Food safety (Tokyo, Japan)最新文献

{"title":"Per- and Poly-fluoroalkyl Substances (PFAS) (Chemicals and Contaminants).","authors":"","doi":"10.14252/foodsafetyfscj.D-25-00009","DOIUrl":"10.14252/foodsafetyfscj.D-25-00009","url":null,"abstract":"<p><p>Food Safety Commission of Japan (FSCJ) conducted a self-tasking risk assessment of per- and poly-fluoroalkyl substances (PFAS) in food. Scientific findings and risk evaluation data regarding PFAS, of international organizations, government agencies in other countries, etc., were reviewed in the current risk assessment. The scientific literature related to three major compounds of PFAS, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS), was surveyed and served for the discussion. Reference doses were derived from two animal experiments* described below. To determine the reference dose, dose estimation models developed by overseas evaluation institutions were adopted for conversion of POD (point of departure) in animal experiments to POD_HED (Human Equivalent Dose). Based on the discussions and estimation, the tolerable daily intake (TDI) was appropriately set as 20 ng/kg body weight/day (2×10^-5 mg/kg body weight/day) for PFOS and as 20 ng/kg body weight/day (2×10^-5 mg/kg body weight/day) for PFOA. Insufficient scientific findings precluded the evaluation to specify a reference dose of PFHxS. The average daily intake in Japan was obtained from the Total Diet Study conducted in a limited number of regions during the fiscal years 2012-2014: PFOS (Lower Bound to Upper Bound (LB-UB)** 0.60-1.1 ng/kg body weight/day, and PFOA (LB-UB) 0.066-0.75 ng/kg body weight/day. These values were lower than the TDIs. Due to the lack of sufficient data on PFAS concentrations and their distribution in various foods, it is necessary to be aware of these intake estimates carrying considerable uncertainty.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement on Use of AI.","authors":"","doi":"10.14252/foodsafetyfscj.D-25-00010","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.D-25-00010","url":null,"abstract":"<p><p>In recent years, as significant progress has been made in artificial intelligence (AI) technology, various peer-reviewed journals have been extending the policies on use of AI. Considering this situation, <b><i>Food Safety</i></b> felt the need to address concerns about the use of the technologies such as Large Language Models (LLMs), chatbots, or image creators in the writing and reviewing of manuscripts. <b><i>Food Safety</i></b> , thus, has compiled a tentative and preliminary guideline for responsible use of AI tools based on the ICMJE Recommendations. Authors and reviewers are expected to refer to this guideline during the manuscript preparation and peer-review process. Guide for Authors for <b><i>Food Safety</i></b> will be updated in response to the comments from authors and reviewers, as well as updates on the ICMJE Recommendations and policies of other journals. Please feel free to contact Editorial Office of <b><i>Food Safety</i></b> if you have any comments or questions about the guideline.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and Conventional Freezing Conditions of Fish for the Prevention of Human Anisakiasis.","authors":"Yukihiro Kodo, Rie Murata, Kohji Mori, Jun Suzuki, Kenji Sadamasu","doi":"10.14252/foodsafetyfscj.D-24-00015","DOIUrl":"10.14252/foodsafetyfscj.D-24-00015","url":null,"abstract":"<p><p>In recent years, rapid freezers have been used to freeze and preserve seafood, with advances in freezing technology. However, limited studies have examined the effect of rapid freezing on the viability of <i>Anisakis</i> larvae in fish muscle. In this study, freezing experiments were conducted on <i>Anisakis</i> larvae alone (bare group) and on larvae embedded in mackerel fish (embedded group) using an air-blast freezer (rapid freezing) as the most popular rapid-freezing method, passing through the zone of maximum ice crystal formation within 30 min, and a natural convection freezer (conventional freezing) set at -20 °C. In the bare group experiments, all larvae died after 8 min of rapid freezing and after more than 2 h of conventional freezing. In the rapid-freezing experiments on the embedded group, only a few larvae were alive when the core temperature of the fish reached -20 °C, whereas all larvae died when the core temperature reached -35 °C. With conventional freezing, only a few larvae were alive for 24 h after freezing at -20 °C. In contrast, all larvae died after freezing at -20 °C for 24 h after the fish core temperature reached -20 °C under both rapid and conventional freezing conditions. In the embedded group, the standard deviation of the time taken for the fish core temperature to reach -20 °C was <15 min for rapid freezing and 171 min for conventional freezing. The results showed that the time taken for the core temperature to reach -20 °C varies by several hours in conventional freezing, depending on the fish size. Thus, the most crucial freezing conditions to avoid anisakiasis are either rapidly freezing the fish to a core temperature of -35 °C or keeping the fish core temperature at -20 °C for at least 24 h.