Comprehensive psychoneuroendocrinology最新文献

{"title":"Empathy at school project: Effects of didactics of emotions® on emotional competence, cortisol secretion and inflammatory profile in primary school children. A controlled longitudinal psychobiological study","authors":"A.G. Bottaccioli , U. Mariani , R. Schiralli , M.G. Mari , M. Pontani , M. Bologna , P. Muzi , S.D. Giannoni , V. Ciummo , S. Necozione , V. Cofini , L. Chiariotti , M. Cuomo , D. Costabile , F. Bottaccioli","doi":"10.1016/j.cpnec.2023.100183","DOIUrl":"10.1016/j.cpnec.2023.100183","url":null,"abstract":"<div><h3>Background</h3><p>There is mounting evidence of the presence of chronic stress among children during primary school: girls and boys under the age of 15 years often experience anxiety, irritability and sleeping problems with negative consequences on scholastic climate and the spread of bullying and dropping out of school. The promotion of emotion regulation within school environment through innovative didactic methodologies represents a valuable tool for teachers and parents to reduce emotional distress and associated risk behaviours and to promote wellbeing.</p></div><div><h3>Aim</h3><p>Our research aims to explore the psychological and biological consequences of teaching emotional training in an experimental group of Italian Primary School children.</p></div><div><h3>Methods</h3><p>A sample of pupils (81 children aged between 6 and 8) was divided into an experimental group (33 subjects) and a control group (30 subjects). A further advanced group of 18 subjects, who have experienced the method in the previous school year, was also included. The experimental study lasted one school year (from October 2021 to May 2022). The following psychological tests were administered to all groups: TEC (Test of Emotion Comprehension) to measure the children's different emotional abilities and the Projective test (PT) 'A person in the rain', to identify the coping skills of children in a stressful condition. Morning salivary cortisol, IL-6 and TNF-alpha assays were conducted in all three groups. Psychological and biological tests were administered at the beginning of the study and at the end of the study.</p></div><div><h3>Results</h3><p>The MR-Anova model for TEC score showed that there was not a significant group effect [Fgroup = 2.24, p = 0.114]. Pairwise comparisons showed that mean score significantly increased only in the Experimental group (pB < 0.001) and at the end of the project there was a significant difference between Experimental group and Control group (pB = 0.012). The mean score of PT test increased significantly from baseline to the end of the project for the Experimental group (pB < 0.001) and for the Advanced group (pB = 0.004). At the end of the project, there were significant differences between the Experimental group and the Control group (pB = 0.004) and between the Advanced group and the Control group (pB < 0.001). Salivary cortisol analysis revealed a significant effect between subjects [Fgroup = 9.66; p < 0.001] and significant effects within subjects with the main effect of the time [Ftime = 35.41; p < 0.001] and the significant interaction “time x group” [Ftimexgroup = 3.38; p = 0.040]. Pairwise comparisons showed that cortisol levels decreased significantly over time only in the Experimental group (pB < 0.001). Regarding to IL-6 levels, there was not a significant effect between subjects [Fgroups = 0.0481; p = 0.953]. The mean level decreased significantly for each group from baseline to post project (pB &","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"14 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068011/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational impact of childhood trauma on hair cortisol concentrations in mothers and their young infants","authors":"Carlinde W. Broeks , Nina Molenaar , Marlies Brouwer , Erica L.T. van den Akker , Elisabeth F.C. van Rossum , Rien Van , Sjoerd A.A. van den Berg , Manon Hillegers , Witte J.G. Hoogendijk , Huibert Burger , Claudi Bockting , Astrid M. Kamperman , Mijke P. Lambregtse-Van den Berg","doi":"10.1016/j.cpnec.2023.100167","DOIUrl":"10.1016/j.cpnec.2023.100167","url":null,"abstract":"<div><h3>Background</h3><p>Alterations in stress regulation and function of the hypothalamic-pituitary-adrenal (HPA) axis during infancy may be a risk factor for the development of psychopathology later in life. Maternal childhood trauma, depression, anxiety and stressful life events are individually associated with HPA axis dysregulation. Less is known about their interdependent influence on maternal and infant stress regulation in at risk populations. In a sample of mothers with a history of depressive-, and/or anxiety disorders and their infants we explored if a history of maternal childhood trauma, current depressive and anxiety symptomatology, and recent life events were associated with maternal and infant long-term cortisol levels three months postpartum.