Emerging trends in drugs, addictions, and health最新文献

{"title":"The Synthetic Cannabinoids ADB-FUBINACA Modulate Mitochondrial Function and Dynamics at Biologically Relevant Concentrations During In Vitro Neurodifferentiation","authors":"R.F. Malheiro,&nbsp;H. Carmo,&nbsp;F. Carvalho,&nbsp;J.P. Silva","doi":"10.1016/j.etdah.2023.100104","DOIUrl":"10.1016/j.etdah.2023.100104","url":null,"abstract":"<div><div>Synthetic cannabinoids (SCs) pose a significant risk to neurodevelopment, as they may disrupt the proper brain development by interfering with the endocannabinoid system. Previously, we demonstrated that the SC ADB-FUBINACA (ADB) enhances neurodifferentiation of NG108-15 neuroblastoma x glioma hybrid cells via CB1 receptor activation. Interestingly, the influence of mitochondria on cellular homeostatic responses has emerged as a central regulator of neural stem cell fate. Thus, here we aimed to evaluate the effects of this SC on mitochondrial function and dynamics during in vitro neurodifferentiation. NG108-15 cells were differentiated in serum-starved (1% FBS) cell culture medium supplemented with 30µM retinoic acid and 10µM forskolin. ADB was added once at the beginning of differentiation at in vivo relevant concentration (between 1 pM and 1 µM). Mitochondrial membrane potential (assessed by TMRE labelling) and intracellular ATP levels (luciferase-based luminescence assay) were evaluated after 24h and 72h. Specific cell-permeable or cell-impermeable CB1R antagonists/ inverse agonists (SR141716A and hemopressin, respectively) were added 20 minutes prior to ADB exposure to assess the role of CB1R in the observed effects. The expression of the mitochondrial fission marker dynamin-related protein 1 (DRP1), fusion marker mitochondrial dynamin-like GTPase (OPA1), and Voltage-dependent anion channel (VDAC) was analyzed by Western-blot at 24 or 72h. ADB (1pM and 1nM) reduced intracellular ATP levels by approximately 30-35% at 24h, which returned to control levels after 72h. These effects were mediated by CB1R signaling, as they were prevented by both SR141716A and hemopressin. Reduced intracellular TMRE retention by around 1.2-1.3-fold was observed for all concentrations tested at 72h, but this effect was not blocked by CB1R antagonists. Notably, while the higher concentration of ADB (1 µM) increased DRP1 levels around 1.6-fold at 24h, the levels of OPA1 and VDAC, an indirect marker of mitochondrial mass, decreased by 1.6 to 2.1-fold at 72h after exposure to 1nM and 1 µM. Overall, ADB seems to disrupt both mitochondrial function and dynamics during the neurodifferentiation process of NG108-15 cells. Different mechanisms seem to underlie mitochondrial function-related effects, as only the modulation of energy supply was dependent on CB1R activation. However, further research is thus required to better understand the mechanisms underlying cannabinoids’ modulation of mitochondrial activity and their role in the SCs-induced enhancement of neurodifferentiation.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Self-Report Antipsychotics Side Effects and Depression in Saudi Arabia","authors":"Y. Al Ruthia","doi":"10.1016/j.etdah.2023.100068","DOIUrl":"10.1016/j.etdah.2023.100068","url":null,"abstract":"<div><h3>Introduction</h3><div>The relationship between antipsychotics’ side effects and depression/anxiety among Arabic-speaking patients with different psychiatric conditions has not been examined before. Therefore, the aim of this study was to examine the association between antipsychotics’ side effects and depression and anxiety.</div></div><div><h3>Methods</h3><div>This was a single-centre prospective cross-sectional study in which Arabic-speaking adult (≥18 yrs.) patients, treated with antipsychotics in Riyadh, Saudi Arabia, were recruited. The Arabic versions of the Glasgow antipsychotic side effect scale (GASS), Patient Health Questionnaire 9-item (PHQ-9), and Generalized Anxiety Scale 7-item (GAD-7) were used to measure antipsychotics’ side effects, depression, and anxiety, respectively. Multiple linear regressions were conducted.</div></div><div><h3>Results</h3><div>One-hundred patients consented to participate and were included in the analysis. The mean age of the patients was 38 years, 72% were females, 40% had a college degree or higher, and 73% had no comorbidities. Patients with higher PHQ-9 scores (β=0.883, 95% CI [0.642–1.126], p&lt;0.0001), and GAD-7 scores (β=0.797, 95% CI [0.412–1.182], p&lt;0.0001) were more likely to have higher GASS scores controlling for age, gender, and education.</div></div><div><h3>Conclusions</h3><div>Patients with more severe forms of depression and anxiety are more likely to report higher rates of antipsychotics’ adverse events.