Comprehensive psychoneuroendocrinology最新文献

{"title":"The systemic immune-inflammation index (SII) as a biomarker for depression in a community sample of adolescents","authors":"Anett Schumacher ,&nbsp;Eric Tu ,&nbsp;Carly Albaum ,&nbsp;Daphne J. Korczak","doi":"10.1016/j.cpnec.2025.100302","DOIUrl":"10.1016/j.cpnec.2025.100302","url":null,"abstract":"<div><h3>Background</h3><div>Depression is associated with increased levels of pro-inflammatory biomarkers in children and adolescents. As research to date has primarily focused on inflammatory cytokines, the potential role of white blood cells (WBCs) and platelets in the inflammatory response is not well understood. This study examines the association of blood cell based inflammatory indices, including the systemic immune-inflammation index (SII), and depressive symptoms in participants in the Adolescent Brain Cognitive Development Study.</div></div><div><h3>Methods</h3><div>Adolescents were recruited from community settings and completed self-report measures of depression symptoms and semi-structured psychiatric interview to determine depression diagnosis. Participants provided blood samples to obtain absolute counts of neutrophil, lymphocyte, monocyte, and platelet levels for calculation of inflammatory indices. The association between depression and inflammatory markers was examined while accounting for participant age, sex, ethnicity, comorbid psychiatric disorder, parental education and annual household income.</div></div><div><h3>Results</h3><div>Of 858 participants (mean age: 12.4 ± 1.1 years; 45 % female), 101 received a diagnosis of a depressive disorder. Greater depressive symptoms were significantly associated with higher neutrophil and platelet levels (<em>β</em> = 0.013 and <em>β</em> = 0.018, respectively) and higher SII (<em>β</em> = 0.012), after adjusting for covariates. Diagnosis of depression was not associated with WBC levels or indices.</div></div><div><h3>Conclusions</h3><div>In this community-based sample of adolescents, greater depressive symptoms were associated with elevated SII and individual white blood cell levels. Future studies using larger, longitudinal clinical samples are needed to confirm the potential role of the SII in adolescent depression, and the involvement of inflammation in early-onset depression.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100302"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A safe path to bariatric surgery: Mental health disorders in pre-operative patients","authors":"Andrew El Alam ,&nbsp;Mohamad Fleifel ,&nbsp;Hicham Baba ,&nbsp;Souha Bayda ,&nbsp;Bertha Maria Nassani ,&nbsp;Jocelyne Azar ,&nbsp;Arnaud Monier","doi":"10.1016/j.cpnec.2025.100300","DOIUrl":"10.1016/j.cpnec.2025.100300","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Obesity is one of the most significant global health concerns. As per the World Health Organization (WHO), obesity currently affects nearly 1.9 billion individuals around the world. Patients suffering from such a metabolic disease exhibit multiple medical conjoint medical conditions, and are predisposed to future high-morbidity and mortality complications. In addition, such patients might suffer from psychiatric compromises, at any time during their lives, that might have contributed to obesity. For many of these patients, bariatric surgery remains one of the leading methodologies in facilitating weight loss.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;To study the prevalence of selected mental health disorders history, including depression, childhood trauma, and eating disorders, plus abnormal eating behaviors in patients with obesity undergoing pre-bariatric surgery evaluation. In addition, we intended to find any inter-associations between different mental health disorders and demographics in such patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In this cross-sectional study, conducted at the Nutrition and Obesity Department at Louis Pasteur Hospital, France, we enrolled 234 patients with obesity undertaking pre-bariatric surgery evaluation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Around 31.2 % of participants had a history of depression, with 46.5 % receiving treatment. Childhood trauma was identified in 22.6 % of patients, and 12.8 % exhibited eating disorders, subclassified into binge eating disorder (6.4 %), bulimia (3.2 %), and night eating syndrome (3.4 %). Abnormal eating behaviors was also prominent in such patients, with 66.2 % engaging in activities such as snacking, hyperphagia, emotional eating, and compulsive eating. Sociodemographic associations showed that females were more likely to be diagnosed with depression, binge eating disorder, and compulsive eating, while males were more prone to hyperphagia. Childhood trauma was significantly associated with depression, binge eating disorder, bulimia, and abnormal eating behaviors. Multinomial logistic regression analysis revealed various