Addiction Biology最新文献

Correction to “The Impact of Physical Activity on Sleep in Alcohol Users: A Systematic Review” 更正“体力活动对酒精使用者睡眠的影响：一项系统综述”。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-04-06 DOI: 10.1111/adb.70156

引用次数: 0

Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure 年轻吸烟者睡眠慢波和纺锤体改变与吸烟严重程度相关。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-04-05 DOI: 10.1111/adb.70149

Shuailin Ding, Ting Xue, Fang Dong, Yongxin Cheng, Yuxin Ma, Juan Wang, Dahua Yu, Kai Yuan

{"title":"Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure","authors":"Shuailin Ding, Ting Xue, Fang Dong, Yongxin Cheng, Yuxin Ma, Juan Wang, Dahua Yu, Kai Yuan","doi":"10.1111/adb.70149","DOIUrl":"10.1111/adb.70149","url":null,"abstract":"Smoking is closely associated with significant disruptions in sleep architecture. Although previous studies have reported altered self-reported sleep quality in adolescent smokers, relatively few studies using polysomnography have objectively examined critical sleep microstructural components (i.e., slow-wave activity and sleep spindle characteristics) in young smokers. This study investigated changes in these electroencephalographic indices in adolescent smokers and their associations with smoking-related characteristics. We recruited 20 young smokers and 16 non-smokers, collecting their overnight polysomnography data. The Fagerström Test for Nicotine Dependence assessed dependence levels, and the pack-year index quantified cumulative smoking exposure. We analysed slow waves (0.5–4.5 Hz) in N3 sleep and spindles (11–16 Hz) in N2 sleep, quantifying parameters via the YASA toolbox. Smokers showed impaired N3 slow-wave integrity (reduced amplitude and slopes) and enhanced N2 spindle activity (increased density, frequency and duration). Slow-wave amplitude reduction correlated negatively with smoking indices, whereas spindle enhancements correlated positively. Sleep slow waves and spindles may serve as biomarkers for sleep quality in young smokers, deepening understanding of the sleep–smoking relationship.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines 精神痛苦与阿片维持治疗之间的相互作用影响循环细胞因子水平。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-29 DOI: 10.1111/adb.70147

Kristin Nygård-Odeh, Hedda Soløy-Nilsen, Magnhild Gangsøy-Kristiansen, Ole-Lars Brekke, Tom Eirik Mollnes, Michael Berk, Jørgen G. Bramness

{"title":"The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines","authors":"Kristin Nygård-Odeh, Hedda Soløy-Nilsen, Magnhild Gangsøy-Kristiansen, Ole-Lars Brekke, Tom Eirik Mollnes, Michael Berk, Jørgen G. Bramness","doi":"10.1111/adb.70147","DOIUrl":"10.1111/adb.70147","url":null,"abstract":"Opioid use modulates parts of the immune system, including cytokines, but with disparate results. Furthermore, several studies have demonstrated a positive correlation between circulating proinflammatory cytokines and mental distress of various kinds. The aim of this study was to investigate the relationship between self-reported mental health symptoms and peripheral circulating cytokines in opioid maintenance treatment patients to see whether the previous disparate results could at least in part be explained by an interaction with mental distress. In a cross-sectional study, we investigated levels of 27 serum cytokines and chemokines using multiplex technology in 120 patients with chronic hepatitis C virus infection. Self-reported mental health symptoms were obtained using SCL-90-R. Among the nonopioid maintenance treatment patients, we found a positive correlation between self-reported mental health symptoms and peripheral circulating cytokines. An opposite trend was found for several of the proinflammatory cytokines in the opioid maintenance treatment patients, which was confirmed through linear regression analysis. We found an interaction between symptom scores and group affiliation on peripherally circulating cytokine levels for four of the cytokines. This report demonstrates that opioids seem to interact with self-reported mental health symptoms in a way that impacts levels of cytokines. We propose that opioids might be associated with a pro-inflammatory dampening and that this should be taken into consideration when analysing cytokine levels.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats 乙酰胆碱酯酶抑制剂多奈哌齐增加大鼠伏隔核多巴胺水平并阻断酒精剥夺效应

