Similar risk of hospitalization and lethality from COVID-19 in transplant recipients and waitlisted patients: A comparative analysis.

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2025-02-28 DOI:10.1016/j.eimce.2025.02.005

Abelardo Claudio Fernández Chávez, Guillermo Yovany Ordoñez León, Eva Elisa Álvarez León, Paloma Moreno Núñez, José Porto Tomás, Jesús María Aranaz Andrés

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Abstract

Introduction: In 2022, Spanish health authorities recommended passive immunisation against COVID-19 for solid organ transplant recipients (SOT), due to their deficient post-vaccination humoral response. Patients on the transplant waiting list (SOTwl) were excluded from this strategy.

Objective: To compare the risk of hospitalisation, ICU admission, and mortality due to COVID-19 between SOT and SOTwl patients.

Methodology: Patients seen in the Preventive Medicine Department at Ramón y Cajal Hospital between 03/14/2020 and 04/13/2022. The relative risk (RR) of hospitalisation, ICU admission, and mortality was estimated among SOT and SOTwl patients, adjusted for age, sex, and vaccine doses.

Results: A total of 1292 patients were analyzed. SOT patients (n=1153) were older and had similar risks of hospitalisation (RR 0.97, 95% CI 0.57-1.64), ICU admission (RR 1.74, 95 % CI 0.44-6.86), and death (RR 0.89, 95% CI 0.45-1.77) compared to SOTwl patients (n=139).

Conclusions: The risks of hospitalisation, ICU admission, and mortality were similar between SOT and SOTwl patients.

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Enfermedades infecciosas y microbiologia clinica (English ed.)

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