predictors for depression, eating disorders, and abnormal eating behaviors across different categories. Notably, depression was associated with unemployment, trauma, and compulsions. Binge eating disorder showed significant associations with trauma and the female sex, while bulimia was notably associated with trauma. Night eating syndrome was inversely related to marriage status. Subgroup analysis further highlighted associations between depression, eating disorders, and abnormal eating behaviors in specific demographic groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;There is a complex link between mental health disorders and eating patterns in individuals with obesity undergoing pre-bariatric surgery evaluation. Understanding this association is important for developing comprehensive preoperative care strategies that address both physica","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100300"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory indices and the risk of depression in individuals with sleep difficulties: A cohort study based on NHANES 2005–2020","authors":"Ruolin Zhu ,&nbsp;Lu Wang ,&nbsp;Xingqi Wu ,&nbsp;Kai Wang","doi":"10.1016/j.cpnec.2025.100299","DOIUrl":"10.1016/j.cpnec.2025.100299","url":null,"abstract":"<div><div>Sleep difficulties are common and often precede depressive disorders. We aimed to explore the associations between systemic inflammatory markers and depression risk in individuals with difficulty sleeping. We utilized data from the National Health and Nutrition Examination Survey (NHANES, 2005–2020), encompassing 7916 participants who reported having difficulty sleeping. The systemic inflammation response index (SIRI) and neutrophil‒platelet ratio (NPR) were calculated using peripheral blood cell counts. Odds ratios (ORs) and 95 % confidence intervals (CIs) of the SIRI/NPR for depression risk were calculated via logistic regression models. Restricted cubic spline (RCS) analysis was used to examine the dose‒response relationships between these indices and depression risk, whereas receiver-operating characteristic (ROC) analysis was used to evaluate their prognostic accuracy for depression risk. Participants in the highest SIRI and NPR quartile groups had significantly greater depression risk than those in the lowest quartile group did (OR (SIRI): 1.50, 95 % CI = 1.10–2.04; OR (NPR): 1.49, 95 % CI = 1.04–2.13). Subgroup analyses revealed consistent associations across different demographics and clinical subgroups. RCS analyses revealed a nonlinear association between depression risk and the SIRI (J-shaped, P nonlinearity &lt;0.001) but not the NPR (P nonlinearity &gt;0.05). ROC analysis revealed moderate discriminative ability for both the SIRI (AUC = 0.66, 95 % CI = 0.64–0.68) and the NPR (AUC = 0.65, 95 % CI = 0.63–0.67) in predicting depression among individuals with difficulty sleeping. These findings suggest that the SIRI and NPR are independently associated with increased depression risk among individuals with difficulty sleeping.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100299"},"PeriodicalIF":2.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a female-male self-selection bias in TSST-based reactive stress research?","authors":"Victoria Xu ,&nbsp;Audrey-Ann Journault ,&nbsp;Samuel Alarie ,&nbsp;Charles-Édouard Giguère ,&nbsp;Emy Beaumont ,&nbsp;Sonia Lupien","doi":"10.1016/j.cpnec.2025.100296","DOIUrl":"10.1016/j.cpnec.2025.100296","url":null,"abstract":"<div><div>A selection bias occurs when a given sample of participants only represents a subset of the population under study, which may subsequently limit the generalizability of findings. While previous studies have noticed a potential female-male selection bias in human stress research, with female participants often being over-represented, no prior research has directly addressed this issue in the context of stress reactivity. This exploratory study aimed to systematically examine this observation. A total of 120 scientific articles (N = 10 103) published from 2014 to 2023 on the topic of human stress reactivity retrieved from PUBMED and PsycINFO were examined to compile sex ratios by study location (United States, Germany, China, Canada, Israel, United Kingdom). The meta-analysis and meta-regression results indicated that females participate in reactive stress studies more frequently than males, although the observed difference is small. Moreover, there is no significant discrepancy regarding male and female participation rates between the countries examined. This result supports a higher female representation level in stress research samples. The findings provide leads for future studies aiming to further investigate the underlying antecedents of selection bias in human stress research. A better understanding of the phenomenon could lead researchers to optimize recruitment methods to obtain more representative samples.