Comprehensive psychoneuroendocrinology最新文献

{"title":"Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity","authors":"Robertas Strumila , Aiste Lengvenyte , Linas Zdanavicius , Robertas Badaras , Edgaras Dlugauskas , Sigita Lesinskiene , Eimantas Matiekus , Martynas Marcinkevicius , Lina Venceviciene , Algirdas Utkus , Andrius Kaminskas , Tomas Petrenas , Jurgita Songailiene , Dalius Vitkus , Laima Ambrozaityte","doi":"10.1016/j.cpnec.2024.100235","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100235","url":null,"abstract":"<div><h3>Introduction</h3><p>Suicidal ideation, an important risk factor for suicide attempts, has an unclear neurobiological basis and is potentially linked to the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and immune-inflammatory systems. While inflammatory markers have been associated with suicide attempts and, to a lower extent suicidal ideation, the data on the role of a stress-response system is less robust, with most studies carried out with cortisol showing inconsistent results. The present study extends on the previous studies implicating stress-response and immune-inflammatory systems in suicidal thoughts and behaviours, focusing on the associations of several stress-response (adrenocorticotropic hormone (ACTH), cortisol, and dehydroepiandrosterone (DHEA)) and immune-inflammatory (C-reactive protein (CRP),interle ukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha)) with suicidal ideation severity in recent suicide attempters, patients with major depressive disorder, and non-psychiatric controls.</p></div><div><h3>Methods</h3><p>This observational study included 156 adults from three Vilnius hospitals, recruited into one of the three groups in equal parts: recent suicide attempters, patients with major depressive disorder in current depressive episode, and non-psychiatric controls. Measures included the Hamilton Depression Rating Scale (HDRS-17) and the Beck Scale for Suicide Ideation/Suicide Severity Index (BSS/SSI), alongside sociodemographic data, alcohol, tobacco use, and morning blood samples, measuring plasma ACTH, cortisol, DHEA, CRP, and IL-6. Data were analysed with non-parametric tests, Kendall's tau correlation, and multivariate linear regression adjusted for confounders.</p></div><div><h3>Results</h3><p>We found a negative correlation between the plasma ACTH levels and suicidal ideation severity (tau = −0.130, p = 0.033), which was driven by the patients with major depressive disorder (tau = −0.237, p = 0.031). Suicidal ideation severity was also negatively correlated with TNF-alpha (tau = −0.231; p < 0.001), positively correlated with IL-6 (tau = 0.154, p = 0.015), and CRP levels (tau = 0.153, p = 0.015), but no differences were observed in group-stratified analyses. The association between plasma ACTH levels and suicidal ideation severity in patients with major depressive disorder remained robust to adjustment for major confounders (adjusted for age, sex, education years, body mass index, smoking status, plasma CRP and PEth concentration (measuring chronic alcohol exposure), and antidepressant use) in the linear regression model (t = −2.71, p = 0.011), as well as additionally adjusting for depression severity (t = −2.99, p = 0.006).</p></div><div><h3>Discussion</h3><p>The present study shows an association between plasma ACTH levels and suicidal ideation severity in patients with major depressive disorder, robust to adjustment for antidepressant use and depression severity. This finding highli","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000110/pdfft?md5=1bb8749f261ef379f26d781d7f96eabe&pid=1-s2.0-S2666497624000110-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair cortisol stability after 5-year storage: Insights from a sample of 17-year-old adolescents","authors":"Eloïse Berger ,&nbsp;Helen Findlay ,&nbsp;Charles-Edouard Giguère ,&nbsp;Sonia Lupien ,&nbsp;Isabelle Ouellet-Morin","doi":"10.1016/j.cpnec.2024.100234","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100234","url":null,"abstract":"<div><h3>Background</h3><p>Hair has become an increasingly valuable medium to investigate the association between chronic stress, stable differences in systemic cortisol secretion and later health. Assessing cortisol in hair has many advantages, notably its non-invasive and retrospective nature, the need for a single biospecimen and convenient storage until analysis. However, few studies offered empirical evidence documenting the long-term temporal stability of hair cortisol concentration (HCC) prior to analysis, especially in humans. Yet, knowing how long hair samples can be stored without compromising the accuracy of cortisol measurement is of crucial importance when planning data collection and analysis. This study examined the stability of HCC in hair samples assayed twice, five years apart.