Emerging trends in drugs, addictions, and health最新文献

{"title":"Evaluating the effectiveness of management-based anti-doping education for young elite Ethiopian athletes","authors":"Zemikael Getu ,&nbsp;Tefera Tadesse ,&nbsp;Sisay Mengestu","doi":"10.1016/j.etdah.2025.100184","DOIUrl":"10.1016/j.etdah.2025.100184","url":null,"abstract":"<div><div>This study evaluated the effectiveness of a novel management-oriented anti-doping intervention to enhance knowledge, attitudes, and ethical decision-making among young elite athletes. A randomized controlled trial involved 321 athletes (Intervention: n=161, 50% female, mean age = 17.2 years, SD = 1.5; Control: n=160, 48% female, Mean age = 17.1 years, SD = 1.4). The intervention, which emphasized stakeholder engagement, resource optimization, and athlete empowerment through interactive learning and peer mentorship, significantly improved all measured outcomes. Specifically, knowledge increased by 45% (p&lt;.001, Eta²=.05), attitudes towards doping enhanced by 30% (p&lt;.001, Eta²=.04), and ethical decision-making skills improved by 35% (p&lt;.001, Eta²=.06). These findings underscore the significance of adopting a management-focused approach in anti-doping education, suggesting that such strategies not only help to establish a clean sports environment but also empower athletes to take ownership of their ethical responsibilities. The implications of this research extend to the broader context of anti-doping education, highlighting the need for innovative and comprehensive strategies that actively involve athletes and stakeholders in the fight against doping in sports.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problematic social media use among school-going adolescents during the COVID-19 pandemic: Correlates with depression, anxiety and loneliness","authors":"Israt Jahan ,&nbsp;Md Saiful Islam ,&nbsp;Muhammad Al Amin Dewan ,&nbsp;Md Saif Mahabub ,&nbsp;Halley M. Pontes","doi":"10.1016/j.etdah.2025.100182","DOIUrl":"10.1016/j.etdah.2025.100182","url":null,"abstract":"<div><h3>Background</h3><div>During the COVID-19 period, online activities such as internet browsing, online gaming, social media use became increasingly popular sources of entertainment for adolescents. However, excessive engagement in social media platforms may lead to problematic social media use (PSMU), which has been associated with negative mental health outcomes.</div></div><div><h3>Objective</h3><div>The present study aimed to investigate the prevalence of PSMU and its association with the psychological factors, including depression, anxiety, and loneliness among school-going adolescents in Bangladesh during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A paper-and-pencil cross sectional survey was carried out between August and September 2021 comprising 543 school-going adolescents (61.0 % males; mean age: 16.13 ± 1.83 years; age range: 9-18 years) recruited through convenience sampling from four selected secondary and higher-secondary schools in Dhaka city, Bangladesh. The self-reported survey included informed consent and questions concerning socio-demographics, lifestyle-related information, and four Bangla version of psychometric instruments (i.e., Patient Health Questionnaire [PHQ-9], Generalized Anxiety Disorder [GAD-7], University of California, Los Angeles [UCLA] Loneliness Scale, and the Bergen Social Media Addiction Scale [BSMAS]).</div></div><div><h3>Results</h3><div>The prevalence of PSMU in the sample was 26.7 %. In the hierarchical regression analysis, higher mean scores of BSMAS (the score indicates the higher severity level of the PSMU) were significantly associated with being in a relationship (β = 0.11, <em>p</em> &lt; 0.01), having depression (β = 0.16, <em>p</em> &lt; 0.01), anxiety (β = 0.11, <em>p</em> ≤ 0.05), and loneliness (β = 0.19, <em>p</em> &lt; 0.01). The model accounted for 17 % of the variance in PSMU, indicating moderate effect sizes and meaningful associations.</div></div><div><h3>Conclusions</h3><div>The findings suggest that PSMU was significantly connected with depression, anxiety, and loneliness during the COVID-19 pandemic. Accordingly, Bangladesh should prioritise school-based digital literacy, peer support, and awareness programs to curb PSMU among adolescents.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming anti-doping education with web-based interactive programs and applications: A scoping review","authors":"K.P. Bingham ,&nbsp;L. Lazuras ,&nbsp;V. Barkoukis ,&nbsp;A.