Food safety (Tokyo, Japan)最新文献_第10页

Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017). 农药（农用化学品）毒理学评价用犬一年重复剂量口服毒性研究综述（农药专家委员会决定，FSCJ，2017年12月21日）。

Food safety (Tokyo, Japan) Pub Date : 2018-12-21 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018008s

引用次数: 1

Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella enterica subsp. enterica serovar Enteritidis in Chickens. 皮下注射肠沙门氏菌油乳剂疫苗对黏膜体液免疫的诱导作用。鸡血清型肠炎。

Food safety (Tokyo, Japan) Pub Date : 2018-11-20 eCollection Date: 2018-12-01 DOI: 10.14252/foodsafetyfscj.2018003

Yuuichi Ishida, Eishi Sakai, Katsuo Sato, Einori Sugiyama, Kazuyuki Mima, Akira Taneno, Hirofumi Shimomura, Longzhu Cui, Yoshikazu Hirai

{"title":"Induction of Mucosal Humoral Immunity by Subcutaneous Injection of an Oil-emulsion Vaccine against Salmonella enterica subsp. enterica serovar Enteritidis in Chickens.","authors":"Yuuichi Ishida, Eishi Sakai, Katsuo Sato, Einori Sugiyama, Kazuyuki Mima, Akira Taneno, Hirofumi Shimomura, Longzhu Cui, Yoshikazu Hirai","doi":"10.14252/foodsafetyfscj.2018003","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018003","url":null,"abstract":"Salmonella enterica subsp. enterica serovar Enteritidis (SE) is one of the major causes of food poisoning. Much effort has been made to develop a vaccine for the prevention of SE colonization and infection in poultry. However, the effect of inactivated whole-cell SE vaccines on the bacterial attachment has not been clarified. This study investigated the immune responses to a killed whole-cell SE vaccine in chickens and the effect of vaccination on the bacterial attachment of SE to cultured Vero cells. A 1 ml dose of 108-109 CFU viable SE bacterial cells was orally administered to chickens at 4 weeks or 10 months post vaccination. The number (CFU) of SE in 1 g of cecal droppings was counted on day 6 after administration. The SE CFUs were significantly lower (p < 0.05) in the vaccinated chickens, not only at 4 weeks but also at 10 months after vaccination, than in the unvaccinated control chickens. Anti-SE IgG and anti-SE IgA were detected using enzyme-linked immunosorbent assay (ELISA) in serum and intestinal and oviduct fluid samples from vaccinated chickens. Adhesion of heat-killed SE cells to Vero cells was reduced by pre-treatment of the bacteria by the vaccinated chicken-derived intestinal fluid, indicating the potential of the vaccine-induced antibody to prevent SE adhesion to epithelial cell surfaces.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Dexamethasone (Veterinary medicinal products). 地塞米松(兽药)。

Food safety (Tokyo, Japan) Pub Date : 2018-09-28 eCollection Date: 2018-09-01 DOI: 10.14252/foodsafetyfscj.2018005s

{"title":"Dexamethasone (Veterinary medicinal products).","authors":"","doi":"10.14252/foodsafetyfscj.2018005s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018005s","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of dexamethasone (CAS No. 50-02-2), a synthetic adrenocortical hormone, using mainly the evaluation reports from the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and the European Medicines Agency (EMEA). Major adverse effects of dexamethasone were observed in the decrease in white blood cell count (WBC), atrophy of thymus and spleen as well as the decrease in adrenal weights, which were found in various toxicity studies. These effects are attributable to the glucocorticoid action. FSCJ supported the EMEA's judgment \"dexamethasone lacks structural similarity with known carcinogens\", and concluded that this drug is unlikely to be carcinogenic. Teratogenicity was observed in rats developmental toxicity studies and the no-observed-adverse-effect level (NOAEL) for fetus was 10 μg/kg bw/day. The effect observed at the lowest dose in various toxicological studies was decreased WBC in rats in an endocrinological study. The NOAEL in this study was 1μg/kg bw/day. JECFA and EMEA specified an acceptable daily intake (ADI) based on the pharmacological action, the induction of tyrosine aminotransferase activity (TAT), in rat liver. However FSCJ judged this endpoint is not appropriate to establish an ADI, because the increase of TAT in response to glucocorticoid was a physiological response, and the relationship of changes in TAT with the toxicological findings was obscure. Consequently, FSCJ specified the ADI for dexamethasone at 0.01μg/kg bw/day, based on NOAEL of 1μg/kg bw/day, which was obtained in rats in an endocrinological study, applying a safety factor of 100.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004926/pdf/foodsafetyfscj-6-139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Antibiotics Resistant Listeria monocytogenes Strains in Nigerian  Ready-to-eat Foods. 尼日利亚耐抗生素单核细胞增生李斯特菌流行情况 即食食品。

