Addiction Biology最新文献

{"title":"Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter","authors":"Yizhou Ma,&nbsp;Ashley Acheson,&nbsp;Corneliu Bolbocean,&nbsp;Mustafa N. Mithaiwala,&nbsp;Si Gao,&nbsp;Neda Jahanshad,&nbsp;Paul M. Thompson,&nbsp;Bhim M. Adhikari,&nbsp;Xiaoming Du,&nbsp;A. Ankeeta,&nbsp;Alia Warner,&nbsp;Antonio F. Pagán,&nbsp;L. Elliot Hong,&nbsp;Peter Kochunov","doi":"10.1111/adb.70089","DOIUrl":"https://doi.org/10.1111/adb.70089","url":null,"abstract":"<p>Family history (FH) of substance use disorders (SUDs) and stressful life events (SLEs) are known risk factors for SUDs in adolescents and young adults. Cross-sectional studies suggest that FH and SLEs affect adolescent white matter (WM) development and form abnormal WM patterns. Here, we examined the effects of FH, SLEs and their interaction on WM integrity in youths in the Adolescent Cognitive Brain Development (ABCD) study at baseline and 2- and 4-year follow-ups. ABCD youths (<i>N</i> = 8939, age ± SD = 9.9 ± 0.6 years, 4302 female) completed baseline diffusion tensor imaging, of which 5661 repeated the scan at 2-year follow-up (age ± SD = 12.0 ± 0.7 years, 2634 female) and 2177 at 4-year follow-up (age ± SD = 14.1 ± 0.7 years, 1007 female). FH was measured as the weighted sum of biological parents and grandparents with alcohol and/or drug problems. SLEs were measured with parental report of life events. WM integrity was measured with fractional anisotropy (FA) of 23 WM tracts. Linear mixed effect models were used to examine the effects of FH, SLEs and their interaction on FA at baseline and longitudinally, modelling family and study site as random intercepts and correcting for multiple comparisons with false discovery rate (FDR) <i>q</i> = 0.05. At baseline, there were no significant effects of FH, SLEs and their interaction on FA after multiple comparison correction when controlling for race, family income and parental education. From baseline to 4-year follow-up, FH significantly negatively interacted with newly occurred SLEs on FA in 19 out of 23 tracts, so that FA at 4-year was lower in youths with both FH and newly occurred SLEs when controlling for baseline FA (<i>β</i>_interaction = −0.049 − −0.018, <i>p</i>_FDR = 6.2 × 10⁻⁵ − 4.7 × 10⁻²). These negative interactions were not significant with shorter time spans (baseline to 2-year follow-up and 2- to 4-year follow-up). In conclusion, we replicated findings from cross-sectional cohorts of the effects of FH and SLEs on lower WM integrity in youths. The study utilized Big Data longitudinal design to show that FH-by-SLE interaction, rather than their independent effects was responsible for developmental WM changes associated with FH of SUDs and life stressors.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Synaptic Activity in the Basolateral Amygdala Is Associated With an Alcohol Use Disorder-Like Vulnerable Phenotype in Male Rats","authors":"Davide Cadeddu,&nbsp;Erika Lucente,&nbsp;Mia Ericson,&nbsp;Bo Söderpalm,&nbsp;Louise Adermark,&nbsp;Ana Domi","doi":"10.1111/adb.70091","DOIUrl":"10.1111/adb.70091","url":null,"abstract":"<p>Alcohol use disorder (AUD) is associated with a loss of control over alcohol use, putatively driven by maladaptive changes in neural circuitries, including the basolateral amygdala (BLA). The BLA, known for its role in emotional regulation and associative learning, contributes to the reinforcement of alcohol-related behaviours, making it a critical target for understanding the underlying mechanisms of vulnerability to AUD. To further outline the role of BLA neurotransmission in AUD, we combined a multisymptomatic 0/3 criteria rodent model with electrophysiological whole-cell recordings to identify the association between neurophysiological parameters in the BLA and vulnerability to AUD-like progression. Our results demonstrate that when assessed after 4 months of voluntary alcohol consumption, rats can be subcategorized as resilient or vulnerable to AUD-like behaviour. Electrophysiological recordings, performed directly after alcohol self-administration, demonstrated that rats manifesting an AUD-like vulnerable phenotype presented a reduced frequency and amplitude of spontaneous excitatory post-synaptic currents (sEPSCs), indicating suppressed activation via glutamatergic inputs. Disinhibition induced by GABAA receptor antagonist did not differ between groups, and field potential recordings demonstrated reduced stimulus/response curves further supporting a hypoglutamatergic state. Additionally, the intrinsic excitability of BLA neurons was selectively decreased in vulnerable rats compared to both resilient and water control rats. Importantly, addiction score correlated with both synaptic transmission and intrinsic excitability of BLA neurons. Overall, our findings suggest that hypoexcitability of BLA neurons may represent a neurobiological underpinning that contributes to the development and persistence of alcohol addiction-like behaviours following protracted alcohol exposure.