Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献

{"title":"Septic olecranon bursitis caused by Wickerhamiella pararugosa","authors":"Santiago Martínez-García, Daniel Navarro de la Cruz, Lucía Martínez-Lamas, Irene Álvarez Losada","doi":"10.1016/j.eimce.2026.503232","DOIUrl":"10.1016/j.eimce.2026.503232","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503232"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlamydia trachomatis screening in young women: From local evidence to public health action","authors":"Santiago Fernandez-Castelao, Mar Vera García","doi":"10.1016/j.eimce.2026.503228","DOIUrl":"10.1016/j.eimce.2026.503228","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503228"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurosyphilis: Descriptive analysis of clinical presentation, diagnosis, treatment, and outcomes","authors":"Luis Toscano Aznar,&nbsp;Francisco Ramón Domínguez Tosso,&nbsp;José Antonio Girón González,&nbsp;Andrés Martín-Aspas","doi":"10.1016/j.eimce.2026.503230","DOIUrl":"10.1016/j.eimce.2026.503230","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the increased incidence of syphilis in Spain, the objective is to analyze the clinical presentation, diagnosis, treatment, and outcomes of neurosyphilis cases managed in our unit.</div></div><div><h3>Methods</h3><div>Retrospective descriptive study (2012–2023) including patients older than 14 years classified as early, late, or asymptomatic clinical forms. Demographic, clinical, and outcome variables were analyzed.</div></div><div><h3>Results</h3><div>Seventeen cases were included (94.1% male), with HIV coinfection in 29.4%. The predominant forms were syphilitic dementia and ocular syphilis (29.4%). Detection of CSF RPR (Rapid Plasma Reagin) was positive in 64.2%. Intravenous penicillin G was administered in 82.3% of cases; two early forms had been treated with intramuscular penicillin. Clinical improvement was observed in 47.1% of patients.</div></div><div><h3>Conclusion</h3><div>An increase in neurosyphilis cases was observed, with acceptable CSF RPR sensitivity. Early forms showed a better prognosis, highlighting the need for clinical follow-up due to the possibility of symptomatic relapses.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503230"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virological reactivation of the hepatitis B virus after simplification of antiretroviral treatment","authors":"Marta Segura Díaz,&nbsp;Sergio Ferra Murcia,&nbsp;Daniel Collado Díaz,&nbsp;Antonio Collado Romacho","doi":"10.1016/j.eimce.2026.503257","DOIUrl":"10.1016/j.eimce.2026.503257","url":null,"abstract":"<div><h3>Introduction</h3><div>Between 5% and 10% of people living with HIV (PLWH) have chronic hepatitis B virus (HBV) infection. Withdrawal of anti-HBV agents during antiretroviral therapy (ART) simplification may increase the risk of viral reactivation.</div></div><div><h3>Methods</h3><div>We report two cases of PLWH with serological evidence of past HBV infection (isolated anti-HBc positivity) who developed HBV reactivation after switching to dual ART regimens lacking anti-HBV activity.</div></div><div><h3>Results</h3><div>A 63-year-old woman developed detectable HBV DNA (659 IU/mL) one month after starting cabotegravir/rilpivirine, and a 55-year-old man showed reactivation (2626 IU/mL) after switching to dolutegravir/rilpivirine. In both cases, reintroduction of anti-HBV therapy achieved viral suppression.</div></div><div><h3>Conclusions</h3><div>ART simplification without HBV-active agents may be associated with HBV DNA reappearance in patients with prior exposure. The clinical significance of low-level viremia remains uncertain, and further studies are needed.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503257"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis caused by Staphylococcus argenteus in a patient with severe pulmonary hypertension: A diagnostic challenge for syndromic molecular methods","authors":"Virginia Pérez Doñate,&nbsp;Olalla Martínez Macías,&nbsp;Ángel Aguilar Escrivá,&nbsp;José Enrique Peiró Anrubia","doi":"10.1016/j.eimce.2026.503229","DOIUrl":"10.1016/j.eimce.2026.503229","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503229"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden dengue burden in migrant visiting friends and relatives travellers: A seroprevalence study in a tertiary Infectious Diseases clinic in Spain","authors":"Aitana Nebot-Ariño,&nbsp;Victoria Lobo-Antuña,&nbsp;María Martínez-Serrano,&nbsp;Miguel García-Deltoro,&nbsp;Magdalena García-Rodríguez","doi":"10.1016/j.eimce.2026.503245","DOIUrl":"10.1016/j.eimce.2026.503245","url":null,"abstract":"<div><h3>Introduction</h3><div>Dengue, a globally prevalent arboviral disease, presents an increasing risk, particularly among migrant populations and travelers visiting friends and relatives (VFR), due to the high incidence of asymptomatic infections and the risk of severe disease in reinfections.