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers.","authors":"","doi":"10.14252/foodsafetyfscj.D-24-00017","DOIUrl":"10.14252/foodsafetyfscj.D-24-00017","url":null,"abstract":"","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 4","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a CYP2J2-Template System and Its Application for Ligand Metabolism Prediction.","authors":"Yasushi Yamazoe, Norie Murayama","doi":"10.14252/foodsafetyfscj.D-24-00010","DOIUrl":"10.14252/foodsafetyfscj.D-24-00010","url":null,"abstract":"<p><p>A Template system for the understanding of human CYP2J2-mediated reactions was constructed from the assembly of the ligands with the introduction of ideas of allowable width, Trigger-residue and the residue-initiated movement of ligands in the active site, which were in common with other Template* systems for human CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP3A4, CYP3A5, and CYP3A7 (Drug Metab Pharmacokinet 2016, 2017, 2019, 2020, 2021, 2022, 2023, 2024, and in press 2024). CYP2J2 system also includes ideas of bi-molecule binding of ligands on the Template. From their placements on the Template and rules for interaction modes, verifications of good and poor substrates, regio/stereo-selectivity, and inhibitory interaction became available faithfully for these ligands. The refined CYP2J2-Template system will thus offer reliable estimations of this human CYP catalysis toward ligands of diverse structures, together with their deciphering information to lead to judgments.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 4","pages":"69-82"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Present Guideline-Focusing Points on FSCJ's Revised Guideline for the Risk Assessment of the Effects of Food on Health for Foodborne Microorganisms and Others (Viruses, Parasites) and Its Supplemental Technical Guidance.","authors":"Noriko Mizutani, Tamao Mizuno, Masako Waki","doi":"10.14252/foodsafetyfscj.D-24-00013","DOIUrl":"10.14252/foodsafetyfscj.D-24-00013","url":null,"abstract":"<p><p>Food Safety Commission of Japan (FSCJ) has recently revised the Guideline for the Risk Assessment of the Effects of Food on Health for Foodborne Microorganisms and Others (Viruses, Parasites) and newly issued its supplemental manual as the \"Technical Guide for the Risk Assessment of the Effects of Food on Health for Foodborne Microorganisms and Others (Viruses, Parasites)\". These documents are based recent evidence and according to the Microbiological Risk Assessment Guidance for Food, Microbiological Risk Assessment Series 36 published by FAO/WHO. This short review describes the main structures and characteristics of these documents.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 4","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium (Third Edition) (Chemicals and Contaminants).","authors":"","doi":"10.14252/foodsafetyfscj.D-24-00011","DOIUrl":"10.14252/foodsafetyfscj.D-24-00011","url":null,"abstract":"<p><p>Exposure to cadmium tends to be higher in Japan than in other countries due to the wide spreading of ore deposits and many mines throughout Japan. The proximal tubule of the kidney is recognized as the most susceptible site to be affected by cadmium exposure. Food Safety Commission of Japan (FSCJ) considered it appropriate to investigate studies of the effects of cadmium intake on renal proximal tubular function using urinary β₂-microglobulin concentration of 1,000 μg/g creatinine as a criterion for the dysfunction. Based on these epidemiological studies, FSCJ established a tolerable weekly intake (TWI) of 7 µg/kg bw per week for cadmium. This value is derived from the results of actual dietary surveys and urinary β₂-microglobulin concentrations in Japan, and not from the results of application of blood or urinary cadmium levels to theoretical models. Therefore, no uncertainty factor is required. The estimated dietary intake of cadmium in 2022 was 2.03 µg/kg bw per week, approximately 30% of the TWI of 7 µg/kg bw per week. Therefore, it is unlikely that dietary cadmium intake in the general Japanese population would cause adverse health effects.