Current research in physiology最新文献

{"title":"L-Arginine supplementation enhanced expression of glucose transporter (GLUT 1) in sickle cell anaemia subjects in the steady state","authors":"W.A. Saka ,&nbsp;C.N. Anigbogu ,&nbsp;M.O. Kehinde ,&nbsp;S.I. Jaja","doi":"10.1016/j.crphys.2022.11.003","DOIUrl":"10.1016/j.crphys.2022.11.003","url":null,"abstract":"<div><p>L-Arginine may have therapeutic value in the management of sickle cell disease and diabetes mellitus. There is very little information on the interaction of GLUT 1 and L-Arginine in sickle cell disease subjects. This study compared the blood levels of Glut 1, fasting blood glucose (FBG) and fasting insulin (FIns) in non-sickle cell anaemia (HbAA) and sickle cell anaemia (HbSS) subjects in the steady state before and following L-Arginine supplementation (1 g/day for 6 weeks). Nitric oxide metabolites, (NO_X), catalase, superoxide dismutase and glutathione peroxidase were also measured in each group of subjects. Correlation coefficients between change (Δ) in Glut 1 and change (Δ) in FBG, Fins, NO_X and antioxidant enzymes respectively were calculated. Before supplementation, Glut 1, NO_X, GP_X and CAT were significantly higher in HbAA subjects while FIns, FBG and MDA were higher in HbSS subjects. In both groups, supplementation significantly increased NO_X, Glut 1 and antioxidant enzymes but decreased MDA. Supplementation increased FIns in HbAA but decreased FBG and FIns in HbSS subjects. In both groups of subjects, ΔGLUT 1 correlated positively with ΔNOX, antioxidant enzymes and Δ[R] but negatively with ΔMDA. ΔGLUT 1 correlated negatively with ΔFBG and ΔFins in HbSS but positively in HbAA. Study thus showed that in the steady state HbSS subjects had lower GLUT 1 but elevated FBG and Fins levels than HbAA subjects. Additionally, L-Arginine increased GLUT I and antioxidant enzymes but decreased Fins, FBG and MDA in HbSS subjects.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"6 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/4a/main.PMC9747353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10424714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells","authors":"Deema Galambo ,&nbsp;Andreas Bergdahl","doi":"10.1016/j.crphys.2022.100097","DOIUrl":"10.1016/j.crphys.2022.100097","url":null,"abstract":"<div><p>Cardiolipin (CL) is a phospholipid molecule found in the inner mitochondrial membrane, where it normally associates with and activates the respiratory complexes. Following myocardial infarction, CL gets released from necrotic cells, consequently affecting neighboring tissues. We have previously demonstrated that physiological concentrations of up to 100 μM CL diminish endothelial cell migration and angiogenic sprouting. Since CL is vital to cellular life, we hypothesized that this molecule may have considerable implications on vascular smooth muscle cells bioenergetics, a key phase in atherogenesis. We examined the acute effects of physiological concentrations of CL on oxidative phosphorylation in permeabilized mice aorta using high-resolution respirometry and a substrate-inhibitor titration protocol. We found that CL significantly lowers LEAK and maximal State 3 respiration. In addition, we found that the acceptor control ratio, representing the coupling between oxidation and phosphorylation, was significantly upregulated by CL. Our findings demonstrate that <em>in situ</em> mitochondrial respiration in permeabilized smooth muscle cells is attenuated when physiological concentrations of CL are applied acutely. This could provide a novel therapy to reduce their dedifferentiation and consequently atherogenesis.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"6 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/07/main.PMC9803913.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10474616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and performance effects of live high train low altitude training for elite endurance athletes: A narrative review","authors":"G. Bonato ,&nbsp;Goodman S.P.J ,&nbsp;Lathlean Tjh","doi":"10.1016/j.crphys.2023.100113","DOIUrl":"https://doi.org/10.1016/j.crphys.2023.100113","url":null,"abstract":"<div><p>Altitude training has become an important training application for athletes due its potential for altering physiology and enhancing performance. This practice is commonly used by athletes, with a popular choice being the live high - train low approach. This model recommends that athletes live at high altitude (1250–3000 m), but train at low altitude or sea-level (0–1200 m). Exposure to altitude often leads to hypoxic stress and in turn stimulates changes in total haemoglobin mass, erythropoietin, and soluble transferrin receptors, which alter further underlying physiology. Through enhanced physiology, improved exercise performance may arise through enhancement of the oxygen transport system which is important for endurance events. Previous investigations into the effects of altitude training on exercise performance have been completed in a range of contexts, including running, cycling, swimming, and triathlon. Often following a LHTL altitude intervention, athletes realise improvements in maximal oxygen consumption capacity, time trial performance and peak power outputs. Although heterogeneity exists among LHTL methodologies, i.e., exposure durations and altitude ranges, we synthesised this data into kilometre hours, and found that the most common hypoxic doses used in LHTL interventions ranged from ∼578–687 km h. As this narrative review demonstrates, there are potential advantages to using altitude training to enhance physiology and improve performance for endurance athletes.