Addiction Biology最新文献

{"title":"Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction","authors":"Bin Zhang,&nbsp;Chen Yang,&nbsp;Yuxiao Zheng,&nbsp;Xinliang Li,&nbsp;Xingguo Wang,&nbsp;Li Yuehui","doi":"10.1111/adb.70005","DOIUrl":"10.1111/adb.70005","url":null,"abstract":"<p>Nan Bao detox capsule (NBDC), derived from ancient Chinese opioid detox protocols, shows promising therapeutic potential in substance abuse disorders, particularly for attenuating methamphetamine (MA) addiction. This study aimed to identify active ingredients, evaluate therapeutic efficacy in an MA addiction rat model and delineate pharmacodynamic mechanisms using metabolomics. In vitro phytochemical profiling characterized 258 drug-related compounds, with 87 prototype entities mainly identified in rat plasma. NBDC significantly attenuated METH-induced behavioural anomalies and modulated neurotransmitter levels, notably increasing brain DA and serotonin (5-HT) content with concomitant upregulation of D1 dopamine receptor (DRD1) and 5-HT1A receptor (5-HT1AR) expression, ameliorating hippocampal pathology. Metabolomic analysis identified histamine receptor as a potential target and revealed the involvement of NBDC in metabolic pathways associated with cocaine addiction, amphetamine abuse and Parkinson's disease. Conclusively, NBDC presents a promising therapeutic agent for mitigating MA addiction through a synergistic interplay of multiple constituents, pharmacological targets and metabolic pathways.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 11","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methamphetamine-related working memory difficulties underpinned by reduced frontoparietal responses","authors":"Robert J. Roy,&nbsp;Muhammad A. Parvaz,&nbsp;Ken T. Wakabayashi,&nbsp;Robert J. R. Blair,&nbsp;Nicholas A. Hubbard","doi":"10.1111/adb.13444","DOIUrl":"https://doi.org/10.1111/adb.13444","url":null,"abstract":"<p>Working memory difficulties are common, debilitating, and may pose barriers to recovery for people who use methamphetamine. Yet, little is known regarding the neural dysfunctions accompanying these difficulties. Here, we acquired cross-sectional, functional magnetic resonance imaging while people with problematic methamphetamine-use experience (MA⁺, <i>n =</i> 65) and people without methamphetamine-use experience (MA⁻, <i>n =</i> 44) performed a parametric <i>n</i>-back task (0-back through 2-back). Performance on tasks administered outside of the scanner, together with <i>n</i>-back performance, afforded to determine a latent dimension of participants' working memory ability. Behavioural results indicated that MA⁺ participants exhibited lower scores on this dimension compared to MA⁻ participants (<i>d =</i> −1.39, <i>p</i> &lt; .001). Whole-brain imaging results also revealed that MA⁺ participants exhibited alterations in load-induced responses predominantly in frontoparietal and default-mode areas. Specifically, while the MA⁻ group exhibited monotonic activation increases within frontoparietal areas and monotonic decreases within default-mode areas from 0-back to 2-back, MA⁺ participants showed a relative attenuation of these load-induced activation patterns (<i>d</i> = −1.55, <i>p</i> &lt; .001). Moreover, increased activations in frontoparietal areas from 0- to 2-back were related to greater working memory ability among MA⁺ participants (<i>r</i> = .560, <i>p</i> = .004). No such effects were observed for default-mode areas. In sum, reductions in working memory ability were observed alongside load-induced dysfunctions in frontoparietal and default-mode areas for people with problematic methamphetamine-use experience. Among them, load-induced activations within frontoparietal areas were found to have a strong and specific relationship to individual differences in working memory ability, indicating a putative neural signature of the working memory difficulties associated with chronic methamphetamine use.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: ‘Sex differences in neural networks recruited by frontloaded binge alcohol drinking’","authors":"Jiayue Xu,&nbsp;Hua Zhao,&nbsp;Ying Wang","doi":"10.1111/adb.70002","DOIUrl":"https://doi.org/10.1111/adb.70002","url":null,"abstract":"&lt;p&gt;We read the published article about ‘Sex differences in neural networks recruited by frontloaded binge alcohol drinking’ by Ardinger et al.,&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; and carried on the in-depth analysis of its content. Using whole brain imaging techniques and graph theory analysis methods, this paper revealed gender differences in alcohol preloading behaviour in brain network activity, providing new insights into gender differences in alcohol use disorders. However, we think there is still room for improvement in the following aspects.