Comprehensive psychoneuroendocrinology最新文献

{"title":"Embracing change: Navigating menopause with the help of mobile health apps in Germany","authors":"Klara Greffin ,&nbsp;Marlene Muehlmann ,&nbsp;Anna Pauleikhoff ,&nbsp;Bita Stelling ,&nbsp;Holger Muehlan ,&nbsp;Michael Stach ,&nbsp;Silke Schmidt ,&nbsp;Samuel Tomczyk","doi":"10.1016/j.cpnec.2025.100320","DOIUrl":"10.1016/j.cpnec.2025.100320","url":null,"abstract":"<div><h3>Background</h3><div>Mobile health applications (mHealth apps) have shown promise as potential solutions for mitigating the negative health impacts of menopause. However, there is a lack of standardized expert and user ratings regarding the quality of these apps, making it difficult to provide evidence-based recommendations. Therefore, this app review aimed to summarize the currently available mHealth apps for menopause in Germany. Subsequently, the identified apps were evaluated, and their quality was assessed.</div></div><div><h3>Methods</h3><div>A web crawler was used to search for mHealth apps related to the predefined search criteria, and information for all included apps was extracted (year of search: 2021). In the second step, healthcare providers and individuals experiencing menopause tested and evaluated the apps using the German version of the Mobile Application Rating Scale (MARS-G).</div></div><div><h3>Results</h3><div>The initial search yielded 6917 apps. Of these, 6879 were excluded, 32 duplicates were removed, three were available only in English, and one was designed for a specific drug treatment. The two remaining apps, Femilog and Mimeno, received low expert ratings (<em>n</em> = 2) for engagement, therapeutic gain, and subjective quality. In the user ratings (<em>n</em> = 4), both apps received average scores across all MARS-G scales.</div></div><div><h3>Conclusion</h3><div>This app review identified two mHealth apps for menopause in German that met the inclusion criteria. Both apps were found to have poor perceived therapeutic gain and received mixed ratings and recommendations from experts and users. Further studies on user experience and efficacy are necessary to make evidence-based recommendations regarding mHealth apps for individuals experiencing menopause.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100320"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep deprivation, sleep irregularity, depressive symptoms, and obesity using the KNHANES 2020","authors":"Jayeun Kim ,&nbsp;Kyuhyun Yoon ,&nbsp;Ji-Eun Park","doi":"10.1016/j.cpnec.2025.100318","DOIUrl":"10.1016/j.cpnec.2025.100318","url":null,"abstract":"<div><div>This study aimed to examine the associations between insufficient sleep and health outcomes, specifically depressive symptoms and obesity, using data from the 2020 Korea National Health and Nutrition Examination Survey (KNHANES) with a cross-sectional study design. A total of 5912 participants (2648 men and 3264 women) were included. Among them, 823 individuals (13.9 %) experienced difficulty with weekday sleep deprivation, and 442 individuals (7.5 %) exhibited weekday-weekend sleep mismatch. The mean sleep duration varied according to age group, underlying disease, and physical activity level. Individuals with sleep deprivation were more likely to have depressive symptoms (OR 3.21, 95 % CI 2.65–3.90) and obesity (OR 1.29, 95 % CI 1.07–1.754). On the basis of these findings, both the duration and regularity of sleep are associated with depressive symptoms and obesity, suggesting that sleep patterns may play important roles in these health outcomes.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100318"},"PeriodicalIF":2.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A few degrees, a lot more stress: Associations between room temperature and reactivity to psychosocial stress","authors":"Kim Fricke ,&nbsp;Marie-Christin Barthel ,&nbsp;Nina Alexander ,&nbsp;Ulf Baumgärtner ,&nbsp;Markus Muehlhan ,&nbsp;Susanne Vogel","doi":"10.1016/j.cpnec.2025.100319","DOIUrl":"10.1016/j.cpnec.2025.100319","url":null,"abstract":"<div><div>Increases in ambient temperatures pose a potential risk to mental and physical health. Heat has already been associated with alterations in bodily stress systems, and stress in turn is another major risk factor for various diseases. Yet, the precise impact of moderate temperature rises on stress reactivity remains unclear. This study investigated associations between moderate room temperature variations (17°C–28 °C) and physiological (cortisol, alpha amylase, heart rate, and mean arterial pressure) and subjective stress reactivity in 73 healthy adult participants exposed to a psychosocial stressor, the Trier Social Stress Test. Higher room temperatures were associated with increased reactivity in both the hypothalamic-pituitary-adrenal axis (cortisol concentrations) and the autonomic nervous system (alpha amylase activity, heart rate, mean arterial pressure), but not subjective stress. These findings highlight a potential pathway through which rising temperatures could exacerbate stress-related health vulnerabilities, even in non-extreme conditions.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100319"},"PeriodicalIF":2.