Addiction Biology最新文献_第10页

Extinction and reinstatement of methamphetamine-induced conditioned place preference in zebrafish 甲基苯丙胺诱导的斑马鱼条件位置偏好的灭绝和恢复

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-14 DOI: 10.1111/adb.13351

Liao-Chen Chen, Ming-Huan Chan, Hwei-Hsien Chen

{"title":"Extinction and reinstatement of methamphetamine-induced conditioned place preference in zebrafish","authors":"Liao-Chen Chen, Ming-Huan Chan, Hwei-Hsien Chen","doi":"10.1111/adb.13351","DOIUrl":"https://doi.org/10.1111/adb.13351","url":null,"abstract":"Conditioned place preference (CPP) paradigm in zebrafish has been used to measure drug reward, but there is limited research on CPP reinstatement to determine relapse vulnerability. The present study aimed to investigate extinction and reinstatement of methamphetamine (MA)-induced CPP in zebrafish and evaluate the model's predictive validity. Zebrafish received different doses of MA (0–60 mg/kg) during CPP training. The preferred dose of MA at 40 mg/kg was used for extinction via either confined or nonconfined procedures. The extinguished CPP was reinstated by administering a priming dose of MA (20 mg/kg) or various stressors. To assess persistent susceptibility to reinstatement, MA CPP and reinstatement were retested following 14 days of abstinence. In addition, the effects of SCH23390, naltrexone, and clonidine on MA CPP during acquisition, expression, or reinstatement phases were monitored. MA induced CPP in a dose-dependent manner. Both nonconfined and confined extinction procedures time-dependently reduced the time spent on the MA-paired side. A priming dose of MA, chasing stress, or yohimbine reinstated the extinguished CPP. After 14 days of abstinence, the MA CPP remained extinguished and was significantly reinstated by MA priming or chasing stress. Similar to the observations in rodents, SCH23390 suppressed the acquisition of MA CPP, naltrexone reduced the expression and MA priming-induced reinstatement, while clonidine prevented stress-induced reinstatement of MA CPP. This work expanded the zebrafish CPP paradigm to include extinction and reinstatement phases, demonstrating predictive validity and highlighting its potential as a valuable tool for exploring drug relapse.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"109171251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens 伏隔核胆碱能中间神经元上甘氨酸受体对乙醇介导的多巴胺升高的调节

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-14 DOI: 10.1111/adb.13349

Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpalm

{"title":"Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens","authors":"Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpalm","doi":"10.1111/adb.13349","DOIUrl":"https://doi.org/10.1111/adb.13349","url":null,"abstract":"Alcohol use disorder is one of the major psychiatric disorders worldwide, and there are many factors and effects contributing to the disorder, for example, the experience of ethanol reward. The rewarding and reinforcing properties of ethanol have been linked to activation of the mesolimbic dopamine system, an effect that appears to involve glycine receptors (GlyRs) in the nucleus accumbens. On which neuronal subtypes these receptors are located is, however, not known. The aim of this study was to explore the role of GlyRs on cholinergic interneurons (CIN) in sustaining extracellular dopamine levels and in ethanol-induced dopamine release. To this end, CIN were ablated by anti-choline acetyltransferase-saporin administered locally in the nucleus accumbens of male Wistar rats. Changes in dopamine levels induced by ablation, ethanol and/or a GlyR antagonist were monitored using in vivo microdialysis. The GlyRs antagonist strychnine depressed extracellular dopamine in a similar manner independent on local ablation, suggesting that GlyRs on CIN are not important for sustaining the extracellular dopamine tone. However, a low concentration of strychnine hampered ethanol-induced dopamine release in sham-treated animals, whilst no reduction was seen in ablated animals, suggesting that GlyRs located on CIN are involved in ethanol-induced dopamine release. Further, in ablated rats, ethanol-induced increases of the extracellular levels of the GlyR agonists glycine and taurine were attenuated. In conclusion, this study suggests that CIN are not important for GlyR-mediated regulation of basal dopamine output, but that CIN ablation blunts the ethanol-induced dopamine release, putatively by reducing the release of GlyR agonists.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"109169257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated metabolomics and network pharmacology to reveal the mechanism of areca nut addiction 综合代谢组学和网络药理学揭示槟榔成瘾机制

