Addiction Biology最新文献

{"title":"Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing","authors":"Jared V. Balbona,&nbsp;Paul Jeffries,&nbsp;Aaron J. Gorelik,&nbsp;Elliot C. Nelson,&nbsp;Ryan Bogdan,&nbsp;Arpana Agrawal,&nbsp;Emma C. Johnson","doi":"10.1111/adb.70066","DOIUrl":"https://doi.org/10.1111/adb.70066","url":null,"abstract":"<p>Although substance use is associated with a shortened lifespan, impeded health and accelerated biological ageing, the factors contributing to the associations between substance use and ageing are poorly understood. We used summary statistics from genome-wide association studies (GWAS) to investigate whether substance involvement (<i>N</i> from 28K to 2M)—including alcohol, tobacco, cannabis and opioid use and use disorders—is genetically correlated with various ageing metrics (<i>N</i> from 162K to 2.7M) and whether these correlations reflect shared genetic etiologies or putative causal relationships. Using Linkage Disequilibrium Score Regression (LDSC), we found widespread evidence of genetic correlations between substance use/use disorders and indices of physical, cognitive and biological ageing. We then employed a series of Mendelian randomization–based approaches, finding significant causal effects of genetic predispositions to both tobacco use disorder and quantity of tobacco smoked on various markers of ageing. Causal effects of problematic alcohol use and cannabis use disorder were also found, though findings were mixed. Evidence of reverse causality (i.e., ageing causing substance use), meanwhile, was scant. Collectively, these results demonstrate strong triangulation across approaches and highlight the importance of integrating genetic insights into public health strategies for reducing the burden of SUDs across the lifespan.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Physical Activity on Sleep in Alcohol Users: A Systematic Review","authors":"Lilou Duquet,&nbsp;Silvio Galli,&nbsp;Emmanuel Haffen,&nbsp;Julie Giustiniani","doi":"10.1111/adb.70050","DOIUrl":"https://doi.org/10.1111/adb.70050","url":null,"abstract":"<p>Alcohol misuse impairs sleep quality and circadian rhythms. Yet, sleep is essential, as a lack of sleep is a predictive factor for addiction and relapse risk in patients with alcohol use disorder (AUD). On the contrary, effective insomnia treatment after withdrawal increases abstinence. Meanwhile, physical activity (PA) has been shown to improve sleep quality and circadian rhythms in nonclinical population. Hence, it would be interesting to assess the impact of PA on sleep in alcohol users with and without dependence. Systematic search was conducted using Prisma guidelines for the screening and ROB-1 for bias analysis of randomized controlled trial (RCT). Out of 4995 studies screened, none assess as main purpose the impact of PA on sleep in alcohol users. Still, 81.8% of the selected studies, in their secondary outcomes, highlight PA's positive association with sleep in alcohol users with or without dependence. Main positive sleep outcomes were insomnia and sleep fragmentation reduction as well as sleep quality and duration improvement. There is a lack of publication regarding the impact of PA on sleep in nonclinical alcohol users and AUD patients. Still, PA appears to enhance sleep in both populations. Further well-designed RCTs are needed to produce robust data. In the first instance, feasibility study should be performed as adhesion can be an issue in the population. Finally, different PA programs (frequency, intensity, time, type and duration) should be compared to determine the optimal dose in different AUD status (intoxication, withdrawal and abstinence).