Addiction Biology最新文献

{"title":"Using Passive Sensing to Isolate a Biosignature for Craving Among Individuals in Early Alcohol Use Disorder Recovery","authors":"Sara Mei,&nbsp;Noah N. Emery,&nbsp;David Eddie","doi":"10.1111/adb.70182","DOIUrl":"10.1111/adb.70182","url":null,"abstract":"<p>Craving is one of the most robust proximal predictors of both treatment dropout and relapse during early recovery for alcohol use disorder (AUD). Craving can onset rapidly, and the ability to accurately detect or modulate cravings varies significantly within- and between-persons. Because of this, craving management is a central feature of most current AUD treatment models. However, impaired interoceptive awareness, which is common in early AUD recovery, can stymie individuals' capacity to implement craving management strategies. Measurement and detection of craving through passive biosensor monitoring could support novel just-in-time adaptive interventions that can mitigate this vulnerability. This study sought to characterize the biosignatures of craving through the measurement of heart rate variability (HRV) using a combination of ambulatory electrocardiogram (ECG) monitoring and ecological momentary assessment (EMA) in individuals in the first year of a current AUD recovery attempt (<i>N =</i> 40, observations = 400). A multilevel negative binomial regression analysis was conducted to estimate correlations between craving and HRV. Results demonstrated that, at the within-person level, high-frequency HRV (HF-HRV; <i>IRR =</i> 1.01, <i>p</i> = 0.013) and SD1 (<i>IRR =</i> 0.97, <i>p</i> = 0.020) were associated with craving at the same moment. Findings highlight HRV as a viable target for passive monitoring in interventions aimed at supporting craving mitigation in early AUD recovery, particularly at the momentary level.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Functional Connectivity in the Reward Circuit in Betel Quid-Dependent Chewers","authors":"Yuegui Cao,&nbsp;Sisi Chen,&nbsp;Jiayu Li,&nbsp;Lingyu Kong,&nbsp;Jincheng He,&nbsp;Fulai Yuan,&nbsp;Jing He,&nbsp;Xueling Zhu","doi":"10.1111/adb.70180","DOIUrl":"10.1111/adb.70180","url":null,"abstract":"<p>Betel quid (BQ) is classified as a Group 1 carcinogen, underscoring a significant public health challenge. Neuroimaging evidence demonstrated that betel quid dependence (BQD) was linked to alterations in reward-related brain regions. However, resting-state functional connectivity (FC) in the reward circuit and their neural correlates with pathophysiological characteristics of BQD remain largely unexplored. We recruited 53 male BQD chewers and 53 male healthy controls (HCs) to participate in this study. Eleven reward circuit seeds, such as ventral striatum (VS), ventromedial prefrontal cortex (VMPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC) and others, were selected. Resting-state functional magnetic resonance imaging (rs-fMRI) data were analysed to evaluate FC between predefined seed regions and the whole brain. Association between aberrant FC and clinical features was further investigated. Relative to HCs, individuals with BQD exhibited altered FC in the reward circuit, mainly in VS, VMPFC, ACC, PCC and thalamus (Th). Correlation analysis indicated that FC between right Th and PCC was negatively correlated with BQD scales and dosage of BQ use in BQD subjects. Our findings provided the first empirical evidence that individuals with BQD showed aberrant resting-state FC in the reward circuit. Additionally, decreased connectivity between right Th and PCC was negatively associated with dependence degree and dosage of BQ use. These results highlighted the importance of the reward circuit in the pathophysiology of BQD and suggested that reward circuit dysfunction could serve as a potential circuit-level biomarker.