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-14 DOI: 10.1111/adb.13352

Moying Li, Xin Pang, Zitao Guo, Yuliang Yang, Zhenghua Gu, Liang Zhang

{"title":"Integrated metabolomics and network pharmacology to reveal the mechanism of areca nut addiction","authors":"Moying Li, Xin Pang, Zitao Guo, Yuliang Yang, Zhenghua Gu, Liang Zhang","doi":"10.1111/adb.13352","DOIUrl":"https://doi.org/10.1111/adb.13352","url":null,"abstract":"As a chewing hobby, areca nut (Areca catechu L.) has become the most common psychoactive substance in the world, besides tobacco, alcohol and caffeinated beverages. Moreover, as a first-class carcinogen designated by International Agency for Research on Cancer, long-term chewing areca nut can result in oral mucosal diseases and even oral cancer. To clarify the potential mechanism of areca nut addiction, an integrated strategy of metabolomics and network pharmacology was adopted in this study. Network pharmacology study indicated that all the key targets related to areca nut addiction could be regulated by arecoline and pointed out the importance of G-protein coupled receptor signalling pathway. Analysis results of mice plasma metabolome and faeces metabolome intervened by arecoline suggested that the component may affect the dopamine system and 5-HT system by regulating phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, primary bile acid biosynthesis, glycerophospholipid metabolism and intestinal flora structure. Moreover, the potential importance of bile acids in formation of addictive behaviour of chewing areca nut was investigated by integrative analysis of the relationships between metabolites and intestinal flora. The study can provide scientific basis for the addiction intervention and treatment of areca nut chewers.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"109169164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles—Mediators of opioid use disorder? 细胞外囊泡-阿片类药物使用障碍的介质?

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-12 DOI: 10.1111/adb.13353

Daniel C. Morris, Alex Zacharek, Zheng G. Zhang, Michael Chopp

{"title":"Extracellular vesicles—Mediators of opioid use disorder?","authors":"Daniel C. Morris, Alex Zacharek, Zheng G. Zhang, Michael Chopp","doi":"10.1111/adb.13353","DOIUrl":"https://doi.org/10.1111/adb.13353","url":null,"abstract":"Opioid use disorder (OUD) is a growing health emergency in the United States leading to an epidemic of overdose deaths. OUD is recognized as an addictive brain disorder resulting in psychological, cognitive and behavioural dysfunction. These observed clinical dysfunctions are a result of cellular changes that occur in the brain. Derangements in inflammation, neurogenesis and synaptic plasticity are observed in the brains of OUD patients. The mechanisms of these derangements are unclear; however, extracellular vesicles (EVs), membrane bound particles containing protein, nucleotides and lipids are currently being investigated as agents that invoke these cellular changes. The primary function of EVs is to facilitate intercellular communication by transfer of cargo (protein, nucleotides and lipids) between cells; however, changes in this cargo have been observed in models of OUD suggesting that EVs may be agents promoting the observed cellular derangements. This review summarizes evidence that altered cargo of EVs, specifically protein and miRNA, in models of OUD promote impairments in neurons, astrocytes and microglial cells. These findings support the premise that opioids alter EVs to detrimentally affect neuro-cellular function resulting in the observed addictive, psychological and neurocognitive deficits in OUD patients.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"109168013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats 雄性和雌性大鼠口服芬太尼自我给药期间负性情绪的快速出现