&lt;/p&gt;&lt;p&gt;First of all, the article focused on alcohol intake, and more behavioural indicators, such as anxiety, depression, and addictive behaviours, can be considered to more comprehensively assess the impact of alcohol preloading behaviours. Physiological indicators such as cortisol levels can also be considered to explore the relationship between alcohol preloading behaviour and stress response.&lt;/p&gt;&lt;p&gt;Second, C57BL/6J mice are commonly used animal models for alcohol research, but their alcohol intake behaviour may be different from that of humans. Other alcohol preference animal models, such as DBA/2 mice, could be considered to enhance the generalizability of the findings. At the same time, the DID paradigm can simulate human alcohol preloading behaviour, but other behavioural paradigms, such as operant conditioning, can be considered for more fine-grained control of alcohol intake behaviour.&lt;/p&gt;&lt;p&gt;Third, the paper clustered brain regions into modules based only on connection strength, and further analysis of the function of each module can be considered, such as using functional connection analysis or functional magnetic resonance imaging, to reveal the role of different modules in alcohol preloading behaviour. Dynamic network analysis methods, such as time series network analysis, can also be considered to explore the effect of alcohol preloading behaviour on dynamic changes in brain functional connectivity.&lt;/p&gt;&lt;p&gt;Then, for the results presentation part, we recommend more advanced network visualization tools, such as Gephi or Cytoscape, to more clearly demonstrate brain network structure and functional connectivity. Multivariate statistical analysis or machine learning algorithms can also be used to analyse the data more deeply.&lt;/p&gt;&lt;p&gt;Finally, the article mainly described the relationship between alcohol preloading behaviour and brain network activity, but lacks causal inference. Brain stimulation techniques or gene knockout techniques can be considered to explore the role of specific brain regions or neurotransmitter systems in alcohol preloading behaviour. The relationship between alcohol preloading behaviour and alcohol use disorder and its potential targets for intervention can also be explored.&lt;/p&gt;&lt;p&gt;We believe that with the above improvements, the article will shed more light on the neural mechanisms of alcohol preloading behaviour and provide new perspectives for understanding gender differences in alc","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142438989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an evaluation method for addictive compounds based on electrical activity of human iPS cell-derived dopaminergic neurons using microelectrode array","authors":"Yuto Ishibashi,&nbsp;Nami Nagafuku,&nbsp;Shingo Kimura,&nbsp;Xiaobo Han,&nbsp;Ikuro Suzuki","doi":"10.1111/adb.13443","DOIUrl":"10.1111/adb.13443","url":null,"abstract":"<p>Addiction is known to occur through the consumption of substances such as pharmaceuticals, illicit drugs, food, alcohol and tobacco. These addictions can be viewed as drug addiction, resulting from the ingestion of chemical substances contained in them. Multiple neural networks, including the reward system, anti-reward/stress system and central immune system in the brain, are believed to be involved in the onset of drug addiction. Although various compound evaluations using microelectrode array (MEA) as an in vitro testing methods to evaluate neural activities have been conducted, methods for assessing addiction have not been established. In this study, we aimed to develop an in vitro method for assessing the addiction of compounds, as an alternative to animal experiments, using human iPS cell-derived dopaminergic neurons with MEA measurements. MEA data before and after chronic exposure revealed specific changes in addictive compounds compared to non-addictive compounds, demonstrating the ability to estimate addiction of compound. Additionally, conducting gene expression analysis on cultured samples after the tests revealed changes in the expression levels of various receptors (nicotine, dopamine and GABA) due to chronic administration of addictive compounds, suggesting the potential interpretation of these expression changes as addiction-like responses in MEA measurements. The addiction assessment method using MEA measurements in human iPS cell-derived dopaminergic neurons conducted in this study proves effective in evaluating addiction of compounds on human neural networks.