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13441529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Value of Tenascin-C, Neopterin and Pro-Inflammatory Cytokines (IFN-γ, TNF-α, IL-6) in Alcohol Use Disorder Treatment Response","authors":"Guleser Akpinar,&nbsp;Gulsen Sener,&nbsp;Enes Faruk Altunkiliç,&nbsp;Emre Yazgec,&nbsp;Alp Batuhan Ozturk,&nbsp;Nuri Mehmet Basan,&nbsp;Huseyin Aycan Ozsemerci","doi":"10.1111/adb.70181","DOIUrl":"https://doi.org/10.1111/adb.70181","url":null,"abstract":"<p>The underlying neurobiological mechanisms of chronic alcohol consumption, particularly neuroinflammation and immune system dysregulation, have been extensively studied in recent years. In this process, the identification of objective biomarkers that can predict treatment response and enable personalized medicine approaches is of critical importance. This study aimed to evaluate the potential predictive value of tenascin-C (TNC), an extracellular matrix protein, neopterin, a marker of cellular immune activation and pro-inflammatory cytokines interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), during the treatment process for alcohol use disorder (AUD). This prospective observational cohort study included 30 patients admitted to an AUD treatment centre and 31 healthy controls. Serum TNC, IL-6, TNF-α and IFN-γ levels were measured using the ELISA method. Clinical outcomes were assessed using the SCL-90-R and API-K scales. Serum samples were collected from patients at admission and on the 7th day of detoxification treatment. Baseline serum TNC levels in the alcohol group (131.78 ± 50.92 ng/mL) were significantly higher than in the healthy control group (63.92 ± 23.85 ng/mL). In the alcohol group, TNC (<i>p</i> = 0.007) and AST (<i>p</i> = 0.025) levels decreased significantly, while vitamin B12 (<i>p</i> = 0.002) and platelet count (<i>p</i> = 0.012) increased. No significant difference was observed in neopterin and cytokine levels (TNF-α, IL-6 and IFN-γ) between baseline and follow-up measurements. Clinical assessments showed significant improvements in depression (<i>p</i> = 0.041), anxiety (<i>p</i> = 0.014) and total symptom scores (<i>p</i> = 0.026) on the SCL-90-R scale. ROC analysis showed that a reduction of 28.22% or more in TNC predicted clinical improvement with an overall accuracy rate of 73.33%.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148553424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala","authors":"Robin Magnard,&nbsp;Daianna Gonzalez-Padilla,&nbsp;Ege A. Yalcinbas,&nbsp;Emma Chaloux-Pinette,&nbsp;Nicholas J. Eagles,&nbsp;Michael S. Totty,&nbsp;Patricia H. Janak,&nbsp;Leonardo Collado-Torres,&nbsp;Kristen R. Maynard","doi":"10.1111/adb.70179","DOIUrl":"10.1111/adb.70179","url":null,"abstract":"<p>Fentanyl is a potent synthetic opioid associated with overdose. However, little is known about fentanyl-induced molecular adaptations in the habenula and amygdala, two brain regions implicated in opioid use and withdrawal. We performed bulk RNA-sequencing in the rat habenula and amygdala to identify transcriptomic changes associated with fentanyl intake. Male rats self-administered intravenous saline or fentanyl over 22–24 days. Ninety minutes following the final session, brains were collected for transcriptomic profiling. In Hb, we identified 453 differentially expressed genes (DEGs) between saline and fentanyl rats, with upregulated genes associated with synaptic transmission and ionic conductance. In the amygdala, we identified 3041 fentanyl-associated DEGs with upregulated genes implicated in metabolic and vesicular functions. Downregulated genes in both regions were enriched for extracellular matrix functions. Integration of DEGs with single-cell RNA-sequencing data from rodents and humans revealed that fentanyl DEGs were enriched in specific habenula and amygdala cell type markers. Furthermore, fentanyl downregulated DEGs in the amygdala were enriched in genes associated with the risk for substance use disorders. Together, we define how fentanyl intake alters transcriptional programs in the rat habenula and amygdala, and we link these changes to specific human cell types and risk genes for neuropsychiatric disorders and addiction.