Encephalitis (Seoul, Korea)最新文献_第8页

Changes in laboratory mice after observation of deceased conspecifics: a pilot suicidality study in animals. 观察死亡同种动物后实验室小鼠的变化:动物自杀试验研究。

Encephalitis (Seoul, Korea) Pub Date : 2021-10-01 DOI: 10.47936/encephalitis.2021.00080

Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu

{"title":"Changes in laboratory mice after observation of deceased conspecifics: a pilot suicidality study in animals.","authors":"Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu","doi":"10.47936/encephalitis.2021.00080","DOIUrl":"https://doi.org/10.47936/encephalitis.2021.00080","url":null,"abstract":"Purpose: Suicidality can be a serious feature of psychiatric symptoms in encephalitis. Investigating the psychiatric behavior associated with suicidality in animal models of encephalitis is important; thus, determining whether normal laboratory animals are aware of death is necessary.Methods: To examine the behavioral and brain activity changes associated with death of conspecifics, laboratory mice were exposed to a cadaveric mouse or an anesthetized mouse. Behavioral tasks associated with anxiety and locomotion were conducted after repeated exposure. Neural activity in the medial prefrontal cortex during the cadaver exploration was investigated using electroencephalographic recordings.Results: During repeated exposure, mice in the cadaver group showed a gradual decrease in time exploring the cadaver, which was not observed in mice in the anesthesia group. The cadaver group also exhibited increased levels of anxiety in the light/dark transition and elevated plus maze tasks and displayed increased locomotor activity in the open field test. In an electrophysiological study, different brain oscillations were observed when mice were exposed to a cadaveric mouse and an anesthetized mouse. Enhanced delta-band activity and reduced theta- and alpha-band activities were observed during cadaver exploration.Conclusion: The present study results showed that experiences involving dead conspecifics strongly affect mouse behavior and brain activity. These findings may be helpful in treating patients with psychiatric symptoms and aid in understanding the concept of death recognition/awareness in laboratory animals.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"1 4","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/d3/encephalitis-2021-00080.PMC10295892.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review. 甲氟喹成功治疗进展性多灶性白质脑病并文献复习。

Encephalitis (Seoul, Korea) Pub Date : 2021-10-01 DOI: 10.47936/encephalitis.2021.00094

Sungjoon Yoon, Yongmoo Kim, Seon-Jae Ahn, Kon Chu

引用次数: 0

Role of inflammasomes in neuroinflammation after ischemic stroke. 炎症小体在缺血性脑卒中后神经炎症中的作用。

Encephalitis (Seoul, Korea) Pub Date : 2021-10-01 DOI: 10.47936/encephalitis.2021.00073

Keun-Hwa Jung, Seung-Yong Seong

引用次数: 1

COVID-19 and encephalitis. COVID-19和脑炎。

Encephalitis (Seoul, Korea) Pub Date : 2021-10-01 DOI: 10.47936/encephalitis.2021.00122

Young-Soo Kim

引用次数: 2

Acute brainstem encephalitis associated with Mycoplasma pneumoniae in an adult: a case report. 急性脑干脑炎与肺炎支原体在成人:1例报告。

Encephalitis (Seoul, Korea) Pub Date : 2021-10-01 DOI: 10.47936/encephalitis.2021.00101

Min-Hee Woo, Jung-Won Shin

{"title":"Acute brainstem encephalitis associated with Mycoplasma pneumoniae in an adult: a case report.","authors":"Min-Hee Woo, Jung-Won Shin","doi":"10.47936/encephalitis.2021.00101","DOIUrl":"https://doi.org/10.47936/encephalitis.2021.00101","url":null,"abstract":"Brainstem encephalitis (BE) associated with Mycoplasma pneumoniae in adults is rare, and the diagnosis is challenging. We describe an uncommon case of BE in an immunocompetent patient. A 43-year-old, otherwise healthy woman visited our emergency department with high fever and a sore throat, and 3 days later she returned with an altered drowsy mental status. Magnetic resonance imaging displayed diffuse swelling in bilateral cerebral regions involving the bilateral pons. The sera tested positive for the immunoglobulin (Ig) M antibody against M. Pneumoniae as detected by an enzyme immunoassay (EIA), and on hospital day 10, the level of IgM index against M. pneumoniae further increased from 1.5 to 2.1. We changed the antibiotic regimen from vancomycin and ceftriaxone to clarithromycin based on detection of M. pneumoniae, and we added intravenous immunoglobulin. After one month, the patient fully recovered from the neurological deficits. A follow-up brain magnetic resonance imaging was performed, which showed completely resolved lesions. Particle agglutination assay (PA) and EIA are both largely used to diagnose M. pneumoniae. Compared to the PA test, the EIA test could be a reliable tool because it separately measures IgM and IgG antibodies. We diagnosed BE associated with M. pneumoniae through EIA with an increasing level of IgM in the acute and subacute paired sera. Early treatment with macrolide antibiotics resulted in a good outcome.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"1 4","pages":"120-123"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/28/encephalitis-2021-00101.PMC10295894.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose interleukin-2 as a novel therapeutic option for refractory paraneoplastic neurologic syndrome: a case of chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy. 低剂量白介素-2作为难治性副肿瘤神经系统综合征的新治疗选择:慢性复发抗ma2 /Ta副肿瘤髓根病1例