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100296"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a multidisciplinary lifestyle intervention on stress-related parameters in people with rheumatoid arthritis and osteoarthritis: secondary analysis of the \"Plants for Joints\" randomized controlled trial","authors":"C.A. Wagenaar ,&nbsp;J. Christiaans ,&nbsp;V. Hermans ,&nbsp;W. Walrabenstein ,&nbsp;F.A. Koopman ,&nbsp;H. van Middendorp ,&nbsp;D. van Schaardenburg","doi":"10.1016/j.cpnec.2025.100298","DOIUrl":"10.1016/j.cpnec.2025.100298","url":null,"abstract":"<div><h3>Objective</h3><div>In two randomized controlled trials, the Plants for Joints (PFJ) multidisciplinary lifestyle intervention reduced signs and symptoms of rheumatoid arthritis (RA), or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared with usual care. This secondary analysis aimed to evaluate the effect of the PFJ intervention on stress-related parameters.</div></div><div><h3>Methods</h3><div>In two PFJ observer-blind randomized controlled trials (RCT), people with (1) RA with low-moderate disease activity or (2) MSOA were randomized to receive the PFJ lifestyle intervention or usual care. The 16-week PFJ intervention consisted of a whole-food plant-based diet, physical activity, and sleep and stress management. This secondary analysis investigated stress-related outcomes including heart rate, heart rate variability (HRV: root square mean of successive differences (RMSSD) and normalised high frequency (HFnorm), salivary cortisol, perceived stress (Perceived Stress Scale 10; PSS-10), and time spent on stress-reducing activities. An intention-to-treat analysis with a linear regression model (HRV) or linear mixed model (cortisol and PSS-10), adjusted for baseline values, was used to analyse between-group differences.</div></div><div><h3>Results</h3><div>77 people with RA and 64 with MSOA completed the RCT. RA participants following the PFJ intervention showed a significant improvement in HFnorm (between-group difference: 6.6; 95 % CI 0.5, 12.6) and an improving trend in RMSSD (4.3; 95 % CI -1.5, 10.1) alongside non-significant reductions of heart rate (3.1; 95 % CI-3.9, 10.1), salivary cortisol (1.3; 95 % CI -0.6, 3.1) and perceived stress (−2.0; 95 % CI -4.4, 0.3), compared to usual care. In participants with MSOA, there were no differences in heart rate, HRV outcomes, cortisol, or perceived stress between the intervention and control group. Both RA and MSOA participants temporarily increased time spent on stress-reducing activities, yet no change from baseline was observed after 16 weeks. In RA participants increased time spent on stress-reducing activities was associated with increased HFnorm.</div></div><div><h3>Conclusion</h3><div>This secondary analysis suggests the PFJ program may have a positive influence on stress-related parameters in people with RA, but not MSOA, compared to usual care.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100298"},"PeriodicalIF":2.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a multimodal intervention on physical health factors and lifestyle in patients with affective disorders – results from a randomized controlled trial","authors":"Ida Schou Ipsen ,&nbsp;Rasmus Schwarz ,&nbsp;Lars Vedel Kessing ,&nbsp;Kamilla W. Miskowiak ,&nbsp;Maj Vinberg","doi":"10.1016/j.cpnec.2025.100295","DOIUrl":"10.1016/j.cpnec.2025.100295","url":null,"abstract":"<div><h3>Background</h3><div>Traditional treatment for affective disorders primarily focuses on symptom management through pharmacotherapy and psychotherapy and rarely addresses co-existing physical impairments.</div></div><div><h3>Methods</h3><div>This randomized controlled trial assessed the impact of a six-month multimodal intervention (AWARE) on physical health in patients with bipolar and unipolar depressive disorders. A total of 103 patients, median age 40.75 years (65 % female), were randomized into the AWARE group (n = 50) or treatment as usual (TAU) group (n = 53). The AWARE intervention included five modules focused on activities of daily living, mood management, social relations, physical health, and cognition, with participants receiving approximately 12 sessions. TAU involved standard psychiatric care, Health outcomes were evaluated on sleep, metabolic markers, substance use, medication side effects, and perceived physical health. Statistical analyses used logistic regression for group comparisons and analysis of covariance for continuous outcomes.</div></div><div><h3>Results</h3><div>The AWARE group had significant improvements in sleep onset latency and reported reduced physical pain affecting daily work compared to TAU. However, no statistically significant differences were found in other physical health outcomes, such as metabolic markers, substance use, medication side effects, or perceived physical health. Study limitations include a modest sample size and a relatively short intervention duration.