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Exercise Intensities on Internet Addiction in Adolescents and Young Adults: A Systematic Review and Network Meta-Analysis","authors":"Min Yu,&nbsp;Yuanyuan Chang,&nbsp;Haobo Kang,&nbsp;Wuyang Mao","doi":"10.1111/adb.70172","DOIUrl":"10.1111/adb.70172","url":null,"abstract":"<p>This study employed a network meta-analysis to evaluate and compare the efficacy of different exercise intensities (light, moderate and vigorous) on internet addiction and related psychological symptoms in adolescents and young adults. We systematically searched eight databases for relevant randomised controlled trials. A total of 22 studies with 1438 samples were included. A pairwise meta-analysis indicated that exercise interventions across all intensities were associated with improvements in internet addiction, anxiety and negative moods, with moderate-intensity additionally improving depression. The results of the network meta-analysis suggested that light-intensity exercise (SMD = −2.61, 95% CI [−4.29, −0.93], <i>p</i> = 0.002), moderate-intensity exercise (SMD = −2.74, 95% CI [−4.25, −1.22], <i>p</i> &lt; 0.0001) and high-intensity exercise (SMD = −2.55, 95% CI [−4.88, −0.22], <i>p</i> = 0.032) may be associated with a reduction in adolescents' internet addiction. Only moderate-intensity exercise may be associated with a reduction in depression (SMD = −1.19, 95% CI [−2.20, −0.18], <i>p</i> = 0.021) and anxiety (SMD = −1.90, 95% CI [−3.50, −0.30], <i>p</i> = 0.02); light-intensity and high-intensity exercise were not significantly associated with a reduction in depression and anxiety. Light-intensity exercise (SMD = −1.63, 95% CI [−2.85, −0.41], <i>p</i> = 0.009) and moderate-intensity exercise (SMD = −1.55, 95% CI [−2.56, −0.54], <i>p</i> = 0.003) may be associated with reductions in other negative moods. According to the probability ranking of the likelihood of the optimal intervention effect, moderate-intensity exercise (SUCRA = 71) ranked highest for interventions in adolescents' internet addiction, depression (SUCRA = 70.2), anxiety (SUCRA = 68.4) and light exercise (SUCRA = 67.9) ranked highest for negative moods. However, owing to the limitations of sample size and the quality of individual studies, the strength of evidence needs to be further validated by more standardised, high-quality studies.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148399172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abuse Potential and Neurotoxic Effects of the Synthetic Cannabinoid 4F-ABUTINACA Self-Administration in Adult Male Rats","authors":"Baobao Shi,&nbsp;Huizhen Liu,&nbsp;Manqing Wu,&nbsp;Yuting Wang,&nbsp;Dan Fu,&nbsp;Lili Wen,&nbsp;Huifen Liu,&nbsp;Peng Xu,&nbsp;Wenhua Zhou,&nbsp;Haitao Wang,&nbsp;Miaojun Lai","doi":"10.1111/adb.70177","DOIUrl":"10.1111/adb.70177","url":null,"abstract":"<p>4F-ABUTINACA, a fourth-generation synthetic cannabinoid, has been identified in branded herbal smoking mixtures and e-cigarettes seized in China. However, its potential for abuse and its corresponding neurotoxic effects remain poorly understood. In the present study, we evaluated the abuse potential of 4F-ABUTINACA using the intravenous self-administration (IVSA) model and assessed anxiety-like behaviour using the open-field test (OFT) and the elevated plus maze test (EPM). Additionally, neuronal injury, apoptosis, alterations in glia expression and the BDNF-TrkB-AKT signalling pathway in multiple brain regions were assessed simultaneously. Rats acquired stable nose-poke operant response for self-administering 4F-ABUTINACA (0.00625 mg·kg⁻¹·infusion⁻¹) and showed significant drug-seeking behaviour induced by conditioned cues. Persistent anxiety-like behaviours were observed both immediately after drug-taking (SA group) and cue-induced reinstatement testing after a 14-day extinction period (CIR group). Histochemical analysis revealed more pronounced neuronal injury and apoptosis in the hippocampus, prefrontal cortex (PFC) and nucleus accumbens (NAc) in the SA group than in the CIR group. Reactive astrogliosis and microgliosis were observed in the hippocampus and the PFC in the SA group, whereas the numbers of microglia and astrocytes decreased in the NAc of the CIR group. We also found the distinct region-specific alterations in the BDNF-TrkB-AKT signalling pathway expression profile between the SA and CIR groups. The present results demonstrate that 4F-ABUTINACA exhibits significant potential for abuse and produces anxiety-like behaviour during both the active drug-taking and cue-induced relapse stages, which are associated with the neuropathological alterations in specific brain regions.