Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献

{"title":"Impact of an ASP intervention on the request for post-treatment control urine cultures in primary care.","authors":"Iker Alonso-González, Maider Zuriarrain-Alonso, Koldo López-Guridi, Paula Lara-Esbrí, Rita Sainz de Rozas, Itxasne Lekue, José Luis Barrios-Andrés","doi":"10.1016/j.eimce.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.09.012","url":null,"abstract":"<p><strong>Introduction: </strong>With the aim of reducing the number of Post-Treatment Control Urine Cultures (UC) from Health Centers in our healthcare area, we conducted an Antimicrobial Stewardship Program (ASP) intervention throughout 2022. To do this, we set out to introduce effective methods to quantify, analyze, and subsequently try to reduce the number of inappropiate UC.</p><p><strong>Methods: </strong>We conducted a prospective and non-restrictive quasi-experimental intervention study with historical and parallel control group to evaluate the impact of the intervention. The UC evaluation was performed by analyzing all the medical records of repeated UC in a period of less than 31 days. UC were classified as: appropriate, inappropriate and doubtful. The study was conducted in 3 phases: phase 1) measurement of the baseline situation; phase 2) intervention in intervention group: simple educational presentations and implementation of a non-restrictive computerized rule, and phase 3) analysis of results in both groups and periods.</p><p><strong>Results: </strong>Looking at the %AUC, we observed that in the control group there was hardly any variation while in the intervention group (IG) these increased by 152.4 (p < 0.001). In addition, in the IG there was a decrease in total UCs of 55.4% (n = 418), representing an estimated savings of €7524. The acceptance of the CR in the IG was 9.6%.</p><p><strong>Conclusions: </strong>This ASP intervention is useful in decreasing the number of IUCs, especially the educational presentations. Achieving this can reduce direct and indirect patient harm and healthcare overload, in addition to improving the management of healthcare resources.</p>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of refractory cytomegalovirus esophagitis in a patient with lymphoma and severe immunosuppression: foscarnet versus maribavir.","authors":"María Ángeles Asencio Egea, José María López-Pintor Huertas, Martín Cabero Becerra, Javier Sánchez López","doi":"10.1016/j.eimce.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.09.013","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the risk of infection from a tick bite in Spain?","authors":"María Cruz Calvo Reyes, Juan Antonio Del Castillo Polo, Esther García-Expósito, Esteban Aznar Cano, Laura Santos Larrégola, María José Sierra Moros, Lucía García-San Miguel","doi":"10.1016/j.eimce.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.eimce.2025.09.009","url":null,"abstract":"<p><strong>Introduction: </strong>The development of parameters to estimate the risk of transmission of infections is one of the objectives of entomological surveillance, included in the National Plan for the Prevention, Surveillance and Control of Vector-Borne Diseases. This study aims to assess the utility of the infection prevalence (IP) of Rickettsia spp., Borrelia burgdorferi, and Crimean-Congo haemorrhagic fever virus (CCHFV) in ticks in Spain, as an indicator of the risk of infection from a tick bite and for temporal and geographical comparisons.</p><p><strong>Methods: </strong>The IP and its 95% confidence interval (95% CI) were calculated for the different microorganism-tick pairs, using data published until April 2024, obtained through a systematic literature review. Studies that included pathogen detection using molecular methods in ticks collected from vegetation (questing ticks) were selected.</p><p><strong>Results: </strong>581 articles were reviewed, and 20 were selected. The IP of Rickettsia spp. in Dermacentor marginatus was 84.4%, in D. reticulatus 45.9%, and in Rhipicephalus sanguineus 21.2%, with some Rickettsia species causing DEBONEL (R. raoultii and R. slovaca) and MSF-like illness (R. massiliae) being the most frequent. The IP of Borrelia burgdorferi sensu lato in Ixodes ricinus was 5.9%. The IP of CCHFV in Hyalomma spp was 0.3%.</p><p><strong>Conclusions: </strong>The IP varies for each pathogen-tick pair, from very high for Rickettsia in Dermacentor, to relatively low for Borrelia in Ixodes and CCHFV in Hyalomma. The infection prevalence in ticks can be a useful indicator, along with other factors, for estimating the risk of infection from a tick bite and conducting population risk assessments in Spain.