Food safety (Tokyo, Japan) Pub Date : 2018-09-28 eCollection Date: 2018-09-01 DOI: 10.14252/foodsafetyfscj.2018002

Daniel O Ebakota, Onilude A Abiodun, Obayagbona O Nosa

{"title":"Prevalence of Antibiotics Resistant Listeria monocytogenes Strains in Nigerian \u2028Ready-to-eat Foods.","authors":"Daniel O Ebakota, Onilude A Abiodun, Obayagbona O Nosa","doi":"10.14252/foodsafetyfscj.2018002","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018002","url":null,"abstract":"The Listerial flora and Listeria monocytogenes bio-load associated with 411 ready-to-eat (RTE) foods sold at several locations in southern Nigeria was evaluated using phenotypic procedures which included serial dilution and pour plate techniques. Selected L. monocytogenes strains phenotypically identified from the RTE foods were further identified using virulence gene markers and 16srRNA amplification procedures. All the 90 L. monocytogenes strains cultured from the RTE foods were subjected to antibiogram analysis using disc diffusion. Some of the antibiotics employed included; Ceftazidine, cefuroxime, gentamicin, ofloxacin, augumentin, tetracycline and erythromycin. L. monocytogenes L. ivanovii, L. grayi, L.welshimeri, L. seeligeri and L. innocua were detected in the RTE foods. Haemolysin (hlyA) gene, Internalin gene (inlA) and invasive gene (iap) were detected in all L. monocytogenes isolates. L. monocytogenes LMEW70 with accession number KY053295 was 93% similar to L. monocytogenes L1846. All the L. monocytogenes isolates were resistant to amoxicillin, cloxacillin, augumentin and ceftazidime.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.2018002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Desmedipham (Pesticides). Desmedipham(杀虫剂)。

Food safety (Tokyo, Japan) Pub Date : 2018-09-28 eCollection Date: 2018-09-01 DOI: 10.14252/foodsafetyfscj.2017018s

{"title":"Desmedipham (Pesticides).","authors":"","doi":"10.14252/foodsafetyfscj.2017018s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2017018s","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of desmedipham (CAS No. 13684-56-5), a carbanilate herbicides, based on results from various studies. Major adverse effects of desmedipham were suppressed body weight, hemolytic anemia, methemoglobinemia and follicular cell hypertrophy in thyroid. Neither carcinogenicity, reproductive toxicity, nor genotoxicity relevant to human health was observed on desmedipham. Desmedipham, at the dose with maternal toxicity, caused external anomalies such as mandibular malformation and cleft palate, visceral anomalies such as ventricular septum defect, and skeletal anomalies such as defect of sternum and asymmetric alignment of seternebral hemicentres in developmental toxicity studies in rats. No teratogenetic effects were observed in rabbits. The lowest no-observed-effect level (NOAEL) obtained in all studies was 3.2 mg/kg bw/day in a two-year combined chronic toxicity/carcinogenicity in rats. FSCJ specified an acceptable (ADI) of 0.032 mg/kg bw/day, applying a safety factor of 100 to the NOAEL. The lowest NOAEL for adverse effects elicited by a single oral administration of desmedipham was 90 mg/kg bw/day obtained from the developmental toxicity study in rabbits (the 2nd study in the Table 2). Consequently, FSCJ specified an acute reference dose (ARfD) of 0.9 mg/kg bw applying a safety factor of 100 to the NOAEL.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004923/pdf/foodsafetyfscj-6-130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dicyclanil (Veterinary Medicinal Products). 双环苯胺(兽药产品)。

Food safety (Tokyo, Japan) Pub Date : 2018-09-28 eCollection Date: 2018-09-01 DOI: 10.14252/foodsafetyfscj.2018007s