</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance","authors":"Amélia Nicot,&nbsp;Pavankumar Yecham,&nbsp;Ilana Serin,&nbsp;David J. Barker,&nbsp;Lauren K. Dobbs","doi":"10.1111/adb.70055","DOIUrl":"https://doi.org/10.1111/adb.70055","url":null,"abstract":"<p>Evidence from human self-report and rodent models indicate that cocaine can induce a negative affective state marked by panic and anxiety, which may reduce future cocaine use or promote co-use with opiates. Dynorphin-mediated signalling within the striatum is associated with negative affect following cocaine withdrawal and stress-induced cocaine seeking. Here, we used a trace conditioning procedure to first establish the optimum parameters to capture this transient cocaine negative affective state in wild-type mice, and then we investigated striatal opioid peptides as a substrate mediating cocaine conditioned place avoidance (CPA). Previous reports indicate that trace conditioning, where drug administration occurs after removal from the conditioning chamber, results in CPA to ethanol, nicotine and amphetamine. We tested different cocaine doses, conditioning session lengths and apparatus types to determine which combination yields the best cocaine CPA. Cocaine CPA was moderately larger at the highest cocaine dose (25 mg/kg), but this did not generalize across apparatus types and the effect was transient; thus, data were collapsed across all parameters. Cocaine conditioning scores were variable but also became more polarized across conditioning, with approximately equal proportions developing preference and avoidance. We then correlated cocaine CPA with striatal gene expression levels of the opioid peptides enkephalin (<i>Penk</i>) and dynorphin (<i>Pdyn</i>) using qPCR. Cocaine CPA was correlated with low <i>Pdyn</i> levels and a low <i>Pdyn</i>:<i>Penk</i> ratio in the ventral, but not dorsal, striatum. Consistent with this, mice with higher striatal <i>Pdyn</i> relative to <i>Penk</i> were more resistant to developing cocaine CPA compared with littermate controls. This approach revealed a subset of subjects sensitive to the aversive state immediately following cocaine administration. Our findings suggest that striatal dynorphin has opposing roles in mediating the aversion associated with acute cocaine intoxication versus cocaine withdrawal.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disulfiram Treatment for Alcohol Abuse","authors":"Colin Brewer,&nbsp;Emmanuel Streel","doi":"10.1111/adb.70061","DOIUrl":"https://doi.org/10.1111/adb.70061","url":null,"abstract":"&lt;p&gt;Dear Editor,&lt;/p&gt;&lt;p&gt;As the authors or co-authors of numerous contributions to the disulfiram (DSF) literature since the 1980s and the co-authors of the first textbook devoted to DSF treatment for some 40 years [&lt;span&gt;1&lt;/span&gt;], we read Schallenberg et al.'s paper [&lt;span&gt;2&lt;/span&gt;] with interest and some anticipatory excitement. Their positive findings are consistent with several other DSF studies in which consumption was carefully supervised. Diligent supervision is crucial for the success of DSF treatment, and it is something that we have stressed since the early 1980s [&lt;span&gt;3&lt;/span&gt;], including the first study that examined the techniques that some patients use to evade or sabotage it [&lt;span&gt;4&lt;/span&gt;]. We were therefore surprised that they do not directly cite these papers and earlier ones. As long ago as the 1960s, Bourne et al. published the first such study [&lt;span&gt;5&lt;/span&gt;], which recorded surprisingly good outcomes in a group of recurrent ‘skid-row’ alcoholic offenders, not normally regarded as promising candidates for treatment. Azrin et al. published one of the first controlled studies of supervised versus unsupervised DSF in 1982 [&lt;span&gt;6&lt;/span&gt;]. Haynes echoed Bourne et al.'s achievements with a 13-fold reduction in alcohol-related offending [&lt;span&gt;7&lt;/span&gt;], whereas Sereny et al. found that outpatient treatment with clinic-supervised DSF was widely accepted when it was made a required condition of continuing treatment after two failures [&lt;span&gt;8&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Equally surprising is their failure to reference either of the two papers which not only reviewed the effectiveness of long-term supervised DSF but also suggested the mechanisms that made supervised DSF so effective [&lt;span&gt;9, 10&lt;/span&gt;], even when DSF was discontinued after a year or two of good progress, as in the OLITA study that they cited. They include exposure and response-prevention, a well-validated treatment for repetitive and/or phobic behaviour. It embodies and facilitates the repeated practice, learning and consolidation of new and more appropriate habits in real-life environments, as opposed to the artificial and protected environments of residential and outpatient clinics.