Addiction Biology最新文献

{"title":"Sex differences in heart rate variability measures that predict alcohol drinking in rats","authors":"Raizel M. Frasier,&nbsp;Phillip A. Starski,&nbsp;Thatiane de Oliveira Sergio,&nbsp;Angela J. Grippo,&nbsp;F. Woodward Hopf","doi":"10.1111/adb.13387","DOIUrl":"10.1111/adb.13387","url":null,"abstract":"<p>Problem alcohol drinking continues to be a substantial cost and burden. In addition, alcohol consumption in women has increased in recent decades, and women can have greater alcohol problems and comorbidities. Thus, there is a significant need for novel therapeutics to enhance sex-specific, individualized treatment. Heart rate (HR) and HR variability (HRV) are of broad interest because they may be both biomarkers for and drivers of pathological states. HRV reflects the dynamic balance between sympathetic (SNS, ‘fight or flight’) and parasympathetic (PNS, ‘rest and digest’) systems. Evidence from human studies suggest PNS predominance in women and SNS in men during autonomic regulation, indicating the possibility of sex differences in risk factors and physiological drivers of problem drinking. To better understand the association between HRV sex differences and alcohol drinking, we examined whether alcohol consumption levels correlated with time domain HRV measures (SDNN and rMSSD) at baseline, at alcohol drinking onset, and across 10 min of drinking, in adult female and male Wistar rats. In particular, we compared both HRV and HR measures under alcohol-only and compulsion-like conditions (alcohol + 10 mg/L quinine), because compulsion can often be a significant barrier to treatment of alcohol misuse. Importantly, previous work supports the possibility that different HRV measures could be interpreted to reflect PNS versus SNS influences. Here, we show that females with higher putative PNS indicators at baseline and at drinking onset had greater alcohol consumption. In contrast, male intake levels related to increased potential SNS measures at drinking onset. Once alcohol was consumed, HR predicted intake level in females, perhaps a pharmacological effect of alcohol. However, HRV changes were greater during compulsion-like intake versus alcohol-only, suggesting HRV changes (reduced SNS in females, reduced PNS and increased HR in males) specifically related to aversion-resistant intake. We find novel and likely clinically relevant autonomic differences associated with biological sex and alcohol drinking, suggesting that different autonomic mechanisms may promote differing aspects of female and male alcohol consumption.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-specific serine/threonine-protein kinase 1 is a substrate of protein kinase C epsilon involved in sex-specific ethanol and anxiety phenotypes","authors":"Michael P. Dugan,&nbsp;Rajani Maiya,&nbsp;Caleb Fleischer,&nbsp;Michal Bajo,&nbsp;Angela E. Snyder,&nbsp;Ashwin Koduri,&nbsp;Sathvik Srinivasan,&nbsp;Marisa Roberto,&nbsp;Robert O. Messing","doi":"10.1111/adb.13388","DOIUrl":"10.1111/adb.13388","url":null,"abstract":"<p>Protein kinase C epsilon (PKCε) regulates behavioural responses to ethanol and plays a role in anxiety-like behaviour, but knowledge is limited on downstream substrates of PKCε that contribute to these behaviours. We recently identified brain-specific serine/threonine-protein kinase 1 (BRSK1) as a substrate of PKCε. Here, we test the hypothesis that BRSK1 mediates responses to ethanol and anxiety-like behaviours that are also PKCε dependent. We used in vitro kinase assays to further validate BRSK1 as a substrate of PKCε and used <i>Brsk1</i>^{<i>−/−</i>} mice to assess the role of BRSK1 in ethanol- and anxiety-related behaviours and in physiological responses to ethanol. We found that BRSK1 is phosphorylated by PKCε at a residue identified in a chemical genetic screen of PKCε substrates in mouse brain. Like <i>Prkce</i>^−/− mice, male and female <i>Brsk1</i>^{<i>−/−</i>} mice were more sensitive than wild-type to the acute sedative-hypnotic effect of alcohol. Unlike <i>Prkce</i>^{<i>−/−</i>} mice, <i>Brsk1</i>^{<i>−/−</i>} mice responded like wild-type to ataxic doses of ethanol. Although in <i>Prkce</i>^−/− mice ethanol consumption and reward are reduced in both sexes, they were reduced only in female <i>Brsk1</i>^{<i>−/−</i>} mice. Ex vivo slice electrophysiology revealed that ethanol-induced facilitation of GABA release in the central amygdala was absent in male <i>Brsk1</i>^{<i>−/−</i>} mice similar to findings in male <i>Prkce</i>^−/− mice. Collectively, these results indicate that BRSK1 is a target of PKCε that mediates some PKCε-dependent responses to ethanol in a sex-specific manner and plays a role distinct from PKCε in anxiety-like behaviour.