Emerging trends in drugs, addictions, and health最新文献

{"title":"A strategy to prioritize emerging drugs of abuse for analysis: Abuse liability testing using intracranial self-stimulation (ICSS) in rats and validation with α-pyrrolidinohexanophenone (α-PHP)","authors":"Tyson R. Baird ,&nbsp;Rachel A. Davies ,&nbsp;Richard A. Glennon ,&nbsp;Michelle R. Peace ,&nbsp;S. Stevens Negus","doi":"10.1016/j.etdah.2021.100004","DOIUrl":"10.1016/j.etdah.2021.100004","url":null,"abstract":"<div><p>Novel psychoactive substances (NPS) threaten public health and safety while also straining the limited resources of forensic laboratories. To efficiently allocate the finite resources available, we propose a new strategy for prioritizing NPS with abuse liability testing using a preclinical behavioral procedure in rats known as intracranial self-stimulation (ICSS). To validate this assay, the recently-scheduled synthetic cathinone α-PHP was compared to cocaine, a mechanistically similar drug of abuse, as a positive control and saline as a negative control. Male Sprague-Dawley rats (n=6) were implanted with electrodes targeting the medial forebrain bundle and trained to respond by lever-press for electrical brain stimulation. The rats were tested with doses of 0.32, 1.0, and 3.2 mg/kg α-PHP as well as 10 mg/kg of cocaine and saline administered by intraperitoneal injection. Neither saline nor 0.32 mg/kg α-PHP altered ICSS response rates compared to baseline levels of responding; however, doses of 1.0 and 3.2 mg/kg α-PHP and 10 mg/kg cocaine facilitated ICSS responding. This ICSS profile suggests that α-PHP has high abuse potential, with a rapid onset of effects and a long duration of action, and supports the decision to schedule this compound. This study demonstrates the ability of ICSS to distinguish between compounds of low and high potential for abuse. A strategy is proposed here to screen NPS using ICSS and classify emerging drugs into four priority categories for further analysis.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39212729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet sourcing and UK end consumer trend interest in the controlled medicines (opioids, sedatives and GABA drugs) in pre and post COVID-19 timeframes","authors":"Mark Whitfield ,&nbsp;Jennifer Germain ,&nbsp;Alice Hillis ,&nbsp;Devina Halsall ,&nbsp;James McVeigh ,&nbsp;Yasir Abbasi ,&nbsp;Marie Claire Van Hout","doi":"10.1016/j.etdah.2021.100027","DOIUrl":"10.1016/j.etdah.2021.100027","url":null,"abstract":"<div><p>Sourcing and self-medication of medicinal pharmaceuticals including those containing opioids obtained from non-regulated online suppliers is a serious public health issue. The main concerns include a lack of quality control, drug side effects, drug interactions, diversion and possible pathway to drug dependence. The internet offers increased availability and accessibility of these medicines through both legal routes obtaining pharmaceuticals on prescription and illegal routes via websites on both the surface and Dark Web. The impact of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) pandemic reduced face-to face access for non-COVID-19 related health conditions and to drug treatment services. This study provides an overview of the extent of online sourcing of UK controlled medicines (opioids, sedatives and GABA drugs) from unregulated suppliers and estimates of customer interest, in particular focusing on the COVID-19 lockdown period in the UK, where access to some healthcare services was limited. Whilst it was not possible to identify an increase for online searches for controlled medicines over the past five years, or during the COVID-19 period, searches remained plentiful, in particular for oxycodone, morphine and diazepam. This study highlights the need for enhanced pharmacovigilance of non-regulated online suppliers and the imperatives of continued health messaging around the potential abuse of these controlled drugs and the dangers of using sites purporting to be regulated pharmacies.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667118221000258/pdfft?md5=1db955518abf773d686be80db52553d1&pid=1-s2.0-S2667118221000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49615347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and perspectives of the public towards the prevalence and harm associated with counterfeit medicines in Lebanon","authors":"Manale Noun ,&nbsp;Layla Nasr ,&nbsp;Iftikhar Khan ,&nbsp;Basel Arafat ,&nbsp;Sulaf Assi","doi":"10.1016/j.etdah.2021.100019","DOIUrl":"10.1016/j.etdah.2021.100019","url":null,"abstract":"<div><p>The Knowledge about the use of counterfeit medicines in Lebanon is still very limited. Thus, the objective of this study was to evaluate the degree of awareness of counterfeit medicines among the Lebanese population and the harm associated with their consumption. A cross-sectional study based on a questionnaire survey has been applied where a semi-structured survey questionnaire was distributed, between June 2017 and May 2018, among 750 participants from 98 Lebanese areas to assess their awareness regarding counterfeit medicines. Seven hundred and four participants completed the questionnaire. 