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-29 DOI: 10.1111/adb.70150

Anna Loftén, Klara Danielsson, Louise Adermark, Bo Söderpalm, Mia Ericson

{"title":"The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats","authors":"Anna Loftén, Klara Danielsson, Louise Adermark, Bo Söderpalm, Mia Ericson","doi":"10.1111/adb.70150","DOIUrl":"10.1111/adb.70150","url":null,"abstract":"Alcohol use disorder is associated with substantial morbidity and mortality arising from both medical consequences and accidents. Currently available pharmacotherapies are limited, and novel treatment options are needed. One putative target for pharmacotherapy is the mesolimbic dopamine system and its major target, the nucleus accumbens. Mesolimbic dopamine signaling is regulated by multiple neurotransmitters, among which acetylcholine is a key modulator. This study investigated whether the acetylcholine esterase inhibitor donepezil affects basal and/or alcohol-induced increases in extracellular dopamine levels in the nucleus accumbens, and whether it influences alcohol consumption in male Wistar rats. Extracellular dopamine levels were measured using in vivo microdialysis, while alcohol intake was assessed using an intermittent two-bottle choice paradigm followed by alcohol deprivation. Systemic administration of donepezil increased extracellular dopamine levels in the nucleus accumbens, an effect blocked by local administration of the muscarinic antagonist scopolamine but not by the nicotinic antagonist mecamylamine, indicating a primarily muscarinic mechanism. Moreover, following donepezil pretreatment, alcohol administration did not produce any further increase in dopamine. Donepezil did not alter voluntary alcohol consumption under intermittent access conditions, but it fully abolished the alcohol deprivation effect. These findings suggest that donepezil modulates accumbal dopamine transmission via muscarinic receptors and may influence neurobiological mechanisms underlying relapse-like drinking.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder 长链非编码RNA OIP5-AS1在酒精使用障碍中的表达及临床意义

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-25 DOI: 10.1111/adb.70146

Meng ya Zhu, Jian Wang, Jia Jia Song, Yue Wang, Bo Zhang

{"title":"Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder","authors":"Meng ya Zhu, Jian Wang, Jia Jia Song, Yue Wang, Bo Zhang","doi":"10.1111/adb.70146","DOIUrl":"10.1111/adb.70146","url":null,"abstract":"The present study aimed to investigate the expression of OIP5-AS1 in alcohol use disorder and to explore its potential clinical relevance. A total of 78 patients with alcohol use disorder and 36 healthy controls were enrolled in this study. Clinical data were collected for all participants. The expression levels of OIP5-AS1 were quantified using quantitative real-time polymerase chain reaction (RT-PCR). Receiver operating characteristic (ROC) analysis was subsequently performed to evaluate the diagnostic value of OIP5-AS1. StarBase-based bioinformatics analysis suggested that OIP5-AS1 may function within a miRNA-mediated regulatory network influencing SERPINA3 expression. OIP5-AS1 expression levels, as determined by RT-PCR, were markedly higher in patients with alcohol use disorder than in healthy controls (p < 0.001). Patients were stratified into high- and low-expression groups based on the median OIP5-AS1 level. Comparative analyses of baseline characteristics and clinical parameters showed that body mass index (BMI) was significantly lower in the high-expression group, and this inverse association between OIP5-AS1 expression and BMI remained statistically significant in subsequent logistic regression analyses. ROC analysis demonstrated that OIP5-AS1 had strong diagnostic performance, yielding an area under the curve of 0.9091 (p < 0.0001), with a sensitivity of 100% and a specificity of 75% at the defined cutoff. In conclusion, OIP5-AS1 expression was significantly increased in patients with alcohol use disorder and was inversely associated with BMI. In addition, OIP5-AS1 demonstrated good diagnostic performance in distinguishing patients with alcohol use disorder from healthy controls. These findings suggest that OIP5-AS1 may have potential clinical relevance in alcohol use disorder and merit further investigation.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder 利用肠道-大脑信号治疗酒精使用障碍

