Comprehensive psychoneuroendocrinology最新文献

{"title":"Moving toward affective immunology: Legacy and future directions","authors":"Jennifer E. Graham-Engeland","doi":"10.1016/j.cpnec.2024.100241","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100241","url":null,"abstract":"<div><p>The term “affective immunology” has recently been used to denote a field focused on the interplay between affective processes (including mood states, specific emotions, and regulatory processes) and various aspects of immune function. The overarching goals of this commentary are <strong>a)</strong> to provide historical underpinnings of this field with a focus on the profound impact of the work of Janice Kiecolt-Glaser, who is further honored in this special issue, <strong>b)</strong> to review important off-shoots of her legacy work in this domain, and <strong>c)</strong> to highlight important future directions for the field. Kiecolt-Glaser's work laid much of the foundation for affective immunology, with groundbreaking research related to depression, hostility and dyadic interactions, loneliness, and other affective patterns, often in the context of holistic models, novel experimental designs, and interventions. Her former mentees (and many of their mentees) have carried on her legacy in these domains, in ways that continue to advance appreciation of how affective processes relate to immune function. There are numerous remaining questions for the field to pursue, including better understanding of the role of emotion regulation, emotional reactivity and recovery, restorative processes, affective variability, and developmental and dynamic social processes. Such work will require greater use of longitudinal and within-person approaches and/or examination of processes in daily life, as well as models that account for interactive and reciprocal processes and which integrate behavior, social context, sociocultural factors, individual differences, and other aspects of health. As more work in these domains continues, building on Kiecolt-Glaser's rich legacy, we move toward the emergence of affective immunology as an important subfield in the domain of psychoneuroimmunology, one which will offer more nuanced understanding of the role of affective processes in immune health.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000171/pdfft?md5=68f6591c26d97af9bdea97d65430df0e&pid=1-s2.0-S2666497624000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics","authors":"Elizabeth A. Lawson","doi":"10.1016/j.cpnec.2024.100242","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100242","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000183/pdfft?md5=e5e7819e17fae76dc147870fc3b466f9&pid=1-s2.0-S2666497624000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intertwining of oxytocin's effects on social affiliation and inflammation","authors":"Marcy A. Kingsbury","doi":"10.1016/j.cpnec.2024.100239","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100239","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000158/pdfft?md5=888163b2175a2e0ec1679a79912a7329&pid=1-s2.0-S2666497624000158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You can't spell distress without stress: Expanding our perspective of the intersection between mental and physical health in cancer survivors","authors":"Megan E. Renna ,&nbsp;M. Rosie Shrout","doi":"10.1016/j.cpnec.2024.100240","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100240","url":null,"abstract":"<div><p>Although many breast cancer survivors adjust to cancer treatment and survivorship, a sizable subgroup of women do not do so, resulting in psychological distress. Over time, this psychological distress can contribute to immune dysfunction and accompanying worsened physical symptoms as women navigate survivorship. Dr. Kiecolt-Glaser's work and mentorship has been integral to our understanding of breast cancer survivors' immune risks, and how behavioral factors may enhance these risks. As a postdoctoral fellow in the Stress and Health Lab, under Dr. Kiecolt-Glaser's mentorship, my research focused on understanding how distress is associated with immune functioning and physical health in breast cancer survivors. In this paper, we highlight Dr. Kiecolt-Glaser's influence on our careers as a strong female research and mentor, the work completed under her mentorship, and how the field of psychoneuroimmunology can continue to expand her research to better understand how distress in the cancer context confers long-term health risks.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266649762400016X/pdfft?md5=f56ad6a92c6fe9e98a1caf294ea457af&pid=1-s2.0-S266649762400016X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019 and its impact on the cognition of older adults: Unraveling the role of inflammation","authors":"Shahrzad Mortazavi ,&nbsp;Vahid Rashedi ,&nbsp;Bahman Cheraghian ,&nbsp;Fatemeh Pourshams ,&nbsp;Saeid Saeidimehr ,&nbsp;Bahram Dehghan ,&nbsp;Maryam Pourshams","doi":"10.1016/j.cpnec.2024.100238","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100238","url":null,"abstract":"<div><h3>Background</h3><p>The Coronavirus Disease 2019 (COVID-19) pandemic significantly impacted the older adult population globally. This study aimed to investigate cognitive function and its relationship with inflammation in older COVID-19 survivors over a three-month follow-up to address concerns about cognitive impairment and its risk factors.