移植受者和等候患者中COVID-19的住院和死亡风险相似：比较分析

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-05-01 DOI:10.1016/j.eimce.2025.02.005

Abelardo Claudio Fernández Chávez , Guillermo Yovany Ordoñez León , Eva Elisa Álvarez León , Paloma Moreno Núñez , José Porto Tomás , Jesús María Aranaz Andrés

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引用次数: 0

摘要

导语：2022年，西班牙卫生当局建议对实体器官移植受者（SOT）进行COVID-19被动免疫接种，因为他们接种疫苗后体液反应不足。在移植等待名单（SOTwl）上的患者被排除在该策略之外。目的：比较SOT和SOTwl患者因COVID-19住院、ICU住院和死亡率的风险。方法：2020年3月14日至2022年4月13日期间在Ramón y Cajal医院预防医学部就诊的患者。估计SOT和SOTwl患者的住院、ICU住院和死亡率的相对风险（RR），并根据年龄、性别和疫苗剂量进行调整。结果：共分析1292例患者。SOT患者（n=1153）年龄较大，与SOTwl患者（n=139）相比，住院（RR 0.97, 95% CI 0.57-1.64）、ICU住院（RR 1.74, 95% CI 0.44-6.86）和死亡（RR 0.89, 95% CI 0.45-1.77）的风险相似。结论：SOT和SOTwl患者的住院风险、ICU入院风险和死亡率相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Similar risk of hospitalization and lethality from COVID-19 in transplant recipients and waitlisted patients: A comparative analysis

Introduction

In 2022, Spanish health authorities recommended passive immunisation against COVID-19 for solid organ transplant recipients (SOT), due to their deficient post-vaccination humoral response. Patients on the transplant waiting list (SOTwl) were excluded from this strategy.

Objective

To compare the risk of hospitalisation, ICU admission, and mortality due to COVID-19 between SOT and SOTwl patients.

Methodology

Patients seen in the Preventive Medicine Department at Ramón y Cajal Hospital between 03/14/2020 and 04/13/2022. The relative risk (RR) of hospitalisation, ICU admission, and mortality was estimated among SOT and SOTwl patients, adjusted for age, sex, and vaccine doses.

Results

A total of 1292 patients were analyzed. SOT patients (n = 1153) were older and had similar risks of hospitalisation (RR 0.97, 95% CI 0.57–1.64), ICU admission (RR 1.74, 95 % CI 0.44–6.86), and death (RR 0.89, 95% CI 0.45–1.77) compared to SOTwl patients (n = 139).

Conclusions

The risks of hospitalisation, ICU admission, and mortality were similar between SOT and SOTwl patients.

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来源期刊

Enfermedades infecciosas y microbiologia clinica (English ed.)

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