</p>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empedobacter falsenii, a rare cause of non-gonococcal urethritis","authors":"Antonio Rosales-Castillo ,&nbsp;Leticia Castellano-Sánchez ,&nbsp;José Gutiérrez-Fernández","doi":"10.1016/j.eimce.2025.09.003","DOIUrl":"10.1016/j.eimce.2025.09.003","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 539-540"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of antimicrobial consumption indicators in the emergency department","authors":"Jesus Ruiz-Ramos ,&nbsp;Álvaro Eloy Monje-López ,&nbsp;Laura Escolà-Vergé ,&nbsp;Sergio Herrera-Mateo ,&nbsp;Héctor Hernández-Ontiveros ,&nbsp;Pol Duch-Llorach ,&nbsp;Edurne Fernández-de-Gamara-Martínez ,&nbsp;María Alba Rivera-Martínez ,&nbsp;Celso Soares Pereira-Batista ,&nbsp;Joaquín López-Contreras","doi":"10.1016/j.eimce.2025.01.010","DOIUrl":"10.1016/j.eimce.2025.01.010","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring antimicrobial use in the emergency department is complex due to the wide variety of existing indicators. We evaluated the differences between various indicators used to evaluate antimicrobial use in these units.</div></div><div><h3>Methods</h3><div>Retrospective analysis of administrative data from all adult patients admitted to an emergency unit (2019–2024). Aggregated quarterly data included the percentage of patients treated, DDDs/100 admissions, DDD/100 patients-day and DOT/100 admissions. An autoregressive integrated moving average (ARIMA) model was used to investigate the association between DDD/100 admissions and the other antimicrobial use indicators.</div></div><div><h3>Findings</h3><div>Annual median antimicrobial drug use measured by DDDs/100 admissions was 11.7 (IQR 10.8–12.4). Significant differences in antimicrobial consumption correlation were noted when comparing DDD/100 admissions and DDD/100 patient-days for cephalosporins, lincosamides, and carbapenems. Significant differences in the comparison between DDD<span> and DOT were found for imipenem, clindamycin, piperacillin–tazobactam, gentamicin, and vancomycin.</span></div></div><div><h3>Conclusions</h3><div>Aggregate antimicrobial use measured by DDDs or DOTs is consistent, though discrepancies in correlation may occur for antibiotics with multiple daily doses. DDD/100 admissions is a suitable indicator, but complementing it with DDD/100 patient-days, DOT, and percentage of patients receiving antibiotics provides valuable information for monitoring antimicrobial use.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 489-495"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-associated pulmonary aspergillosis (CAPA): Current perspectives","authors":"Patricia Monzo-Gallo ,&nbsp;Carolina Garcia-Vidal","doi":"10.1016/j.eimce.2025.07.001","DOIUrl":"10.1016/j.eimce.2025.07.001","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 459-460"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is antiparasitic treatment beneficial in chronic subarachnoid neurocysticercosis? A comparative case series","authors":"Mireia Angerri-Nadal ,&nbsp;Pablo Arroyo-Pereiro ,&nbsp;Georgina Sauque ,&nbsp;Ivan Pelegrin ,&nbsp;Antonio Martínez-Yélamos ,&nbsp;Sergio Martínez-Yélamos ,&nbsp;Carmen Cabellos ,&nbsp;Albert Muñoz-Vendrell","doi":"10.1016/j.eimce.2025.05.005","DOIUrl":"10.1016/j.eimce.2025.05.005","url":null,"abstract":"<div><h3>Background</h3><div>Neurocysticercosis is particularly severe when affecting the subarachnoid space. While antiparasitic therapy effectively controls the infection, it can lead to significant complications, especially in subarachnoid neurocysticercosis (SUBNCC). This study aims to characterize a cohort of patients with SUBNCC, with a focus on their clinical course depending on therapeutic interventions.</div></div><div><h3>Methods</h3><div>We conducted an observational, retrospective study involving patients diagnosed with SUBNCC at a tertiary hospital between November 1985 and July 2022. The primary endpoint was to delineate the clinical progression and demographic features of the cohort. A secondary objective was to compare relapse rates between patients receiving antiparasitic treatment and those who did not.</div></div><div><h3>Results</h3><div>Fifteen patients were included, with a median age of 31 years (range 24–54), and 53% were female. The most common countries of origin were Bolivia and Ecuador, with a median duration from immigration of 8.1 years (range 3–16). Approximately 46.7% of patients experienced at least one relapse, with rates of 46% in patients initially treated with antiparasitic medication and 50% in those treated with steroids alone. Complication rates were similar between both groups. Comparison of time to relapse between episodes treated with antiparasitic medication versus corticosteroids alone revealed no statistically significant difference (27 episodes in total; 17 treated with antiparasitic medication versus 10 with corticosteroids only; <em>p</em> <!