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NPS: Challenges and Future Outlooks – the Analytical Toxicologists’ Points of View","authors":"V. Abbate,&nbsp;M. Vigar,&nbsp;C. Watkins,&nbsp;J. Clifford,&nbsp;M. Jones","doi":"10.1016/j.etdah.2023.100061","DOIUrl":"10.1016/j.etdah.2023.100061","url":null,"abstract":"<div><div>In recent years, the global market for novel psychoactive substances (NPS) has continued to grow rapidly, presenting significant challenges for analytical toxicologists. Indeed, the constant emergence and the evolving nature of NPS requires their rapid detection and identification; studies on their pharmacokinetics; and ideally the prediction of future analogues to try and stay ahead of the competition with illicit NPS manufacturers. This presentation will provide an overview, from the analytical toxicologists’ point of view, of the current challenges and future outlooks for detecting, identifying, and predicting NPS. It will explore both recent efforts in my group, and what we plan to do in the near future to tackle the emergence of NPS using multidisciplinary approaches. I will discuss the importance of both emerging analytical tools and techniques, including portable instruments, for the rapid and on-site detection and identification of NPS. Finally, I will briefly mention how computational methods could simplify substance identification and aid in predicting the emergence of NPS. It is hoped that some of the described approaches will have positive implications for public health and safety and will create opportunities to promote exchange between various stakeholders, including basic scientists/toxicologists, clinicians, and policy makers.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saudi Forensic Toxicologists are Paving the Road Toward National and Regional Early Warning Systems (EWS) on the New Psychoactive Substance (NPS)","authors":"F.F. Alzahrani","doi":"10.1016/j.etdah.2023.100069","DOIUrl":"10.1016/j.etdah.2023.100069","url":null,"abstract":"<div><div>The global expansion of NPS encouraged the proposal of alternative policies that seem to be effective in protecting public health. In Europe, the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and Europol, with their partners, operate the EU Early Warning System (EWS), which disseminates information on trends in drug abuse across the EU member states, Turkey, and Norway. Since NPS market is so dynamic, less developed countries, with limited analytical capabilities and lack of legislations, are in danger of NPS outbreak. In Saudi Arabia, we believe that there is a recognized opportunity for more systematic use and timely triangulation of existing data to rapidly assess and identify emerging illicit drug trends. The overarching aim of this scoping study was to determine the feasibility of establishing a national early warning system (EWS). The objectives were to identify existing data sources routinely collected and collated; and identify and describe the data sources feasible for inclusion in an EWS. A national level brainstorming, among forensic toxicologists, was carried out for months through online meetings, conference talks and epidemiological surveys, to identify and convince stakeholders, estimate the possible danger, and promote the idea of establishing a national NPS. From forensic toxicologist point of view, the analytical data of biological samples and seized material strongly suggests that there is an urgent need for national and regional EWSs. In this conference, we would like to share the most recent developments and our long-term goals and future plans. We firmly believe that establishment of a national EWS must be done in close collaboration with the existing international agencies, like the UNODC, the EMCDDA, or the EWS. Also, it must be supported by awareness campaigns showing the dangers of NPS use for potential consumers.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel NPS Monitoring System in Victoria, Australia","authors":"S. Greene,&nbsp;B. Syjanen,&nbsp;S. Hodgson,&nbsp;R. Abouchedid,&nbsp;J. Schumann","doi":"10.1016/j.etdah.2023.100094","DOIUrl":"10.1016/j.etdah.2023.100094","url":null,"abstract":"<div><div>Traditional data sources utilised in monitoring NPS use within a community are limited by slow translation of information, and inability to identify NPS causing actual harm. The Emerging Drugs Network of Australia VIC (EDNAV) is a novel NPS monitoring system collecting clinical and analytical data on patients presenting to a network of 16 metropolitan and regional Emergency Departments with reported or suspected illicit drug toxicity. Blood samples are analyzed using liquid chromatography / mass spectrometry for over 700 common pharmaceutical drugs and NPS. Deidentified clinical and analytical data stored in a secure online clinical registry are synthesised into a weekly report which is utilised by a multi-disciplinary team to identify high risk signals. A novel risk matrix is used to grade severity of signals. Signals classified as threats are translated rapidly into harm reduction messaging and provide to at risk communities through multiple modes of communication. In the past two years, over 2000 acute cases have undergone comprehensive toxicological analysis leading to 750 NPS detections (66 distinct NPS) and the issuance of associated public health alerts, and the characterization of a range of NPS toxicity.