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The glucagon-like peptide-1 and other endocrine responses to alcohol ingestion in women with versus without metabolic surgery","authors":"Mariel Molina-Castro,&nbsp;Neda Seyedsadjadi,&nbsp;Danisa Nieto,&nbsp;Lorenzo Leggio,&nbsp;Blair Rowitz,&nbsp;Marta Yanina Pepino","doi":"10.1111/adb.13441","DOIUrl":"10.1111/adb.13441","url":null,"abstract":"<p>Glucagon-like peptide-1 (GLP-1)-based therapies, effective in treating obesity and type 2 diabetes, hold potential for reducing alcohol-seeking behaviour. However, the understanding of how alcohol consumption affects endogenous GLP-1 responses—important for understanding GLP-1-based therapies' potential in addressing alcohol misuse—is limited, given the absence of placebo-controlled studies examining these effects. This study aimed to determine the acute effects of alcohol ingestion on GLP-1 and other peptides and evaluate whether metabolic surgery, which increases GLP-1 responses, blood alcohol concentrations (BAC) and alcohol misuse risk, influences this effect. Additionally, we assessed the acute effects of alcohol on plasma glucose and insulin concentrations. Using a placebo-controlled crossover study, we examined hormonal and glucose responses after oral alcohol consumption (0.5 g/kg of fat-free mass) versus placebo drinks in 18 women who underwent metabolic surgery &lt;5 years ago and in 14 non-operated controls (equivalent in age, body mass index [BMI], race and alcohol consumption patterns). Women had a mean (SD) age of 41 (10) years and a BMI of 33 (5) kg/m². Compared with the control group, the surgery group exhibited a higher peak BAC (0.99 [0.20] g/L vs. 0.75 [0.16] g/L; <i>P</i> &lt; 0.005). Alcohol decreased GLP-1 by 34% (95% CI, 16%–52%) in both groups and decreased ghrelin more in the control (27%) than in the surgery group (13%). Alcohol modestly decreased plasma glucose and transiently increased insulin secretion in both groups (<i>P</i> &lt; 0.05). However, alcohol lowered blood glucose concentrations to the hypoglycaemic range in 28% of the women in the surgery group versus none in the control group. These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's ‘apéritif’ effect. This study also highlights the potential increase in alcohol-related hypoglycaemic effects after metabolic surgery.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbitofrontal cortex to dorsal striatum circuit is critical for incubation of oxycodone craving after forced abstinence","authors":"Hongyu Lin,&nbsp;Adedayo Olaniran,&nbsp;Xiang Luo,&nbsp;Jessica Strauch,&nbsp;Megan A. M. Burke,&nbsp;Chloe L. Matheson,&nbsp;Xuan Li","doi":"10.1111/adb.13440","DOIUrl":"10.1111/adb.13440","url":null,"abstract":"<p>Relapse is a major challenge in treating opioid addiction, including oxycodone. During abstinence, oxycodone seeking progressively increases, a phenomenon termed incubation of oxycodone craving. We previously demonstrated a causal role of orbitofrontal cortex (OFC) in this incubation. Here, we studied the interaction between glutamatergic projections from OFC and dopamine 1-family receptor (D1R) signaling in dorsal striatum (DS) in this incubation in male rats. We first examined the causal role of D1R signalling in DS in incubated oxycodone seeking. Next, we combined fluorescence-conjugated cholera toxin subunit B (CTb-555, a retrograde tracer) with Fos (a neuronal activity marker) to assess whether the activation of OFC→DS projections was associated with incubated oxycodone seeking. We then used a pharmacological asymmetrical disconnection procedure to examine the role of the interaction between projections from OFC and D1R signalling in DS in incubated oxycodone seeking. We also tested the effect of unilateral pharmacological inactivation of OFC or unilateral D1R blockade of DS on incubated oxycodone seeking. Finally, we assessed whether contralateral disconnection of OFC→DS projections impacted non-incubated oxycodone seeking on abstinence day 1. We found that D1R blockade in DS decreased incubated oxycodone seeking and OFC→DS projections were activated during incubated oxycodone seeking. Moreover, anatomical disconnection of OFC→DS projections, but not unilateral inactivation of OFC or unilateral D1R blockade in DS, decreased incubated oxycodone seeking. Lastly, contralateral disconnection of OFC→DS projections had no effect on oxycodone seeking on abstinence day 1. Together, these results demonstrated a causal role of OFC→DS projections in incubation of oxycodone craving.