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-25 DOI: 10.1111/adb.70144

Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen-Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff

{"title":"Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder","authors":"Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen-Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff","doi":"10.1111/adb.70144","DOIUrl":"10.1111/adb.70144","url":null,"abstract":"According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and these medications are not uniformly effective and are not widely used. We now describe studies of a small molecule, novel chemical entity called Nezavist, which shows promise as a medication to treat AUD and possibly other addictive disorders. Nezavist acts as a positive allosteric modulator at a novel site on the GABAA receptor, but pharmacokinetic analysis demonstrates that Nezavist does not enter the CNS. However, Nezavist effectively reduces relapse to chronic alcohol consumption in alcohol-dependent animals in two widely used models. An important goal of the current studies is to provide evidence for the hypothesis that Nezavist acts in the intestine to stimulate vagus nerve afferents that project to the brainstem (nucleus tractus solitarius), leading to reduced inflammation in the brain that may alleviate alcohol ‘craving’ during abstinence from alcohol. It is hoped that the presentation of the current results will stimulate interest in further confirmation of the mechanism of action of Nezavist, with the intent of developing a new and effective medication for treatment for AUD.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Difference in Brain Responses During Short Abstinence in People With Internet Gaming Disorder 网络游戏障碍患者短暂戒断期间脑反应的性别差异

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-25 DOI: 10.1111/adb.70145

Shaoyu Cui, Xuefeng Xu, Guangheng Dong

{"title":"Sex Difference in Brain Responses During Short Abstinence in People With Internet Gaming Disorder","authors":"Shaoyu Cui, Xuefeng Xu, Guangheng Dong","doi":"10.1111/adb.70145","DOIUrl":"10.1111/adb.70145","url":null,"abstract":"Withdrawal or the adverse response to abstinence is a significant marker of addiction; however, the neural features of internet gaming disorder (IGD), especially the effects of sex under abstinence, have rarely been examined. This study aimed to examine brain reactions in IGD patients after short-term abstinence and the differences between the sexes. Thirty males and 30 females with IGDs and 30 males and 30 females recreational game users (RGUs) were recruited. Resting-state fMRI data were collected after 1.5 h without gaming. In the IGD and RGU groups, we found atypical brain areas with concurrent degree centrality (DC) and regional homogeneity (ReHo) changes. We then performed functional connectivity (FC) analysis and two-factor ANOVA on these regions to compare IGD and RGU and test for sex differences. Compared with RGUs, IGD subjects presented abnormal cerebral areas with concurrent DC and ReHo abnormalities. After short-term abstinence, IGD and RGU patients presented abnormal prefrontal lobe and insula FC values. Subsequent sex difference analyses focused on the superior frontal gyrus (SFG), middle frontal gyrus (MFG), inferior frontal gyrus (IFG) and insula. ANOVA followed by FDR-corrected post hoc comparisons revealed that IGD males exhibited significantly greater prefrontal and insula FC than females after short-term abstinence. Specifically, males showed markedly enhanced FC in multiple prefrontal regions and the insula, with effect sizes (Cohen's d) ranging from medium to large, confirming both the efficacy and reliability of the observed differences. Compared with RGUs, IGD patients presented FC changes in executive control and reward processing brain regions. With respect to sex differences, short-term abstinence may have altered cognitive control functions more in males than in females and increased internet gaming severity in males. These findings suggest that males are more susceptible to IGD.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Neural Response to Theta-Burst Stimulation Predicts Long-Term Relapse in Patients with Alcohol Use Disorder: A Pilot fMRI Study” 更正“对θ -爆发刺激的神经反应预测酒精使用障碍患者的长期复发：一项先导功能磁共振成像研究”。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-22 DOI: 10.1111/adb.70148