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model","authors":"Hui Chen ,&nbsp;Jindong Mao ,&nbsp;Min Wang ,&nbsp;Qian Zhang ,&nbsp;Rui Zheng ,&nbsp;Yumei Wu ,&nbsp;Xue Ma ,&nbsp;Qingquan Liu","doi":"10.1016/j.cpnec.2025.100317","DOIUrl":"10.1016/j.cpnec.2025.100317","url":null,"abstract":"<div><div>Osteocalcin (OCN), an active substance produced by bone tissue, has demonstrated potential in alleviating depressive symptoms and exerting extensive regulatory effects on glial cells in animals by participating in the communication between bone and brain, while its precise mechanisms within the central nervous system (CNS) still not fully understood. In this study, we validated the antidepressant effects of OCN in depressive mice induced by chronic unpredictable mild stress (CUMS), and conducted a comprehensive assessment of the functional impacts of OCN in hippocampus using proteomic analysis. Additionally, the effects of OCN on astrocytes were investigated. Behavioral tests suggested that OCN significantly ameliorated the depressive - like behaviors of mice exposed to CUMS, manifesting by the reduced immobility time in the tail suspension test and forced swimming test. Results from the proteomic analysis showed that 117 differentially expressed proteins were found between the CUMS group and the CUMS + OCN group. The subcellular localization of these proteins was mostly enriched in the cytoplasm and cell membrane, involving in various cellular physiological processes. Importantly, we found that OCN influenced glycophagy in astrocytes in the hippocampus. These findings uncover the antidepressant efficacy of OCN, along with its target and mechanisms of action, providing a theoretical foundation for the in - depth exploration of the crucial physiological functions of OCN in the brain.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100317"},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenomenon of hypocortisolism in individuals with obesity","authors":"Benedict Herhaus,&nbsp;Liza Mekschrat,&nbsp;Katja Petrowski","doi":"10.1016/j.cpnec.2025.100316","DOIUrl":"10.1016/j.cpnec.2025.100316","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity has been associated with abnormalities of the hypothalamic-pituitary-adrenocortical (HPA)-axis. The aim of this study was to investigate patterns of cortisol stress reactivity and basal resting levels in individuals with obesity and healthy weight controls.</div></div><div><h3>Methods</h3><div>Forty-seven individuals with obesity (BMI: 33.60 ± 4.09 kg/m²) and 47 age- and gender-matched healthy weight controls (BMI: 22.58 ± 1.89 kg/m²) underwent the Trier Social Stress Test (TSST) and a resting condition. Based on the salivary cortisol measurement during the TSST, individuals with obesity and the healthy weight controls were categorized into high/low cortisol reactivity group.</div></div><div><h3>Results</h3><div>Obese low cortisol reactors demonstrated significantly lower basal cortisol resting levels compared to obese high cortisol reactors and healthy weight high/low cortisol reactors (<em>F</em>_(1,90) = 7.780, <em>p</em> ≤ .001, <em>η2</em> = .21). In individuals with obesity, we found an overlap between the high cortisol reactivity group and the high basal cortisol level group in the resting condition as well as between the low cortisol reactivity group and the low basal cortisol level group during the resting condition (<em>x</em>^<em>2</em> = 7.671, <em>df</em> = 1, <em>p</em> ≤ .01, Cramér's V = .40). This overlap could not be observed in the healthy weight controls.</div></div><div><h3>Conclusions</h3><div>In conclusion, patterns of cortisol stress reactivity and basal resting levels were observed in the individuals with obesity but not in the healthy weight controls. The present data suggest that obesity may lead to the phenomenon of basal hypocortisolism.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100316"},"PeriodicalIF":2.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting concerns about falling to modulate biological stress systems: Effects of a multicomponent randomized controlled trial in older adults","authors":"Anja Müller ,&nbsp;Robert Kob ,&nbsp;Cornel Christian Sieber ,&nbsp;Ellen Freiberger ,&nbsp;Nicolas Rohleder ,&nbsp;Sabine Britting","doi":"10.1016/j.cpnec.2025.100315","DOIUrl":"10.1016/j.cpnec.2025.100315","url":null,"abstract":"<div><h3>Introduction</h3><div>Concerns about falling (CaF) are common in older adults and may act as a chronic stressor affecting physical activity, psychological well-being and physiological regulation. This study examined the impact of a 16-week multimodal exercise intervention on CaF, stress pathways, and peripheral inflammation in older adults.</div></div><div><h3>Methods</h3><div>In the randomized, controlled FEARFALL study, 160 community-dwelling older adults (aged ≥70 years) were assigned to either an intervention group (IG) or a sham control group (SCG). The IG received a multimodal exercise program, while the SCG engaged in low-intensity activities. Three psychological questionnaires were used to assess CaF: Falls Efficacy Scale-International [FES-I] (fear of falling); Falls Efficacy Scale-International Avoidance Behavior [FES-IAB] (avoidance behavior); Updated Perceived Control of Falling Scale [UP-CoF] (perceived control). Hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) activity was determined using saliva samples (cortisol, alpha-amylase), inflammatory markers using blood samples (C-reactive protein [CRP], Interleukin 6 [IL-6]).