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148377547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interplay Between Sleep Disturbance, Glymphatic Dysfunction and Altered Brain Networks in Internet Gaming Disorder: A Multimodal Neuroimaging Study","authors":"Jiawen Tian,&nbsp;Hui Zhang,&nbsp;Xinyu Wang,&nbsp;Hongyu Zhang,&nbsp;Longyao Ma,&nbsp;Bohui Mei,&nbsp;Mengzhe Zhang,&nbsp;Yan Lang,&nbsp;Yarui Wei,&nbsp;Shaoqiang Han,&nbsp;Qingqing Lv,&nbsp;Yong Zhang","doi":"10.1111/adb.70175","DOIUrl":"10.1111/adb.70175","url":null,"abstract":"<p>Sleep disturbances are common in individuals with Internet gaming disorder (IGD), yet the neurobiological links between poor sleep quality and addictive symptoms remain unclear. The glymphatic system contributes to cerebrospinal fluid–interstitial fluid exchange and metabolic waste clearance, processes that are closely related to sleep physiology. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) provides a non-invasive MRI-based marker related to glymphatic system function. In parallel, middle frontal gyrus (MFG)–centred functional connectivity may reflect prefrontal network alterations associated with cognitive control and addiction severity in IGD. The study included 30 individuals with IGD and 37 demographically matched healthy controls (HCs). All participants underwent diffusion tensor imaging and resting-state functional MRI. DTI-ALPS was used to assess glymphatic system–related function. Resting-state functional connectivity analysis was performed using the MFG as the seed region. Group differences in ALPS indices were tested while controlling for age, education years and mean framewise displacement. Within the IGD group, correlation analyses were conducted to examine associations among ALPS indices, PSQI scores, MFG-centred functional connectivity and IAT scores. Individuals with IGD showed significantly lower mean and left ALPS indices than HCs. The right ALPS index showed a non-significant trend towards reduction. Within the IGD group, higher PSQI scores were associated with lower mean, left and right ALPS indices, suggesting that poorer subjective sleep quality was related to reduced glymphatic system–related function. MFG-centred functional connectivity analysis showed increased connectivity mainly involving medial and superior frontal regions and decreased connectivity involving subcortical regions. Stronger MFG-centred functional connectivity was positively correlated with IAT scores, indicating an association with greater addiction severity. This study integrates DTI-ALPS and MFG-centred resting-state functional connectivity to examine sleep-related glymphatic alterations and prefrontal network changes in IGD. Lower ALPS indices were associated with poorer sleep quality, whereas stronger MFG-centred connectivity was associated with greater addiction severity. These findings support a potential sleep–glymphatic–prefrontal network framework for understanding IGD. Longitudinal and interventional studies are needed to clarify the directionality of these associations.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Cognitive Evolution in Alcohol Use Disorder Patients: Role of Inflammation, Time of Abstinence and Apolipoprotein Profile","authors":"Berta Escudero,&nbsp;Ricardo Olmos,&nbsp;Francisco Arias,&nbsp;Laura Orio","doi":"10.1111/adb.70174","DOIUrl":"10.1111/adb.70174","url":null,"abstract":"<p>Alcohol use disorder (AUD) is linked to cognitive deficits that can persist even after prolonged abstinence. Research highlighted associations between plasma apolipoproteins and cognition in AUD. This study examines the longitudinal evolution of plasma apolipoproteins and inflammation in AUD patients during early and prolonged abstinence and their association with cognitive recovery. Thirty-three AUD patients from an outpatient hospital alcoholism programme were evaluated at baseline (<i>t</i> = 0), 6 months (<i>t</i> = 1) and 12 months (<i>t</i> = 2), along with 34 healthy controls. Cognitive performance was assessed using the TEDCA test, which measures general cognitive function (GCF). Biological assessments included plasma pro-inflammatory biomarkers (LPS