</p></div><div><h3>Methods</h3><p>We randomly selected from a larger distribution of HCC measured in 17-year-old participants 39 hair samples to be reanalyzed five years later, under the same general conditions. Samples were assayed in duplicate using a luminescence immunoassay and compared with the original HCC using the Lin's concordance correlation coefficient (CCC), Bland-Altman plot analysis and Wilcoxon rank test.</p></div><div><h3>Results</h3><p>Findings indicated a good concordance and temporal stability between the two samples assayed five years apart (CCC [95% confidence interval] = 0.84 [0.72–0.91]), although a small decrease in HCC was noted 5 years later (8.4% reduction, p = 0.001).</p></div><div><h3>Conclusion</h3><p>Our study confirms that hair samples, when stored at room temperature and away from sunlight, can be assayed for at least five years without risking a loss of precision in HCC measurement.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000109/pdfft?md5=a57c2d83031683ff4596468414199459&pid=1-s2.0-S2666497624000109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair hormone data from Syrian refugee children: Perspectives from a two-year longitudinal study","authors":"Andrew K. May ,&nbsp;Demelza Smeeth ,&nbsp;Fiona McEwen ,&nbsp;Patricia Moghames ,&nbsp;Elie Karam ,&nbsp;Michael J. Rieder ,&nbsp;Abdelbaset A. Elzagallaai ,&nbsp;Stan van Uum ,&nbsp;Michael Pluess","doi":"10.1016/j.cpnec.2024.100231","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100231","url":null,"abstract":"<div><p>For numerous issues of convenience and acceptability, hair hormone data have been increasingly incorporated in the field of war trauma and forced displacement, allowing retrospective examination of several biological metrics thought to covary with refugees’ mental health. As a relatively new research method, however, there remain several complexities and uncertainties surrounding the use of hair hormones, from initial hair sampling to final statistical analysis, many of which are underappreciated in the extant literature, and restrict the potential utility of hair hormones. To promote awareness, we provide a narrative overview of our experiences collecting and analyzing hair hormone data in a large cohort of Syrian refugee children (<em>n</em> = 1594), across two sampling waves spaced 12 months apart. We highlight both the challenges faced, and the promising results obtained thus far, and draw comparisons to other prominent studies in this field. Recommendations are provided to future researchers, with emphasis on longitudinal study designs, thorough collection and reporting of hair-related variables, and careful adherence to current laboratory guidelines and practices.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000079/pdfft?md5=dc68c583a011ee7ad24e19b54ef200d2&pid=1-s2.0-S2666497624000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feigned annoyance and frustration test to activate the sympathoadrenal medullary system","authors":"Ted W. Gehrig III ,&nbsp;Lee S. Berk ,&nbsp;Robert I. Dudley ,&nbsp;Jo A. Smith ,&nbsp;Lida Gharibvand ,&nbsp;Everett B. Lohman III","doi":"10.1016/j.cpnec.2024.100232","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100232","url":null,"abstract":"<div><p>When perceived as threatening, social interactions have been shown to trigger the sympathoadrenal medullary system as well as the hypothalamic-pituitary-adrenal axis resulting in a physiologic stress response. The allostatic load placed on human health and physiology in the context of acute and chronic stress can have profound health consequences. The purpose of this study was to develop a protocol for a lab-based stress stimulus using social-evaluative threat. While several valid, stress-stimulating protocols exist, we sought to develop one that triggered a physiologic response, did not require significant lab resources, and could be completed in around 10 min. We included 53 participants (29 men and 24 women) and exposed them to a modified version of the Stroop Color-Word Interference Task during which the participants were made to feel they were performing the task poorly while the lead researcher feigned annoyance and frustration. After exposure to this Feigned Annoyance and Frustration (FAF) Test, both the men and women in this study demonstrated a statistically significant and clinically meaningful increase in subjective stress on the visual analog scale. Additionally, the men in this study demonstrated a statistically significant increase in heart rate and salivary α-amylase concentrations after exposure to the test. The women in this study did not demonstrate a statistically significant increase in the physiologic stress biomarkers. This protocol for the FAF Test shows promise to researchers with limited time and resources who are interested in experimentally activating the sympathoadrenal medullary system.