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of drug-nondrug choice procedure to model maladaptive behavioural allocation to opioid use in rats","authors":"Setareh Azizzadeh,&nbsp;Milad Rahimpour,&nbsp;Kamran Rakhshan,&nbsp;Bahador Makkiabadi,&nbsp;Esmail Riahi","doi":"10.1111/adb.13442","DOIUrl":"10.1111/adb.13442","url":null,"abstract":"<p>Increased allocation of behaviour to substance abuse at the expense of personal and social rewards is a hallmark of addiction that is reflected in several of DSM-5 criteria for diagnosis of substance use disorder. Previous studies focused on refining the self-administration (SA) model to better emulate an addictive state in laboratory animals. Here, we employed concurrent SA of sucrose pellets and morphine as two competing natural and drug rewards, respectively, to validate the feasibility of capturing pathological behavioural allocation in rats. A custom-made three-lever operant chamber was used. With one active and one inactive lever presented, rats were trained to self-administer morphine (0.5 mg/kg/infusion; 2 h/day) under a fixed-ratio 1 (FR-1) schedule until a stable response was achieved. Next, they were trained to self-administer morphine in the presence of a third lever dispensing sucrose pellets (20 mg) under FR-1. Concurrent morphine-sucrose SA sessions (2 h/day) were continued until stable morphine taking behaviour was re-established. In another experiment, rats first established stable sucrose pellet SA (2 h/day, FR-1) and then were trained to take morphine (0.5 mg/kg/infusion; 2 h/day). Subsequently, all rats underwent extinction training, in which morphine was replaced with saline while sucrose pellets were still available upon lever pressing, followed by cue-induced reinstatement of morphine seeking behaviour. Results showed that rats retained morphine SA when sucrose pellets were also available, but they showed binge-like sucrose intake when morphine was removed during the extinction sessions. However, morphine SA did not develop in rats that had previously established sucrose pellet SA. In conclusion, morphine SA developed even in the presence of a potent competing nondrug reward in rats. Adding an effort-based contingent delivery of a natural reward to the standard SA model, this protocol may provide an improved model of drug addiction in laboratory animals.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 10","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies","authors":"Hollis C. Karoly,&nbsp;Katelyn T. Kirk-Provencher,&nbsp;Joseph P. Schacht,&nbsp;Joshua L. Gowin","doi":"10.1111/adb.13439","DOIUrl":"https://doi.org/10.1111/adb.13439","url":null,"abstract":"<p>Alcohol exposure affects brain structure, but the extent to which its effects differ across development remains unclear. Several countries are considering changes to recommended guidelines for alcohol consumption, so high-quality evidence is needed. Many studies have been conducted among small samples, but recent efforts have been made to acquire large samples to characterize alcohol's effects on the brain on a population level. Several large-scale consortia have acquired such samples, but this evidence has not been synthesized across the lifespan. We conducted a systematic review of large-scale neuroimaging studies examining effects of alcohol exposure on brain structure at multiple developmental stages. We included studies with an alcohol-exposed sample of at least <i>N</i> = 100 from the following consortia: ABCD, ENIGMA, NCANDA, IMAGEN, Framingham Offspring Study, HCP and UK BioBank. Twenty-seven studies were included, examining prenatal (<i>N</i> = 1), adolescent (<i>N</i> = 9), low-to-moderate-level adult (<i>N</i> = 11) and heavy adult (<i>N</i> = 7) exposure. Prenatal exposure was associated with greater brain volume at ages 9–10, but contemporaneous alcohol consumption during adolescence and adulthood was associated with smaller volume/thickness. Both low-to-moderate consumption and heavy consumption were characterized by smaller volume and thickness in frontal, temporal and parietal regions, and reductions in insula, cingulate and subcortical structures. Adolescent consumption had similar effects, with less consistent evidence for smaller cingulate, insula and subcortical volume. In sum, prenatal exposure was associated with larger volume, while adolescent and adult alcohol exposure was associated with smaller volume and thickness, suggesting that regional patterns of effects of alcohol are similar in adolescence and adulthood.