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Connectivity of the Cingulate Cortex in Alcohol Use Disorder: Exploring Its Association With Mindfulness","authors":"Niklaus Denier,&nbsp;Kevin Zahnd,&nbsp;Maria Stein,&nbsp;Franz Moggi,&nbsp;Zeno Kupper,&nbsp;Andrea Federspiel,&nbsp;Roland Wiest,&nbsp;Matthias Grieder,&nbsp;Leila M. Soravia,&nbsp;Tobias Bracht","doi":"10.1111/adb.70036","DOIUrl":"https://doi.org/10.1111/adb.70036","url":null,"abstract":"<p>Alcohol use disorder (AUD) represents a significant challenge in mental health. Severe AUD is characterized by uncontrolled alcohol consumption and is associated with dysregulation in brain circuits responsible for reward, motivation, decision-making, affect, and stress response. Mindfulness is known to positively influence those dysregulations and may enhance abstinence-related self-efficacy (confidence in resisting alcohol consumption), which is one of the best predictors for abstinence following inpatient treatment. Large-scale networks underlie mindfulness, including the default mode and salience network. This study aims to investigate the role of the cingulum bundle (CB) in patients with AUD, which bridges these two networks in relation to mindfulness and abstinence-related self-efficacy. We conducted a study with 39 recently abstinent inpatients with AUD and 18 healthy controls. Mindfulness and self-efficacy were assessed using standardized and validated self-report questionnaires. Structural and resting state functional magnetic resonance imaging (MRI) data were acquired to examine structural and functional connectivity of the cingulate cortex. Our findings showed reduced structural and functional connectivity of the CB in AUD patients with a highly positive association between these metrics. Overall, mindfulness correlated strongly with abstinence-related self-efficacy. We found no association of trait mindfulness and structural and functional findings of the cingulate cortex. However, exploratory analyses suggest a positive association between CB number of streamlines and mindfulness factors ‘acceptance’ and ‘decentring’, and abstinence-related self-efficacy. This is the first study indicating that patients with AUD have structural and functional impairments of the CB. These alterations could be associated with reduced mindfulness and self-efficacy.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PACAP Signalling Network in the Nucleus Accumbens Core Regulates Reinstatement Behaviour in Rat","authors":"Samrat Bose,&nbsp;Gregory Simandl,&nbsp;Evan M. Hess,&nbsp;Linghai Kong,&nbsp;Nicholas J. Raddatz,&nbsp;Brian Maunze,&nbsp;SuJean Choi,&nbsp;David A. Baker","doi":"10.1111/adb.70090","DOIUrl":"10.1111/adb.70090","url":null,"abstract":"<p>Cocaine use disorder (CUD) lacks FDA-approved treatments, partly due to the difficulty of creating therapeutics that target behaviour-related neural circuits without disrupting signalling throughout the brain. One promising candidate for circuit-selective neuromodulation is pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide with pleiotropic behavioural actions whose signalling network spans the gut–brain axis. Here, we investigated the potential existence and function of an endogenous PACAP signalling network within the nucleus accumbens core (NAcc), which is a structure that integrates emotional, cognitive and reward processes underlying behaviour. We found that PACAP and its cognate receptor, PAC1R, are endogenously expressed in the rat NAcc and that PACAP mRNA is present in medial prefrontal cortical projections to the NAcc. Behaviourally, intra-NAcc infusions of PACAP_1–38 (450 ng/500 nL) did not induce seeking behaviour. Instead, it blocked cocaine-primed reinstatement (10 mg/kg, intraperitoneal [ip]). Intra-NAcc PACAP_1–38 (450 ng/500 nL) also blocked reinstatement driven by coinfusion of the D1-like dopamine receptor agonist (SKF81297, 3 μg/500 nL) but not the D2-like dopamine receptor agonist (sumanirole, 100 ng/500 nL). These findings are notable because previous studies have shown D1-like and D2-like dopamine receptors in the NAcc regulate distinct processes and circuits. Collectively, these studies provide novel insights into the behaviour-modulating actions of central PACAP signalling within the NAcc. Taken together with prior findings, the results underscore the need for additional research to reveal the precise behavioural processes and mechanisms that can be regulated by the full PACAP signalling network, which may reveal how to target this system to develop targeted therapeutics.