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000080/pdfft?md5=5edaa9852216c416e59cbc0f36ddb5c5&pid=1-s2.0-S2666497624000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin and its links through scientific lineage","authors":"Suma Jacob","doi":"10.1016/j.cpnec.2024.100230","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100230","url":null,"abstract":"<div><p>Scientific inquiry and methodology are based on third person objectivity. Yet, as humans we experience everything through our first-person lens and second-person relational learning. The purpose of this review is to share the journey of discoveries about science and oxytocin from this author's unique and diverse perspective. Hormones are signaling molecules and long distant messengers required to regulate an organism's physiology and behavior. Oxytocin has taken the lead as the most investigated neurohormone that modulates social cognition, influences parenting behaviors, facilitates within or across-species bonding, and even biologically buffers against stressors such as isolation. Our increasing understanding that social connection, community belonging, and trust in others influence both physical and mental health outcomes, has led to numerous intervention and treatment oxytocin studies across a myriad of conditions. No longer just a way to facilitate female reproduction and lactation, oxytocin is now viewed as the “social influencer” that affects not just women but also men along with its closely related neurohormone, vasopressin. This review uses the narrative lens to illustrate how scientific lineage shapes what we study and how investigating oxytocin has been a microcosm to macrocosm metaphor for our collective social learning as a scientific community.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000067/pdfft?md5=95797da5d909a3edbbc69fa8ff5533eb&pid=1-s2.0-S2666497624000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140160677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary results of anti-inflammatory cytokine concentrations predicting therapy outcome in panic disorder","authors":"Vanessa Renner ,&nbsp;Rupert Conrad ,&nbsp;Clemens Kirschbaum ,&nbsp;Thomas Lorenz ,&nbsp;Katja Petrowski","doi":"10.1016/j.cpnec.2024.100227","DOIUrl":"10.1016/j.cpnec.2024.100227","url":null,"abstract":"<div><h3>Background</h3><p>Patients with panic disorder (PD) show alterations of the immune reactivity to acute stress, which could serve as a marker for effective treatment. Nevertheless, the effect of immune reactivity under acute stress before treatment on therapy outcome remains unclear.</p></div><div><h3>Methods</h3><p>A total of <em>N</em> = 16 PD patients performed the Trier Social Test. Blood sample collection of anti-inflammatory cytokine IL-10 accompanied the TSST. The Mobility Inventory was handed out for the assessment of avoidance behavior before and after treatment. Area under the curve with respect to the ground (AUC_G) and increase (AUC_I) were calculated for assessed cytokine levels and were used as predictors for therapy outcome in regression analyses.</p></div><div><h3>Results</h3><p>AUC_G significantly predicts avoidance behavior in company after treatment (<em>β</em> = −0.007, <em>p</em> = .033) but not avoidance behavior alone (<em>β</em> = −0.003, <em>p</em> = .264). AUC_I does not significantly predict therapy outcome.</p></div><div><h3>Conclusion</h3><p>Higher concentrations of anti-inflammatory cytokine IL-10 under acute stress before treatment predicts less avoidance behavior in company after therapy. Immune markers seem to play a crucial role in the maintenance of mental disorders such as PD. Underlying mechanisms and IL-10 as a marker for individualized treatments should be investigated in future studies.