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-08 DOI: 10.1111/adb.13344

Kevin R. Coffey, William B. Nickelson, Aliyah J. Dawkins, John F. Neumaier

{"title":"Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats","authors":"Kevin R. Coffey, William B. Nickelson, Aliyah J. Dawkins, John F. Neumaier","doi":"10.1111/adb.13344","DOIUrl":"10.1111/adb.13344","url":null,"abstract":"Opioid use disorder has become an epidemic in the United States, fuelled by the widespread availability of fentanyl, which produces rapid and intense euphoria followed by severe withdrawal and emotional distress. We developed a new preclinical model of fentanyl seeking in outbred male and female rats using volitional oral self-administration (SA) that can be readily applied in labs without intravascular access. Using a traditional two-lever operant procedure, rats learned to take oral fentanyl vigorously, escalated intake across sessions, and readily reinstated responding to conditioned cues after extinction. Oral SA also revealed individual and sex differences that are essential to studying substance use risk propensity. During a behavioural economics task, rats displayed inelastic demand curves and maintained stable intake across a wide range of fentanyl concentrations. Oral SA was also neatly patterned, with distinct ‘loading’ and ‘maintenance’ phases of responding within each session. Using our software DeepSqueak, we analysed ultrasonic vocalizations (USVs), which are innate expressions of current emotional state in rats. Rats produced 50 kHz USVs during loading then shifted quickly to 22 kHz calls despite ongoing maintenance of oral fentanyl taking, reflecting a transition to negative reinforcement. Using fibre photometry, we found that the lateral habenula differentially processed drug cues and drug consumption depending on affective state, with potentiated modulation by drug cues and consumption during the negative affective maintenance phase. Together, these results indicate a rapid progression from positive to negative reinforcement occurs even within an active drug taking session, revealing a within-session opponent process.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine 下丘脑-缰核回路调节可卡因诱导的精神运动反应

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-11-03 DOI: 10.1111/adb.13354

Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Kim

{"title":"A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine","authors":"Dan Bi Ahn, Han Byeol Jang, Yeonhee Ryu, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Kim","doi":"10.1111/adb.13354","DOIUrl":"10.1111/adb.13354","url":null,"abstract":"Administration of cocaine increases synaptic dopamine levels by blocking dopamine reuptake and leads to increased locomotor activity and compulsive drug-seeking behaviour. It has been suggested that the lateral hypothalamus (LH) or lateral habenula (LHb) is involved in drug-seeking behaviours. To explore the role of the LH and the LHb in cocaine-induced psychomotor responses, we tested whether modulation of the LH or the LH-LHb circuit affects cocaine-induced locomotion. Cocaine-induced locomotor activity and dopamine release were suppressed by the activation of the LH with 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide (PEPA), an AMPA receptor agonist. When the LH was inhibited by microinjection of a GABA receptor agonists mixture prior to cocaine injection, the cocaine's effects were enhanced. Furthermore, optogenetic activation of the LH-LHb circuit attenuated the cocaine-induced locomotion, while optogenetic inhibition of the LH-LHb circuit increased it. In vivo extracellular recording found that the LH sent a glutamatergic projection to the LHb. These findings suggest that the LH glutamatergic projection to the LHb plays an active role in the modulation of cocaine-induced psychomotor responses.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135818279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fentanyl-induced respiratory depression in rodents is inhibited by bioabsorbable, subcutaneous naltrexone implants at 3.5 months 芬太尼引起的啮齿动物呼吸抑制在3.5个月时被生物可吸收的皮下纳曲酮植入物所抑制

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-10-27 DOI: 10.1111/adb.13350

