Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献

Impact of MALDI-TOF implementation and antimicrobial stewardship programs on the optimization of antibiotic therapy in Staphylococcus aureus bloodstream infections. MALDI-TOF实施和抗菌药物管理方案对优化金黄色葡萄球菌血流感染抗生素治疗的影响。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-13 DOI: 10.1016/j.eimce.2025.06.017

Sara Vela-Bernal, Carlos Bea-Serrano, Ana Isabel de Gracia-Leon, Andreu Belmonte-Domingo, Carolina Pinto-Pla, Ana Ferrer-Ribera, Andrea de Castro-Oliver, Ignacio Torres, Javier Colomina, María Rosa Oltra-Sempere

{"title":"Impact of MALDI-TOF implementation and antimicrobial stewardship programs on the optimization of antibiotic therapy in Staphylococcus aureus bloodstream infections.","authors":"Sara Vela-Bernal, Carlos Bea-Serrano, Ana Isabel de Gracia-Leon, Andreu Belmonte-Domingo, Carolina Pinto-Pla, Ana Ferrer-Ribera, Andrea de Castro-Oliver, Ignacio Torres, Javier Colomina, María Rosa Oltra-Sempere","doi":"10.1016/j.eimce.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.06.017","url":null,"abstract":"Introduction: Rapid pathogen identification is key in the management of bloodstream infections. Antimicrobial stewardship programs (ASPs) have been shown to reduce resistance, adverse effects, and healthcare costs. MALDI-TOF MS enables fast and accurate microbial identification. This study evaluates the impact of its implementation on antibiotic therapy adequacy and mortality in Staphylococcus aureus bacteremia.Methods: A quasi-experimental pre-post study was conducted at a university hospital, covering two periods: June 2015/April 2017 (pre) and June 2021/April 2023 (post). The impact of MALDI-TOF on antibiotic adequacy and mortality was analyzed.Results: A total of 176 episodes were included (85 pre, 91 post). No significant epidemiological differences were observed between groups, although higher rates of sepsis and septic shock were noted in the post phase. MALDI-TOF was associated with improved antibiotic adjustment (3.51 vs. 1.75 days; P < .001). A non-significant trend toward lower early mortality was observed in the post-intervention group (P = .06). Mortality was associated with higher comorbidity (Charlson index), sepsis/septic shock, and MRSA bacteremia.Conclusion: The implementation of MALDI-TOF, in conjunction with a multidisciplinary ASP, enhances early adjustment of empirical antibiotic therapy and may be associated with reduced early mortality in S. aureus bacteremia. Incorporating rapid diagnostics, especially for MRSA detection, is a key strategy to improve clinical outcomes.","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor about "Comparative analysis of acute respiratory infections of viral etiology in children under 6 months with and without nirsevimab in the Balearic Islands (2022-2023 and 2023-2024)". 致编辑的关于“巴利阿里群岛（2022-2023年和2023-2024年）6个月以下使用和不使用nirseimab的儿童急性呼吸道病毒病因感染的比较分析”的信。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-13 DOI: 10.1016/j.eimce.2025.06.016

Paula Corihuela Menéndez, Sacramento M Segovia López, Alejandra Méndez Sánchez, Lara González García

引用次数: 0

Mediastinal fibrosis as a complication of Histoplasma capsulatum infection in an immunocompromised patient. 免疫功能低下患者荚膜组织浆体感染的纵隔纤维化并发症。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-11 DOI: 10.1016/j.eimce.2025.09.007

Susana Laura García Aguilera, Beatriz Villar Navas, Alba Mohedano Sánchez, Nerea Mohino Farré

引用次数: 0

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-08 DOI: 10.1016/j.eimce.2025.09.015

Cristian Mateo León, Noelia Hernando Parreño, Diego García Martínez de Artola

引用次数: 0

Breast prothesis infection due to Burkholderia cenocepacia. 假体感染引起的伯克霍尔德菌。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-06 DOI: 10.1016/j.eimce.2025.09.014

María Alonso Girón, Laura Sante Fernández, Eulalia Vives Rodríguez, José Andrés Agulla Budiño

引用次数: 0

ARDS due to acute daptomycin-induced eosinophilic pneumonia. 急性达托霉素所致嗜酸性肺炎致急性呼吸窘迫综合征。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-06 DOI: 10.1016/j.eimce.2025.09.005