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of External Influences on Drug Trends at Music Festivals in New Zealand, 2018 to 2023","authors":"L. Philip,&nbsp;C. Black,&nbsp;G. Powell,&nbsp;L. Clark,&nbsp;C. Johnson,&nbsp;O. Johnson","doi":"10.1016/j.etdah.2023.100108","DOIUrl":"10.1016/j.etdah.2023.100108","url":null,"abstract":"<div><h3>Introduction</h3><div>Changes in the drug trends seen at music festivals in New Zealand may be influenced by factors, such as the availability of the drugs, enforcement activities, media attention and legislative changes to drug checking services. The Institute of Environmental Science and Research Ltd (ESR) was involved in testing samples collected from music festivals since 2018. In 2021, drug checking was legalised and ESR has since become an authorised drug checking provider.</div></div><div><h3>Methods</h3><div>Samples from music festivals in New Zealand between 2018 and 2023 were analyzed for the presence of controlled drugs. Festivals from before the legalisation of drug checking are compared to festivals after drug checking legalisation. Samples were analyzed using a combination of Fourier Transform infrared spectroscopy (FTIR) and/or gas chromatography-mass spectrometry (GC-MS).</div></div><div><h3>Results</h3><div>A summary of the recent trends in drugs collected from music festivals in New Zealand will be presented, along with some possible explanations of the observed changes. This builds from a previous presentation at the NPS conference in 2021.</div></div><div><h3>Conclusions</h3><div>Media attention and enforcement activities may result in temporary changes to the drug landscape seen at music festivals. Similarly, the COVID-19 pandemic had effects on the importation of many substances due to border closures which has shown to influence the availability of some substances available. A third influence on drug trends at music festivals is legislation regarding drug checking services, their availability and accessibility.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NPS: Emerging Trends and its Control Mechanism","authors":"A. Rahman","doi":"10.1016/j.etdah.2023.100115","DOIUrl":"10.1016/j.etdah.2023.100115","url":null,"abstract":"<div><div>Millions and millions peace-starved people, first-hand users of tech-life all over the world are, arguably, facing untold sufferings, derived from trifle affairs to state- concerned issues in terms of injustice, inequality, cruelty, deprivation, unlimited expectations of worldly gains, loneliness, mental slavery, etc. This spectrum of life-style is inevitably changing more and going bad to worse situation as days to come. To mitigate this detrimental phases of life, most people reportedly are taking shelter primarily on drugs, especially on NPS, as a quick panacea. Novel psychoactive substances (NPS) are now dominating in every corner of the world, using as recreational drugs rather than medicinal purpose bypassing traditional drugs to circumvent the international control. Dethroning NPS mobility and reducing its demand, following steps would be actionable so far. Evolving inventions of cutting-edge technology are detaching human being from the Nature and natural things. This phenomenon pushes increasingly mass people to embrace hopelessness, believe less and loneliness mostly of the world. Consequently, they are trying wildly to receive alternatives, especially NPS. Coming back to nature, to emphasize on strengthening the mental, ethical, and spiritual health of human being instead of AI. Paying a plenty of attentions for cementing human values in every family and community will create noteworthy outcome as congenial atmosphere in the society. This situation will contribute to reduce dramatically NPS demand.</div><div>Human being are paying huge cost and receiving untold sufferings owing to drug (NPS) menace. Global connectivity and advanced technology have aggravated the drug-induced problems multi steps ahead. Emerging trends of NPS can be clamped down by reducing demand through establishing values of human being in every lifestyles that would spread a ray of great expectation to build peaceful universe.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Articulation of Masculinities amongst Men who Use(d) Image and Performance Enhancing Drugs","authors":"H.D. Townshend,&nbsp;A. Tippett,&nbsp;O. Corazza,&nbsp;K. van de Ven","doi":"10.1016/j.etdah.2023.100128","DOIUrl":"10.1016/j.etdah.2023.100128","url":null,"abstract":"<div><div>The motivations for consumption of Image and Performance Enhancement Drugs (IPEDs) have been widely explored in recent years, particularly due to the identification of wide-ranging associated public health concerns. The majority demographic of those consuming these substances are men, primarily utilising these substances in pursuit of physical appearance and/or performance goals. Historically, consumers of IPEDs were understood to be those predominantly intent on athletic pursuits, for sporting performance or bodybuilding. More recently, though, there