Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献_第9页

Vaccination trends in people with HIV infection participanting in the hospital-based survey of patients infected with HIV, 2006–2021 2006-2021 年参与医院艾滋病病毒感染者调查的艾滋病病毒感染者的疫苗接种趋势。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2023.07.006

{"title":"Vaccination trends in people with HIV infection participanting in the hospital-based survey of patients infected with HIV, 2006–2021","authors":"","doi":"10.1016/j.eimce.2023.07.006","DOIUrl":"10.1016/j.eimce.2023.07.006","url":null,"abstract":"<div><h3>Objective</h3><p><span>To assess the trend in hepatitis A, hepatitis B, pneumococcal, tetanus and </span>seasonal influenza<span><span> vaccination in people with </span>HIV infection and to analyse associated factors.</span></p></div><div><h3>Methods</h3><p>The Hospital Survey of Patients with HIV, an annual cross-sectional study conducted on a fixed day (2006−2021), was used. Inpatients and outpatients were included. Trends in vaccination and associated factors were analysed using logistic regression.</p></div><div><h3>Results</h3><p>A total of 8643 participants were included. Vaccination rates increased to 65.3% for hepatitis A, 83.7% for hepatitis B, 49.3% for tetanus<span>, 68.9% for pneumococcal and 74.5% for seasonal influenza<span><span> in 2021. Factors positively associated with vaccination were older age for pneumococcal and influenza vaccination; higher educational level for hepatitis A and tetanus; living in a closed institutions or prison for tetanus, pneumococcal and influenza; and having acquired HIV through sex between men for hepatitis A, B and pneumococcal. In addition, being on antiretroviral treatment and having a high CD4 count were positively associated with vaccination for all these diseases. Factors inversely associated with vaccination were being older (hepatitis A, B and tetanus), being an immigrant (tetanus and seasonal influenza) and being an </span>injection drug user/ex-user for hepatitis A and B.</span></span></p></div><div><h3>Conclusions</h3><p>Vaccination in people with HIV has increased in the study period. The results are in line with the recommendations in this population, although there is still room to reach the established vaccination indicators.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 339-346"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations on the implementation of the Clinical Microbiology and Parasitology training program in Spanish hospitals: A national survey 关于在西班牙医院实施临床微生物学和寄生虫学培训计划的考虑:一项全国性调查。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2023.11.002

{"title":"Considerations on the implementation of the Clinical Microbiology and Parasitology training program in Spanish hospitals: A national survey","authors":"","doi":"10.1016/j.eimce.2023.11.002","DOIUrl":"10.1016/j.eimce.2023.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>The specialty of Microbiology and Parasitology is a four-year multidisciplinary training with a central role in the diagnosis and epidemiological surveillance of infectious diseases.</p><p>The aim of this study is to analyze the degree of implementation of the official program and the degree of satisfaction of residents with their training.</p></div><div><h3>Methods</h3><p>We conducted an online survey distributed in eight sections to which active residents of the Specialty of Clinical Microbiology and Parasitology had access.</p></div><div><h3>Results</h3><p>A total of 69 responses were received, with a predominance of residents from the regions of Madrid (43.5%) and of FIR admission route (55%).</p><p>The areas in which the residents feel best prepared correspond to systematic bacteriology, antimicrobials and clinical aspects of microbiology. The areas with the worst preparation, on the other hand, are mycology, parasitology and microbiological emergencies.</p><p>There are significant differences between the clinical rotation time for residents with MIR access pathway with respect to residents with other degrees.</p><p>Respondents perceive a high degree of responsibility and a medium agreement with the quality of teaching. Attendance at clinical sessions and external rotations is frequent.</p><p>Research activity is perceived as complicated, both at the level of doctoral studies and with respect to entering research lines and the publication of scientific results.</p></div><div><h3>Conclusion</h3><p>Some points of improvement of the training itinerary have been identified that need to be reinforced. Likewise, it would be interesting to seek a better balance between care, teaching and research activities.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 361-366"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug burden index in people living with HIV over 50 years of age in a real clinical practice cohort 真实临床实践队列中 50 岁以上艾滋病毒感染者的药物负担指数。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2023.04.023