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitual Drug Intake Is Hard to Change: On the Discussion About Habits and Compulsions in Drug Addiction","authors":"Andreas Heinz,&nbsp;Stefan Gutwinski,&nbsp;Eva Friedel,&nbsp;Nadja Samia Bahr,&nbsp;Rainer Spanagel,&nbsp;Gaetano Di Chiara","doi":"10.1111/adb.70081","DOIUrl":"https://doi.org/10.1111/adb.70081","url":null,"abstract":"&lt;p&gt;In our recent opinion paper in &lt;i&gt;Addiction Biology&lt;/i&gt; ‘Does compulsion explain addiction’? [&lt;span&gt;1&lt;/span&gt;], we criticize that compulsive behaviour as defined primarily from the perspective of animal experimentation falls short of the clinical phenomenon. In particular, we argue that animal models of compulsion with immediate punishment do not adequately reflect long-term negative outcomes in human addiction. We also discuss that compulsive behaviour in OCD and addiction differ phenomenologically. Finally, we opine that human drug use can become a habit, but this does not imply a general loss of goal-directed decision-making. Instead, we claim that ‘individuals with drug addiction are neither automatons carrying out habitual behaviour without cognitive control nor merely individuals making bad choices’. Altogether, we conclude that habit formation can contribute to drug intake, as long as habitual behaviour is regarded as dimensionally but not categorically different from goal-directed decision-making and modifiable by human cognition. This statement is supported by studies from the ReCoDe consortium [&lt;span&gt;2&lt;/span&gt;] and by a recent meta-analysis of the habit construct in animal models of alcohol use disorder [&lt;span&gt;3&lt;/span&gt;], which did not indicate a strict habit-goal dichotomy. Instead, this meta-analysis suggests (i) a nuanced transition between goal directed and habitual decision making and (ii) distinguishes habitual responding from compulsivity [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Karen Ersche [&lt;span&gt;4&lt;/span&gt;] criticizes our paper and suggests that OCD and addiction have more in common than we describe. She states that positive and negative reinforcement are associated with both drug intake and OCD, with which we agree. However, we disagree with Ersche's definition of compulsion as ‘ongoing actions that have become inappropriate to the immediate context’, because this definition is too broad and would, for example, include behaviours observed in bipolar and psychotic disorders unrelated to both OCD and addiction.&lt;/p&gt;&lt;p&gt;At one point, Ersche seems to confuse our criticism of the concept of compulsion in addiction with Lee Hogarth's criticism of the habit construct when she directly refers to one of his publications [&lt;span&gt;5&lt;/span&gt;] which, however, was not cited in our opinion paper. In fact, we are not simply ‘rejecting’ the habit theory of addiction. Instead, we argue that the dual-system approach posits a categorical distinction between a habit and a goal-directed brain system, whereas nuanced transitions between these behavioural control systems occur in animals [&lt;span&gt;3&lt;/span&gt;] and humans [&lt;span&gt;6&lt;/span&gt;]. Thus, we argue that there is no overall loss of goal-directed behaviour, nor a general over-reliance on habits in individuals with drug addiction, but drug use itself can become a ‘habit’, that is, a bias toward drug-seeking in certain (e.g., stressful) circumstances [&lt;span&gt;7&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Lee Hogarth [&lt;span&gt;8&lt;/span&gt;] challenges our claim that","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 10","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect and Mechanism of Magnesium Valproate on Methamphetamine-Addicted Rats","authors":"Yuanrong Li,&nbsp;Lixin Wang,&nbsp;Youhui Sun,&nbsp;Xuyi Wang","doi":"10.1111/adb.70084","DOIUrl":"https://doi.org/10.1111/adb.70084","url":null,"abstract":"<p>Valproate may hold promise as a treatment for addiction. However, there are limited studies examining the effects of magnesium valproate (VPA-Mg) on methamphetamine (MA) addiction, and the relevant mechanisms have not been thoroughly discussed. This study aims to explore the potential therapeutic effects of VPA-Mg on MA addiction and to investigate its possible mechanisms. The effects of VPA-Mg on MA addiction were investigated using conditioned place preference (CPP) and behavioural sensitisation models in rats. VPA-Mg was administered during CPP formation and extinction phases to evaluate its effects on