has been greater diffusion of these substances, with growing non-sporting populations consuming them in pursuit of increased muscularity or other body image goals. A novel mixed-methodologies approach consisting of two studies was utilised, consisting of a netnography investigating posts across four major online fitness forums, and a cross-sectional survey investigation, involving an in-depth qualitative analysis utilising images and original data. Results suggest that societal contemporary ideals of the masculine body, particularly as they are presented online and, in the media, are increasingly sexualised. This objectification then fosters the internalisation of body image concerns, ultimately influencing the motivation for the consumption of IPEDs. Hence, it becomes imperative to recognise masculinities as a pivotal focal point for the facilitation of efficient harm reduction strategies and the development of educational resources pertaining to IPEDs.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of the Brazilian Drug Control System: Case Study of ADB-FUBIATA, a Psychotropic NPS","authors":"M.L.S. Macedo,&nbsp;L. dos Santos Lopes,&nbsp;G.H. Giudice,&nbsp;R. de Morais Souza","doi":"10.1016/j.etdah.2023.100103","DOIUrl":"10.1016/j.etdah.2023.100103","url":null,"abstract":"<div><h3>Introduction</h3><div>The New Psychoactive Substances (NPS) market is very dynamic, requiring new legislative approaches to tackle the drug problem. Brazil has improved the Drug Scheduling System, making the process more agile, which allows fast scheduling of NPS. The Working Group conceived between Anvisa and the Ministry of Justice, brings together experts of health regulation, forensics, law enforcement and drug policy, and posed a significant role in evolving the Brazilian Drug Control System.</div></div><div><h3>Methods</h3><div>The Working Group created an online form to facilitate and accelerate drug notification from brazilian Police. Through this tool, in 11/19/2021, Anvisa received a communication regarding the synthetic cannabinoid ADB-FUBIATA, a psychotropic NPS. This molecule was also reported in Brazilian Early Warning System.</div></div><div><h3>Results</h3><div>ADB-FUBIATA is now a prohibited substance. The ban took place about two months after the drug notification.</div></div><div><h3>Conclusions</h3><div>The NPS market continues to shift and diversify at an alarming speed, posing a significant risk to public health and a challenge to drug policy. Brazil has made substance scheduling faster through the implementation of an online notification form and the establishment of an Early Warning System. ADB-FUBIATA is an example of improved communication between those involved with the drug problem.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Psychoactive Substances in Bangladesh: the Urgent Need for Evidence-based Policy and Prevention Measures","authors":"M. Hasan","doi":"10.1016/j.etdah.2023.100096","DOIUrl":"10.1016/j.etdah.2023.100096","url":null,"abstract":"<div><h3>Introduction</h3><div>New Psychoactive Substances (NPS) are a growing public health concern in Bangladesh, with increasing availability and use of these substances among young people and marginalized populations. The lack of a comprehensive and evidence-based approach to prevent and control NPS use poses significant challenges to Bangladesh's national drug policy. This paper aims to highlight the urgent need for evidence-based policy and prevention measures to address the NPS crisis in Bangladesh.</div></div><div><h3>Methods</h3><div>A review of existing literature on NPS use in Bangladesh was conducted to identify the gaps in knowledge and policy. The literature review included studies that evaluated the prevalence, harms, regulatory approaches, and control measures of NPS in Bangladesh.</div></div><div><h3>Results</h3><div>The results of the literature review suggest that NPS use is increasing in Bangladesh, with limited knowledge of the extent and nature of the problem. The regulatory response to NPS is reactive, with a lack of focus on prevention and harm reduction. The limited availability of data on NPS and the lack of an evidence-based approach to policy and prevention measures are significant gaps in addressing the NPS crisis in Bangladesh.</div></div><div><h3>Conclusions</h3><div>The increasing use of NPS in Bangladesh calls for a proactive and evidence-based approach to policy and prevention measures. There is an urgent need for coordinated efforts between regulatory agencies, health professionals, and civil society to prevent and control NPS use. The development of a national strategy for the prevention and control of NPS, along with capacity building of regulatory agencies and health professionals, may be necessary to address the growing threat of NPS in Bangladesh. The findings of this paper highlight the need for further research and collaboration to better understand the trends, harms, and regulatory challenges associated with NPS in Bangladesh.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}