引用次数: 0

The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal 丁丙诺啡悖论：丁丙诺啡如何触发和解决阿片类药物戒断。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-09 DOI: 10.1111/adb.70126

Mehdi Haghdoost, Jennifer LaBranche, Matthew Roberts, Victor W. Li, Jane J. Kim, James S. H. Wong, Pouya Azar

{"title":"The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal","authors":"Mehdi Haghdoost, Jennifer LaBranche, Matthew Roberts, Victor W. Li, Jane J. Kim, James S. H. Wong, Pouya Azar","doi":"10.1111/adb.70126","DOIUrl":"10.1111/adb.70126","url":null,"abstract":"Buprenorphine (BUP) offers a therapeutic approach for opioid use disorder (OUD) due to its unique pharmacodynamic properties, primarily as a partial agonist with high affinity for the mu-opioid receptor (MOR). BUP's partial agonism and ceiling effect on respiratory depression enhance its safety profile. However, BUP can induce precipitated withdrawal when administered after a full agonist, leading to severe withdrawal symptoms. This Perspective builds on prior work that has linked BUP's high-affinity partial agonism to precipitated withdrawal and low-dose induction strategies. We focus on how BUP's capacity to promote MOR externalization, together with its activity at the nociceptin opioid peptide (NOP) receptor, can help explain why it precipitates withdrawal when administered in the presence of full agonists yet relieves withdrawal once spontaneous withdrawal has begun. Understanding these mechanisms is critical for optimizing BUP protocols in OUD treatment and informs the potential development of new biased MOR agonists (i.e., ligands that preferentially activate specific signalling pathways) for addiction therapy.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits 芬太尼、甲基苯丙胺和多物质使用对大鼠运动敏化和社会行为的不同影响：迷幻治疗逆转社会缺陷。

IF 2.6 3区医学

Addiction Biology Pub Date : 2026-03-05 DOI: 10.1111/adb.70132

Leah M. Salinsky, Kyra C. Diaz, Joshua L. Fox, Shawn M. Panh, Susan M. Ferguson

{"title":"Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits","authors":"Leah M. Salinsky, Kyra C. Diaz, Joshua L. Fox, Shawn M. Panh, Susan M. Ferguson","doi":"10.1111/adb.70132","DOIUrl":"10.1111/adb.70132","url":null,"abstract":"Polysubstance use of opioids and stimulants is increasingly common among individuals with a substance use disorder, yet most researchers examine these substances in isolation. This gap limits our understanding of the effects of polysubstance use and how these differ from single substance use. Here, we examined the impact of single versus polysubstance exposure of fentanyl and methamphetamine on locomotor sensitisation and social behaviour in male and female rats. In addition, as recent evidence has suggested the potential for psychedelic compounds to decrease facets of both opioid and stimulant use disorders, we tested whether the psychedelic R-(−)2,5-dimethoxy-4-iodoamphetamine (DOI) can reverse drug withdrawal-induced social deficits. Baseline sociability was assessed in male and female Sprague–Dawley rats using DeepLabCut and Simple Behavioral Analysis (SimBA). Rats then received injections of saline, methamphetamine (1 mg/kg) and/or fentanyl (20 μg/kg) for 14 days, and locomotion was measured. All rats then underwent 10 days of withdrawal followed by a reassessment of sociability. The following day, all subjects received DOI (0.3 mg/kg; 30 min) and were reassessed for sociability. Our results indicate that the development of locomotor sensitisation and drug withdrawal-induced social deficits vary as a function of drug class, drug history and sex. In addition, acute DOI treatment is sufficient to reverse social deficits as well as enhance social interactions in females. The findings from these experiments suggest a potential therapeutic role of psychedelics in mitigating the social deficits that are associated with withdrawal from polysubstance use of opioids and stimulants.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"31 3","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0