55.4% purchased medicines regularly. The main sources of medicines were pharmacies (52.6%), government clinics (16.3%) and private clinics (8.7%). The most common purchased medicines were lifesaving ones (80%). In the majority of cases (71.9%), participants could not identify the manufacturer country. Overall, 46.2% of the participants were aware of counterfeit medicines. 5.4% of the participants experienced self-reporting adverse effects, among which 89.5% of cases were reported to pharmacists or other authorities. Despite the risk, 4.7% of participants were willing to buy a potential counterfeit medicine. In fact, 56. 4% of the participants associated low harm level with the use of counterfeit medicines. Despite their awareness of counterfeit drugs-associated risks, the majority of participants tend to buy them again. Informative public health campaign and health professionals training, to prevent counterfeit medicines-associated harms, should be implemented.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54368802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality involving New Psychoactive Substances across Europe, 2016-2017","authors":"Hugo López-Pelayo ,&nbsp;Julian Vicente ,&nbsp;Ana Gallegos ,&nbsp;Andrew McAuley ,&nbsp;Yalçın Büyük ,&nbsp;Martin White ,&nbsp;Isabelle Giraudon","doi":"10.1016/j.etdah.2021.100016","DOIUrl":"10.1016/j.etdah.2021.100016","url":null,"abstract":"<div><h3>Background-Aims</h3><p>New psychoactive substances (NPS) are new narcotic or psychotropic drugs that are not controlled by the drug conventions of the United Nations. In the last 10 years, numerous NPS have been identified in Europe but there is no comprehensive overview of mortality related to them. This study aims to estimate the mortality related to NPS in Europe in 2016 and 2017.</p></div><div><h3>Methods</h3><p>The number of drug-related deaths (DRD) 2016-2017 was retrieved from a) the annual national reports of European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) countries (Statistical Bulletin (2018/2019) and ‘Harms and harm reduction workbooks’ (2017/2018)) and b) EMCDDA Risk Assessment Reports of the EU Early Warning System on several specific NPS (2017-2018). Population data was retrieved from Eurostat (2016/2017). Incidence of DRD and of DRD involving at least one NPS was calculated.</p></div><div><h3>Findings</h3><p>Of all DRD recorded in Europe, 11.7% in 2016 and 18.1% in 2017 involved at least one NPS (NPS-DRD), from 2.7 to 4.9 deaths per million of 15 to 64-year-old inhabitants. Between 2016 and 2017, a significant increase was observed (30%, odds ratio 1.33, CI95% 1.26-1.45, <em>p</em> &lt; 0.0001) and in particular, DRD involving novel benzodiazepines, novel opioids and synthetic cannabinoids (<em>p &lt;</em> 0.0001). In 2016 and2017, 72.8% and 76.8% of cases were concentrated in the UK and Turkey (combined), related mainly to Etizolam and synthetic cannabinoids respectively.</p></div><div><h3>Interpretation</h3><p>In 2017, one in six drug-related deaths in Europe involved NPS, and the proportion and numbers increased from 2016 levels, although three out of four cases were concentrated in only two countries and a few substances. To fully understand the public health implications of NPS, further monitoring on NPS-DRD and their distribution in Europe is needed.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54369276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of two potent synthetic opioids carfentanil and 3-methylfentanyl in forensic investigations during a four-year period 2017‒2020","authors":"Carolina Noble ,&nbsp;Donna M. Papsun ,&nbsp;Stephanie Diaz ,&nbsp;Barry K. Logan","doi":"10.1016/j.etdah.2021.100022","DOIUrl":"10.1016/j.etdah.2021.100022","url":null,"abstract":"<div><p>There has been an alarming increase of novel synthetic opioids (NSOs) in the illegal drug market since 2016. These substances are still detected in forensic case investigations in biological samples as well as in seized materials. Although NSOs are steadily emerging, other potent “old” synthetic opioids are still circulating and involved in fatal overdose cases. This is the case of the potent designer drugs carfentanil and 3-methylfentanyl. These drugs were associated with several deaths since at least 20 years ago, and they are still a public health threat.</p><p>In this study, we presented postmortem (PM) forensic cases that were positive for carfentanil or 3-methylfentanyl over a four-year period 2017–2020. Quantitative confirmation was via a quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS)-based method that targets 21 designer opioids, able to differentiate isomers such as cis- and trans-3-methylfentanyl, with a limit of quantification of 0.05 ng/mL.