Anacardic Acid (Exempted Substances*1) (Feeds, Fertilizers, etc.).

Food safety (Tokyo, Japan) Pub Date : 2025-06-27 eCollection Date: 2025-06-01 DOI:10.14252/foodsafetyfscj.D-25-00019
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Abstract

Food Safety Commission of Japan (FSCJ) conducted a risk assessment of anacardic acid (CAS No. 11034-77-8) in response to the request from the Ministry of Health, Labour and Welfare (MHLW) in line with the application for a new designation of cashew nutshell liquid (CNSL) as a feed additive. Anacardic acid, a major substance of CNSL, is an alkyl phenol suppressing methane production in the first rumen of cattle. Submitted documents for the feed additive designation was used for the current evaluation. The data used in the assessment include fate in animals (cattle and others), tissue residues (cattle), genotoxicity, acute toxicity (mice), and subacute toxicity (mice). FSCJ determined the non-observed-adverse-effect level (NOAEL) of 600 mg/kg bw per day for the females and 1,000 mg/kg bw per day (the maximum dose) for the males. Although chronic toxicity and carcinogenicity studies for anacardic acid have not conducted, possible concerns of chronic effects would be anticipated from the results of the subacute toxicity study, and also considering the low residue of anacardic acid and the long-term food experience of cashew nuts containing the anacardic acid. In Japan, CNSL containing anacardic acid has been applied as a feed ingredient to livestock since 2012. No safety issue has been reported on livestock or their products due to this feed ingredient. FSCJ concluded that anacardic acid would not harm human health through the residues in food as long as used ordinally as a feed additive.

无心酸(豁免物质*1)(饲料、肥料等)。
应厚生劳动省(MHLW)的要求,日本食品安全委员会(FSCJ)根据新指定腰果果液(CNSL)作为饲料添加剂的申请,对无心酸(CAS号11034-77-8)进行了风险评估。无心酸是一种抑制牛第一瘤胃甲烷生成的烷基酚,是CNSL的主要物质。提交的饲料添加剂指定文件用于当前的评估。评估中使用的数据包括动物(牛和其他动物)的死亡情况、组织残留(牛)、遗传毒性、急性毒性(小鼠)和亚急性毒性(小鼠)。FSCJ确定了雌性每天600 mg/kg体重和雄性每天1000 mg/kg体重(最大剂量)的非观察不良反应水平(NOAEL)。虽然目前还没有对心酸的慢性毒性和致癌性进行研究,但从亚急性毒性研究的结果,以及考虑到心酸的低残留和含有心酸的腰果的长期食用经验,可能会对慢性影响产生担忧。在日本,自2012年以来,含有无心脏酸的CNSL已被用作牲畜饲料成分。没有关于这种饲料成分对牲畜或其产品造成安全问题的报道。FSCJ认为,只要正常作为饲料添加剂使用,就不会通过食品中的残留危害人体健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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