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000031/pdfft?md5=57ab0b414a7d3e498318df984113de50&pid=1-s2.0-S2666497624000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effort-reward and overcommitment at work and psychiatric symptoms in healthcare professionals: The mediation role of allostatic load","authors":"Daniela Coelho ,&nbsp;Siomara Yamaguchi ,&nbsp;Alaa Harb ,&nbsp;Juliana N. Souza-Talarico","doi":"10.1016/j.cpnec.2024.100225","DOIUrl":"10.1016/j.cpnec.2024.100225","url":null,"abstract":"<div><h3>Background</h3><p>Despite decades of advancement to support interventions for managing work-related stress, mental health issues have significantly escalated among healthcare professionals. Effort-reward imbalance (ERI) and overcommitment in the workplace are linked to several psychiatric disorders. However, the underlying biological mechanisms remain unclear. This study investigated whether ERI and overcommitment among healthcare professionals were linked to Allostatic Load (AL) and whether AL mediates the relationship between ERI, overcommitment and mental health issues.</p></div><div><h3>Methods</h3><p>One hundred forty-two nursing workers (n = 142; 90.1 % female, mean age: 39.5 ± 9.6) were randomly recruited from a university hospital in Sao Paulo, Brazil, and applied the ERI scale that assesses work effort, reward, and overcommitment. The Perceived Stress Scale (PSS), The Beck Depression Inventory (BDI), and the Self-Report Questionnaire for psychiatric symptoms (SRQ-20) evaluated the mental health outcomes. Ten neuroendocrine, metabolic, immunologic and cardiovascular biomarkers were analyzed, and values were transformed into an AL index using clinical reference cutoffs.</p></div><div><h3>Results</h3><p>Linear regression adjusted for covariates showed that higher scores for overcommitment were associated with higher AL indexes, which in turn were associated with higher SRQ-20, but not with PSS and DBI scores. As expected, higher scores for effort, lower for reward, and higher ERI were associated with higher scores for PSS, SRQ-20, and DBI, but not with AL index. Direct effect estimates showed that overcommitment was directly associated with higher SRQ-20 scores, and indirectly via AL.</p></div><div><h3>Conclusion</h3><p>Our study reveals that overcommitment, rather than ERI, was linked to increased AL in healthcare workers. Additionally, AL mediates the relationship between overcommitment and higher psychiatric symptoms, highlighting a key mechanism by which work stress can lead to mental health problems. Individual's responses to high work demands need to be considered when designing predictive models and interventions for mental health issues.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000018/pdfft?md5=7e5a5f23ad3f167ef8830efb677e1ceb&pid=1-s2.0-S2666497624000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive psychological effects of seated acupressure massage are associated with a rise in plasma oxytocin without affecting CGRP levels or circulating IL-6","authors":"Florentine Fricker ,&nbsp;Marie-Virginie Barbotte ,&nbsp;Gaétan Pallot ,&nbsp;Nouhaila Radoua ,&nbsp;Gabriele Sorci ,&nbsp;Marie Heitz ,&nbsp;Grégory Brison ,&nbsp;Edith Sales-Vuillemin ,&nbsp;Jean-Louis Connat","doi":"10.1016/j.cpnec.2023.100220","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100220","url":null,"abstract":"<div><p>Work-related stress is a major public health issue. Given the relationship between acute stress responses and health, finding strategies to deal with the unpleasant symptoms brought on by stress is essential. Massage therapy is a popular stress-reduction technique, but its effectiveness has yet to be shown. In that matter, this study investigates the effects of a 17-minute session of seated Amma massage on young healthy people. Subjective stress perception, anxiety and self-confidence were assessed before and after the massage using the Spielberger State Anxiety Scale (STAI-Y, Spielberger et al., 1983) and the Competitive State Anxiety Inventory (EEAC, Cury et al., 1999), together with cardiovascular parameters. Cortisol, CGRP, IL-6, and oxytocin plasma levels were measured before and after the massage to investigate its possible mode of action. This study enrolled 59 people: 33 receiving the massage, and 26 controls only seated on the massage chair.</p><p>Interaction Time x Group demonstrates significant differences for all psychological measurements (STAI, EEAC) before and after the Amma massage, showing a beneficial effect of this treatment, in particular on perceived anxiety and self-confidence. No evidence was found of any correlation between cortisol plasma levels and psychological outcomes. No relationship was shown between the decrease of perceived stress and measured CGRP or IL-6 release, but the data demonstrated that heart frequency could be slightly decreased. The oxytocin plasma levels were significantly increased by the massage and could be responsible for the recovery of psychological outcomes.