healthy cows were divided into two groups (<i>n</i> = 15 in each): (I) a control group fed the standard diet, and (II) an experimental group. CFA was introduced into the diet of Group II during the entire transit period at a dose of 50 g per animal per day; moreover, all animals received Pen-Strep 400 antibiotics to prevent endometritis and other pathologies. The microbial community composition from the endometrium and rectal chyme biotopes was assessed using targeted next-generation sequencing.</p><p><strong>Results: </strong>Significant changes were observed in the composition and predicted metabolic pathways due to the CFA administration, with the endometrial microbiota being more responsive to CFA than the intestinal chyme microbiome. Remarkably, the Actinobacteriota representatives disappeared in the endometrium of Group II animals compared to controls, whose content ranged from 0.34 to 3.3%. The use of CFA also resulted in a less pronounced effect in four predicted metabolic pathways for microbial degradation of catechol in the endometrium compared to controls (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Our findings support the concept of a relationship between the gut microbiome and the reproductive system microflora of cows, as we observed changes in the composition and predicted metabolic pathways of the endometrial microbiota after orally administering CFA. This emphasizes the need for an integrated approach combining the correction of microecological disorders in the intestines and the reproductive system simultaneously.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"17 1","pages":"25725"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomass-Based Microbial Protein Production: A Review of Processing and Properties.","authors":"Tawakalt Ayodele, Abodunrin Tijani, Musiliu Liadi, Kudirat Alarape, Clairmont Clementson, Ademola Hammed","doi":"10.31083/j.fbe1604040","DOIUrl":"10.31083/j.fbe1604040","url":null,"abstract":"<p><p>A rise in population and societal changes have increased pressure on resources required to meet the growing demand for food and changing dietary preferences. The increasing demand for animal protein is concerning and raises questions regarding sustainability due to its environmental impact. Subsequently, scientists seek alternative proteins, such as microbial proteins (MPs), as an environmentally friendly choice. The production of MPs promotes benefits, including reducing deforestation and CO₂ emissions. Several microorganism types, such as bacteria, yeast, fungi, and algae, use a variety of substrates for MP production, from agricultural residues to lignocellulosic biomass. These complex substrates, including lignocellulosic biomass, are converted to fermentable sugar through either chemical, physical, or biological methods. Indeed, fermentation can occur through submerged cultures or other methods. However, this depends on the substrate and microorganisms being utilized. MPs have properties that make them versatile and useful ingredients in various applications. Using residues and lignocellulosic biomass as raw materials for producing MPs offers sustainability, cost-effectiveness, and waste reduction advantages. These properties are consistent with the principles established by green chemistry, which aims to conserve resources effectively and operate sustainably in all areas. This review highlights the importance of studying manufacturing aspects and the characteristics associated with MPs, which can be implemented to solve problems and encourage novel methods in the global food/feed industry.</p>","PeriodicalId":73068,"journal":{"name":"Frontiers in bioscience (Elite edition)","volume":"16 4","pages":"40"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}