MA-induced CPP formation and reinstatement. Behavioural sensitisation assessed the impact of VPA-Mg during sensitisation induction and expression phases, with spontaneous activity and MA dosing optimised beforehand. Furthermore, western blotting was performed on brain regions including the prefrontal cortex (PFC), hippocampus (Hip), nucleus accumbens (NAc) and ventral tegmental area (VTA) to measure glycogen synthase kinase 3 beta (GSK-3β) and dopamine transporter (DAT) protein levels. VPA-Mg did not exhibit a significant impact on MA-induced CPP formation. VPA-Mg significantly reduced the establishment and expression of MA-induced behavioural sensitisation (<i>p</i> &lt; 0.01). Pre-treatment with VPA-Mg for 3 days before the expression period also inhibited sensitisation (<i>p</i> &lt; 0.05). In addition, the ratio of p-GSK-3β to t-GSK-3β in the PFC, Hip and VTA of rats with behavioural sensitisation significantly decreased, and the expression of DAT decreased significantly (<i>p</i> &lt; 0.01). VPA-Mg can reverse the increase in GSK-3β activity in the Hip and the decrease in DAT in the PFC and Hip caused by repeated MA use (<i>p</i> &lt; 0.05). VPA-Mg exhibits anti-addictive effects on MA dependence and relapse prevention. GSK-3β activation and DAT downregulation in addiction-related brain regions (PFC, Hip, VTA) are closely linked to MA addiction, suggesting potential therapeutic targets. VPA-Mg may exert its effects by modulating these pathways, particularly in the PFC and Hip.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons","authors":"Michaela E. Price,&nbsp;Hailey X. Egido-Betancourt,&nbsp;Sarah E. Sizer,&nbsp;Brian P. Parrish,&nbsp;Nancy J. Alexander,&nbsp;Kimberly F. Raab-Graham,&nbsp;Brian A. McCool","doi":"10.1111/adb.70080","DOIUrl":"https://doi.org/10.1111/adb.70080","url":null,"abstract":"<p>Unique populations of basolateral amygdala (BLA) neurons regulate anxiety and reward through projections targeting downstream regions like the bed nucleus of the stria terminalis (BNST) and nucleus accumbens (NAC). We showed previously that withdrawal from chronic ethanol exposure (CIE/WD) produced population- and sex-specific alterations to distinct glutamatergic inputs. The current study examined GABAergic function in these distinct populations (BLA^NAC and BLA^BNST neurons). We found that CIE/WD diminished feed-forward GABA release from lateral paracapsular cells (LPCs) specifically onto male BLA^NAC neurons. Pharmacological manipulations showed this dysregulation was caused by the enhanced activity of μ-opioid receptors. CIE/WD did not alter evoked GABA release from local interneurons onto either population. However, females expressed greater GABA release from these local interneurons compared to males. Immunostaining and confocal microscopy revealed lower colocalization between the GABA vesicular transporter, vGAT and parvalbumin in females, indicating that greater GABA releases from local interneurons in this sex may be a compensatory response to lower levels of perisomatic innervation by PV⁺ interneurons. Consistent with this, there were no sex differences related to spontaneous GABAergic synaptic events although CIE/WD decreased their frequency specifically in BLA^BNST neurons from both sexes. Altogether, these findings demonstrate that CIE/WD dynamically alters GABAergic function in an input-, sex- and population-specific fashion. Moreover, there are basal sex differences in both the anatomy of BLA GABAergic synapses and their function.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Interleukin-1β in Whole Blood as a Candidate Biomarker for Alcohol Use Disorder Risk Based on AUDIT Scores","authors":"Irina Balan,&nbsp;Alejandro G. Lopez,&nbsp;Thomas Gilmore,&nbsp;Michael Bremmer,&nbsp;Todd K. O'Buckley,&nbsp;Kai Xia,&nbsp;Christian S. Hendershot,&nbsp;A. Leslie Morrow","doi":"10.1111/adb.70088","DOIUrl":"10.1111/adb.70088","url":null,"abstract":"<p>Alcohol use disorder (AUD) is associated with chronic inflammation and immune dysregulation, yet no validated immune-based markers exist to support assessment or monitoring. This study identifies interleukin-1 beta (IL-1β) in whole blood as a promising candidate biomarker of AUD risk, based on Alcohol Use Disorders Identification Test (AUDIT) scores. Twenty-eight non–treatment-seeking adults, with AUDIT scores between 2 and 22, provided whole blood samples. We aimed to identify biomarkers that signal immune changes associated with early AUDIT score risk, where interventions may be most effective. Luminex multiplex immunoassays quantified 14 immune-related mediators in combined cell lysates and supernatants. IL-1β, IL-18, IL-7 and CCL11 were significantly elevated in individuals