Food safety (Tokyo, Japan)最新文献_第10页

Quantitative Analysis of Houseflies-mediated Food Contamination with Bacteria. 家蝇介导的食物细菌污染的定量分析。

Food safety (Tokyo, Japan) Pub Date : 2019-03-29 eCollection Date: 2019-03-01 DOI: 10.14252/foodsafetyfscj.2018013

Akira Fukuda, Masaru Usui, Chinami Masui, Yutaka Tamura

引用次数: 6

Food safety (Tokyo, Japan) Pub Date : 2019-03-29 eCollection Date: 2019-03-01 DOI: 10.14252/foodsafetyfscj.2018011s

{"title":"Flubenziamide (Pesticides).","authors":"","doi":"10.14252/foodsafetyfscj.2018011s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018011s","url":null,"abstract":"The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of flubendiamide (CAS No. 272451-65-7), an iodophthalimide insecticide for the setting of an acceptable daily intake (ADI) in 2006. FSCJ now has assessed this insecticide for the setting of an acute reference dose (ARfD). Data including fate in animals (rats and mice) and residues in crops (burdock roots, pumpkins and others) were newly submitted. Major adverse effects of flubendiamide include hepatocellular hypertrophy, fatty changes in hepatocytes, follicular epithelial cell hypertrophy in thyroid and ocular enlarged eye in rats. No neurotoxicity, carcinogenicity, reproductive toxicity, teratogenicity, neurodevelopmental toxicity and genotoxicity were observed. The lowest no-observed-adverse-effect level (NOAEL) in the toxicological studies was 1.70 mg/kg body weight/day in a two-year carcinogenicity study in rats. FSCJ confirmed an ADI of 0.017 mg/kg bw/day after applying a safety factor of 100 to the NOAEL. Adverse effects elicited by a single oral administration of flubendiamide would be abnormalities in eyes such as ocular hypertrophy and iris adhesion in offspring, which were obtained in a two-generation reproductive toxicity study, a one-generation reproductive toxicity study and a neurodevelopmental toxicity study in rats. FSCJ judged that these studies may be applicable to set the ARfD for lactating women in relation to the exposure of flubendiamide to offspring after the birth through breast milk. By taking into account the overall evaluations of the two-generation reproductive toxicity study, one-generation reproductive toxicity study and neurodevelopmental toxicity study in rats, FSCJ judged NOAEL of 15.0 mg/kg bw/day as for an overall NOAEL, and consequently specified an ARfD of 0.15 mg/kg bw/day for lactating women by applying a safety factor of 100 to the NOAEL.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"7 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37593944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate. 小鼠口服重铬酸钠不会增加突变频率

Food safety (Tokyo, Japan) Pub Date : 2019-03-13 eCollection Date: 2019-03-01 DOI: 10.14252/foodsafetyfscj.2018014

Yasunobu Aoki, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi

引用次数: 0

Flubenziamide (Pesticides) Flubenziamide ( Pesticides)

Food safety (Tokyo, Japan) Pub Date : 2019-01-01 DOI: 10.14252/foodsafetyfscj.2018011

引用次数: 2

Fumonisins (Natural Toxins and Mycotoxins). 伏马菌素(天然毒素和真菌毒素)。

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018006s

{"title":"Fumonisins (Natural Toxins and Mycotoxins).","authors":"","doi":"10.14252/foodsafetyfscj.2018006s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018006s","url":null,"abstract":"The Food Safety Commission of Japan (FSCJ) conducted a self-tasking assessment of mycotoxins, fumonisin B1 (FB1 CAS No. 116355-83-0), fumonisin B2 (FB2 CAS No. 116355-84-1), and fumonisin B3 (FB3 CAS No. 136379-59-4). Hepatotoxicity and/or nephrotoxicity were commonly observed in experimental animals given orally purified FB1, and the sex-related differences were observed in rats and mice. Species differences were also identified: Increased incidences of liver tumors in female mice and of kidney tumors in male rats were observed in chronic toxicity/carcinogenicity studies. Fumonisins did not show appreciable genotoxicity both the in vivo and in vitro tests. FSCJ judged fumonisins as non-genotoxic carcinogens from the results of various toxicological studies on fumonisins, and thus specified a tolerable daily intake (TDI) of 2 μg/mg bw/day for fumonisins (FB1, FB2 and FB3, alone or by combination), after applying an uncertainty factor of 100 to the lowest no-observed-adverse-effect level (NOAEL) of 0.21 mg/kg bw/day in subacute toxicity study in rats. The estimated exposure levels of fumonisins among high consumers such as toddlers are still below the TDI. Therefore, FSCJ concluded that adverse effect of fumonisin on human health through food are unlikely under the current situation in Japan.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"6 4","pages":"160-161"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.2018006s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of a bacteriophage-based Method for Detection of Escherichia Coli O157:H7 in Fresh Vegetables. 基于噬菌体的新鲜蔬菜中大肠杆菌O157:H7检测方法的建立

