Food safety (Tokyo, Japan)最新文献

Cashew Nut Shell Liquid (CNSL) (Feeds, Fertilizers, etc.). 腰果壳液（CNSL）（饲料、肥料等）。

Food safety (Tokyo, Japan) Pub Date : 2025-06-28 eCollection Date: 2025-06-01 DOI: 10.14252/foodsafetyfscj.D-25-00020

引用次数: 0

Anacardic Acid (Exempted Substances*¹) (Feeds, Fertilizers, etc.). 无心酸（豁免物质*1）（饲料、肥料等）。

Food safety (Tokyo, Japan) Pub Date : 2025-06-27 eCollection Date: 2025-06-01 DOI: 10.14252/foodsafetyfscj.D-25-00019

{"title":"Anacardic Acid (Exempted Substances*1) (Feeds, Fertilizers, etc.).","authors":"","doi":"10.14252/foodsafetyfscj.D-25-00019","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.D-25-00019","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of anacardic acid (CAS No. 11034-77-8) in response to the request from the Ministry of Health, Labour and Welfare (MHLW) in line with the application for a new designation of cashew nutshell liquid (CNSL) as a feed additive. Anacardic acid, a major substance of CNSL, is an alkyl phenol suppressing methane production in the first rumen of cattle. Submitted documents for the feed additive designation was used for the current evaluation. The data used in the assessment include fate in animals (cattle and others), tissue residues (cattle), genotoxicity, acute toxicity (mice), and subacute toxicity (mice). FSCJ determined the non-observed-adverse-effect level (NOAEL) of 600 mg/kg bw per day for the females and 1,000 mg/kg bw per day (the maximum dose) for the males. Although chronic toxicity and carcinogenicity studies for anacardic acid have not conducted, possible concerns of chronic effects would be anticipated from the results of the subacute toxicity study, and also considering the low residue of anacardic acid and the long-term food experience of cashew nuts containing the anacardic acid. In Japan, CNSL containing anacardic acid has been applied as a feed ingredient to livestock since 2012. No safety issue has been reported on livestock or their products due to this feed ingredient. FSCJ concluded that anacardic acid would not harm human health through the residues in food as long as used ordinally as a feed additive.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 2","pages":"34-35"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pentoxazone (Second Edition) (Pesticides). 戊氧唑酮（第二版）（农药）。

Food safety (Tokyo, Japan) Pub Date : 2025-06-27 eCollection Date: 2025-06-01 DOI: 10.14252/foodsafetyfscj.D-25-00014

引用次数: 0

Detection of Single Cell Contamination of Salmonella in Foods by SALX System and NIHSJ-01 and Estimation of LOD₉₅. SALX系统和NIHSJ-01检测食品中沙门氏菌单细胞污染及LOD95的估计

Food safety (Tokyo, Japan) Pub Date : 2025-06-27 eCollection Date: 2025-06-01 DOI: 10.14252/foodsafetyfscj.D-25-00008

Hideaki Matsuoka, Takatoshi Moriyama, Natsuko Koshimizu, Norimasa Takatani, Tomonori Yoshida, Yoshiomi Shimabara, Tomoe Hirai, Kazuhide Nakajima, Shizunobu Igimi, Mikako Saito

{"title":"Detection of Single Cell Contamination of Salmonella in Foods by SALX System and NIHSJ-01 and Estimation of LOD95.","authors":"Hideaki Matsuoka, Takatoshi Moriyama, Natsuko Koshimizu, Norimasa Takatani, Tomonori Yoshida, Yoshiomi Shimabara, Tomoe Hirai, Kazuhide Nakajima, Shizunobu Igimi, Mikako Saito","doi":"10.14252/foodsafetyfscj.D-25-00008","DOIUrl":"10.14252/foodsafetyfscj.D-25-00008","url":null,"abstract":"A novel idea of statistical analytical procedure for the level of detection (LOD) was demonstrated by its successful application to qualitative test methods for Salmonella, SALX System and NIHSJ-01. Salmonella cells of a hydrogen sulfide-producing strain FSD287 and a non-hydrogen sulfide-producing strain FSD347 were added to beef and shrimp food samples using a cell sorter to achieve bacterial cell concentration of 1, 5, and 10 cfu/25g-test portion (tp). The colony forming probability (CFP) of the added cells was estimated by means of 10×10 sorting plates. All of test portions containing FSD287 or FSD347 were decided to be positive by SALX System. NIHSJ-01 using CHROMagar® Salmonella (CHS) decided test portions of each of both strains to be positive, while NIHSJ-01 using desoxycholate hydrogen sulfide lactose (DHL) agar decided selectively only FSD287-test portions to be positive. All blank test portions were negative. To evaluate the level of detection at 95% probability (LOD95), in addition to test results, we introduced virtual results of blank conditions approaching zero. As a result, LOD95 for every case was estimated to be lower than 0.326 cfu/tp indicating that both methods were able to detect 1 cfu/tp at higher than 95% probability. Therefore, our protocol for statistical analysis for LOD was feasible for the verification of the test methods that meet the requirement of detecting small number (minimum 1 cfu/25g-tp) of target micro-organisms in food test portions.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 2","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revised Guidelines for the Risk Assessment of Food Additives in Japan. 日本食品添加剂风险评估修订指南》。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI: 10.14252/foodsafetyfscj.D-24-00018