</p></div><div><h3>Methods</h3><p>Data were available of 89 mothers and 49 infants. All mothers fulfilled criteria for a lifetime depressive or anxiety disorder. Diagnosis was established with a diagnostic interview. Current depressive symptomatology was assessed with the Edinburgh Postnatal Depression Scale (EPDS), current anxiety with the State-Trait Anxiety Inventory (STAI), maternal childhood trauma with the Childhood Trauma Questionnaire (CTQ) and recent life events with the Everyday Problem Checklist (EPC). Maternal and infant hair cortisol concentrations (HCC) were quantified with liquid chromatography with tandem mass spectrometry (LC-MS/MS) three months after birth. Total scores of the CTQ and subscales, EPDS, STAI, and EPC were regressed on maternal and infant HCC using regression analyses. Differences in HCC regarding trauma history were tested with t-tests. Potential confounders were identified and adjusted for.</p></div><div><h3>Results</h3><p>In regression analyses, a positive curvilinear relationship was found between CTQ total score and maternal HCC (n = 83, B = 0.076, SE 0.033, p = .021), but not for current depression (n = 88, B = −0.001, SE 0.011, p = .931), current anxiety (n = 88, B = 0.002, SE 0.004, p = .650) or recent life events (n = 89, B = 0.018, SE 0.032, p = .568). Analyses were adjusted for confounders. A negative linear relationship was found between maternal CTQ score and infant HCC (n = 49, β = −0.264, B = −0.006, SE 0.003, p = .052), but not for current maternal depression (n = 45, β = −0.182, B = −0.011, SE 0.008, p = .164), current maternal anxiety (n = 45, β = −0.209, B = −0.005, SE 0.003, p = .113) or recent life events (n = 46, β = −0.128, B = −0.022, SE 0.023, p = .325). Analyses were adjusted for relevant infant hair characteristics. Specifically, maternal emotional and physical neglect were related to HCC in both mothers and infants.</p></div><div><h3>Conclusions</h3><p>Results suggest that maternal childhood trauma is more prominent in altering maternal and infant long-term cortisol levels than perinatal depressive and anxiety symptomatology or recent life stressors in mothers with a history of depressive and/or anxiety disorders, and their infants","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"14 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/ac/main.PMC9930158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10769336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is oxytocin receptor signaling really dispensable for social attachment?","authors":"Joshua S. Danoff, Emma A. Whelan, Jessica J. Connelly","doi":"10.1016/j.cpnec.2023.100178","DOIUrl":"10.1016/j.cpnec.2023.100178","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"14 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/e9/main.PMC9981807.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10836636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute effects of a single dose of psilocybin on biomarkers of inflammation in healthy humans: An open-label preliminary investigation","authors":"Daniel Rødbro Burmester ,&nbsp;Martin Korsbak Madsen ,&nbsp;Attila Szabo ,&nbsp;Sagar Sanjay Aripaka ,&nbsp;Dea Siggaard Stenbæk ,&nbsp;Vibe G. Frokjaer ,&nbsp;Betina Elfving ,&nbsp;Jens D. Mikkelsen ,&nbsp;Gitte Moos Knudsen ,&nbsp;Patrick MacDonald Fisher","doi":"10.1016/j.cpnec.2022.100163","DOIUrl":"10.1016/j.cpnec.2022.100163","url":null,"abstract":"<div><h3>Rationale</h3><p>Psilocybin is a serotonergic psychedelic that has gained prominent attention recently as a potential therapeutic for neuropsychiatric disorders including Major Depressive Disorder. Pre-clinical and initial studies in humans suggest that serotonin 2A receptor agonists, including serotonergic psychedelics, have anti-inflammatory effects. This may contribute to its therapeutic effects as previous studies indicate a link between neuropsychiatric disorders and inflammatory processes. However, the effect of psilocybin on biomarkers of inflammation has not been evaluated in humans.</p></div><div><h3>Objectives</h3><p>Investigate the effect of a single dose of psilocybin on peripheral biomarkers of inflammation in healthy humans.</p></div><div><h3>Methods</h3><p>Blood samples were collected from 16 healthy participants before and one day after the administration of a single oral dose of psilocybin (mean dose: 0.22 mg/kg) and subsequently analyzed for concentrations of high-sensitivity C-reactive protein (hsCRP), tumor-necrosis-factor (TNF) and soluble urokinase plasminogen activator receptor (suPAR). Change in inflammatory markers was evaluated using a paired <em>t</em>-test where p &lt; 0.05 was considered statistically significant.</p></div><div><h3>Results</h3><p>We did not observe statistically significant changes in any of the above biomarkers of inflammation (all Cohen's d ≤ 0.31; all p ≥ 0.23).</p></div><div><h3>Conclusions</h3><p>Our data do not support that a single dose of psilocybin reduces biomarkers of inflammation in healthy individuals one day after administration. Nevertheless, we suggest that future studies consider additional markers of inflammation, including markers of neuroinflammation, and evaluate potential anti-inflammatory effects of psilocybin therapy in clinical cohorts where more prominent effects may be observable.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/3d/main.PMC9761602.