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenome-wide association study on methamphetamine dependence","authors":"Toshiyuki Shirai,&nbsp;Satoshi Okazaki,&nbsp;Takaki Tanifuji,&nbsp;Ikuo Otsuka,&nbsp;Tadasu Horai,&nbsp;Kentaro Mouri,&nbsp;Yukihiro Takemura,&nbsp;Katsuro Aso,&nbsp;Noriya Yamamoto,&nbsp;Akitoyo Hishimoto","doi":"10.1111/adb.13383","DOIUrl":"10.1111/adb.13383","url":null,"abstract":"<p>Repeated abuse of methamphetamine (METH) can cause dependence, repeated relapse of psychotic symptoms, compulsive drug-seeking behaviour, and various neurological symptoms. These long-term biological changes may be associated with epigenetic mechanisms; however, the association between METH use and epigenetic mechanisms has been poorly investigated. Thus, we performed an epigenome-wide association study of METH dependence using genomic DNA extracted from the blood samples of 24 patients with METH dependence and 24 normal controls. All participants were of Japanese descent. We tested the association between METH dependence and DNA methylation using linear regression analysis. We found epigenome-wide significant associations at four CpG sites, one of which occurred in the <i>CNOT1</i> gene and another in the <i>PUM1</i> gene. We especially noted the <i>CNOT1</i> and <i>PUM1</i> genes as well as several other genes that indicated some degree of association with METH dependence. Among the relatively enriched Gene Ontology terms, we were interested in terms of mRNA metabolism, respirasome, and excitatory extracellular ligand-gated ion channel activity. Among the relatively enriched Kyoto Encyclopedia of Genes and Genome pathways, we noted pathways of several neurological diseases. Our results indicate that genetic changes akin to those in other psychiatric or neurodegenerative disorders may also occur via epigenetic mechanisms in patients with METH dependence.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference","authors":"Yujing Wang,&nbsp;Fan Duan,&nbsp;Junda Li,&nbsp;Xiangyu Li,&nbsp;Lingling Xia,&nbsp;Wei Zhao,&nbsp;Ze Wang,&nbsp;Xun Song,&nbsp;Juan Chen,&nbsp;Jingjing Wang,&nbsp;Yue Wang,&nbsp;Jing Zhang,&nbsp;Xiaochu Zhang,&nbsp;Dongliang Jiao","doi":"10.1111/adb.13382","DOIUrl":"10.1111/adb.13382","url":null,"abstract":"<p>Methamphetamine (METH) is a highly addictive psycho-stimulant that induces addictive behaviour by stimulating increased dopamine release in the nucleus accumbens (NAc). The sarco/endoplasmic reticulum calcium ion transport ATPases (SERCA or ATP2A) is a calcium ion (Ca2+) pump in the endoplasmic reticulum (ER) membrane. SERCA2b is a SERCA subtype mainly distributed in the central nervous system. This study used conditioned place preference (CPP), a translational drug reward model, to observe the effects of SERCA and SERCA2b on METH-CPP in mice. Result suggested that the activity of SERCA was significantly decreased in NAc after METH-CPP. Intraperitoneal SERCA agonist CDN1163 injection or bilateral CDN1163 microinjection in the NAc inhibited METH-CPP formation. SERCA2b overexpression by the Adeno-associated virus can reduce the DA release of NAc and inhibit METH-CPP formation. Although microinjection of SERCA inhibitor thapsigargin in the bilateral NAc did not significantly aggravate METH-CPP, interference with SERCA2b expression in NAc by adeno-associated virus increased DA release and promoted METH-CPP formation. METH reduced the SERCA ability to transport Ca2+ into the ER in SHSY5Y cells in vitro, which was reversed by CDN1163. This study revealed that METH dysregulates intracellular calcium balance by downregulating SERCA2b function, increasing DA release in NAc and inducing METH-CPP formation. Drugs that target SERCA2b may have the potential to treat METH addiction.