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 3","pages":"67-68"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical Variation of Antimicrobial Resistance of <i>Salmonella</i> in Japanese Chicken.","authors":"Yoshimasa Sasaki, Tetsuya Ikeda, Yoshika Momose, Kenzo Yonemitsu, Masashi Uema, Tetsuo Asai","doi":"10.14252/foodsafetyfscj.D-24-00002","DOIUrl":"10.14252/foodsafetyfscj.D-24-00002","url":null,"abstract":"<p><p>Chicken is a potent source of <i>Salmonella</i> infection in humans. Occasionally, patients with severe <i>Salmonella</i> enteritis require antimicrobial therapy. Antimicrobials are used to prevent and treat bacterial infections in broiler and breeder farms. Herein, we investigated the prevalence and antimicrobial resistance of <i>Salmonella</i> in 337 vacuum-packed chicken breast products manufactured in Japan between June and December 2021. <i>Salmonella</i> was isolated from 287 samples (85.2%). Among the products from Eastern Japan, the lowest <i>Salmonella</i> prevalence was observed in those processed in September (65.6%), which was significantly (<i>p</i> < 0.05) lower than that in November or December. Among the products from Western Japan, the lowest <i>Salmonella</i> prevalence was observed in those processed in August (61.9%), which was significantly (<i>p</i> < 0.05) lower than that in June, November, and December. The most frequent serovar was <i>Salmonella</i> Schwarzengrund (223 isolates), followed by <i>S.</i> Infantis (53 isolates), <i>S.</i> Manhattan (9 isolates), and <i>S.</i> Enteritidis (1 isolate). High rates of antimicrobial resistance were observed for streptomycin (64.5%), kanamycin (50.2%), tetracycline (65.2%), nalidixic acid (11.5%), and trimethoprim (35.9%). Resistance rates against these five antimicrobials in <i>S</i>. Schwarzengrund isolates were markedly higher in the isolates from Western Japan than in those from Eastern Japan. All 287 <i>Salmonella</i> isolates were susceptible to ciprofloxacin which belongs to fluoroquinolones and cefotaxime which belongs to third-generation cephalosporins. <i>Salmonella</i> prevalence in chicken products in Japan was found to be extremely high; therefore, chicken meat should be thoroughly heated before consumption. In Japan, fluoroquinolones and third-generation cephalosporins are recommended as the first- and second-choice antimicrobials for patients with severe <i>Salmonella</i> enteritis, respectively. The results of this study show that administering fluoroquinolones or third-generation cephalosporins is an effective option for patients with <i>Salmonella</i> enteritis caused by consuming chicken meat, and efficient strategies for <i>Salmonella</i> management on broiler farms and chicken-processing plants need to be developed.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 3","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3-Nitrooxypropanol (Feed Additives).","authors":"","doi":"10.14252/foodsafetyfscj.D-24-00008","DOIUrl":"10.14252/foodsafetyfscj.D-24-00008","url":null,"abstract":"<p><p>Food Safety Commission of Japan (FSCJ) conducted a risk assessment of 3-nitrooxypropanol (3-NOP) (CAS No. 100502-66-7), using the evaluation documents for feed additive designation. This feed additive is a nitrate ester of 1,3-propanediol developed to reduce methane generated in the first stomach of cattle (rumen). The data used in the assessment include the fate in animals (mice, rats, cattle), residues (cattle), genotoxicity, acute toxicity (rats), subacute toxicity (mice, rats and dogs), chronic toxicity/carcinogenicity (rats), reproductive/developmental toxicity (rats and rabbits), and others. The lowest no-observed-adverse-effect level (NOAEL) for possible adverse effects of 3-NOP was 100 mg/kg bw per day in 52-chronic toxicity, 104-week chronic toxicity/carcinogenicity, and two-generation reproductive toxicity studies in rats. Given this, FSCJ specified an acceptable daily intake (ADI) of 1 mg/kg bw per day by applying a safety factor of 100 to the NOAEL.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 2","pages":"52-53"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinofumelin (Pesticides).","authors":"","doi":"10.14252/foodsafetyfscj.D-24-00009","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.D-24-00009","url":null,"abstract":"<p><p>Food Safety Commission of Japan (FSCJ) conducted a risk assessment of quinofumelin (CAS No. 861647-84-9), a quinoline fungicide, based on submitted documents. The data used in the assessment are fate in plants (including paddy rice and tomatoes), residues in crops, fate in livestock (goats and chickens), residues in livestock products, fate in animals (rats), subacute toxicity (rats, mice, and dogs), chronic toxicity (dogs), combined chronic toxicity/carcinogenicity (rats), carcinogenicity (mice), acute neurotoxicity (rats), subacute neurotoxicity (rats), two-generation reproductive toxicity (rats), developmental toxicity (rats and rabbits), and genotoxicity. FSCJ specified an acceptable daily intake (ADI) of 0.03 mg/kg bw per day, and consequently specified an acute reference dose (ARfD) of 0.3 mg/kg bw per day after applying a safety factor of 100 based on the NOAEL.</p>","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"12 2","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}