-M. Elbe ,&nbsp;L. Moustakas ,&nbsp;N. Ntoumanis","doi":"10.1016/j.etdah.2025.100175","DOIUrl":"10.1016/j.etdah.2025.100175","url":null,"abstract":"<div><h3>Background</h3><div>Doping has become a global social, moral and institutional challenge that has serious consequences for athletes and the integrity of sports. Since educational tools are deemed not to be sufficiently effective in minimizing doping, the benefits of digital and web-based (desktop and/or mobile) interventions are being explored.</div></div><div><h3>Objective</h3><div>The present study undertakes a scoping review of research on web-based anti-doping interventions to provide an overview of peer-reviewed studies that have examined their effectiveness in raising awareness of doping among athletes and exercisers.</div></div><div><h3>Design</h3><div>Online databases were used to identify nine papers that examine a web-based anti-doping intervention. The review maps out the key PICO (population, intervention, comparator, outcome) characteristics of each web-based program and their effectiveness in reducing the risk for engaging in doping use.</div></div><div><h3>Results</h3><div>The scoping review reveals that only seven web-based anti-doping interventions have been tested worldwide and that four appear to have been successful. Three studies present a different view of web-based anti-doping interventions and indicate they may be partially effective.</div></div><div><h3>Conclusions</h3><div>The review suggests that newly emerging web-based anti-doping interventions have shown some success in improving knowledge and awareness of doping, reducing favourable attitudes towards doping, and reducing doping susceptibility. The review paves the way for future projects and encourages researchers to utilise cutting-edge technologies to ensure interventions are innovative, impactful and contemporaneous.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Conventional and Alternative Biological Matrices in Evaluating the Extend of Use of New Psychoactive Substances (NPS)","authors":"D. Florou,&nbsp;V.A. Boumba","doi":"10.1016/j.etdah.2025.100217","DOIUrl":"10.1016/j.etdah.2025.100217","url":null,"abstract":"<div><h3>Introduction</h3><div>New Psychoactive Substances (NPS) have flooded the illicit drug market, mimicked the effects of controlled substances while evading legal restrictions due to structural variations. Their widespread availability have led to significant public health concerns, including acute intoxication and fatalities. Consequently, developing effective detection methods is crucial to safeguard public health and enhance toxicological analysis capabilities.</div></div><div><h3>Methods</h3><div>Conventional biological specimens include mainly blood and urine, while non-conventional mainly refer to hair. Hair testing is particularly beneficial for assessing past, chronic, sub-chronic, and, in certain cases, even acute exposure to xenobiotics, with a detection window extending up to several months. It is non-invasive, simple to collect, and allows for retrospective analysis. However, it is less effective for detecting acute exposure and may be influenced by environmental factors, leading to false results. Conversely, blood tests are effective for documenting recent drug use and are the only analyses that can correlate drug concentrations with symptomatology.</div></div><div><h3>Conclusions</h3><div>The selection between hair and blood testing for NPS detection hinges on the investigation's objectives, recent or historical substance use, cost, time, and invasiveness. Given the pervasive presence of NPS in various communities, hair analysis offers a valuable tool for assessing the extent of use among different populations.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychedelic Assisted Psychotherapy (PAP): the Geneva University Hospital model","authors":"F. Seragnoli","doi":"10.1016/j.etdah.2025.100256","DOIUrl":"10.1016/j.etdah.2025.100256","url":null,"abstract":"<div><h3>Introduction</h3><div>Psychedelic Assisted Psychotherapy (PAP) has been legal in Switzerland since 2014 under supervised exceptional medical use with MDMA, LSD and Psilocybin with case by case authorisations delivered from the Federal Office of Public Health. In particular, since 2021, we have implemented a clinical activity at Geneva University Hospital (HUG) for treatment resistant patients using LSD and psilocybin. We hereby present the treatment model we developed and the first clinical results on the treated patients’ population.</div></div><div><h3>Methods</h3><div>Treatment resistant patients diagnosed with depression, anxiety and addiction followed a PAP protocol consisting in preparation, dosing and integration sessions. Cognitive behavioral therapy framework was used to guide these interventions, in order for the psychedelic personal experience session to be inscribed within a psychotherapeutic process involving psychoeducation, objective clarification, and behavioral activation.