Takahiro Inoue, Daisuke Ikeda, Maako Sugiyama, Asami Suenaga, Minoru Kawashima, Emiko Kondo, Takashi Umemura

{"title":"Revised Guidelines for the Risk Assessment of Food Additives in Japan.","authors":"Takahiro Inoue, Daisuke Ikeda, Maako Sugiyama, Asami Suenaga, Minoru Kawashima, Emiko Kondo, Takashi Umemura","doi":"10.14252/foodsafetyfscj.D-24-00018","DOIUrl":"10.14252/foodsafetyfscj.D-24-00018","url":null,"abstract":"In September 2021, the Food Safety Commission of Japan (FSCJ) revised its 2010 guidelines for the risk assessment of food additives. The revised guidelines, titled Guidelines for the Risk Assessment of Food Additives, incorporate updated international trends in toxicity testing and reflect the experience gained from prior assessments. The revised guidelines are composed of the following 4 chapters: Chapter 1. General Provisions; Chapter 2. Detailed Exposition; Chapter 3. Approach for the risk assessment of processing aids; and Chapter 4. Approach for the risk assessment of additives in foods used as breast milk substitutes for infants under four months old. A central feature of the revised guidelines is the organization of risk assessment into four distinct steps: hazard identification, hazard characterization (toxicological assessment), exposure assessment, and risk characterization. These steps, based on the Codex Alimentarius principles, ensure a thorough and systematic evaluation of food additives. The guidelines also introduce the Threshold of Toxicological Concern (TTC) approach for processing aids and guideline for assessing the additives used as breast milk substitutes for infants under four months old, considering their specific characteristics. This paper provides an overview of these key updates, and offer a structured approach to enhance transparency and consistency risk assessment practices for food additives in Japan.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferimzone (Third Edition) (Pesticides). Ferimzone（第三版）（农药）。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI: 10.14252/foodsafetyfscj.D-25-00007

{"title":"Ferimzone (Third Edition) (Pesticides).","authors":"","doi":"10.14252/foodsafetyfscj.D-25-00007","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.D-25-00007","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a risk assessment of ferimzone (CAS No. 89269-64-7), a pyrimidine hydrazone fungicide, based on submitted documents. A request for reevaluation was made under the Agricultural Chemical Regulation Act. Additional information was submitted by the Ministry of Agriculture, Forestry and Fisheries, which included data on residues in crops (paddy rice) and in livestock products (cattle and chickens), fate in livestock (goats and chickens), and also related published scientific literatures. Major adverse effects of ferimzone were observed in the liver (including centrilobular hypertrophy of hepatocytes) and blood (anemia). Adverse effects were observed on neither fertility, teratogenicity, nor genotoxicity. The lowest no-observed-adverse-effect level (NOAEL) obtained from these studies was 1.94 mg/kg bw per day in the two-year combined chronic toxicity/carcinogenicity study in rats. FSCJ specified an acceptable daily intake (ADI) of 0.019 mg/kg bw per day by applying a safety factor of 100 to this NOAEL. The lowest value was a NOAEL of 30 mg/kg bw per day in the general pharmacological study in mice and rats, as well as the one-year chronic toxicity study in dogs. FSCJ specified an acute reference dose (ARfD) of 0.3 mg/kg bw by applying a safety factor of 100 to this NOAEL.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Per- and Poly-fluoroalkyl Substances (PFAS) (Chemicals and Contaminants). 全氟和多氟烷基物质（PFAS）（化学品和污染物）。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI: 10.14252/foodsafetyfscj.D-25-00009