&lt;/p&gt;&lt;p&gt;They also make the common mistake of describing DSF as ‘aversive’, even though in most studies, the majority of patients never risk drinking while taking it. It is therefore more correctly described as a ‘deterrent’ drug, and it deters drinking in the same way that speed cameras deter speeding without most drivers having to be fined first. A similar deterrent effect is seen in studies of ‘instant justice’ programmes for repeat driving while intoxicated (DWI) offenders, in which failure to produce a negative breathalyser test every morning and evening at their local police station results in instant, unappealable overnight imprisonment (an alcohol-sensitive electronic ankle tag is an alternative) [&lt;span&gt;11&lt;/span&gt;]. Despite many of them clearly qualifying for a diagnosis of alcohol use disord","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4-HIAA Blocks Methamphetamine-Induced Conditioned Place Preference in Mice Through Modulation of the 5-HT Pathway in the Nucleus Accumbens","authors":"Yanan Wu,&nbsp;Ju Ran,&nbsp;Jinqiu Mo,&nbsp;Jing Wang","doi":"10.1111/adb.70063","DOIUrl":"https://doi.org/10.1111/adb.70063","url":null,"abstract":"<p>4-hydroxyindole-3-acetic acid (4-HIAA) is a metabolite of psilocin. Here, we explored the ability of 4-HIAA to cross the blood–brain barrier and its potential effects on methamphetamine (METH)-induced conditioned place preference (CPP) in mice. Treatment with 1-mg/kg 4-HIAA inhibited CPP formation during the acquisition phase, promoted METH extinction and inhibited METH relapse. Furthermore, the regulatory effect of 4-HIAA on METH was underscored by altered 5-HT expression in the nucleus accumbens. Collectively, our findings provide novel insights into the molecular mechanisms of the 4-HIAA-induced blockade of the acquisition, extinction and reinstatement of METH-induced CPP.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 7","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions","authors":"Gabin Drouard,&nbsp;Teemu Palviainen,&nbsp;Chia-Ling Kuo,&nbsp;Breno S. Diniz,&nbsp;Xiaoling Wang,&nbsp;Miina Ollikainen,&nbsp;Antti Latvala,&nbsp;Jaakko Kaprio","doi":"10.1111/adb.70045","DOIUrl":"https://doi.org/10.1111/adb.70045","url":null,"abstract":"<p>Studies investigating proteomic associations with alcohol consumption and the genetic links of these proteins to alcohol-related traits are scarce. The aims of our study were (1) to identify proteins associated with alcohol consumption and (2) to investigate the molecular pathways and genetics linking the identified proteins to alcohol consumption and related sociomedical conditions. We generated proteomic and genotypic data from blood samples of 387 Finnish twins (age range: 56–70) and calculated polygenic risk scores (PRSs) of eight alcohol-related traits: obesity, alcohol dependence, number of drinks per week, number of cigarettes per day, major depressive disorders (MDDs), schizophrenia, externalising behaviour and educational attainment. We identified 20 (out of 2321) proteins associated with alcohol consumption, expressed as log ethanol grams per month, after Bonferroni correction and adjustment for BMI, sex and age. Within-pair analyses in monozygotic twin pairs showed that some of the identified associations persisted after accounting for genetic confounding. While only the PRS representing genetic risk for the number of alcoholic drinks per week was associated with alcohol consumption, several proteins were associated with PRSs, in particular the PRS of MDD. All identified proteins were significantly replicated in the UK Biobank, and pathway analysis suggested their collective connection to alcohol consumption might be explained by oxidative stress and cell damage. In conclusion, we identified several alcohol-associated plasma proteins whose levels are also linked to genetic risk for mental illness and substance use. Our study suggests the potential of proteins as biomarkers for early detection of alcohol-related disorders.