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10785863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer Acknowledgement","authors":"","doi":"10.1016/j.cpnec.2023.100176","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100176","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49788688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders","authors":"Donatella Marazziti ,&nbsp;C. Sue Carter ,&nbsp;Claudia Carmassi ,&nbsp;Alessandra Della Vecchia ,&nbsp;Federico Mucci ,&nbsp;Giovanni Pagni ,&nbsp;Manuel G. Carbone ,&nbsp;Stefano Baroni ,&nbsp;Gino Giannaccini ,&nbsp;Lionella Palego ,&nbsp;Liliana Dell’Osso","doi":"10.1016/j.cpnec.2022.100165","DOIUrl":"10.1016/j.cpnec.2022.100165","url":null,"abstract":"<div><p>Oxytocin (OT) is involved in the regulation of physiological processes and emotional states, with increasing evidence for its beneficial actions being mediated by the autonomic and immune systems. Growing evidence suggests that OT plays a role in the pathophysiology of different psychiatric disorders. Given the limited information in humans the aim of this study was to retrospectively explore plasma OT levels in psychiatric patients, particularly focusing on sex-related differences, as compared with healthy controls. The patients studied here were divided into three groups diagnosed with obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). Plasma OT levels were significantly different between healthy men and women, with the latter showing higher values, while none of the three psychiatric groups showed sex-related differences in the parameters measured here. The intergroup analyses showed that the OT levels were significantly higher in OCD, lower in PTSD and even more reduced in MDD patients than in healthy subjects. These differences were also confirmed when gender was considered, with the exception of PTSD men, in whom OT levels were similar to those of healthy men. The present results indicated that OT levels were higher amongst healthy women than men, while a sex difference was less apparent or reversed in psychiatric patients. Reductions in sex differences in psychopathologies may be related to differential vulnerabilities in processes associated with basic adaptive and social functions.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/b7/main.PMC9800179.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2023 ISPNE Dirk Hellhammer Award","authors":"","doi":"10.1016/j.cpnec.2023.100175","DOIUrl":"10.1016/j.cpnec.2023.100175","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44053068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health, war trauma, and migration: The contribution of Comprehensive Psychoneuroendocrinology","authors":"Robert Dantzer","doi":"10.1016/j.cpnec.2023.100168","DOIUrl":"10.1016/j.cpnec.2023.100168","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/46/main.PMC9979260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9402786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2023 ISPNE Bruce McEwen Lifetime Achievement Award","authors":"","doi":"10.1016/j.cpnec.2023.100177","DOIUrl":"10.1016/j.cpnec.2023.100177","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49124250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum oxytocin correlated with later logical memory in older Japanese women: A 7-year follow-up study","authors":"Yutaka Kunitake ,&nbsp;Yoshito Mizoguchi ,&nbsp;Yoshiomi Imamura ,&nbsp;Hiroko Kunitake ,&nbsp;Ryuzo Orihashi ,&nbsp;Jun Matsushima ,&nbsp;Hiroshi Tateishi ,&nbsp;Toru Murakawa-Hirachi ,&nbsp;Shigeto Yamada ,&nbsp;Akira Monji","doi":"10.1016/j.cpnec.2022.100166","DOIUrl":"10.1016/j.cpnec.2022.100166","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to investigate the longitudinal relationship between serum oxytocin and logical memory among older adults in rural Japan and clarify sex differences in this relationship.</p></div><div><h3>Measurements</h3><p>The first survey was conducted from October 2009 to March 2011 (Time 1) and the second from November 2016 to September 2017 (Time 2). The final analysis for Time 1 included 385 participants (median age 75 years, interquartile range [IQR] 70–81 years) and that for Time 2 included 76 participants (median age 80 years, IQR 76–83 years). We assessed cognition, logical memory, and living conditions, and measured serum oxytocin levels. Logical memory was evaluated using the Wechsler Memory Scale-Revised Logical Memory II delayed recall part A (LM II-DR). Serum oxytocin was measured using the enzyme immunoassay method.</p></div><div><h3>Results</h3><p>The median (IQR) oxytocin level among men (n = 20) was 34 (16–78) pg/mL at Time 1 and 53 (28–140) pg/mL at Time 2. The median (IQR) oxytocin level among women (n = 56) was 117 (35–412) pg/mL at Time 1 and 76 (32–145) pg/mL at Time 2. The median oxytocin level among women at Time 2 was significantly lower than that at Time 1 (<em>p</em> = 0.004). The multivariate analysis showed that for women, LM II-DR score at Time 2 was positively associated with oxytocin level at Time 1 (<em>p</em> = 0.042) and negatively associated with age (<em>p</em> = 0.02).</p></div><div><h3>Conclusions</h3><p>Our study suggests that maintaining high oxytocin levels in older women may prevent age-related decline in logical memory.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"13 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/46/main.PMC9807821.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}