{"title":"Per- and Poly-fluoroalkyl Substances (PFAS) (Chemicals and Contaminants).","authors":"","doi":"10.14252/foodsafetyfscj.D-25-00009","DOIUrl":"10.14252/foodsafetyfscj.D-25-00009","url":null,"abstract":"Food Safety Commission of Japan (FSCJ) conducted a self-tasking risk assessment of per- and poly-fluoroalkyl substances (PFAS) in food. Scientific findings and risk evaluation data regarding PFAS, of international organizations, government agencies in other countries, etc., were reviewed in the current risk assessment. The scientific literature related to three major compounds of PFAS, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS), was surveyed and served for the discussion. Reference doses were derived from two animal experiments* described below. To determine the reference dose, dose estimation models developed by overseas evaluation institutions were adopted for conversion of POD (point of departure) in animal experiments to PODHED (Human Equivalent Dose). Based on the discussions and estimation, the tolerable daily intake (TDI) was appropriately set as 20 ng/kg body weight/day (2×10-5 mg/kg body weight/day) for PFOS and as 20 ng/kg body weight/day (2×10-5 mg/kg body weight/day) for PFOA. Insufficient scientific findings precluded the evaluation to specify a reference dose of PFHxS. The average daily intake in Japan was obtained from the Total Diet Study conducted in a limited number of regions during the fiscal years 2012-2014: PFOS (Lower Bound to Upper Bound (LB-UB)** 0.60-1.1 ng/kg body weight/day, and PFOA (LB-UB) 0.066-0.75 ng/kg body weight/day. These values were lower than the TDIs. Due to the lack of sufficient data on PFAS concentrations and their distribution in various foods, it is necessary to be aware of these intake estimates carrying considerable uncertainty.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Announcement on Use of AI. 关于使用人工智能的公告。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI: 10.14252/foodsafetyfscj.D-25-00010

引用次数: 0

Rapid and Conventional Freezing Conditions of Fish for the Prevention of Human Anisakiasis. 预防人类异尖线虫病的鱼类快速和常规冷冻条件。

Food safety (Tokyo, Japan) Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI: 10.14252/foodsafetyfscj.D-24-00015

Yukihiro Kodo, Rie Murata, Kohji Mori, Jun Suzuki, Kenji Sadamasu

{"title":"Rapid and Conventional Freezing Conditions of Fish for the Prevention of Human Anisakiasis.","authors":"Yukihiro Kodo, Rie Murata, Kohji Mori, Jun Suzuki, Kenji Sadamasu","doi":"10.14252/foodsafetyfscj.D-24-00015","DOIUrl":"10.14252/foodsafetyfscj.D-24-00015","url":null,"abstract":"In recent years, rapid freezers have been used to freeze and preserve seafood, with advances in freezing technology. However, limited studies have examined the effect of rapid freezing on the viability of Anisakis larvae in fish muscle. In this study, freezing experiments were conducted on Anisakis larvae alone (bare group) and on larvae embedded in mackerel fish (embedded group) using an air-blast freezer (rapid freezing) as the most popular rapid-freezing method, passing through the zone of maximum ice crystal formation within 30 min, and a natural convection freezer (conventional freezing) set at -20 °C. In the bare group experiments, all larvae died after 8 min of rapid freezing and after more than 2 h of conventional freezing. In the rapid-freezing experiments on the embedded group, only a few larvae were alive when the core temperature of the fish reached -20 °C, whereas all larvae died when the core temperature reached -35 °C. With conventional freezing, only a few larvae were alive for 24 h after freezing at -20 °C. In contrast, all larvae died after freezing at -20 °C for 24 h after the fish core temperature reached -20 °C under both rapid and conventional freezing conditions. In the embedded group, the standard deviation of the time taken for the fish core temperature to reach -20 °C was <15 min for rapid freezing and 171 min for conventional freezing. The results showed that the time taken for the core temperature to reach -20 °C varies by several hours in conventional freezing, depending on the fish size. Thus, the most crucial freezing conditions to avoid anisakiasis are either rapidly freezing the fish to a core temperature of -35 °C or keeping the fish core temperature at -20 °C for at least 24 h.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"13 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment of Reviewers. 审稿人致谢。

Food safety (Tokyo, Japan) Pub Date : 2024-12-20 eCollection Date: 2024-12-01 DOI: 10.14252/foodsafetyfscj.D-24-00017

引用次数: 0