Paloma Albacete Ródenas, María Martín Bautista, Jorge Néstor Ribero, Beatriz Arcos Pulido

引用次数: 0

Human gut microbiome study through metagenomics: Recent advances and challenges for clinical implementation. 通过宏基因组学研究人类肠道微生物组：临床实施的最新进展和挑战。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-06 DOI: 10.1016/j.eimce.2025.09.011

Cristina Jiménez-Arroyo, Natalia Molinero, Rosa Del Campo, Susana Delgado, M Victoria Moreno-Arribas

{"title":"Human gut microbiome study through metagenomics: Recent advances and challenges for clinical implementation.","authors":"Cristina Jiménez-Arroyo, Natalia Molinero, Rosa Del Campo, Susana Delgado, M Victoria Moreno-Arribas","doi":"10.1016/j.eimce.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.09.011","url":null,"abstract":"Metagenomics has decisively advanced the study of the gut microbiome, enabling a better understanding of its importance for human health. Metataxonomics, based on the sequencing of the 16S rRNA gene, provides taxonomic profiles of prokaryotes, while shotgun metagenomics allows a comprehensive characterization of all DNA present in a sample. With adequate sequencing depth, the latter increases taxonomic resolution to the strain level and provides detailed information on the functional potential of the microbiota. However, the lack of standardization in sample collection and processing, sequencing technologies, and data management limits the comparability of results and their implementation in clinical laboratories. This review offers a practical and updated framework on metagenomic methodologies, data analysis, and the application of artificial intelligence tools, highlighting advances and best practices to facilitate the integration of functional microbiome analysis into clinical practice and to overcome current challenges.","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of two chemiluminescent assays in determining rubella IgG in sera with low levels of specific IgG. 两种化学发光法测定低特异性IgG血清中风疹IgG的性能。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-04 DOI: 10.1016/j.eimce.2025.09.008

José María Serrano Romero, Antonio Sampedro Padilla, José Pablo Mazuelas Teatino, Javier Rodríguez-Granger, Juan Antonio Reguera, Fernando Cobo, José María Navarro Marí

{"title":"Performance of two chemiluminescent assays in determining rubella IgG in sera with low levels of specific IgG.","authors":"José María Serrano Romero, Antonio Sampedro Padilla, José Pablo Mazuelas Teatino, Javier Rodríguez-Granger, Juan Antonio Reguera, Fernando Cobo, José María Navarro Marí","doi":"10.1016/j.eimce.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.09.008","url":null,"abstract":"Introduction: Rubella is a generally mild viral infection, but it carries the risk of potentially severe complications, especially during pregnancy. Immunity to rubella is determined using commercial chemiluminescent immunoassays, calibrated with international standards. Despite this, discrepancies have been observed in the results obtained by different methods.Methods: This study evaluates the performance of two chemiluminescent immunoassays (CLIAs) (Alinity i® Rubella IgG and Atellica IM® Rubella IgG) in determining rubella immunity in patient sera with low levels of anti-rubella virus (RV) IgG, using immunoblot (IB) as the reference method.Results: 101 sera were analyzed, with 72 (71.3%) classified by IB as positive and 28 (27.7%) as negative. Both assays showed 100% specificity, with sensitivity ranging from 15% for Alinity i® to 66% for Atellica IM®. The concordance between IB and CLIA Atellica was 75% when equivocal results were considered negative and 95% when considered positive, whereas for CLIA Alinity, it was 39% and 66%, respectively.Conclusions: The evaluated CLIA showed discrepancies in determining rubella immunity, highlight inadequate standardisation in the quantification of specific IgG, which could lead to errors in patient management, incorrect classification of immune status, and unnecessary revaccinations in this patient population.","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient with septic picture, urothelial carcinoma and lung lesions. 有脓毒症、尿路上皮癌及肺部病变的病人。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-04 DOI: 10.1016/j.eimce.2025.09.006

Mónica Pilar Ariza Samper, Sara Sanz Sanz, Desiré Gil Pérez, Jesús Viñuelas Bayón

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Mycolicibacterium iranicum in a patient with bronchiectasis: Clinical importance and diagnostic difficulties. 1例支气管扩张患者的分枝杆菌：临床重要性和诊断困难。

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-10-04 DOI: 10.1016/j.eimce.2025.09.010

Diego González Polo, David Vázquez Gómez, Nieves Gutiérrez Zufiaurre

引用次数: 0