</div></div><div><h3>Results</h3><div>We present preliminary data on symptom reduction gathered systematically with pre-post validated questionnaires. We discuss cognitive behavioral models to explain the specific characteristics of PAP like: insight, metacognition and general psychotherapeutic factors.</div></div><div><h3>Conclusions</h3><div>PAP is a safe and useful form of psychotherapy which can be applied routinely in a hospital clinical setting. PAP can be used for a variety of diagnoses with treatment resistant patients.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criminalization of New Psychoactive Substances in Poland – Law in the Face of Changing Reality","authors":"K. Tkaczyk-Rymanowska","doi":"10.1016/j.etdah.2025.100258","DOIUrl":"10.1016/j.etdah.2025.100258","url":null,"abstract":"<div><div>In recent years, Poland, like many other European Union countries, has been faced with the phenomenon of the emergence of new psychoactive substances, the rapid chemical turnover of which and the circumvention of classic drug regulations have led to the need to revise the previous legislative approach and drug policy. The poster presents the development of legal instruments for the criminalization of trade in and possession of NPS in Poland. The main legal and practical problems related to the enforcement of regulations have been indicated, including difficulties in defining NPS, legislative delays, and limited effectiveness of repression. Additionally, the challenges related to keeping up with the changing chemical and market reality have been signaled. The conclusion proposes directions for reforms: strengthening the flexibility of the legislative system, developing prevention, and the need to integrating criminal actions with public health policy. Effective combating NPS requires not only repression, but also modern, interdisciplinary response tools.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Cyclohexylpentylone – Newcomer to the NZ Synthetic Drug Market","authors":"C. Black,&nbsp;A. Mayer,&nbsp;B. Copp","doi":"10.1016/j.etdah.2025.100198","DOIUrl":"10.1016/j.etdah.2025.100198","url":null,"abstract":"<div><h3>Introduction</h3><div>In 2024, full structure elucidation was achieved for a novel synthetic cathinone, N-cyclohexyl pentylone. Synthetic stimulants, including cathinones, represent the largest group of NPS and are increasingly dominating the global drug market. These compounds have diverse structures that are difficult to rapidly identify and characterise using screening methods which rely on database comparisons. Due to the rapidly changing landscape of NPS, drug laboratories are struggling to keep up with the rate at which these novel substances are appearing.</div></div><div><h3>Methods</h3><div>The Institute of Environmental Science and Research (ESR) provides assistance to Drug Checking Service providers in instances where identification in the field is unsuccessful. Where a novel substance or structural isomers are encountered, techniques including high-resolution MS and NMR spectroscopy are employed. Results/</div></div><div><h3>Conclusions</h3><div>Characterisation of N-cyclohexylpenylone was achieved and has since been detected on several occasions within New Zealand. This NPS has also emerged in the U.S, demonstrating the need for the development of an analytical strategy for the rapid detection and identification of newly emerging NPS to effectively assist in the protection of public health. It also highlights the need for effective data sharing within the Forensic Community.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking Simulations of Kratom Alkaloids to Serotonin 5-HT Receptors","authors":"T. Mizuguchi","doi":"10.1016/j.etdah.2025.100243","DOIUrl":"10.1016/j.etdah.2025.100243","url":null,"abstract":"<div><h3>Introduction</h3><div>Kratom (Mitragyna speciosa), a tropical plant from the coffee family native to Southeast Asia, has a long history of use as a traditional herbal remedy, particularly for pain relief and mood enhancement. While its opioid-like effects have raised concerns about dependence, emerging research suggests that certain kratom alkaloids also interact with the brain’s serotonin system. Notably, some alkaloids may bind to 5-HT receptors, opening potential avenues for treating conditions such as anxiety, depression, and schizophrenia.</div></div><div><h3>Methods</h3><div>In this study, we employed molecular docking and computer simulations to explore how kratom-derived alkaloids interact with serotonin receptors—particularly the 5-HT1A subtype.