-->=<!--> <!-->0.376).</div></div><div><h3>Conclusions</h3><div>In patients with SUBNCC, clinical relapses managed with corticosteroids alone do not appear to result in worse outcomes in terms of complications and relapse rates compared to those managed with antiparasitic medication.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 476-482"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Oropouche virus among international travelers: A growing concern in non-endemic areas","authors":"Aida Peiró-Mestres ,&nbsp;Elisa Riera ,&nbsp;Claudia Flores Calderón ,&nbsp;Jessica Navero-Castillejos ,&nbsp;Miguel J. Martinez ,&nbsp;Daniel Camprubí-Ferrer","doi":"10.1016/j.eimce.2025.01.009","DOIUrl":"10.1016/j.eimce.2025.01.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Oropouche fever is an emerging disease caused by an arthropod-borne virus, Oropouche virus. This virus is mainly circulating in Central and South America. In 2024 they have been reported an ongoing outbreak.</div></div><div><h3>Methods</h3><div>For this study, travelers returning from endemic areas with dengue-like symptoms and negative results for dengue from March to October 2024, were tested for Oropouche through RT-PCR.</div></div><div><h3>Results</h3><div>Among 43 patients tested, we detected an imported case of Oropouche fever imported from Cuba in a traveler presenting biphasic fever and neurological symptoms. The virus was detected by RT-PCR in urine samples collected more than one month after the onset of symptoms, suggesting prolonged viral shedding and expanding the diagnostic period for molecular confirmation of the infection.</div></div><div><h3>Conclusion</h3><div>Although only few cases have been yet reported in European travelers, the expansion of the virus in the Americas supports laboratory preparedness and clinical awareness.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 523-526"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of tropical dermatitis","authors":"Miguel Morante-Ruiz ,&nbsp;Lidia Carbonero-Jiménez ,&nbsp;Francisco Javier González-Gasca ,&nbsp;María Antonia Sepúlveda-Berrocal","doi":"10.1016/j.eimce.2025.02.018","DOIUrl":"10.1016/j.eimce.2025.02.018","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 531-533"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of new HIV diagnoses made in hospital emergency departments through the “Leave Your Mark” program","authors":"Phillipe Calpe Delgado ,&nbsp;Patricia Muñoz ,&nbsp;Alberto Pizarro Portillo ,&nbsp;Virginia Álvarez Rodríguez ,&nbsp;Ángel Iván Díaz Salado ,&nbsp;Isabel Arenas Berenguer ,&nbsp;Marta Álvarez Alonso ,&nbsp;Esther Gargallo García ,&nbsp;Fátima Fernández Salgado ,&nbsp;Alma Elena Real Martín ,&nbsp;Irene Cabrera Rodrigo ,&nbsp;Anaura Carrasquel Regalade ,&nbsp;María Ángeles Moreno Planelles ,&nbsp;Margarita Jurado Otero ,&nbsp;Rodrigo Sanz Lorente ,&nbsp;Luis Pérez Ordoño ,&nbsp;Ana Carrero Fernández ,&nbsp;Juan González del Castillo ,&nbsp;representing the Madrid HIV network","doi":"10.1016/j.eimce.2025.05.006","DOIUrl":"10.1016/j.eimce.2025.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The Leave Your Mark (DTH) program launched recommendations for HIV screening in emergency departments (ED) when patients presented with certain conditions. It is unknown whether the profile of patients diagnosed in the ED is similar to those reported for general population in epidemiological reports.</div></div><div><h3>Methods</h3><div>Retrospective study evaluating the characteristics of patients with new HIV diagnosed in 17 ED over a one-year period was developed. Demographic data (sex at birth, age, country of birth), sexual and risk behaviour, diagnosis in ED, number of emergency visits in previous five years, time from the ED to the specific HIV consultation, and from ED to start antiretroviral treatment were recorded. Information on the first CD4 and viral load was also collected.</div></div><div><h3>Results</h3><div>A total of 169 patients were included. There were 122 (72.2%) migrants, 57 (32.5%) heterosexual, and injection drug use was the transmission route in 14 (8.3%) cases. Data reported for the general population were 49.8%, 25.7%, and 1.7%, respectively. Late diagnosis was found in 80 (47.3%) patients (reported figures by the Ministry, 48.7%). Compared to Spanish, migrant were more frequently women (13.1% vs. 6.4%), heterosexual (38.5% vs. 21.3%), and had worse immunological status [median CD4 count of 310 (IQR 132–457) vs. 444 (IQR 215−607)].</div></div><div><h3>Conclusion</h3><div>ED can play a key role in diagnosing a different patient profile that may not seek care at other healthcare levels.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 8","pages":"Pages 496-503"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}