{"title":"Drug burden index in people living with HIV over 50 years of age in a real clinical practice cohort","authors":"","doi":"10.1016/j.eimce.2023.04.023","DOIUrl":"10.1016/j.eimce.2023.04.023","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine DBI and its relationship with polypharmacy<span> and pharmacotherapeutic complexity (PC) in a cohort of PLWH over 50 years of age at follow-up of pharmacotherapy in a tertiary hospital.</span></p></div><div><h3>Methods</h3><p>Observational and retrospective study that included PLWH in active antiretroviral treatment over 50 years of age who have been followed up in outpatient pharmacy services. Pharmacotherapeutic complexity was estimated through Medication Regimen Complexity Index (MRCI). Collected variables included comorbidities, current prescriptions and its classification according to anticholinergic and sedative activity and associated risk of falls.</p></div><div><h3>Results</h3><p>Studied population included 251 patients (85.7% men; median age: 58 years, interquartile range: 54–61). There was a high prevalence of high DBI scores (49.2%). High DBI was significantly correlated with a high PC, polypharmacy, psychiatric comorbidity and substances abuse (<em>p</em>  =85), antidepressant drugs (N06A) (<em>n</em>  <span>41) and antiepileptic drugs (N03A) (</span><em>n</em>  =18). Most frequent drugs associated with risk of falls were anxiolytics (N05B) (<em>n</em>  =61) and antidepressants (N06A) (<em>n</em>  <!-->41).</p></div><div><h3>Conclusion</h3><p>The DBI score in older PLWH is high and it is related to PC, polypharmacy, mental diseases and substance abuse as is the prevalence of fall-related drugs. Control of these parameters as well as the reduction of the sedative and anticholinergic load should be included in the lines of work in the pharmaceutical care of people living with HIV+.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 347-353"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparison of culture media for the detection of Legionella spp. in sanitary water samples: Adaptation to ISO 11731:2017 用于检测卫生水样中军团菌属的培养基比较：适应 ISO 11731:2017。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.05.007

{"title":"Comparison of culture media for the detection of Legionella spp. in sanitary water samples: Adaptation to ISO 11731:2017","authors":"","doi":"10.1016/j.eimce.2024.05.007","DOIUrl":"10.1016/j.eimce.2024.05.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Water sample culturing is the reference method to detect <span><span>Legionella</span></span><span> spp. in sanitary facilities. Until 2017, UNE-EN ISO 11731 only included the GVPC<span> medium, which inhibits interfering microbiota but hinders the growth of </span></span><em>Legionella</em> spp. To improve its recovery, the new standard incorporates the BCYE medium into the working protocol.</p></div><div><h3>Methods</h3><p><span>We inoculated 1306 sanitary water samples onto BCYE and GVPC according to an accredited internal procedure. We compared the number of cfu/L of </span><em>Legionella</em> spp. detected in both media.</p></div><div><h3>Results</h3><p><span>The median in BCYE was 2000 cfu/L higher than in GVPC (</span><em>P</em><span> = .000). In the presence of high amounts of interfering microbiota, both media were similar; in the absence<span> or low interfering microbiota BCYE was four times more sensitive than GVPC (</span></span><em>P</em> = .000).</p></div><div><h3>Conclusion</h3><p>Including BCYE in the analysis of sanitary water significantly improves the recovery of <em>Legionella</em> spp. in low contaminated samples.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 373-376"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the limitations of the tuberculous meningitis diagnosis 结核性脑膜炎诊断的局限性。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.03.008

引用次数: 0

Answer to diagnostic limitations in tuberculous meningitis 结核性脑膜炎诊断局限性的答案。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.06.003

引用次数: 0

Elizabethkingia anophelis bacteraemia in a patient with pneumonia 一名肺炎患者的伊丽莎白金丝菌（Elizabethkingia anophelis）菌血症。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.06.006

引用次数: 0

Enhancing pneumococcal bacteraemia diagnosis: A comparative assessment of culture-independent assays (MALDI–TOF–MS Sepsityper® module and a lateral flow inmunochromatography test) 加强肺炎球菌菌血症诊断：对不依赖培养的检测方法（MALDI-TOF-MS Sepsityper® 模块和侧流免疫层析检测）进行比较评估。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.02.011