</p><p>We conclude that seated acupressure Amma massage could be a useful tool to ameliorate quality of life at work.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000541/pdfft?md5=26ade99077a1564dcfb7816373c05d00&pid=1-s2.0-S2666497623000541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139653908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Psychoneuroimmunological Model of Moral Distress and Health in healthcare workers: Toward individual and system-level solutions","authors":"Annina Seiler ,&nbsp;Aimee Milliken ,&nbsp;Richard E. Leiter ,&nbsp;David Blum ,&nbsp;George M. Slavich","doi":"10.1016/j.cpnec.2024.100226","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100226","url":null,"abstract":"<div><p>Healthcare is presently experiencing a global workforce crisis, marked by the inability of hospitals to retain qualified healthcare workers. Indeed, poor working conditions and staff shortages have contributed to structural collapse and placed a heavy toll on healthcare workers’ (HCWs) well-being, with many suffering from stress, exhaustion, demoralization, and burnout. An additional factor driving qualified HCWs away is the repeated experience of moral distress, or the inability to act according to internally held moral values and perceived ethical obligations due to internal and external constraints. Despite general awareness of this crisis, we currently lack an organized understanding of how stress leads to poor health, wellbeing, and performance in healthcare workers. To address this critical issue, we first review the literature on moral distress, stress, and health in HCWs. Second, we summarize the biobehavioral pathways linking occupational and interpersonal stressors to health in this population, focusing on neuroendocrine, immune, genetic, and epigenetic processes. Third, we propose a novel Psychoneuroimmunological Model of Moral Distress and Health in HCWs based on this literature. Finally, we discuss evidence-based individual- and system-level interventions for preventing stress and promoting resilience at work. Throughout this review, we underscore that stress levels in HCWs are a major public health concern, and that a combination of system-level and individual-level interventions are necessary to address preventable health care harm and foster resilience in this population, including new health policies, mental health initiatives, and additional translational research.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266649762400002X/pdfft?md5=795a99cf2b7843eaaa54083cbe498fbd&pid=1-s2.0-S266649762400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in hair cortisol in a New Zealand community sample during the Covid-19 pandemic","authors":"Elizabeth Broadbent ,&nbsp;Urs Nater ,&nbsp;Nadine Skoluda ,&nbsp;Norina Gasteiger ,&nbsp;Ru Jia ,&nbsp;Trudie Chalder ,&nbsp;Mikaela Law ,&nbsp;Kavita Vedhara","doi":"10.1016/j.cpnec.2024.100228","DOIUrl":"10.1016/j.cpnec.2024.100228","url":null,"abstract":"<div><h3>Background</h3><p>Evidence suggests that countries with higher Covid-19 infection rates experienced poorer mental health. This study examined whether hair cortisol reduced over time in New Zealand, a country that managed to eliminate the virus in the first year of the pandemic due to an initial strict lockdown.</p></div><div><h3>Methods</h3><p>A longitudinal cohort study assessed self-reported stress, anxiety and depression and collected hair samples that were analyzed for cortisol, across two waves in 2020. The sample consisted of 44 adults who each returned two 3 cm hair samples and completed self-reports. Hair cortisol was assessed per centimetre.</p></div><div><h3>Results</h3><p>Hair cortisol reduced over time (F (5, 99.126) = 10.15, p &lt; .001, partial eta squared = 0.19), as did anxiety and depression. Higher hair cortisol was significantly associated with more negative life events reported at wave two (r = 0.30 segment 1, r = 0.34 segment 2, p &lt; .05), but not anxiety or depression.</p></div><div><h3>Conclusions</h3><p>Strict virus control measures may not only reduce infection rates, but also reduce psychological distress, and hair cortisol over time.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000043/pdfft?md5=5f4770a3ccf9ec48c8b5458fde98a977&pid=1-s2.0-S2666497624000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}