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional single-center study among adult migrants from dengue-endemic countries under follow-up in the Infectious Diseases clinic of a tertiary hospital in Valencia, Spain (July–December 2024). Stratified proportional random sampling by nationality was used. Dengue IgG was determined by ELISA including NS1-based confirmation to minimise flavivirus cross-reactivity; Zika and yellow fever IgG were also assessed. A structured interviewer-administered questionnaire captured sociodemographic data, VFR status, travel patterns, dengue-related knowledge, and use of preventive measures.</div></div><div><h3>Results</h3><div>Among 317 participants (55.2% women; median age 44 years), the median duration of residence in Spain was 16 years (IQR 5–21) and most originated from South America (67.8%), followed by Africa (18.0%), Southeast Asia (7.6%), and Central America/Caribbean (6.6%); 65.6% met criteria for VFR travellers. Overall dengue IgG seroprevalence was 53.0% (95% CI 47.3–58.6), highest in Central America/Caribbean (71.4%) and South America (57.2%), and substantial in Africa (43.9%) and Asia (20.8%). Only 32.7% of seropositive individuals recalled a previous dengue episode. While 71.3% had heard of dengue, only 37.5% recognised severe dengue and 10.1% were aware of dengue vaccines; 0.9% had ever been vaccinated. Preventive measures during travel were reported by 41.0%, and only 19.2% had sought pre-travel advice. In bivariate analyses, origin from the Americas, prior dengue infection, family history of dengue, dengue-related knowledge, and yellow fever or Zika IgG positivity were associated with seropositivity, whereas use of preventive measures, VFR status, and immunosuppression were not associated. In multivariable analysis, only prior dengue infection, Zika IgG positivity, and yellow fever IgG positivity remained independently associated.</div></div><div><h3>Conclusions</h3><div>Long-term migrants from dengue-endemic regions in Spain show a high burden of prior dengue infection, including a substantial seroprevalence among individuals from Africa, where dengue transmission has traditionally been considered limited. These findings suggest that dengue exposure in African populations may be higher than previously assumed; however, given the limited sample size and potential selection bias, this observation should be considered hypothesis-generating. Incorporating dengue serology and tailored preventive strategies into routine care of migrant VFRs may reduce the risk of severe dengue and improve preparedness in Europe amid expanding <em>Aedes</em> transmission.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503245"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunistic screening and early diagnosis of Chlamydia trachomatis infection in sexually active women in a rural area of the Basque Country","authors":"Amaia Cuñado,&nbsp;Iratxe Ocerin,&nbsp;Josune Mendiola,&nbsp;Maitane Arrastia,&nbsp;Luis Piñeiro","doi":"10.1016/j.eimce.2026.503063","DOIUrl":"10.1016/j.eimce.2026.503063","url":null,"abstract":"<div><h3>Introduction</h3><div>The incidence of <em>Chlamydia trachomatis</em> (CT) infection has increased in recent years, especially in young women, and can have significant consequences for their sexual and reproductive health.</div></div><div><h3>Methods</h3><div>Between February/2017–June/2017, screening for CT infection was offered to women aged 18–35 years who attended the Midwife/Gynecology clinic at Mendaro Hospital (Gipuzkoa), and it was extended between September/2017-February/2021 in those aged 18−25. After providing consent, a clinical-epidemiological survey was completed and a genital sample was obtained. CT was detected using a commercial PCR technique.</div></div><div><h3>Results</h3><div>A total of 558 women were studied: 412 aged 18–25 years and 146 aged 26–35 years. The prevalence of infection was 7.3% (95%CI 5.4–9.9%), 9.0% in those aged ≤25 years and 2.7% in those older than 25 (<em>p</em> = 0.013). The prevalence was higher in symptomatic women, with more sexual partners, and inconsistent condom use.