</p></div><div><h3>Methods</h3><p>In this descriptive-analytical study, 177 hospitalized COVID-19 patients aged &gt;60 were assessed from July 2021 to February 2022. Psychiatric, global cognitive assessments and activities of daily living were conducted at discharge, 1 month, and 3 months post-discharge. Statistical analyses were conducted using SPSS Version 24. The evolution of cognitive status over time was evaluated using the Repeated Measures Test. The study probed into the association between inflammatory markers and cognitive function through the Pearson correlation test and the Mann–Whitney <em>U</em> test. Additionally, the link between anxiety/depression and cognitive performance was examined using the Pearson correlation.</p></div><div><h3>Results</h3><p>Results indicated that higher levels of C-reactive protein (CRP), D-dimer, and Lactate Dehydrogenase (LDH) were correlated to reduced cognitive performance. Conversely, Erythrocyte Sedimentation Rate (ESR) and Creatine Phosphokinase (CPK) did not exhibit a significant relationship with cognitive scores. A positive correlation was observed between improved cognitive function (reflected by higher GPCOG scores) and lower levels of anxiety and depression (indicated by lower scores on the Hospital Anxiety and Depression Scale). Over the study period, cognitive function and anxiety scores showed an upward trend, whereas symptoms of depression and challenges in daily activities remained consistent.</p></div><div><h3>Conclusions</h3><p>The study highlights the enduring effects and detrimental role of inflammation on overall cognitive abilities among older survivors of COVID-19. It underscores the urgent need for specialized interventions and rehabilitative strategies to facilitate sustained cognitive recuperation among these individuals.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000146/pdfft?md5=2dc2c05daeb93885d05caf7089fcb087&pid=1-s2.0-S2666497624000146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to’ The vagal paradox: A polyvagal solution’ [Compr. Psychoneuroendocrinology 16C (2023) 100200]","authors":"Stephen W. Porges","doi":"10.1016/j.cpnec.2024.100233","DOIUrl":"10.1016/j.cpnec.2024.100233","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000092/pdfft?md5=23e648f26c86d003638debb16c08dd55&pid=1-s2.0-S2666497624000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140773098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe PTSD is marked by reduced oxytocin and elevated vasopressin","authors":"Alexander J. Horn ,&nbsp;Steve Cole ,&nbsp;Hans P. Nazarloo ,&nbsp;Nazarloo Parmida ,&nbsp;John M. Davis ,&nbsp;David Carrier ,&nbsp;Craig Bryan ,&nbsp;C. Sue Carter","doi":"10.1016/j.cpnec.2024.100236","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100236","url":null,"abstract":"<div><p>Neuroendocrine analyses of posttraumatic stress disorder (PTSD) have generally focused on hypothalamic-pituitary-adrenal (HPA) axis alterations. In the present analyses, we examine two additional neuroendocrine factors that have been previously implicated in biological stress responses: oxytocin (OT) and arginine vasopressin (AVP). Here we examined basal neuropeptide status in military veterans clinically diagnosed with PTSD (n = 29) and in two non-traumatized comparison groups with previous stress exposure (n = 11 SWAT trainees and n = 21 ultramarathon runners). PTSD patients showed low levels of plasma OT and high levels of AVP. The ratio of AVP/OT robustly related to PTSD status, and emerged as a statistically plausible mediator of relationships between the number of personal traumatic experiences and subsequent PTSD symptom burden. Over the course of behavioral therapy for PTSD, measures of OT showed a significant but modest normalization. Plasma cortisol levels were not statistically different among the three groups. This study suggests that AVP/OT ratios may represent a neuroendocrine predictor of severe PTSD, as well as a potential treatment response biomarker.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000122/pdfft?md5=65ed3dbc67c6f898c0b215d5473888a2&pid=1-s2.0-S2666497624000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity","authors":"Robertas Strumila ,&nbsp;Aiste Lengvenyte ,&nbsp;Linas Zdanavicius ,&nbsp;Robertas Badaras ,&nbsp;Edgaras Dlugauskas ,&nbsp;Sigita Lesinskiene ,&nbsp;Eimantas Matiekus ,&nbsp;Martynas Marcinkevicius ,&nbsp;Lina Venceviciene ,&nbsp;Algirdas Utkus ,&nbsp;Andrius Kaminskas ,&nbsp;Tomas Petrenas ,&nbsp;Jurgita Songailiene ,&nbsp;Dalius Vitkus ,&nbsp;Laima Ambrozaityte","doi":"10.1016/j.cpnec.2024.100235","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100235","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;p&gt;Suicidal ideation, an important risk factor for suicide attempts, has an unclear neurobiological basis and is potentially linked to the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and immune-inflammatory systems. While inflammatory markers have been associated with suicide attempts and, to a lower extent suicidal ideation, the data on the role of a stress-response system is less robust, with most studies carried out with cortisol showing inconsistent results. The present study extends on the previous studies implicating stress-response and immune-inflammatory systems in suicidal thoughts and behaviours, focusing on the associations of several stress-response (adrenocorticotropic hormone (ACTH), cortisol, and dehydroepiandrosterone (DHEA)) and immune-inflammatory (C-reactive protein (CRP),interle ukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha)) with suicidal ideation severity in recent suicide attempters, patients with major depressive disorder, and non-psychiatric controls.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;This observational study included 156 adults from three Vilnius hospitals, recruited into one of the three groups in equal parts: recent suicide attempters, patients with major depressive disorder in current depressive episode, and non-psychiatric controls. Measures included the Hamilton Depression Rating Scale (HDRS-17) and the Beck Scale for Suicide Ideation/Suicide Severity Index (BSS/SSI), alongside sociodemographic data, alcohol, tobacco use, and morning blood samples, measuring plasma ACTH, cortisol, DHEA, CRP, and IL-6. Data were analysed with non-parametric tests, Kendall's tau correlation, and multivariate linear regression adjusted for confounders.