</p><p>A total of 1136 and 153 PM cases were received in the laboratory from different regions of the United States positive for carfentanil and 3-methylfentanyl, respectively. PM peripheral blood ranged from 0.050‒32 ng/mL for carfentanil, and 0.057‒7.2 and 0.057‒2.2 ng/mL for cis- and trans-3-methylfentanil, respectively. During this period, fentanyl was the most common concomitant drug detected within these cases. Heroin and cocaine were also highly prevalent in those cases positive for carfentanil. Other NSOs such as 2-furanylfentanyl, cyclopropylfentanyl and para-fluorobutyrylfentanyl were also significant findings in positive carfentanil cases. For 3-methylfentanyl, cocaine was the second most prevalent co-occurrence drug, while heroin decreased over the years in those cases where 3-methylfentanyl was confirmed.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48957114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing the new open access Journal Emerging Trends in Drugs, Addiction, and Health","authors":"K.P.C. Kuypers ,&nbsp;F.S. Bersani ,&nbsp;R. Bruno ,&nbsp;B.K. Vicknasingam ,&nbsp;A. Roman-Urrestarazu ,&nbsp;O. Corazza","doi":"10.1016/j.etdah.2020.100001","DOIUrl":"https://doi.org/10.1016/j.etdah.2020.100001","url":null,"abstract":"","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2020.100001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71790379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fitspiration on social media: Body-image and other psychopathological risks among young adults. A narrative review","authors":"Ilaria Cataldo ,&nbsp;Ilaria De Luca ,&nbsp;Valentina Giorgetti ,&nbsp;Dorotea Cicconcelli ,&nbsp;Francesco Saverio Bersani ,&nbsp;Claudio Imperatori ,&nbsp;Samira Abdi ,&nbsp;Attilio Negri ,&nbsp;Gianluca Esposito ,&nbsp;Ornella Corazza","doi":"10.1016/j.etdah.2021.100010","DOIUrl":"https://doi.org/10.1016/j.etdah.2021.100010","url":null,"abstract":"<div><h3>Background</h3><p>The use of social media is popular in the health and the beauty industry, with an increasing number of brands using web platforms to promote their products. Among the recently-emerged trends, “fitspiration” (also abbreviated as “fitspo”) has raised health concerns. Evidence suggested that fitspiration contents, although originally conceived to promote a healthier lifestyle, often portray distressful themes that can lead to unhealthy thoughts and behaviours (e.g., body image and eating disturbances, excessive exercising, misuse of supplements). Despite its popularity, the knowledge on this trend is limited and relatively few studies explored its psychological impact on young people below 25-year-old.</p></div><div><h3>Methods</h3><p>A narrative literature search was conducted in order to provide an overview of the evidence linking fitspiration trends on social media to mental health disturbances.</p></div><div><h3>Results</h3><p>Various factors related to psychopathological risks have been associated with the exposure to fitspiration contents, which we have clustered in the following main topics: (i) exercise addiction and compulsive exercise; (ii) body dissatisfaction and objectification; (iii) appearance-related anxiety and depressive symptoms, self-esteem; (iv) excessive control of eating habits; (v) use of enhancing drugs; (vi) quality of life.</p></div><div><h3>Conclusion</h3><p>A wide range of negative psychological effects associated with fitspiration contents on social media were identified. Additional research is required to further elucidate the phenomenon, to determine the extent of the harm for young people, and to develop preventive mental health strategies.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71790363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illicit substances detected through high-resolution MS analysis in urine samples are associated with greater symptom burden in patients with psychosis","authors":"Silje Skrede ,&nbsp;Jon Andsnes Berg ,&nbsp;Kjell Ove Fossan ,&nbsp;Christoffer Bartz-Johannessen ,&nbsp;Else-Marie Løberg ,&nbsp;Rune Andreas Kroken ,&nbsp;Erik Johnsen","doi":"10.1016/j.etdah.2021.100024","DOIUrl":"10.1016/j.etdah.2021.100024","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence of new psychoactive substances (NPS) in acute psychotic patients has not been investigated systematically. We applied a highly sensitive and specific mass spectrometry method for detection of NPS as well as traditional drugs of abuse (including illicit or prescription substances) in order to assess their prevalence and associations with symptom severity. Identification of these substances is useful in both the diagnostic process and evaluation of treatment effects.</p></div><div><h3>Methods</h3><p>Demographic data, results from the Positive and Negative Syndrome Score (PANSS) and Calgary Depression Scale for Schizophrenia (CDSS) and urine samples from admission were collected from 53 patients recruited into a clinical study of psychosis during 2014-2017. Urine samples were analysed with liquid chromatography high resolution mass spectrometry (LC-QTOF-MS), through both highly specific detection of 191 substances using internal standards and untargeted screening by means of pre-defined libraries. PANSS and CDSS scores in patients with or without drugs of abuse were compared.