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"6 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944123000160/pdfft?md5=2c6e5923c92680537983ff650968b895&pid=1-s2.0-S2665944123000160-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138475110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of thermal variation on the cardiac thermal limits of a eurythermal marine teleost (Girella nigricans)","authors":"Gail D. Schwieterman,&nbsp;Emily A. Hardison,&nbsp;Erika J. Eliason","doi":"10.1016/j.crphys.2022.02.002","DOIUrl":"10.1016/j.crphys.2022.02.002","url":null,"abstract":"<div><p>Although most animals live in complex, thermally variable environments, the impact of this variability on specific physiological systems is still unresolved. The ectotherm heart is known to change in both structure and function to ensure appropriate oxygen delivery under different thermal regimes, but the plasticity of the upper thermal limits of the heart under stable or variable thermal acclimation conditions remains unknown. To investigate the role of thermal variability on cardiac acclimation potential, we acclimated a eurythermal fish, opaleye (<em>Girella nigricans</em>), to three static temperature treatments (13, 16, and 19 °C) as well as two oscillating treatments which cycled between maximum and minimum temperatures every 12 h (13–19 °C and 16–22 °C). These temperatures and daily thermal ranges were chosen to mimic the conditions observed in the rocky intertidal environments in Santa Barbara, CA, USA where the fish were collected. We hypothesized that increasing temperature would increase upper thermal limits of the heart, and that variable acclimations would result in broader acute thermal performance curves (TPCs) compared to static acclimations. We measured maximum heart rate during acute warming to determine cardiac thermal performance (i.e., the temperature corresponding to the onset of cardiac arrythmia, the temperature at maximum heart rate, absolute maximum heart rate, and the Arrhenius breakpoint temperature) and construct acute TPCs. Rising static acclimation temperatures increased upper thermal limits but had no impact on peak maximum heart rate. The warmest static temperature did, however, cause a narrowing of the acute TPC. Fish acclimated to variable conditions had the same upper thermal limits compared to fish acclimated to static conditions with the same mean temperature in all metrics of thermal performance. Further, there was no significant broadening of the acute TPC. This study suggests that cardiac plasticity is robust to thermal variation in this eurythermal fish.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 109-117"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944122000098/pdfft?md5=7b63e610140b43eaaacf9348a332bf2a&pid=1-s2.0-S2665944122000098-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48325598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the ventricle limit cardiac contraction rate in the anoxic turtle (Trachemys scripta)? II. In vivo and in vitro assessment of the prevalence of cardiac arrhythmia and atrioventricular block","authors":"Molly Garner,&nbsp;Riley G. Barber,&nbsp;Jace Cussins,&nbsp;Diarmid Hall,&nbsp;Jessica Reisinger,&nbsp;Jonathan A.W. Stecyk","doi":"10.1016/j.crphys.2022.07.002","DOIUrl":"10.1016/j.crphys.2022.07.002","url":null,"abstract":"<div><p>Previous studies have reported evidence of atrio-ventricular (AV) block in the oxygen-limited <em>Trachemys scripta</em> heart. However, if cardiac arrhythmia occurs in live turtles during prolonged anoxia exposure remains unknown. Here, we compare the effects of prolonged anoxic submergence and subsequent reoxygenation on cardiac electrical activity through <em>in vivo</em> electrocardiogram (ECG) recordings of 21 °C- and 5 °C-acclimated turtles to assess the prevalence of cardiac arrhythmia. Additionally, to elucidate the influence of extracellular conditions on the prominence of cardiac arrhythmia, we exposed spontaneously contracting <em>T. scripta</em> right atrium and electrically coupled ventricle strip preparations to extracellular conditions that sequentially and additively approximated the shift from the normoxic to anoxic extracellular condition of warm- and cold-acclimated turtles. Cardiac arrhythmia was prominent in 21 °C anoxic turtles. Arrhythmia was qualitatively evidenced by groupings of contractions in pairs and trios and quantified by an increased coefficient of variation of the RR interval. Similarly, exposure to combined anoxia, acidosis, and hyperkalemia induced arrhythmia <em>in vitro</em> that was not counteracted by hypercalcemia or combined hypercalcemia and heightened adrenergic stimulation. By comparison, cold acclimation primed the turtle heart to be resilient to cardiac arrhythmia. Although cardiac irregularities were present intermittently, no change in the variation of the RR interval occurred <em>in vivo</em> with prolonged anoxia exposure at 5 °C. Moreover, the <em>in vitro</em> studies at 5 °C highlighted the importance of adrenergic stimulation in counteracting AV block. Finally, at both acclimation temperatures, cardiac arrhythmia and irregularities ceased upon reoxygenation, indicating that the <em>T. scripta</em> heart recovers from anoxia-induced disruptions to cardiac excitation.