</div></div><div><h3>Conclusion</h3><div>The high prevalence of CT infection in women aged ≤25 years indicates the need to implement screening strategies to prevent the consequences of infection and its transmission.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503063"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central venous catheter-associated infection by Staphylococcus condimenti: Case report and literature review","authors":"Sergio Alemán Belando,&nbsp;Antonio Sánchez Guirao,&nbsp;Mónica Martínez Martínez,&nbsp;Alberto Carmona Bayonas","doi":"10.1016/j.eimce.2026.503252","DOIUrl":"10.1016/j.eimce.2026.503252","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503252"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular conjunctivitis in adults due to Chlamydia trachomatis: a descriptive case series in a tertiary hospital","authors":"Jesús E. Guevara Osorio,&nbsp;Teresa Nebreda Mayoral,&nbsp;Milagros Cuervo Abarquero,&nbsp;Silvia Rojo Rello,&nbsp;Ignacio López Miñarro,&nbsp;David Galarreta Mira","doi":"10.1016/j.eimce.2026.503243","DOIUrl":"10.1016/j.eimce.2026.503243","url":null,"abstract":"<div><h3>Introduction</h3><div>Follicular conjunctivitis caused by <em>Chlamydia trachomatis</em> is an uncommon infection and represents an extragenital manifestation of sexual transmission, and it may be underdiagnosed.</div></div><div><h3>Objective</h3><div>To confirm the presence of <em>C. trachomatis</em> in adults with follicular conjunctivitis and to describe its clinical and epidemiological characteristics.</div></div><div><h3>Methods</h3><div>Retrospective descriptive study (2024–2025) in patients ≥18 years old with suspected follicular conjunctivitis caused by <em>C. trachomatis</em>. Detection was carried out using real-time PCR (FluoroType® STI VER 1.0, Hain Lifescience).</div></div><div><h3>Results</h3><div>A total of 9,430 NAATs were performed on genital samples in adult patients; 414 tested positive for <em>C. trachomatis</em>. Of these patients with confirmed genital infection, 19 presented clinical suspicion of follicular conjunctivitis and underwent NAAT on conjunctival exudate, confirming the presence <em>of C. trachomatis.</em> The mean age (SD) was 30.1 (10.2) years; among the positives with follicular conjunctivitis, 53.3% were men. All showed clinical resistance to common antibiotic eye drops and improved after systemic treatment.</div></div><div><h3>Conclusions</h3><div>Although infections by <em>C. trachomatis</em> have increased, their presentation as follicular conjunctivitis continues to be rare in Spain.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503243"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications of point-of-care ultrasound for infectious diseases in older adults","authors":"Emilio Guirao-Arrabal,&nbsp;Fidel Moreno-Verdejo,&nbsp;José Antonio Peregrina-Rivas,&nbsp;Marta Fernández Toral,&nbsp;Alberto Benavente Fernández","doi":"10.1016/j.eimce.2026.503263","DOIUrl":"10.1016/j.eimce.2026.503263","url":null,"abstract":"<div><div>Older adults with suspected infection pose diagnostic and therapeutic challenges due to immunosenescence, chronic low-grade inflammation that develops with advancing age (inflammaging), frailty, and frequent atypical presentations. Fever may be absent, focal signs are often subtle, and biomarkers lack specificity, leading to diagnostic uncertainty, delayed treatment, and frequent overuse of broad-spectrum antibiotics. Point-of-Care Ultrasound (POCUS) extends the physical examination at the bedside, enabling rapid integration of anatomical and functional data without exposing frail patients to unnecessary transfers or delays.</div><div>This narrative review proposes a structured multi-organ POCUS protocol for elderly patients with suspected infection based on three pillars: (1) systematic identification of the infectious focus through a craniocaudal scan of lungs, pleura, hepatobiliary system, kidneys, spleen, peritoneal cavity, and heart; (2) haemodynamic assessment using an enhanced rapid ultrasound for shock and hypotension (RUSH) framework with dynamic parameters such as left ventricular outflow tract-velocity–time integral (LVOT-VTI) and venous congestion to guide individualised fluid resuscitation; and (3) ultrasound-guided source control.</div><div>The Focused INfection Diagnosis-POCUS (FIND-POCUS) algorithm provides a rapid, reproducible bedside strategy requiring prospective validation.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"44 8","pages":"Article 503263"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}