Advances in experimental medicine and biology最新文献_第5页

Monocytic Phagocytes in the Immunopathogenesis of Cytokine Storm Syndromes. 细胞因子风暴综合征免疫发病机制中的单核吞噬细胞

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_12

Pui Y Lee

引用次数: 0

Murine Models of Secondary Cytokine Storm Syndromes. 继发性细胞因子风暴综合征的小鼠模型

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_34

Ellen Brisse, Emely L Verweyen, Amber De Visscher, Christoph Kessel, Carine H Wouters, Patrick Matthys

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Other Immunomodulatory Treatment for Cytokine Storm Syndromes. 细胞因子风暴综合征的其他免疫调节治疗。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_40

Ezgi Deniz Batu, Seza Ozen

引用次数: 0

Bacteria-Associated Cytokine Storm Syndrome. 细菌相关细胞因子风暴综合征

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_19

Esraa M Eloseily, Randy Q Cron

{"title":"Bacteria-Associated Cytokine Storm Syndrome.","authors":"Esraa M Eloseily, Randy Q Cron","doi":"10.1007/978-3-031-59815-9_19","DOIUrl":"https://doi.org/10.1007/978-3-031-59815-9_19","url":null,"abstract":"While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections. It is also important to note that an underlying precipitating infection might not be clinically obvious as the CSS clinical picture can mimic an infectious process or an overwhelming septicemia. It is important to detect such an underlying treatable condition. In addition, infections can also be acquired during the course of CSS due to the concurrent immune suppression with treatment. Optimal CSS outcomes require treating bacterial infections when recognized.CSS should always be suspected in patients presenting with a sepsis-like or multi-organ dysfunction picture. There are many criteria proposed to diagnose CSS in general, with HLH-2004 being the most commonly used. Alternatively, criteria have been proposed for CSS occurring in specific underlying conditions such as systemic lupus erythematosus (SLE) or systemic juvenile idiopathic arthritis (sJIA). However, waiting for many of these criteria to be fulfilled could lead to significant delay in diagnosis, and the physician needs a high index of suspicion for CSS in critically ill febrile hospitalized patients in order to properly recognize the condition. Thus, there should be diagnostic equipoise between CSS and infections, including bacterial, in this population. In this chapter, we discuss the more common bacterial precipitants of CSS with many of the cases being discussed in the pediatric age group.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of the COVID-19 Pandemic on Teaching, Learning, Assessment, and Wellbeing in Higher Education. COVID-19 大流行对高等教育教学、学习、评估和福祉的影响。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61943-4_17

Alessandro Siani

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Addressing Chronic Conditions and Social Determinants of Health During the COVID-19 Pandemic. 在 COVID-19 大流行期间应对慢性疾病和健康的社会决定因素。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61943-4_22

Hani Serag, Lima Ghulmi, Hanaa S Sallam, Monique Ferguson, Bushra Manakatt

{"title":"Addressing Chronic Conditions and Social Determinants of Health During the COVID-19 Pandemic.","authors":"Hani Serag, Lima Ghulmi, Hanaa S Sallam, Monique Ferguson, Bushra Manakatt","doi":"10.1007/978-3-031-61943-4_22","DOIUrl":"https://doi.org/10.1007/978-3-031-61943-4_22","url":null,"abstract":"Chronic conditions or diseases are defined as persistent conditions lasting ≥ 1 year requiring either ongoing medical attention or limiting daily living or both (Agency for Healthcare Research and Quality (AHRQ) in Programs: SHARE approach workshop, Agency for Healthcare Research and Quality (AHRQ) (2016) Programs: SHARE approach workshop 2016. https://www.ahrq.gov/professionals/education/curriculum-tools/shareddecisionmaking/workshop/index.html . Accessed 20 Jan 2017). Physical chronic conditions, including diabetes, hypertension, heart disease, arthritis, and stroke, are prevalent, especially in the older population. Over 90% of older adults have at least 1 and 77% have ≥ 2 chronic conditions (American Diabetes Association (ADA) in Statistics about diabetes, American Diabetes Association (ADA) (2023) Statistics about diabetes. https://diabetes.org/about-us/statistics/about-diabetes . Accessed 20 Apr 2023). Chronic conditions account for $4.1 trillion of the nation's annual healthcare expenditure (Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion in Health and economic costs of chronic conditions, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion. Health and Economic Costs of Chronic Conditions (2022). https://www.cdc.gov/chronicdisease/about/costs/index.htm . Accessed 7 Jan 2023). There are marked disparities based on age, color, and income, with older people, people of color, and lower-income people having higher treatment costs or even lost wages in response to having chronic conditions. Chronic conditions are the on-the-top leading causes for death with diabetes being the top 7th in the USA in 2019 (Ferguson in Metabolic Syndrome Related Dis, Ferguson et al., Metab Syndr Relat Disord 21:177-187, 2023).","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Presentation and Therapy of Ebstein Anomaly. 爱博斯坦畸形的临床表现和治疗。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-44087-8_56