{"title":"Enhancing pneumococcal bacteraemia diagnosis: A comparative assessment of culture-independent assays (MALDI–TOF–MS Sepsityper® module and a lateral flow inmunochromatography test)","authors":"","doi":"10.1016/j.eimce.2024.02.011","DOIUrl":"10.1016/j.eimce.2024.02.011","url":null,"abstract":"<div><h3>Introduction</h3><p>Pneumococcal bacteraemia is a major contributor to global morbidity and mortality. Traditional culture-based methods lack sensitivity and are time-consuming. This study aimed to assess the effectiveness of two culture-independent assays, the MALDI–TOF–MS Sepsityper® module and the lateral flow inmunochromatography test (LFICT) with the Standard F® <em>Streptococcus pneumoniae</em>, directly from positive blood culture (BC) bottles.</p></div><div><h3>Methods</h3><p>A prospective study was conducted from December 2021 to July 2022. For all BC positives for <span><span>S. pneumoniae</span></span> a double centrifugation protocol was implemented. The resulting pellet was subsequently processed using both techniques.</p></div><div><h3>Results</h3><p>The LFICT showed exceptional performance with 100% sensitivity and specificity, outperforming the MALDI–TOF–MS Sepsityper® module, which achieved 85.2% sensitivity and 100% specificity. Nevertheless, the combination of these assays offers a robust and comprehensive approach to diagnosis.</p></div><div><h3>Conclusions</h3><p>The simultaneous use of both techniques offers a promising alternative that can be integrated into routine practices directly from BC samples.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 377-379"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of reinfection of joint prosthesis after 2-stage replacement (infection of the 2nd stage prosthesis): A multicenter study 描述两期置换术后关节假体再感染（第二期假体感染）的情况：一项多中心研究。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2023.07.002

{"title":"Description of reinfection of joint prosthesis after 2-stage replacement (infection of the 2nd stage prosthesis): A multicenter study","authors":"","doi":"10.1016/j.eimce.2023.07.002","DOIUrl":"10.1016/j.eimce.2023.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Two-stage exchange is the gold standard in the surgical management of prosthetic joint infection (PJI). However, perioperative reinfections (RePJI) can occur to newly inserted prosthesis, which highlights the importance of an adequate antibiotic prophylaxis<span>, although there is scarce evidence in this field. Our objective was to evaluate the characteristics of RePJI, its prognosis and the antibiotic prophylaxis that is commonly used in second-stage surgery.</span></p></div><div><h3>Methods</h3><p>Multicentric retrospective observational study in Spanish hospitals including patients with RePJI between 2009 and 2018.</p></div><div><h3>Results</h3><p>We included 92 patients with RePJI from 12 hospitals. The most frequent isolated microorganism was <span><span>Staphylococcus epidermidis</span></span> in 35 cases (38.5%); 61.1% of staphylococci were methiciliin-resistant. In 12 cases (13%), the same microoganism causing the primary PJI was isolated in RePJI. When comparing with the microbiology of primary PJI, there were more cases caused by Gram-negative bacteria (the most frequent was <span><span>Pseudomonas</span></span><span> spp.) and less by Gram-positive bacteria. Failure occured in 69 cases (75%). There were 43 different courses of antibiotic prophylaxis after the second-stage surgery; the most frequent was a unique preoperative cefazolin dose, but most patients received prophylaxis before and after the second-stage surgery (61 cases).</span></p></div><div><h3>Conclusions</h3><p>The most frequent microorganisms in RePJI are coagulase-negative staphylococci, although Gram-negative bacteria, especially <em>Pseudomonas</em> spp. are also common. There is a significant heterogeneity in antibiotic prophylaxis for a second-stage surgery. ReIPJI treatment has a high failure rate.</p></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"42 7","pages":"Pages 354-360"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9905387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Vaccination in adults with HIV in Spain: Where are we? 西班牙成人艾滋病毒感染者的疫苗接种：我们在哪里？

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-08-01 DOI: 10.1016/j.eimce.2024.06.007

Esteban Martinez

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