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Elastography Increases Readiness for Change in Inpatients With Alcohol Use Disorder: The ELISA Pilot Study","authors":"Stephanie M. Rutledge,&nbsp;Rohit R. Nathani,&nbsp;Patricia Miguez Arosemena,&nbsp;Daniel Suter,&nbsp;David Lehman,&nbsp;Timothy Brennan,&nbsp;Gene Y. Im","doi":"10.1111/adb.70043","DOIUrl":"https://doi.org/10.1111/adb.70043","url":null,"abstract":"<p>Opportunistic interventions (OIs) are health events facilitated by healthcare providers through education that can motivate individuals to adopt risk-reducing behaviours. Our aim was to evaluate transient elastography (TE) as an OI in patients with AUD by assessing changes in validated psychometric scores (PS) of alcohol insight and readiness for change. In this prospective, proof-of-concept pilot study, patients with AUD without TE in the past year were enrolled from an inpatient addiction unit. At baseline, three PS assessing insight and readiness to change were administered: Hanil Alcohol Insight Scale (HAIS), revised Readiness Ruler (RR) and Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES-8A). TE was performed, interpreted, and followed by repeat PS testing. The primary outcome was change in PS. Secondary outcomes were prevalence of fibrosis and steatosis on TE, alcohol use and linkage to hepatology care. From 4 January 2022 to 4 January 2023, 23 patients were enrolled: mean age: 51 years (SD ± 12), 74% male, 61% White and all with severe AUD, and mean of 20 (± 9) daily drinks, 286 g (± 127 g) or 35.7 (± 15.9) units of alcohol, for a median of 14 years (IQR 10–21.5). After TE, there were significant increases in revised RR and SOCRATES-8A from 5 to 8.6 (± 2.1, <i>p</i> &lt; 0.01) and 81.5 to 85.0 (± 8.0, <i>p</i> = 0.04), respectively, indicating improved motivation and readiness for change. HAIS did not change: 11.1–11.0 (± 3, <i>p</i> = 0.36). Cirrhosis and steatosis grade ≥ 2 were detected in 4/23 (17%) and 8/23 (35%), respectively. In this pilot study, performing and interpreting results of TE to inpatients with AUD increase readiness for change and efficiently detects advanced fibrosis.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine","authors":"Wadzanai Masvosva,&nbsp;Marko Lehtonen,&nbsp;Mika Martiskainen,&nbsp;Jari Tiihonen,&nbsp;Pekka J. Karhunen,&nbsp;Kati Hanhineva,&nbsp;Jaana Rysä,&nbsp;Eloise Kok,&nbsp;Olli Kärkkäinen","doi":"10.1111/adb.70064","DOIUrl":"https://doi.org/10.1111/adb.70064","url":null,"abstract":"<p>Cigarette smoking is the single most significant cause of preventable death in the world. Tobacco smoking causes exposure to thousands of chemicals and disrupts biological pathways. It impacts several organs, including the brain, where its effects are mediated by nicotinic acetylcholine receptors. Women seem to be more susceptible to the negative health effects of smoking. In this study, we focused on the changes in the metabolic profile of human postmortem frontal cortex and cerebrospinal fluid (CSF) samples associated with high levels of the nicotine metabolite cotinine. We used non-targeted metabolomics to analyse post-mortem frontal cortex and CSF samples from the Tampere Sudden Death Study cohort. We identified 137 cases (24 females) with high cotinine levels, indicating nicotine exposure. For controls, we identified 82 subjects (20 females) with no cotinine in the frontal cortex or CSF samples and no known history of smoking based on medical records and autopsy reports. Cases had significantly higher levels of 1-methylhistamine (Cohen's <i>d</i> = 0.66, <i>p</i> &lt; 0.0001) and N-acetylputrescine (<i>d</i> = 0.84, <i>p</i> &lt; 0.0001), and lower levels of aspartic acid (<i>d</i> = −0.53, <i>p</i> &lt; 0.001), 3-methylhistidine (<i>d</i> = −0.58, <i>p</i> = 0.0004) and taurine (<i>d</i> = −0.47, <i>p</i> = 0.0002) in the frontal cortex compared to controls. Compared to the frontal cortex, differences between cases and controls were smaller in the CSF samples. Most of the observed differences were similar in both sexes, with a few exceptions like low ergothioneine levels, observed especially in female cases. In conclusion, smoking or nicotine exposure is associated with alterations in metabolites linked to increased oxidative stress and neuroinflammation, as well as reduced neurotransmitter levels in the frontal cortex.