{"title":"Dicyclanil (Veterinary Medicinal Products).","authors":"","doi":"10.14252/foodsafetyfscj.2018007s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2018007s","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of dicycranil (CAS No. 112636-83-6), a pyrimidine-derived insect growth regulator, using the evaluation reports from the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the European Medicines Agency (EMEA), and also the Australian government. In an 18-month chronic toxicity/carcinogenicity study in mice, increased incidences of hepatocellular adenomas and carcinomas were observed in females in the 500 ppm group. In spite of a recent experiment implying the possible indirect genotoxicity of dicyclanil on the carcinogenicity, dicyclanil is unlikely to exert the carcinogenicity in vivo through the genotoxic mechanism judging from other studies. FSCJ recognized it as feasible to set the threshold value. Adverse effects detected at the lowest dose in various toxicological studies were the increased plasma levels of cholesterol and phospholipid at 100 ppm (equivalent to 2.7 mg/kg bw/day in males and 3.5 mg/kg bw/day in females) in a 90-day subacute toxicity study in dogs. No-observed-adverse-effect level (NOAEL) of this study was 20 ppm (equivalent to 0.61 mg/kg bw/day in males and 0.71 mg/kg bw/day in females). On the other hand, the NOAEL in a long term study, a 12-month chronic toxicity study in dogs was 25 ppm (equivalent to 0.71 mg/kg bw/day in males) based on increased level of plasma cholesterol observed only in males at 150 ppm (equivalent to 4.4 mg/kg bw/day in males and 5.1 mg/kg bw/day in females). The increased cholesterol levels in plasma were common in both studies in dogs. It was appropriate to choose the NOAEL for the effect on cholesterol in the longer term treatment, and thus FSCJ adopted the NOAEL of 0.71 mg/kg bw/day. Consequently, FSCJ specified the ADI of 0.0071 mg/kg bw/day for dicyclanil based on the NOAEL of 0.71 mg/kg bw/day in the 12-month chronic toxicity study in dogs, by applying a safety factor of 100.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004925/pdf/foodsafetyfscj-6-136.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dexamethasone (Veterinary medicinal products). 地塞米松（兽药）。

Food safety (Tokyo, Japan) Pub Date : 2018-09-01 DOI: 10.14252/foodsafetyfscj.2017005s

{"title":"Dexamethasone (Veterinary medicinal products).","authors":"","doi":"10.14252/foodsafetyfscj.2017005s","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.2017005s","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of dexamethasone (CAS No. 50-02-2), a synthetic adrenocortical hormone, using mainly the evaluation reports from the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and the European Medicines Agency (EMEA). Major adverse effects of dexamethasone were observed in the decrease in white blood cell count (WBC), atrophy of thymus and spleen as well as the decrease in adrenal weights, which were found in various toxicity studies. These effects are attributable to the glucocorticoid action. FSCJ supported the EMEA's judgment \"dexamethasone lacks structural similarity with known carcinogens\", and concluded that this drug is unlikely to be carcinogenic. Teratogenicity was observed in rats developmental toxicity studies and the no-observed-adverse-effect level (NOAEL) for fetus was 10 μg/kg bw/day. The effect observed at the lowest dose in various toxicological studies was decreased WBC in rats in an endocrinological study. The NOAEL in this study was 1μg/kg bw/day. JECFA and EMEA specified an acceptable daily intake (ADI) based on the pharmacological action, the induction of tyrosine aminotransferase activity (TAT), in rat liver. However FSCJ judged this endpoint is not appropriate to establish an ADI, because the increase of TAT in response to glucocorticoid was a physiological response, and the relationship of changes in TAT with the toxicological findings was obscure. Consequently, FSCJ specified the ADI for dexamethasone at 0.01μg/kg bw/day, based on NOAEL of 1μg/kg bw/day, which was obtained in rats in an endocrinological study, applying a safety factor of 100.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.2017005s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43161249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Staphylococcal Enterotoxins: Food Poisoning and Detection Methods 葡萄球菌肠毒素：食物中毒及检测方法

Food safety (Tokyo, Japan) Pub Date : 2018-07-04 DOI: 10.1201/9781315109091-9

Xin Wang, Yinduo Ji

引用次数: 0

Campylobacter Species 弯曲杆菌物种

Food safety (Tokyo, Japan) Pub Date : 2018-07-04 DOI: 10.1201/9781315109091-12

引用次数: 25

Salmonella Species 沙门氏菌的物种

Food safety (Tokyo, Japan) Pub Date : 2018-07-04 DOI: 10.1201/9781315109091-11

MILk ChOCOLATe

引用次数: 125