</p></div><div><h3>Results</h3><p>Potential drugs of abuse, i.e. drugs that could be used in a controlled therapeutic or a non-prescribed manner, were detected in samples from 20 of the 53 patients. Seven samples contained illicit drugs, but no NPS were detected. In this small patient subgroup, PANSS total score and CDSS score were significantly higher than in patients with negative urine sample results.</p></div><div><h3>Conclusion</h3><p>Drug screening could play an important role in the differential diagnostic evaluation of patients admitted with psychotic symptoms. Although no NPS were detected in the study population, we found other substances that were associated with psychotic and depressive symptoms.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54368835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study to assess the cardiovascular risk of chronic cannabis smoking through electrocardiograph (ECG)","authors":"Pawan Kumar Shukla ,&nbsp;Rishi Sharma ,&nbsp;Raviprakash Meshram ,&nbsp;Anindya Das ,&nbsp;Binaya Kumar Bastia","doi":"10.1016/j.etdah.2021.100026","DOIUrl":"10.1016/j.etdah.2021.100026","url":null,"abstract":"<div><h3>Background</h3><p>Cannabis is one of the most consumed illicit drugs in India. Long term effects of cannabis smoking on the cardiovascular system are still not fully known. The present study explores cardiovascular abnormalities in asymptomatic cannabis smokers by comparing their electrocardiogram (ECG) with tobacco smokers and non-smokers.</p></div><div><h3>Methods</h3><p>The study included 50 participants in each of the three groups: cannabis, tobacco and non-smokers, between the age group 18–40 years. ECG was recorded and the following parameters were compared: Age, Heart rate, RR-interval, P-wave, PR-interval, QRS-complex, QT-interval, QTc-interval, ST-segment and T-wave duration.</p></div><div><h3>Results</h3><p>The mean age of cannabis smokers, tobacco smokers, and non-smokers were 26.44, 31.22 and 31.34, respectively. Cannabis smokers were younger than tobacco smokers and non-smokers. All the participants reported to us were males. The QRS complex duration was shortened in cannabis smokers compared to tobacco smokers. The ST-segment duration was shorter among tobacco smokers compared to non-smokers.</p></div><div><h3>Conclusions</h3><p>The study proposes cannabis as a potential risk factor for adverse cardiac events as an acute and chronic effect. Clinicians could also use our findings to correlate cardiac complaints of a cannabis dependent patient. ECG could be a quick and affordable modality for investigating such patients. The subjects of the cannabis group had younger age than subjects of the other groups.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667118221000246/pdfft?md5=1825b94101fc174dd90538f74c635b1e&pid=1-s2.0-S2667118221000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54368869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the dad–A review on the biopsychosocial influences of drug abuse on father-infant interaction","authors":"Jovin Jie Ning Lee ,&nbsp;Ilaria Cataldo ,&nbsp;Aurora Coppola ,&nbsp;Ornella Corazza ,&nbsp;Gianluca Esposito","doi":"10.1016/j.etdah.2021.100015","DOIUrl":"10.1016/j.etdah.2021.100015","url":null,"abstract":"<div><p>Substance use disorder (SUD) is an issue of concern that can have inter- generational impacts. Fathers affected by this disorder can exhibit atypical parenting that leaves pronounced, adverse consequences for the child, espe cially during a critical window for development, such as neonatal life and infancy. However, factors sustaining paternal drug use and its associated health outcomes remain elusive. The present review provides a systematic literature search of the scientific evidence published until February 2021 on PubMed Central, Scopus, PsycInfo, and PubMed databases. Adopting a biopsychosocial model, this review provides comprehensive insights into the issue, detailing: (i) the neurobiological correlates of paternal substance use and atypical parenting mechanisms, (ii) influence of drug consumption on paternal psychological state, and (iii) the social environment modulating the social dynamics central to fathers with SUD. Attention is also paid to the bidirectional relationships between paternal drug abuse and fatherhood, which has been severely neglected so far. Findings shed new light on the importance of paternal contributions to the father-child interaction, supporting the formulation of more targeted multidisciplinary interventions aimed at restoring such a crucial and overlooked relationship.</p></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"1 ","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.etdah.2021.100015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54369266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}