</div></div><div><h3>Conclusion</h3><div>While the AWARE intervention improved sleep and pain management, it did not significantly affect other health markers. Future research should involve longer intervention periods, larger sample sizes, and a comprehensive approach to both mental and physical health.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100295"},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol awakening response in pregnant women with depressive disorders: a potential marker of recovery status from pregnancy to postpartum","authors":"Carlinde W. Broeks ,&nbsp;Babette Bais ,&nbsp;Rien Van ,&nbsp;Hilmar H. Bijma ,&nbsp;Elisabeth F.C. van Rossum ,&nbsp;Witte J.G. Hoogendijk ,&nbsp;Mijke P. Lambregtse-Van den Berg ,&nbsp;Astrid M. Kamperman","doi":"10.1016/j.cpnec.2025.100297","DOIUrl":"10.1016/j.cpnec.2025.100297","url":null,"abstract":"<div><h3>Introduction</h3><div>Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to peripartum depression, potentially contributing to symptom persistence. This study examines the relationship between the cortisol awakening response (CAR) during pregnancy and depressive symptom reduction postpartum.</div></div><div><h3>Methods</h3><div>Pregnant women with a current depressive episode were included in this study, part of a larger RCT on bright light therapy. At baseline (12–32 weeks of pregnancy), participants provided saliva samples at awakening, +30, and +60 min post-awakening. The CAR was assessed using three measures: area under the curve relative to ground (AUCg), area under the curve relative to increase (AUCi), and peak reactivity (difference between awakening and +30 min cortisol levels). Depressive symptoms were measured using the Hamilton Depression Rating Scale (HAM-D) at baseline and two months postpartum. Linear regression models assessed associations between CAR measures and depressive symptom change, adjusting for relevant covariates.</div></div><div><h3>Results</h3><div>The study included 55 pregnant women (mean age: 32.3 years, SD 4.8; mean gestational age: 19.7 weeks). Mean HAM-D scores decreased from 16.7 (SD 5.3) at baseline to 5.7 (SD 5.6) postpartum. Higher AUCi during pregnancy was associated with less symptom reduction postpartum (unadjusted β = 0.36, p = .02; adjusted β = 0.36, p = .02), as was peak cortisol reactivity (unadjusted β = 0.33, p = .03; adjusted β = 0.32, p = .03), while AUCg showed no significant association with symptom change (unadjusted p = .19; adjusted p = .28).</div></div><div><h3>Conclusion</h3><div>Higher AUCi and peak cortisol reactivity of the cortisol awakening response during pregnancy were linked to persistence of depressive symptoms postpartum, suggesting that heightened cortisol reactivity to awakening may indicate persistent stress vulnerability in peripartum depression. Total cortisol output (AUCg) was not predictive of recovery. These findings underscore the potential relevance of stress reactivity over basal cortisol levels in peripartum depression and highlight the need for further research in larger samples to elucidate the usefulness in clinical practice.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100297"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the metabolic signature of intermittent explosive disorder: Preliminary evidence and potential mechanisms for altered bilirubin metabolism","authors":"Jeffrey B. Schwimmer ,&nbsp;Murray B. Stein ,&nbsp;Emil F. Coccaro ,&nbsp;Alejandro D. Meruelo","doi":"10.1016/j.cpnec.2025.100294","DOIUrl":"10.1016/j.cpnec.2025.100294","url":null,"abstract":"<div><div>Intermittent Explosive Disorder (IED) is characterized by impulsive aggression and emotional dysregulation, yet its systemic biological underpinnings remain poorly understood. This study examined bilirubin metabolism and systemic biomarkers as indicators of metabolic vulnerability in individuals with IED. Laboratory data for total and indirect bilirubin and white blood cell (WBC) count were analyzed in individuals with IED and a demographically and clinically matched general population (GP) control group. A 10:1 nearest-neighbor propensity score matching procedure was used to balance covariates including age, sex, race, ethnicity, body mass index (BMI), and alcohol and tobacco use. Participants with hepatobiliary or inflammatory conditions were excluded to reduce heterogeneity and confounding. Group comparisons used unique individuals with biomarker values averaged across timepoints.</div><div>Individuals with IED showed lower total and indirect bilirubin levels compared to matched controls, with a moderate effect size for indirect bilirubin (d = −0.37) and a small effect for total bilirubin (d = −0.10). WBC differences were minimal (d = −0.12). Linear mixed-effects models incorporating repeated measures yielded consistent results, though none of the group differences reached statistical significance, likely due to limited sample size in the IED group. Sensitivity analyses suggested bilirubin findings were more robust to unmeasured confounding than WBC.