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 292-301"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/80/main.PMC9287599.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40630811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of M3 receptors in regulation of electrical activity deteriorates in the rat heart during ageing","authors":"Svetlana V. Tapilina ,&nbsp;Alexandra D. Ivanova ,&nbsp;Tatiana S. Filatova ,&nbsp;Pavel A. Galenko-Yaroshevsky ,&nbsp;Denis V. Abramochkin","doi":"10.1016/j.crphys.2021.12.001","DOIUrl":"10.1016/j.crphys.2021.12.001","url":null,"abstract":"<div><p>Ageing is a complex process which affects all systems of the organism and therefore changes the environment where the heart is working. In this study we demonstrate the ageing-related changes in the mechanisms of parasympathetic regulation of mammalian heart. Electrophysiological effects produced by selective activation of M3-cholinoreceptors were compared in isolated cardiac preparations from young adult (4 months), adult (1 year) and ageing (2 years) rats using sharp glass microelectrode technique. M3-receptors were activated with muscarinic agonist pilocarpine (10^-5M) in the presence of selective M2 antagonist AQ-RA741 (10^-7M). In atrial and ventricular myocardium from young rats M3 stimulation induced shortening of action potentials(APs), while no significant effect was observed in both elder groups. The main mechanism of M3-induced AP shortening is inhibition of L-type Ca²⁺ current, estimated using whole-cell patch-clamp. It was negligible in atrial myocytes from ageing animals in comparison with young rats. The loss of sensitivity to stimulation of M3-receptors is due to decrease in M3 gene expression, shown by RT-PCR both in atrial and ventricular samples from ageing rats. Thus, in ageing rat heart M3-receptors are down-regulated and not involved in regulation of electrical activity.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/4a/main.PMC8685909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39869481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical properties of H+-Ca2+-exchanger in the myometrium mitochondria","authors":"Yurii V. Danylovych,&nbsp;Hanna V. Danylovych,&nbsp;Oksana V. Kolomiets,&nbsp;Marina D. Sviatnenko,&nbsp;Sergiy O. Kosterin","doi":"10.1016/j.crphys.2022.09.005","DOIUrl":"10.1016/j.crphys.2022.09.005","url":null,"abstract":"<div><p>Some biochemical properties of the H⁺-Ca²⁺-exchanger in uterine smooth muscle mitochondria have been described. The experiments were performed on a suspension of isolated mitochondria from the myometrium of rats. Methods of confocal microscopy, spectrofluorimetry and photon correlation spectroscopy were used. Fluo-4 probe was used to record changes in ionized Ca²⁺ in the matrix and cytosol; pH changes in the matrix were evaluated with BCECF. It was experimentally proved that in the myometrium instead of Na⁺-Ca²⁺-exchanger the H⁺-Ca²⁺-exchanger functions. It was activated at a physiological pH value, was carried out in stoichiometry 1: 1 and was electrogenic. The transport system was modulated by magnesium ions and the diuretic amiloride, but was not sensitive to changes in the concentration of extra-mitochondrial potassium ions. H⁺-Ca²⁺-exchanger was suppressed by antibodies against the LETM1 protein. Calmodulin may act as a regulator of H⁺-Ca²⁺-exchanger by inhibiting it.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 369-380"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/cd/main.PMC9513619.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40385187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of carbohydrate-electrolyte dissolved alkaline electrolyzed water on physiological responses during exercise under heat stress in physically active men","authors":"Shohei Dobashi ,&nbsp;Tomohiro Kobayashi ,&nbsp;Yoshinori Tanaka ,&nbsp;Yudai Shibayama ,&nbsp;Katsuhiro Koyama","doi":"10.1016/j.crphys.2022.09.007","DOIUrl":"10.1016/j.crphys.2022.09.007","url":null,"abstract":"<div><h3>Purpose</h3><p>This study investigated the effects of 1400 mL intake of alkaline electrolyzed water (AEW) or purified water (PW) into which carbohydrate-electrolyte (CE) was dissolved on improving physiological responses during exercise under heat stress.