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Transcranial Magnetic Stimulation in Patients With Opioid Use Disorder: A Double-Blind, Placebo-Controlled Randomized Trial","authors":"Soner Guldas,&nbsp;Selim Tumkaya,&nbsp;Bengu Yucens","doi":"10.1111/adb.70057","DOIUrl":"https://doi.org/10.1111/adb.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Opioid use disorder (OUD) is a chronic, relapsing brain disorder. The efficacy of brain stimulation methods in the treatment of OUD has been increasingly investigated. However, the efficacy of deep transcranial magnetic stimulation, namely, wide-volume TMS, in the treatment of OUD has not been investigated. The aim of this randomized, double-blind, sham-controlled add-on study was to evaluate the efficacy of wide-volume TMS using a double-cone coil in participants with OUD. A total of 55 OUD patients were recruited and randomized to receive either active or sham TMS. Active wide-volume TMS treatment was applied to the left dorsolateral prefrontal cortex (DLPFC) in the active TMS group using a double-cone coil, twice daily for 2 weeks, at a frequency of 10 Hz. Sham TMS was also applied to the same region in the placebo group using a placebo coil. Opioid Craving Visual Analogue Scale (OC-VAS), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS) and Barratt Impulsiveness Scale-11 (BIS-11) were measured before treatment, at the end of treatment, and 2 months after treatment. A total of 21 patients from the active TMS group and 19 patients from the sham TMS group completed the study. Although the active TMS group exhibited more reduction in craving and a less pronounced increase in buprenorphine-naloxone dose during the treatment period compared to the sham group, these differences did not reach statistical significance. This study suggests that while wide-volume TMS using a double-cone coil applied to the left DLPFC was well tolerated, it did not produce statistically significant improvements in craving, depression, anxiety, or impulsivity when compared to the sham treatment. However, the observed trends warrant further investigation with larger sample sizes and refined protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> <b>Trial Registration:</b> This trial was registered at ClinicalTrials.gov (NCT06081985)</h3>\u0000 </section>\u0000 </div>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Post-Retrieval Strategies to Reduce Drug Craving in Methamphetamine Use Disorders","authors":"Junjiao Li,&nbsp;Yuanyuan Dong,&nbsp;Wei Chen,&nbsp;Jian Wang,&nbsp;Xifu Zheng","doi":"10.1111/adb.70049","DOIUrl":"https://doi.org/10.1111/adb.70049","url":null,"abstract":"<p>Post-retrieval interventions based on memory reconsolidation have shown promise in reducing addiction-related memories. However, research on methamphetamine (MA) use, particularly in humans, remains limited. This study aimed to evaluate the efficacy of a post-retrieval intervention paradigm in managing methamphetamine use disorder (MUD) with 46 individuals from a compulsory drug rehabilitation centre. A single-blind design was employed, with participants randomly assigned to one of three groups: (1) retrieval–no intervention, (2) retrieval–extinction and (3) retrieval–cognitive task. The study involved baseline testing, followed by memory retrieval using MA cues, and one of the three interventions during the memory reconsolidation window. The interventions were as follows: (1) no further intervention after retrieval, (2) extinction training and (3) playing Tetris after memory reactivation. Relapse was assessed through physiological and psychological indicators, with a focus on both spontaneous and cue-induced relapse of MUD memory. The results showed that both retrieval–extinction and retrieval–cognitive task showed benefits in reducing cravings and preventing relapse in MUD compared to retrieval alone. Physiological and psychological indicators of MA memory relapse showed weak correlation and differed across several dimensions. These findings suggest new strategies for MUD intervention and provide valuable insights for clinical treatment. Limitations of the study are also discussed.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"30 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}