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal preconception alcohol consumption increased Angiotensin II-mediated vasoconstriction in male offspring cerebral arteries via oxidative stress-AT1R pathway","authors":"Ze Zhang,&nbsp;Yumeng Zhang,&nbsp;Mingxing Liu,&nbsp;Hongyu Su,&nbsp;Yun He,&nbsp;Qiutong Zheng,&nbsp;Zhice Xu,&nbsp;Jiaqi Tang","doi":"10.1111/adb.13385","DOIUrl":"10.1111/adb.13385","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Alcohol consumption is popular worldwidely and closely associated with cardiovascular diseases. Influences of paternal preconception alcohol consumption on offspring cerebral arteries are largely unknown. Male rats were randomly given alcohol or water before being mated with alcohol-naive females to produce alcohol- and control-sired offspring. Middle cerebral artery (MCA) was tested with a Danish Myo Technology wire myograph, patch-clamp, IONOPTIX, immunofluorescence and quantitative PCR. Alcohol consumption enhanced angiotensin II (AngII)-mediated constriction in male offspring MCA mainly via AT1R. PD123,319 only augmented AngII-induced constriction in control offspring. AngII and Bay K8644 induced stronger intracellular calcium transient in vascular smooth muscle cells (VSMCs) from MCA of alcohol offspring. L-type voltage-dependent calcium channel (L-Ca²⁺) current at baseline and after AngII-stimulation was higher in VSMCs. Influence of large-conductance calcium-activated potassium channel (BK_C_a) was lower. Caffeine induced stronger constriction and intracellular calcium release in alcohol offspring. Superoxide anion was higher in alcohol MCA than control. Tempol and thenoyltrifluoroacetone alleviated AngII-mediated contractions, while inhibition was significantly higher in alcohol group. The mitochondria were swollen in alcohol MCA. Despite lower Kcnma1 and Prkce expression, many genes expressions were higher in alcohol group. Hypoxia induced reactive oxygen species production and increased AT1R expression in control MCA and rat aorta smooth muscle cell line. In conclusion, this study firstly demonstrated paternal preconception alcohol potentiated AngII-mediated vasoconstriction in offspring MCA via ROS-AT1R. Alcohol consumption increased intracellular calcium via L-Ca²⁺ channel and endoplasmic reticulum and decreased BK_Ca function. The present study provided new information for male reproductive health and developmental origin of cerebrovascular diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of interventions on smoking cessation: A systematic review and network meta-analysis","authors":"Ying Li,&nbsp;Lei Gao,&nbsp;Yaqing Chao,&nbsp;Jianhua Wang,&nbsp;Tianci Qin,&nbsp;Xiaohua Zhou,&nbsp;Xiaoan Chen,&nbsp;Lingyu Hou,&nbsp;linlin Lu","doi":"10.1111/adb.13376","DOIUrl":"10.1111/adb.13376","url":null,"abstract":"<p>A network meta-analysis (NMA) including randomized controlled trials (RCTs) was conducted to evaluate the effects of different interventions on smoking cessation. Studies were collected from online databases including PubMed, EMBASE, Cochrane Library, and Web of Science based on inclusion and exclusion criteria. Eligible studies were further examined in the NMA to compare the effect of 14 interventions on smoking cessation. Thirty-four studies were examined in the NMA, including a total of 14 interventions and 28 733 participants. The results showed that health education (HE; odds ratio ([OR] = 200.29, 95% CI [1.62, 24 794.61])), other interventions (OI; OR = 29.79, 95% CI [1.07, 882.17]) and multimodal interventions (MUIs; OR = 100.16, 95% CI [2.06, 4867.24]) were better than self-help material (SHM). HE (OR = 243.31, 95% CI [1.39, 42531.33]), MUI (OR = 121.67, 95% CI [1.64, 9004.86]) and financial incentive (FI; OR = 14.09, 95% CI [1.21, 164.31]) had positive effects on smoking cessation rate than smoking cessation or quitting APP (QA). Ranking results showed that HE (83.6%) and motivation interviewing (MI; 69.6%) had better short-term effects on smoking cessation. HE and MUI provided more smoking cessation benefits than SHM and QA. FI was more effective at quitting smoking than QA. Also, HE and MI were more likely to be optimal smoking cessation interventions.