Jeffrey D. Benner, Steven M. Cohen, Joseph A. Hollenbaugh, Marc Fishman

{"title":"Fentanyl-induced respiratory depression in rodents is inhibited by bioabsorbable, subcutaneous naltrexone implants at 3.5 months","authors":"Jeffrey D. Benner, Steven M. Cohen, Joseph A. Hollenbaugh, Marc Fishman","doi":"10.1111/adb.13350","DOIUrl":"10.1111/adb.13350","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 The aim of this study is to determine if extended-release, bioabsorbable, subcutaneous naltrexone (NTX) implants inhibit respiratory depression after an IV injection of fentanyl. Bioabsorbable implants fabricated from two different release-controlling polymers, poly-D-L-lactide (PDLLA) and polycaprolactone (PCL), alone (placebo) or containing NTX, were subcutaneously implanted in Sprague Dawley rats. After 3.5 months of implantation, the rodents were administered an IV bolus of fentanyl through the tail vein. The placebo implant rats received a dose of 4 micrograms (mcg) - (10 mcg/kg/dose), while the NTX implanted animals received a dose of 8 mcg (20 mcg/kg/dose). The minimum active dose of fentanyl that caused a > 50 ± 2% depression in the respiration rate in the placebo implanted rodents was 4 mcg. The respiration rate of the placebo implanted rats dropped from 208 ± 14 breaths/minute at predose, to 84 ± 12 breaths/minute (p = 0.0003) at 2 min. In contrast, all NTX implanted animals easily tolerated twice the dose of 8 mcg of fentanyl without any significant reduction in respiration rate. The mean respiration rate = increased from 164 ± 22 breaths/minute at predose to 178 ± 17 breaths/minute (p = 0.24) at 2 min. The mean plasma concentrations of NTX, 3.5 months after implantation, ranged from 7.4 (±1.1) ng/mL to 80.3 (±37.5) ng/mL. Bioabsorbable implants containing NTX effectively blocked fentanyl-induced respiratory depression in rodents as compared with placebo implants, 3.5 months after implantation.\u0000 </section>\u0000 </div>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136263667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The changes of intrinsic connectivity contrast in young smokers 年轻吸烟者内在连通性的变化对比

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-10-27 DOI: 10.1111/adb.13347

Yang Zhou, Ting Xue, Yongxin Cheng, Juan Wang, Fang Dong, Shaodi Jia, Fan Zhang, Xiaoqing Wang, Xiaoqi Lv, Hongde Wang, Kai Yuan, Dahua Yu

{"title":"The changes of intrinsic connectivity contrast in young smokers","authors":"Yang Zhou, Ting Xue, Yongxin Cheng, Juan Wang, Fang Dong, Shaodi Jia, Fan Zhang, Xiaoqing Wang, Xiaoqi Lv, Hongde Wang, Kai Yuan, Dahua Yu","doi":"10.1111/adb.13347","DOIUrl":"10.1111/adb.13347","url":null,"abstract":"Previous studies demonstrated that reward circuit plays an important role in smoking. The differences of functional and structural connectivity were found among several brain regions such as thalamus and frontal lobe. However, few studies focused on functional connectivity (FC) in whole-brain voxel level of young smokers. In this study, intrinsic connectivity contrast (ICC) was used to perform voxel-based whole-brain analyses in 55 young smokers and 55 matched non-smokers to identify brain regions with significant group differences. ICC results showed that the connectivity of young smokers in medial frontal cortex (MedFC), supramarginal gyrus anterior division left (L_aSMG), central opercular cortex left (L_CO) and middle frontal gyrus left (L_MidFG) showed a significantly lower trend compared with the non-smokers. The seed-based FC analysis about MedFC indicated that young smokers showed reduced connectivity between the MedFC and left hippocampus, left amygdala compared to non-smokers. Correlation analysis showed that the ICC of MedFC in young smokers was significantly negatively correlated with Fagerstrom test for nicotine dependence (FTND) and Questionnaire on Smoking Urges (QSU). The FC between the MedFC and left hippocampus, left amygdala was significantly negatively correlated with Pack_years. The mediation analysis indicated that ICC of MedFC completely mediated FTND and QSU of young smokers. The results suggest that nicotine accumulation may affect the communication of the frontal lobe with the whole brain to some extent, leading to changes in smoking cravings. The above research also provides in-depth insights into the mechanism of adolescent smoking addiction and related intervention treatment.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136235060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3 青少年接触蔗糖会通过Smad3增加成年期可卡因介导的行为