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder","authors":"Cagdas Türkmen,&nbsp;Haoye Tan,&nbsp;Sarah Gerhardt,&nbsp;Emilie Bougelet,&nbsp;Maria Bernardo,&nbsp;Noah Machunze,&nbsp;Yasmin Grauduszus,&nbsp;Maurizio Sicorello,&nbsp;Traute Demirakca,&nbsp;Falk Kiefer,&nbsp;Sabine Vollstädt-Klein","doi":"10.1111/adb.13438","DOIUrl":"https://doi.org/10.1111/adb.13438","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous studies have established a connection between adverse childhood experiences (ACE) and alcohol use disorder (AUD), both of which are associated with alterations in grey matter volume (GMV) and cortical thickness (CT). The current study aimed to assess the neurobiological impact of ACE specifically in the context of AUD, as well as the role of maltreatment type (i.e., abuse or neglect) and timing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Structural MRI data were collected from 35 adults with AUD (mean age: 40; 31% female) and 28 healthy controls (mean age: 36; 61% female). ACE were assessed retrospectively using the Childhood Trauma Questionnaire, and the Maltreatment and Abuse Chronology interview. Global and regional GMV and CT were estimated using voxel- and surface-based morphometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Relative to the healthy controls, the AUD group had significantly reduced CT in the left inferior frontal gyrus, left circular sulcus of the insula and subcentral gyrus and sulci (cluster C1), and in the central sulcus and precentral gyrus (cluster C2). Within the AUD group, a reduction of CT in cluster C1 was significantly associated with higher severity of ACE and AUD. Type and timing analyses revealed a significant association between higher levels of abuse at ages 13 to 15 and reduced CT in cluster C1 within the AUD group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In adults with AUD, abuse experienced during early adolescence is associated with reduced CT in regions involved in inhibitory control, indicating the potential relevance of cognitive pathways in the association between ACE and AUD. Longitudinal studies are needed to confirm and expand upon current findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in neural networks recruited by frontloaded binge alcohol drinking","authors":"Cherish E. Ardinger,&nbsp;Yueyi Chen,&nbsp;Adam Kimbrough,&nbsp;Nicholas J. Grahame,&nbsp;Christopher C. Lapish","doi":"10.1111/adb.13434","DOIUrl":"https://doi.org/10.1111/adb.13434","url":null,"abstract":"<p>Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access. This study aimed to identify brain regions involved in frontloading. Whole brain imaging was performed in 63 C57Bl/6J (32 female, 31 male) mice that underwent 8 days of binge drinking using drinking-in-the-dark (DID). On Days 1–7 mice received 20% (v/v) alcohol or water for 2 h. Intake was measured in 1-min bins using volumetric sippers. On Day 8 mice were perfused 80 min into the DID session and brains were extracted. Brains were processed to stain for Fos protein using iDISCO+. Following light sheet imaging, ClearMap2.1 was used to register brains to the Allen Brain Atlas and detect Fos+ cells. For network analyses, Day 8 drinking patterns were used to characterize mice as frontloaders or non-frontloaders using a change-point analysis. Functional correlation matrices were calculated for each group from log₁₀ Fos values. Euclidean distances were calculated from these <i>R</i> values and clustering was used to determine modules (highly connected groups of brain regions). In males, alcohol access decreased modularity (three modules in both frontloaders and non-frontloaders) as compared to water (seven modules). In females, an opposite effect was observed. Alcohol access (nine modules for frontloaders) increased modularity as compared to water (five modules). Further, different brain regions served as hubs in frontloaders as compared to control groups. In conclusion, alcohol consumption led to fewer, but more densely connected, groups of brain regions in males but not females and we identify several brain-wide signatures of frontloading.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 9","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}