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes","authors":"Jalil Rasgado-Toledo,&nbsp;Victor Issa-Garcia,&nbsp;Ruth Alcalá-Lozano,&nbsp;Eduardo A. Garza-Villarreal,&nbsp;Gabriel González-Escamilla","doi":"10.1111/adb.13381","DOIUrl":"10.1111/adb.13381","url":null,"abstract":"<p>Cocaine use disorder (CUD) is a worldwide public health condition that is suggested to induce pathological changes in macrostructure and microstructure. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as a potential treatment for CUD symptoms. Here, we sought to elucidate whether rTMS induces changes in white matter (WM) microstructure in frontostriatal circuits after 2 weeks of therapy in patients with CUD and to test whether baseline WM microstructure of the same circuits affects clinical improvement. This study consisted of a 2-week, parallel-group, double-blind, randomized controlled clinical trial (acute phase) (sham [<i>n</i> = 23] and active [<i>n</i> = 27]), in which patients received two daily sessions of rTMS on the left dorsolateral prefrontal cortex (lDLPFC) as an add-on treatment. T1-weighted and high angular resolution diffusion-weighted imaging (DWI-HARDI) at baseline and 2 weeks after served to evaluate WM microstructure. After active rTMS, results showed a significant increase in neurite density compared with sham rTMS in WM tracts connecting lDLPFC with left and right ventromedial prefrontal cortex (vmPFC). Similarly, rTMS showed a reduction in orientation dispersion in WM tracts connecting lDLPFC with the left caudate nucleus, left thalamus, and left vmPFC. Results also showed a greater reduction in craving Visual Analogue Scale (VAS) after rTMS when baseline intra-cellular volume fraction (ICVF) was low in WM tracts connecting left caudate nucleus with substantia nigra and left pallidum, as well as left thalamus with substantia nigra and left pallidum. Our results evidence rTMS-induced WM microstructural changes in fronto-striato-thalamic circuits and support its efficacy as a therapeutic tool in treating CUD. Further, individual clinical improvement may rely on the patient's individual structural connectivity integrity.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Isopropylbenzylamine-induced conditioned place preference, sensitization behaviour and self-administration in rodents","authors":"Miaojun Lai,&nbsp;Dan Fu,&nbsp;Xiangyu Li,&nbsp;Dingding Zhuang,&nbsp;Majie Wang,&nbsp;Zeming Xu,&nbsp;Huifen Liu,&nbsp;Haowei Shen,&nbsp;Peng Xu,&nbsp;Wenhua Zhou","doi":"10.1111/adb.13370","DOIUrl":"10.1111/adb.13370","url":null,"abstract":"<p><i>N</i>-Isopropylbenzylamine (<i>N</i>-ipb), a chain isomer of methamphetamine (METH) with similar physical properties, has been used as a substitute for METH in seized drug samples. However, the abuse potential of <i>N</i>-ipb remains unclear. Therefore, this study aimed to evaluate the abuse potential of <i>N</i>-ipb in comparison to METH, by using conditioned place preference (CPP), locomotor sensitization and intravenous self-administration tests. The results showed that <i>N</i>-ipb at a dose of 3 mg·kg⁻¹ significantly induced CPP in mice, which was comparable to the effect of METH at 1 mg·kg⁻¹. Either acute or repeated <i>N</i>-ipb injections (1 or 3 mg·kg⁻¹) failed to raise the locomotor activity. However, acute treatment with 10 mg·kg⁻¹ <i>N</i>-ipb elevated the locomotor activity compared with saline, while chronic injection of 10 mg·kg⁻¹ <i>N</i>-ipb induced a delayed and attenuated sensitization compared with 1 mg·kg⁻¹ METH. Rats could acquire <i>N</i>-ipb self-administration at a dose of 1 mg·kg⁻¹·infusion⁻¹, and a typical inverted U-shaped dose–response curve was obtained for <i>N</i>-ipb. The mean dose of <i>N</i>-ipb that maintained the maximum response was greater than that of METH, indicating that <i>N</i>-ipb is less potent for reinforcement than METH. In the economic behavioural analysis, comparison of essential values derived from the demand elasticity revealed that <i>N</i>-ipb is less efficacy as a reinforcer than METH. The present data demonstrate that <i>N</i>-ipb functions as a reinforcer and has a potential for abuse. However, the potency of psychomotor stimulation and the reinforcing effectiveness of <i>N</i>-ipb are lower than those of METH.