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-10-27 DOI: 10.1111/adb.13346

Amy M. Gancarz, Raveena Parmar, Treefa Shwani, Moriah M. Cobb, Michelle N. Crawford, Jacob R. Watson, Lisa Evans, Michael A. Kausch, Craig T. Werner, David M. Dietz

{"title":"Adolescent exposure to sucrose increases cocaine-mediated behaviours in adulthood via Smad3","authors":"Amy M. Gancarz, Raveena Parmar, Treefa Shwani, Moriah M. Cobb, Michelle N. Crawford, Jacob R. Watson, Lisa Evans, Michael A. Kausch, Craig T. Werner, David M. Dietz","doi":"10.1111/adb.13346","DOIUrl":"10.1111/adb.13346","url":null,"abstract":"Adolescence, a critical period of developmental period, is marked by neurobiological changes influenced by environmental factors. Here, we show how exposure to sucrose, which is ubiquitously available in modern diets, results in changes in behavioural response to cocaine as an adult. Rats were given daily access to either 10% sucrose or water during the adolescent period (PND28–42). Following this period, rats are left undisturbed until they reach adulthood. In adulthood, rats were tested for (i) acquisition of a low dose of cocaine, (ii) progressive ratio (PR) test, and (iii) resistance to punished cocaine taking. Sucrose exposure resulted in significant alterations in all behavioural measures. To determine the neurobiological mechanisms leading to such behavioural adaptations, we find that adolescent sucrose exposure results in an upregulation of the transcription factor Smad3 in the nucleus accumbens (NAc) when compared with water-exposed controls. Transiently blocking the active form of this transcription factor (HSV-dnSmad3) during adolescence mitigated the enhanced cocaine vulnerability-like behaviours observed in adulthood. These findings suggest that prior exposure to sucrose during adolescence can heighten the reinforcing effects of cocaine. Furthermore, they identify the TGF-beta pathway and Smad3 as playing a key role in mediating enduring and long-lasting adaptations that contribute to sucrose-induced susceptibility to cocaine. Taken together, these results have important implications for development and suggest that adolescent sucrose exposure may persistently enhance the susceptibility to substance abuse.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 12","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136235053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder 异常神经解剖学模式作为可卡因使用障碍的潜在诊断生物标志物。

IF 3.4 3区医学

Addiction Biology Pub Date : 2023-10-12 DOI: 10.1111/adb.13348

Hui Xu, Cheng Xu, Yunyu Guo, Yike Hu, Guanghui Bai, Meimei Du

{"title":"Abnormal neuroanatomical patterns as potential diagnostic biomarkers for cocaine use disorder","authors":"Hui Xu, Cheng Xu, Yunyu Guo, Yike Hu, Guanghui Bai, Meimei Du","doi":"10.1111/adb.13348","DOIUrl":"10.1111/adb.13348","url":null,"abstract":"Cocaine use disorder (CUD) is a global health problem with serious consequences for both individuals and society. Previous studies on abnormal anatomical patterns in CUD have mainly used voxel-based morphometry to investigate grey matter volume changes, while surface-based morphometry (SBM) has been found to provide detail information on cortical thickness (CT), surface area and cortical meancurve, which can contribute to a better understanding of structural brain changes associated with CUD. In this study, SBM was conducted to investigate abnormal neuroanatomical patterns in CUD and whether these abnormal patterns could be used as potential diagnostic biomarkers for CUD. Sixty-eight CUD individuals and 52 matched healthy controls were enrolled, and all participants performed once MRI scanning and clinical assessments. We found that CUD individuals exhibited altered morphological indicators across widespread brain regions and these abnormal anatomical alterations were significantly predictive of CUD status. Furthermore, the CT reduction of right insula was significantly associated with years of cocaine use in CUD. These findings revealed the association of abnormal anatomical patterns in specific brain regions in CUD, which further improve the understanding of CUD pathophysiology and provide the alternative diagnostic biomarkers for CUD.","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"28 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49684018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0