and LBP) and several apolipoproteins (APOAI, APOAII, APOB, APOCII, APOE, APOJ and APOM). AUD patients showed elevated plasma LPS, APOAI, APOE, APOJ and downregulated APOM, which all normalized at <i>t</i> = 1, whereas cognitive improvement was significant at t = 2 compared to controls. Mixed-effects models including all covariates and within-between person decomposition, followed by correlation matrix and reduced mixed models sensitivity analysis support robust associations between better GCF and (1) the duration of abstinence and (2) within-person reductions in LPS, although apolipoprotein changes should be considered exploratory at this level. Prolonged abstinence in AUD patients normalizes plasma peripheral inflammation and apolipoprotein levels and improves cognition. Although APOAI and APOM showed opposite trajectories, as opposite biomarkers in AUD diagnosis reported previously, only the duration of abstinence and normalization of within-person blood LPS levels over time emerged as predictors of cognitive recovery.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Learning Mechanisms in Alcohol Use Disorders”","authors":"","doi":"10.1111/adb.70178","DOIUrl":"10.1111/adb.70178","url":null,"abstract":"<p>\u0000 <span>A. Heinz</span>, <span>S. Icoez</span>, <span>Y. Treusch</span>, <span>G. Chiara</span>, and <span>M. G. Halil</span>, “ <span>Learning Mechanisms in Alcohol Use Disorders</span>,” <i>Addiction Biology</i> <span>31</span>, no. <span>6</span> (<span>2026</span>): e70168, https://doi.org/10.1111/adb.70168.\u0000 </p><p>In this article, the ‘Author Contributions’ section was incorrect. The writing of the original draft was attributed to Melissa G. Halil, whereas it should have been attributed to Andreas Heinz. It should have been: “Andreas Heinz wrote the original draft, conceptualized and supervised the manuscript. Selin Icoez and Yvonne Treusch contributed to writing and editing of the manuscript. Gaetano Di Chiara contributed to writing, reviewing, and editing, including critical revisions of the manuscript. Melissa G. Halil contributed to writing, review, editing, and project administration. All authors reviewed and approved the final manuscript.”</p><p>The authors apologize for this error.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Brain Structural Covariance Networks of Cortical Thickness in Cocaine Use Disorder","authors":"Linkai Chen,&nbsp;Youling Li,&nbsp;Jie Chen,&nbsp;Junshen Zhang,&nbsp;Xinyu Ma,&nbsp;Qiuling Cai,&nbsp;Guanghui Bai,&nbsp;Meimei Du","doi":"10.1111/adb.70176","DOIUrl":"https://doi.org/10.1111/adb.70176","url":null,"abstract":"<p>Cocaine use disorder (CUD) is a serious global public health problem, characterized by compulsive drug seeking and impaired cognitive control. Previous studies using voxel-based morphometry (VBM) or surface-based morphometry (SBM) have identified regional alterations in grey matter volume and cortical thickness (CT); purely local morphological analyses are insufficient to capture coordinated patterns of interregional change. In this study, we employed structural covariance networks (SCNs) analysis to investigate abnormalities in the macroscopic topological organization of the brain in individuals with CUD, based on CT measures. A total of 68 patients with CUD and 52 healthy controls (HCs) were included from the OpenNeuro database. The results demonstrated that the CUD group exhibited a significantly reduced global clustering coefficient and a shift in small-world properties, with network topology becoming more closely aligned with a lattice-like configuration. In addition, CUD showed disrupted rich-club connectivity, particularly within core frontoparietal regions. Notably, no significant group differences were observed in network robustness against random failure or targeted attack. Together, these findings indicated an imbalance between network integration and segregation in the structural brain networks of individuals with CUD, providing a novel network-level perspective on the pathophysiology of addiction and suggesting potential utility as a diagnostic neurobiological marker.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 7","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}