Encephalitis (Seoul, Korea) Pub Date : 2021-07-01 DOI: 10.47936/encephalitis.2021.00038

Seon-Jae Ahn, Han-Sang Lee, Woo-Jin Lee, Kon Chu

引用次数: 0

Paraneoplastic encephalitis associated with renal cell carcinoma. 与肾细胞癌相关的副肿瘤脑炎。

Encephalitis (Seoul, Korea) Pub Date : 2021-07-01 DOI: 10.47936/encephalitis.2021.00059

Yoonhyuk Jang, SeonDeuk Kim, Kon Chu, Sang Kun Lee, Soon-Tae Lee

{"title":"Paraneoplastic encephalitis associated with renal cell carcinoma.","authors":"Yoonhyuk Jang, SeonDeuk Kim, Kon Chu, Sang Kun Lee, Soon-Tae Lee","doi":"10.47936/encephalitis.2021.00059","DOIUrl":"https://doi.org/10.47936/encephalitis.2021.00059","url":null,"abstract":"Purpose: Paraneoplastic encephalitis is autoimmune encephalitis accompanied by tumors. Renal cell carcinoma (RCC) is a kidney cancer originating from various types of renal cells and rarely has been associated with paraneoplastic neurologic manifestation. We identified a case series of paraneoplastic encephalitis-associated RCC.Methods: From a prospective institutional cohort, we identified autoimmune encephalitis patients with RCC. The association between RCC and encephalitis was determined by the following criteria: (1) possible autoimmune encephalitis according to the operational autoimmune encephalitis diagnostic criteria and (2) RCC simultaneously diagnosed with neurological manifestation of encephalitis.Results: A total of three patients presented encephalitis accompanied by RCC. Two patients had clear cell RCC, and one had chromophobe RCC. All patients showed limbic encephalitis with cognitive decline, memory impairment, or seizure. Brain magnetic resonance imaging showed T2 hyperintensities at the mesial temporal lobe in two patients with clear cell RCC but no remarkable findings in one patient with chromophobe RCC. While one patient who had early surgery within one month of RCC onset had a favorable response to the treatment, the other two patients showed a partial response and a detrimental result.Conclusion: Paraneoplastic encephalitis associated with RCC presented as limbic encephalitis and was responsive to immunotherapy combined with tumor resection. As our cases identified, RCC should be considered as a cause of seronegative autoimmune encephalitis.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"1 3","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/a1/encephalitis-2021-00059.PMC10295882.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epstein-Barr virus-associated acute disseminated encephalomyelitis successfully treated with rituximab: a case report. 利妥昔单抗成功治疗eb病毒相关急性播散性脑脊髓炎1例

Encephalitis (Seoul, Korea) Pub Date : 2021-07-01 DOI: 10.47936/encephalitis.2021.00066

Seoyeon Kim, Seon-Jae Ahn, Kon Chu

引用次数: 3

Understanding new-onset refractory status epilepticus from an immunological point of view. 从免疫学角度理解新发难治性癫痫持续状态。

Encephalitis (Seoul, Korea) Pub Date : 2021-07-01 DOI: 10.47936/encephalitis.2021.00045

Yong-Won Shin

引用次数: 3

Proportion of peripheral regulatory T cells in patients with autoimmune encephalitis. 自身免疫性脑炎患者外周血调节性T细胞的比例

Encephalitis (Seoul, Korea) Pub Date : 2021-07-01 DOI: 10.47936/encephalitis.2021.00052

Jung-Ick Byun, Ji-Yeon Bae, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Manho Kim, Sang Kun Lee, Kon Chu

{"title":"Proportion of peripheral regulatory T cells in patients with autoimmune encephalitis.","authors":"Jung-Ick Byun, Ji-Yeon Bae, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Manho Kim, Sang Kun Lee, Kon Chu","doi":"10.47936/encephalitis.2021.00052","DOIUrl":"https://doi.org/10.47936/encephalitis.2021.00052","url":null,"abstract":"Purpose: Regulatory T cells (Tregs) play a crucial role in maintaining immune tolerance. Any deficiency or dysfunction of the Tregs can influence the pathogenesis of autoimmune disease. This study aimed to assess the role of Tregs among patients with autoimmune encephalitis (AE) with different autoantibody types and to evaluate their association with clinical features.Methods: This was a cross-sectional observational study involving 29 patients with AE. Peripheral blood was sampled from each patient for flow cytometric analysis. Proportions of CD4+CD25+ and CD4+CD25+Foxp3+ Tregs were calculated and compared between the antibody types (synaptic, paraneoplastic, and undetermined). Associations between the proportion of Tregs and clinical features were also evaluated.Results: Five patients had synaptic autoantibodies, five had paraneoplastic autoantibodies, and the others were of an undetermined type. The proportion of CD4+CD25+ Tregs tended to be higher in those with paraneoplastic antibodies than in those with synaptic antibodies (post-hoc p = 0.028) and undetermined antibody status (post-hoc p = 0.043). A significant negative correlation was found between the proportion of Tregs and the initial modified Rankin score (r = -0.391, p = 0.036). Those who received intravenous immunoglobulin had lower proportions of Tregs than those who did not.Conclusion: The results of the present study suggest that Tregs may play different roles according to the type of AE and may be linked to disease severity.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"1 3","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/4e/encephalitis-2021-00052.PMC10295879.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1