Nikolaus A Haas, David J Driscoll, Silke Rickert-Sperling

引用次数: 0

Current Status of Vaccine Development for Monkeypox Virus. 猴痘病毒疫苗研发现状。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-57165-7_18

Amber Rastogi, Manoj Kumar

{"title":"Current Status of Vaccine Development for Monkeypox Virus.","authors":"Amber Rastogi, Manoj Kumar","doi":"10.1007/978-3-031-57165-7_18","DOIUrl":"10.1007/978-3-031-57165-7_18","url":null,"abstract":"Monkeypox virus (MPXV) of poxviridae family causes a zoonotic disease called monkeypox (Mpox). MPXV cases have a fatality ratio ranging from 0 to 11% globally and have been more prevalent in children. There are three generations of smallpox vaccines that protect against MPXV. First and second generation of the vaccinia virus (VACV) vaccine protects MPXV. However, various adverse side effects were associated with the first and second generations of vaccines. In contrast, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) replication-incompetent vaccine shows fewer adverse effects and a significant amount of neutralizing antibodies in mammalian cells. A third-generation Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) was approved to prevent Mpox in 2019. Recently, MVA-BN-based Imvanex, Imvamune, and JYNNEOS vaccines have also been administered against MPXV. Globally, the World Health Organization (WHO) declared a global health emergency in May 2022 due to increased MPXV cases. Various computational studies have also designed a multi-epitope-based vaccine against the MPXV. In the multi-epitope-based vaccine, different epitopes like B-cell, Cytotoxic T Lymphocyte (CTL), CD8+, and CD4+ epitopes were derived from MPXV proteins. Further, these epitopes were linked with the help of various linkers to design a multi-epitope vaccine against MPXV. In summary, we have provided an overview of the current status of the vaccine against MPXV.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Multi-pronged Approach to Addressing Global Poxviruses Vaccine Inequity: A Case of Monkeypox. 多管齐下解决全球痘病毒疫苗不公平问题：猴痘案例。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-57165-7_20

Barbara W K Son, Otioli W Wambalaba, Wamukota Francis Wambalaba

{"title":"A Multi-pronged Approach to Addressing Global Poxviruses Vaccine Inequity: A Case of Monkeypox.","authors":"Barbara W K Son, Otioli W Wambalaba, Wamukota Francis Wambalaba","doi":"10.1007/978-3-031-57165-7_20","DOIUrl":"10.1007/978-3-031-57165-7_20","url":null,"abstract":"Monkeypox has been endemic in Congo and Nigeria for at least five decades. Since early May 2022, there have been numerous unprecedented outbreaks throughout the world in places without any previously reported cases. While a majority of the diagnosed cases have been within Europe and the Americas, several cases have occurred in non-endemic African countries. As of December 2022, 82,999 cases had been reported globally, prompting concern among the World Health Organization (WHO) members. While the WHO has not labeled this epidemic a Global Health Emergency, member states have begun to put forward plans to consolidate their emergency vaccine stockpiles and share the limited number of vaccines made by the single FDA-approved manufacturer, Bavarian Nordic. Many countries are concerned about how vaccines will be shared. Some of the larger donor States are positioned to be the biggest beneficiaries of vaccine sharing, while States from areas that have been suffering from the virus since the 1970s have not been allocated any. This pattern of vaccine distribution echoes that seen during the early part of the COVID-19 pandemic. Due to the similarities between Monkeypox and Smallpox, contact precautions and vaccination seem to be effective strategies to combat its rapid spread. We aim to evaluate how an eradication program model similar to that used for Smallpox can be applied to Monkeypox, and whether it can address vaccine inequity. To do this, we use a multi-pronged approach targeting disease surveillance, vaccine awareness, manufacturing, cost, and distribution strategies.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molluscum Contagiosum Virus: Biology and Immune Response. 传染性软疣病毒：生物学和免疫反应。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-57165-7_10

Luigi Santacroce, Thea Magrone

引用次数: 0