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;We found a negative correlation between the plasma ACTH levels and suicidal ideation severity (tau = −0.130, p = 0.033), which was driven by the patients with major depressive disorder (tau = −0.237, p = 0.031). Suicidal ideation severity was also negatively correlated with TNF-alpha (tau = −0.231; p &lt; 0.001), positively correlated with IL-6 (tau = 0.154, p = 0.015), and CRP levels (tau = 0.153, p = 0.015), but no differences were observed in group-stratified analyses. The association between plasma ACTH levels and suicidal ideation severity in patients with major depressive disorder remained robust to adjustment for major confounders (adjusted for age, sex, education years, body mass index, smoking status, plasma CRP and PEth concentration (measuring chronic alcohol exposure), and antidepressant use) in the linear regression model (t = −2.71, p = 0.011), as well as additionally adjusting for depression severity (t = −2.99, p = 0.006).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;p&gt;The present study shows an association between plasma ACTH levels and suicidal ideation severity in patients with major depressive disorder, robust to adjustment for antidepressant use and depression severity. This finding highli","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000110/pdfft?md5=1bb8749f261ef379f26d781d7f96eabe&pid=1-s2.0-S2666497624000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair cortisol stability after 5-year storage: Insights from a sample of 17-year-old adolescents","authors":"Eloïse Berger ,&nbsp;Helen Findlay ,&nbsp;Charles-Edouard Giguère ,&nbsp;Sonia Lupien ,&nbsp;Isabelle Ouellet-Morin","doi":"10.1016/j.cpnec.2024.100234","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100234","url":null,"abstract":"<div><h3>Background</h3><p>Hair has become an increasingly valuable medium to investigate the association between chronic stress, stable differences in systemic cortisol secretion and later health. Assessing cortisol in hair has many advantages, notably its non-invasive and retrospective nature, the need for a single biospecimen and convenient storage until analysis. However, few studies offered empirical evidence documenting the long-term temporal stability of hair cortisol concentration (HCC) prior to analysis, especially in humans. Yet, knowing how long hair samples can be stored without compromising the accuracy of cortisol measurement is of crucial importance when planning data collection and analysis. This study examined the stability of HCC in hair samples assayed twice, five years apart.</p></div><div><h3>Methods</h3><p>We randomly selected from a larger distribution of HCC measured in 17-year-old participants 39 hair samples to be reanalyzed five years later, under the same general conditions. Samples were assayed in duplicate using a luminescence immunoassay and compared with the original HCC using the Lin's concordance correlation coefficient (CCC), Bland-Altman plot analysis and Wilcoxon rank test.</p></div><div><h3>Results</h3><p>Findings indicated a good concordance and temporal stability between the two samples assayed five years apart (CCC [95% confidence interval] = 0.84 [0.72–0.91]), although a small decrease in HCC was noted 5 years later (8.4% reduction, p = 0.001).</p></div><div><h3>Conclusion</h3><p>Our study confirms that hair samples, when stored at room temperature and away from sunlight, can be assayed for at least five years without risking a loss of precision in HCC measurement.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000109/pdfft?md5=a57c2d83031683ff4596468414199459&pid=1-s2.0-S2666497624000109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair hormone data from Syrian refugee children: Perspectives from a two-year longitudinal study","authors":"Andrew K. May ,&nbsp;Demelza Smeeth ,&nbsp;Fiona McEwen ,&nbsp;Patricia Moghames ,&nbsp;Elie Karam ,&nbsp;Michael J. Rieder ,&nbsp;Abdelbaset A. Elzagallaai ,&nbsp;Stan van Uum ,&nbsp;Michael Pluess","doi":"10.1016/j.cpnec.2024.100231","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100231","url":null,"abstract":"<div><p>For numerous issues of convenience and acceptability, hair hormone data have been increasingly incorporated in the field of war trauma and forced displacement, allowing retrospective examination of several biological metrics thought to covary with refugees’ mental health. As a relatively new research method, however, there remain several complexities and uncertainties surrounding the use of hair hormones, from initial hair sampling to final statistical analysis, many of which are underappreciated in the extant literature, and restrict the potential utility of hair hormones. To promote awareness, we provide a narrative overview of our experiences collecting and analyzing hair hormone data in a large cohort of Syrian refugee children (<em>n</em> = 1594), across two sampling waves spaced 12 months apart. We highlight both the challenges faced, and the promising results obtained thus far, and draw comparisons to other prominent studies in this field. Recommendations are provided to future researchers, with emphasis on longitudinal study designs, thorough collection and reporting of hair-related variables, and careful adherence to current laboratory guidelines and practices.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000079/pdfft?md5=dc68c583a011ee7ad24e19b54ef200d2&pid=1-s2.0-S2666497624000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}