with higher AUDIT scores. IL-1β showed the largest effect size (Cohen's <i>d</i>) and was the most consistent predictor of both AUDIT and AUDIT-Consumption (AUDIT-C) scores across random forest and linear regression analyses. Moderated multiple regression (MMR) confirmed that IL-1β predicted both scores independent of other immune mediators. Receiver operating characteristic (ROC) analyses demonstrated discriminative potential, with IL-1β achieving an AUC of 0.81 (good discrimination) for AUDIT ≥ 6 (true positive rate [TPR] = 0.71; false positive rate [FPR] = 0.14) and an AUC of 0.94 (excellent discrimination) for AUDIT-C thresholds (TPR = 0.80; FPR = 0.00). Principal component analysis (PCA) revealed greater immune variability in the high-risk group, particularly among proinflammatory mediators, suggesting immune dysregulation. This study demonstrates the utility of integrating whole blood immune profiling with high-sensitivity multiplex immunoassays, and applying both traditional statistical methods and machine learning to explore potential biomarkers for AUD risk. IL-1β is a statistically robust and clinically relevant candidate biomarker of AUD risk assessed by AUDIT scores. These findings require replication in larger, independent samples to determine their translational potential in addiction medicine.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of LVV-H7 in Alcohol-Induced Reward Mechanisms","authors":"Przemyslaw Mielczarek,&nbsp;Kinga Hartman,&nbsp;Eagle Yi-Kung Huang,&nbsp;Ewa Gibula-Tarlowska,&nbsp;Pawel Grochecki,&nbsp;Tymoteusz Slowik,&nbsp;Jolanta H. Kotlinska,&nbsp;Jerzy Silberring,&nbsp;Anna Drabik","doi":"10.1111/adb.70086","DOIUrl":"https://doi.org/10.1111/adb.70086","url":null,"abstract":"<p>This study aimed to investigate the role of LVV-hemorphin-7 (LVV-H7) in alcohol dependence. LVV-H7 is a short peptide derived from the cleavage of haemoglobin chains that binds to opioid receptors and plays diverse roles in various physiological and pathological processes. Additionally, LVV-H7 is cleaved at higher concentrations in the presence of alcohol. We conducted behavioural experiments in animal models and performed proteomic analyses of CNS tissues from alcohol-addicted rats to identify LVV-H7 binding partners. Using fluorescent microscopy, we confirmed the blood–brain barrier (BBB) permeability of synthesized LVV-H7 and its releasing enzyme inhibitor, pepstatin. Our results revealed a dose-dependent correlation between LVV-H7 quantities and alcohol levels. Mass spectrometry-based analyses identified LVV-H7's protein-binding targets in CNS tissues of addicted rats and the enzymes responsible for their degradation. These findings highlight the significant role of LVV-H7 in the mechanisms underlying alcohol dependence and indicate the potential role of hemorphin as a therapeutic target.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Different Sports on Reducing Mobile Phone Addiction: A Systematic Review and Network Meta-Analysis","authors":"Ying Li,&nbsp;Jianhua Zhang,&nbsp;Zhaojun Luo,&nbsp;Dan Tao,&nbsp;Lizhong Wen","doi":"10.1111/adb.70087","DOIUrl":"https://doi.org/10.1111/adb.70087","url":null,"abstract":"<p>This study employed network meta-analysis to evaluate the impact of several exercise interventions on mobile phone addiction. The aim is to determine the most effective exercise intervention measures and establish a reference for future intervention measures to improve mobile phone addiction. We systematically searched the relevant literature on the Web of Science, PubMed, Embase, Cochrane Library, China Knowledge, Wanfang and other domestic and foreign databases. We assessed the risk of bias according to the revised Cochrane Randomised Trial Bias Risk tool and performed traditional and Web-based meta-analyses using Review Manager 5.3 and Stata 14.0. The traditional meta-results showed that exercise intervention was superior to the control group in improving mobile phone addiction (SMD = −1.05, 95%CI −1.62, −0.48). Network meta-analysis results show that aerobic exercise (AE) is superior to other sports in reducing the total score of mobile phone addiction among teenagers, and the probability of aerobics becoming the best intervention for mobile phone addiction among teenagers is the highest (SUCRA = 95.6%). Exercise intervention can reduce the score of mobile phone addiction, while AE has more advantages in improving mobile phone addiction. However, due to the influence of sample size and the quality of the included literature, it is recommended that the results be further verified in the future.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 9","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}