</div></div><div><h3>Results</h3><div>We found that mitragynine, kratom’s principal psychoactive compound, exhibits a higher binding affinity to the 5-HT1A receptor than ajmalicine and binds at a distinct site on the receptor, suggesting a unique mechanism of action. By analyzing these structural interactions, we identified key molecular features influencing receptor affinity.</div></div><div><h3>Conclusions</h3><div>Our findings shed light on how kratom alkaloids may modulate serotonergic signaling and support the development of novel kratom-based therapeutics targeting neuropsychiatric disorders.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New substances, new psychoses","authors":"G. Bersani","doi":"10.1016/j.etdah.2025.100196","DOIUrl":"10.1016/j.etdah.2025.100196","url":null,"abstract":"<div><div>Consensual clinical experience indicates that in recent years the spread of an increasingly large and heterogeneous number of psychoactive substances is leading to substantial changes in the phenomenology and course of mental disorders, particularly psychotic disorders. NPS play a central role in this change and contribute, in a powerful yet highly variable manner, to the presence of previously undescribed clinical entities. The clinical constructs of Substance Use Disorder and Dual Diagnosis now appear insufficient to describe the breadth and complexity of the phenomenon. Some new clinical categories have been described, not yet included in official nosographic systems, such as spiceophrenia, synthetic psychosis, lysergic psychoma, hallucinogen persistent perceptual disorder, and others, in an attempt to recognize clinical forms of highly variable psychopathological conditions. In fact, the traditional diagnostic categories of psychiatry, particularly those of psychotic disorders and mood disorders, no longer appear capable of realistically describing the clinical variability of the psychopathological pictures of psychotic patients. Furthermore, it is necessary to consider the marked clinical and outcome changes that the widespread use of psychoactive substances induces in the clinical presentations of patients already suffering from mental disorders, so that the clinical presentations of, for example, schizophrenia or bipolar disorder very often appear significantly altered in their symptomatology and course. On a strictly clinical level, certain psychopathological features appear more consistently associated with the use of psychoactive substances, such as greater severity of paranoid symptoms, high frequency of exacerbations, mood instability, dysregulation of emotions and behavior, early cognitive decline, and resistance to traditional pharmacological treatments. This is a clinical landscape of enormous significance, which shows how the clinical presentations and diagnostic categories of traditional psychiatry have progressively and severely changed.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designer Benzodiazepines and Related Novel Psychoactive Substances (NPS) in Seized Tablets in Ireland 2019-2025","authors":"C. May,&nbsp;J. Carroll,&nbsp;D. Fox,&nbsp;J. Roche,&nbsp;M. Nevin,&nbsp;L. McMenemy,&nbsp;K. Stepniak,&nbsp;J. Roche,&nbsp;R. Kennedy","doi":"10.1016/j.etdah.2025.100241","DOIUrl":"10.1016/j.etdah.2025.100241","url":null,"abstract":"<div><h3>Introduction</h3><div>Benzodiazepines are a widely prescribed medication used to treat anxiety, panic disorders, insomnia and seizures. The misuse of this class of drugs in Ireland has increased over the last eight years with a 70% increase in persons participating in drug treatment programmes being treated for benzodiazepines as the main problem. A recent publication from the Health Research Board (HRB) indicated that benzodiazepines and related NPS were implicated in more than 50% of drug poisoning deaths in Ireland in 2021.</div></div><div><h3>Methods</h3><div>Data collated from Forensic Science Ireland’s (FSI) LIMS system show that FSI receives, on average, almost 700,000 seized benzodiazepine type tablets each year since 2019. Legitimate pharmaceutical presentations are submitted for analysis as well as falsified (fake) pharmaceutical presentations.</div></div><div><h3>Results</h3><div>Data showing the seizure trends during this timeline of many different drugs and NPS will be presented. The changes to the controlled drug law in Ireland and how these have influenced this market will also be presented.</div></div><div><h3>Conclusions</h3><div>Many falsified (fake) pharmaceutical tablets were encountered during this period.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"5 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}