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018010

Hoang A Hoang, Nguyen T T Nhung

{"title":"Development of a bacteriophage-based Method for Detection of Escherichia Coli O157:H7 in Fresh Vegetables.","authors":"Hoang A Hoang, Nguyen T T Nhung","doi":"10.14252/foodsafetyfscj.2018010","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018010","url":null,"abstract":"In this study, a method using a recombinant phage for detection of E. coli O157:H7 in fresh vegetables was investigated. Four kinds of fresh vegetables, i.e. lettuce (Lactuca sativa), mustard greens (Brassica juncea), coriander (Coriandrum sativum), and soybean sprouts were selected since they are commonly used in meals in Vietnam. Firstly, a phage-based method was investigated for detection of E. coli O157:H7 in the four types of vegetables. To support the detection by suppressing growth of background bacteria in vegetables, selective antibiotics, i.e. novobiocin (N) and vancomycin (V) in combination with BHI medium were examined. Secondly, quality of the method was evaluated in terms of sensitivity, specificity, and rapidity. The method enabled the detection of E. coli O157:H7 inoculated at 103, 102, or 101 CFU/ 10 mL of sterile 0.8% NaCl containing 5 g of vegetable and in the presence of several Gram-positive and Gram-negative bacteria inoculated at 107 CFU/10 mL. The time for detection was approximately 16.5 hours for E. coli O157:H7 inoculated at 10 CFU/10 mL of sterile 0.8% NaCl containing 5 g of vegetable. The limit of detection was considered to be 2 CFU g-1 vegetable.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"6 4","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.2018010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acknowledgement for Reviewing. 审阅致谢。

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018015

引用次数: 0

Association of Salmonella Serotypes with Quinolone Resistance in Broilers. 肉鸡沙门氏菌血清型与喹诺酮类药物耐药性的关系。

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018012

Ayumi Nakatsuchi, Mizuho Inagaki, Michiyo Sugiyama, Masaru Usui, Tetsuo Asai

{"title":"Association of Salmonella Serotypes with Quinolone Resistance in Broilers.","authors":"Ayumi Nakatsuchi, Mizuho Inagaki, Michiyo Sugiyama, Masaru Usui, Tetsuo Asai","doi":"10.14252/foodsafetyfscj.2018012","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018012","url":null,"abstract":"Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of quinolone-resistant bacterial variants in three Salmonella serotypes S. Infantis, S. Schwarzengrund, and S. Manhattan-which are mainly found in broiler industries in Japan. Emergence frequency tests for quinolone-resistant variants using enrofloxacin-containing agar plates and sequence analysis in the quinolone resistance-determining region (QRDR) of gyrA in DNA gyrase were performed. The results showed no significant difference in the emergence frequency among the three serotypes, and most of the resistant variants had mutations in the QRDR region. These findings suggest that differences in the serotypes tested are not associated with the emergence frequency of quinolone-resistant variants.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"6 4","pages":"156-159"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.2018012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017). 农药（农用化学品）毒理学评价用犬一年重复剂量口服毒性研究综述（农药专家委员会决定，FSCJ，2017年12月21日）。

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018008s

引用次数: 1

Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella enterica subsp. enterica serovar Enteritidis in Chickens. 皮下注射肠沙门氏菌油乳剂疫苗对黏膜体液免疫的诱导作用。鸡血清型肠炎。

Food safety (Tokyo, Japan) Pub Date : 2018-11-20 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018003

Yuuichi Ishida, Eishi Sakai, Katsuo Sato, Einori Sugiyama, Kazuyuki Mima, Akira Taneno, Hirofumi Shimomura, Longzhu Cui, Yoshikazu Hirai

{"title":"Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella enterica subsp. enterica serovar Enteritidis in Chickens.","authors":"Yuuichi Ishida, Eishi Sakai, Katsuo Sato, Einori Sugiyama, Kazuyuki Mima, Akira Taneno, Hirofumi Shimomura, Longzhu Cui, Yoshikazu Hirai","doi":"10.14252/foodsafetyfscj.2018003","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018003","url":null,"abstract":"Salmonella enterica subsp. enterica serovar Enteritidis (SE) is one of the major causes of food poisoning. Much effort has been made to develop a vaccine for the prevention of SE colonization and infection in poultry. However, the effect of inactivated whole-cell SE vaccines on the bacterial attachment has not been clarified. This study investigated the immune responses to a killed whole-cell SE vaccine in chickens and the effect of vaccination on the bacterial attachment of SE to cultured Vero cells. A 1 ml dose of 108-109 CFU viable SE bacterial cells was orally administered to chickens at 4 weeks or 10 months post vaccination. The number (CFU) of SE in 1 g of cecal droppings was counted on day 6 after administration. The SE CFUs were significantly lower (p < 0.05) in the vaccinated chickens, not only at 4 weeks but also at 10 months after vaccination, than in the unvaccinated control chickens. Anti-SE IgG and anti-SE IgA were detected using enzyme-linked immunosorbent assay (ELISA) in serum and intestinal and oviduct fluid samples from vaccinated chickens. Adhesion of heat-killed SE cells to Vero cells was reduced by pre-treatment of the bacteria by the vaccinated chicken-derived intestinal fluid, indicating the potential of the vaccine-induced antibody to prevent SE adhesion to epithelial cell surfaces.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"6 4","pages":"151-155"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4