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural response to threat and reward among young adults at risk for alcohol use disorder","authors":"Katelyn T. Kirk-Provencher,&nbsp;Rosa H. Hakimi,&nbsp;Keinada Andereas,&nbsp;Anne E. Penner,&nbsp;Joshua L. Gowin","doi":"10.1111/adb.13378","DOIUrl":"10.1111/adb.13378","url":null,"abstract":"<p>Alcohol use disorder (AUD) is heritable. Thus, young adults with positive family histories represent an at-risk group relative to those without a family history, and if studied at a time when both groups have similar levels of alcohol use, it provides an opportunity to identify neural processing patterns associated with risk for AUD. Previous studies have shown that diminished response to potential reward is associated with genetic risk for AUD, but it is unclear how threat may modulate this response. We used a modified Monetary Incentive Delay task during fMRI to examine neural correlates of the interaction between threat and reward anticipation in a sample of young adults with (<i>n</i> = 31) and without (<i>n</i> = 44) family histories of harmful alcohol use. We found an interaction (<i>p</i> = 0.048) between cue and group in the right nucleus accumbens where the family history positive group showed less differentiation to the anticipation of gaining $5 and losing $5 relative to gaining $0. The family history-positive group also reported less excitement for trials to gain $5 relative to gaining $0 (<i>p</i> &lt; 0.001). Family history-positive individuals showed less activation in the left insula during both safe and threat blocks compared to family history-negative individuals (<i>p</i> = 0.005), but the groups did not differ as a function of threat (<i>p</i> &gt; 0.70). Young adults with, relative to without, enriched risk for AUD may have diminished reward processing via both neural and behavioural markers to potential rewarding and negative consequences. Neural response to threat may not be a contributing factor to risk at this stage.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphine exposure modulates dimensional bias and set formation in anthropoids","authors":"Sadegh Ghasemian,&nbsp;Alexander J. Pascoe,&nbsp;Marzieh M. Vardanjani,&nbsp;Zakia Z. Haque,&nbsp;Anna Ignatavicius,&nbsp;Daniel J. Fehring,&nbsp;Vahid Sheibani,&nbsp;Farshad A. Mansouri","doi":"10.1111/adb.13380","DOIUrl":"10.1111/adb.13380","url":null,"abstract":"<p>Humans demonstrate significant behavioural advantages with particular perceptual dimensions (such as colour or shape) and when the relevant dimension is repeated in consecutive trials. These dimension-related behavioural modulations are significantly altered in neuropsychological and addiction disorders; however, their underlying mechanisms remain unclear. Here, we studied whether these behavioural modulations exist in other trichromatic primate species and whether repeated exposure to opioids influences them. In a target detection task where the target-defining dimension (colour or shape) changed trial by trial, humans exhibited shorter response time (RT) and smaller event-related electrodermal activity with colour dimension; however, macaque monkeys had shorter RT with shape dimension. Although the dimensional biases were in the opposite directions, both species were faster when the relevant dimension was repeated, compared with conditions when it changed, across consecutive trials. These indicate that both species formed dimensional sets and that resulted in a significant ‘switch cost’. Scheduled and repeated exposures to morphine, which is analogous to its clinical and recreational use, significantly augmented the dimensional bias in monkeys and also changed the switch cost depending on the relevant dimension. These cognitive effects occurred when monkeys were in abstinence periods (not under acute morphine effects) but expressing significant morphine-induced conditioned place preference. These findings indicate that significant dimensional biases and set formation are evolutionarily preserved in humans' and monkeys' cognition and that repeated exposure to morphine interacts with their manifestation. Shared neural mechanisms might be involved in the long-lasting effects of morphine and expression of dimensional biases and set formation in anthropoids.</p>","PeriodicalId":7289,"journal":{"name":"Addiction Biology","volume":"29 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/adb.13380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}