</div><div>These results highlight a potential hepatobiliary or metabolic signature in IED, rather than a primary inflammatory process. Given the preliminary nature of the findings, absence of cytokine data, and limited statistical power, results should be interpreted cautiously and warrant replication in larger samples with broader inflammatory and lifestyle profiling.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100294"},"PeriodicalIF":2.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panic attack symptoms in patients with diabetic peripheral neuropathy","authors":"Nayden H. Manolov ,&nbsp;Arman Sh Postadzhiyan ,&nbsp;Sonya M. Karabeliova ,&nbsp;Peter M. Marinov","doi":"10.1016/j.cpnec.2025.100292","DOIUrl":"10.1016/j.cpnec.2025.100292","url":null,"abstract":"<div><div>Assessment of diabetic peripheral neuropathy (DPN) usually focuses on nerve damage resulting from hyperglycaemia. However, screening for common psychiatric disorders may improve the recognition of psychopathology in patients with DPN.</div><div>This epidemiological cohort study aimed to evaluate the prevalence of panic attack symptoms in patients with DPN compared toa control group of healthy individuals without type 2 diabetes mellitusorDPN.Additionally, this study sought to compare the severity of these symptoms between the two groups.The study was conducted via a survey over three years in an accredited practice of physicians at the Medical University-Sofia.</div><div>A total of267 participants were included, comprising 83 patients with DPN and 184healthy controls. Both groups completed the Prime-MD Patient Health Questionnaire. The results indicated significant differences between the two study groups(<em>t</em>[127.513] = 3.293; <em>p</em> &lt; 0.01), and patients with DPN had a higher prevalence of panic attack symptoms than those in the control group.Furthermore, significant differences were observed in the severity of panic attack symptoms within the DPN group (<em>t</em>[(81] = 2.017, <em>p</em> &lt; 0.05).Patients who had experienced DPN for more than one year reported more severe symptoms than those who had experienced it for less than oneyear. Our results indicate that the high prevalence of panic attack symptoms inpatients with DPN highlights the need for integrated screening for psychiatric disorders within the overall management plan for diabetes mellitus.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100292"},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight-based discrimination and cortisol output: A systematic review","authors":"Maria A. Kalantzis ,&nbsp;Daniel M. Maitland ,&nbsp;Miranda Yannon ,&nbsp;Christina Gaggiano ,&nbsp;Jinbo He ,&nbsp;Aldo Barrita ,&nbsp;Lorelai Symmes ,&nbsp;William H. O'Brien","doi":"10.1016/j.cpnec.2025.100290","DOIUrl":"10.1016/j.cpnec.2025.100290","url":null,"abstract":"<div><div>Discrimination based on weight status (or weight-related discrimination/stigma) may be related to greater physical and mental health concerns via physiological and psychological phenotypes of stress. Cortisol output, a biomarker of stress, has been measured in relation to weight stigma and weight-related discrimination. This systematic review aims to synthesize existing research on the relationship between weight-related discrimination and cortisol output, evaluate methodological approaches for measuring these constructs, and identify research gaps regarding contextual factors influencing this relationship. A comprehensive search was conducted across multiple databases (PsycINFO, Scopus, ProQuest, and PubMed) from February 1 to July 1, 2024, resulting in 11 eligible studies that examined weight discrimination in relation to cortisol levels. Studies were assessed for quality using the NHLBI Study Quality Assessment Tool, and inter-rater reliability for coding was established at 90 %. The findings revealed a range of sample sizes (45–4341) and diverse participant characteristics, including variations in age, race, and body mass index (BMI). About half (N = 5) of the included studies reported a positive relation between weight stigma and cortisol output. The review also uncovered significant limitations in current methodologies, particularly concerning contextual factors and other marginalized identities, such as socioeconomic status and food insecurity, along with measuring other forms of discrimination in tandem with weight stigma, such as racial discrimination. These findings underscore the need for future research to adopt a more intersectional approach in examining the multifaceted nature of weight stigma and how it relates to a greater stress response in multiple marginalized identities, as well as including longitudinal modeling of weight stigma's impact on biomarkers for stress.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100290"},"PeriodicalIF":2.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}