</p></div><div><h3>Methods</h3><p>This double-blinded, crossover randomized controlled trial included 10 male participants who completed two exercise trials in a hot environment (35 °C, ambient temperature, and 50% relative humidity) after consuming CE-dissolved PW (P-CE) or CE-dissolved AEW (A-CE). The exercise trial consisted of running for 30 min on a treadmill (at an intensity corresponding to 65% of heart rate reserve adjusted for heat stress conditions) and repeated sprint cycling (10 × 7-s maximal sprint cycling), with a 35-min rest interval between the two exercises, followed by a 30-min post-exercise recovery period. Before and after running, and after cycling, the participants drank P-CE (hydrogen concentration of 0 ppm, pH 3.8) or A-CE (0.3 ppm, pH 4.1). Blood samples were obtained before, during (rest interval between running and cycling), and post-exercise.</p></div><div><h3>Results</h3><p>Repeated sprint performance and oxidative stress response did not differ between the P-CE and A-CE trials. A-CE consumption significantly attenuated the increase in blood lactate concentration during the running exercise but not during repeated sprint cycling under heat stress conditions.</p></div><div><h3>Conclusion</h3><p>Our findings suggested that A-CE did not significantly affect repeated sprint performance; however, the attenuated elevation in blood lactate by A-CE ingestion implies a partial enhancement of endurance performance during submaximal exercise under heat stress.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 389-398"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/b2/main.PMC9525732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping the cardiac response to hypoxia: NO and its partners in teleost fish","authors":"Sandra Imbrogno ,&nbsp;Tiziano Verri ,&nbsp;Mariacristina Filice ,&nbsp;Amilcare Barca ,&nbsp;Roberta Schiavone ,&nbsp;Alfonsina Gattuso ,&nbsp;Maria Carmela Cerra","doi":"10.1016/j.crphys.2022.03.006","DOIUrl":"10.1016/j.crphys.2022.03.006","url":null,"abstract":"<div><p>The reduced availability of dissolved oxygen is a common stressor in aquatic habitats that affects the ability of the heart to ensure tissue oxygen supply. Among key signalling molecules activated during cardiac hypoxic stress, nitric oxide (NO) has emerged as a central player involved in the related adaptive responses. Here, we outline the role of the nitrergic control in modulating tolerance and adaptation of teleost heart to hypoxia, as well as major molecular players that participate in the complex NO network. The purpose is to provide a framework in which to depict how the heart deals with limitations in oxygen supply. In this perspective, defining the relational interplay between the multiple (sets of) proteins that, due to the gene duplication events that occurred during the teleost fish evolutive radiation, do operate in parallel with similar functions in the (different) heart (districts) and other body districts under low levels of oxygen supply, represents a next goal of the comparative research in teleost fish cardiac physiology.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 193-202"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944122000189/pdfft?md5=e85c0654a32aada6bde0c0b1ef544f60&pid=1-s2.0-S2665944122000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44451941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sudden change of heart: Warm acclimation can produce a rapid adjustment of maximum heart rate and cardiac thermal sensitivity in rainbow trout","authors":"Matthew J.H. Gilbert ,&nbsp;Olivia A. Adams ,&nbsp;Anthony P. Farrell","doi":"10.1016/j.crphys.2022.03.003","DOIUrl":"10.1016/j.crphys.2022.03.003","url":null,"abstract":"<div><p>Warm acclimation in fish is often characterized by an increase in heat tolerance and a reduction in physiological rates to improve the scope to respond to additional challenges including further warming. The speed of these responses can determine their effectiveness. However, acclimation rates vary across levels of biological organization and are poorly understood in part because most research is conducted after an acclimation period of &gt;3 weeks, when acclimation is presumed to be complete. Here we show that when rainbow trout were transferred from 10 to 18 °C, over 50% of the total reduction of maximum heart rate (ƒ_Hmax) (i.e. the thermal compensation at moderate temperatures) occurred within 72 h, with further compensation occurring more gradually over the following 25 days. Also, the ability to increase ƒ_Hmax with acute warming improved within 24 h resulting in a 30% rise in peak ƒ_Hmax, but this ultimately declined again with prolonged (28 days) exposure to 18 °C. In contrast with some previous studies, upper critical temperatures for ƒ_Hmax did not increase. Nonetheless, we demonstrate that rapid cardiac plasticity is possible in rainbow trout and likely blunts the impacts of thermal variation over relatively short timescales, such as that associated with heat waves and migration between water bodies.</p></div>","PeriodicalId":72753,"journal":{"name":"Current research in physiology","volume":"5 ","pages":"Pages 179-183"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665944122000153/pdfft?md5=ab7e1bbd47e781464a2696304389478b&pid=1-s2.0-S2665944122000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41900514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}