</div></div><div><h3>Results</h3><div>There were significant improvements in CaF over time and perceived control in both groups (FES-I: <em>β</em> = −6.645, 95 %-CI [-10.56, −2.73], <em>p</em> = .001; UP-CoF: <em>β</em> = 3.911, 95 %-CI [1.24, 6.58], <em>p</em> = .004). Diurnal cortisol slope normalized after the intervention (<em>β</em> = −0.014, 95 %-CI [-0.03, 0.00], <em>p</em> = .014), while other neuroendocrine and inflammatory markers remained unchanged.</div></div><div><h3>Conclusion</h3><div>A multimodal short-term intervention reduced psychological aspects of CaF, while physiological stress and inflammatory parameters may require more intensive or longer-term interventions. Findings support CaF as a biopsychosocial stressor and highlight the efficacy of multimodal programs in enhancing coping in older adults.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100315"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder","authors":"Sebastian Laufer ,&nbsp;Johannes Bohn ,&nbsp;Sinha Engel ,&nbsp;Hannah Klusmann ,&nbsp;Nadine Skoluda ,&nbsp;Urs M. Nater ,&nbsp;Christine Knaevelsrud ,&nbsp;Sarah Schumacher","doi":"10.1016/j.cpnec.2025.100314","DOIUrl":"10.1016/j.cpnec.2025.100314","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Poor sleep quality is a persistent and debilitating symptom of major depressive disorder (MDD), with dysregulations in the biological stress system constituting a potential underlying physiological mechanism. Accordingly, a psychotherapeutic intervention may affect the interplay between sleep quality, MDD and the biological stress system.We examined how basal cortisol, and alpha-amylase levels correspond to perceived sleep quality during an internet-based intervention for MDD. Furthermore, we investigated how changes in sleep quality during the intervention relate to changes in these biological stress system markers. We hypothesized that: 1) short-term and long-term sleep quality would improve during the intervention, 2a) across assessment time points, poor sleep quality would be associated with higher cortisol and alpha-amylase concentrations, and 2b) pre-to-post intervention improvements in sleep quality (treatment response) would be associated with pre-to-post decreases in both biological markers, compared to non-response.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We analyzed forty-one participants (age: 35 ± 12y; females: 82.6 %) suffering from mild to moderate MDD. The cognitive behavioral internet-based intervention consisted of seven weekly writing-based modules with individualized feedback. Participants collected 12 saliva samples at home over two consecutive weekdays at pre-, mid-, and post-intervention. Outcome parameters of the cortisol and alpha-amylase diurnal profiles were the awakening responses, the total diurnal output, and the diurnal slopes. Self-reported sleep quality was retrospectively assessed for the night before (short-term) and for the two-week period preceding saliva collection (long-term). Treatment response was determined using the reliable change index of the pre-to-post, two-week sleep quality difference scores. Hypotheses 1 and 2a were tested using random intercept hierarchical linear models, Hypothesis 2b was tested using linear regressions with age, biological sex, BMI and medication use on the day of sampling as covariates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Long-term sleep quality increased significantly from pre-to post-intervention (d = 0.78; p &lt; 0.001), partially confirming Hypothesis 1. Contrary to the expected effect of Hypothesis 2a, poor long-term sleep quality at pre-intervention was associated with a blunted cortisol awakening response (CAR; p &lt; 0.05). Post-hoc analyses showed an association of pre-to-post CAR changes and pre-intervention sleep quality (p &lt; 0.01) indicating that individuals with higher pre-intervention sleep problems, on average, exhibited a pre-to-post increase in the CAR. The responder analyses showed that individuals with a marked pre-to-post sleep quality increase (i.e., responders) showed a higher increase in the CAR, compared to non-responders (p &lt; 0.05), which again ran contrary to the effect proposed in Hypothesis 2b.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100314"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotics use increases the risk of breast cancer in Women: Findings from systematic review and meta-analysis of observational studies","authors":"Mehdi Karimi ,&nbsp;Fatemeh Ziyafati Kafi ,&nbsp;Samira Pirzad ,&nbsp;Seyed Morteza Ali Pourfaraji ,&nbsp;Sharareh Jahangiri","doi":"10.1016/j.cpnec.2025.100313","DOIUrl":"10.1016/j.cpnec.2025.100313","url":null,"abstract":"<div><h3>Background and objective</h3><div>Emerging evidence suggests Antipsychotics may influence cancer risk through prolactin elevation. While studies have explored the potential link between antipsychotic use and breast cancer risk, findings remain inconsistent. A comprehensive synthesis of existing data is needed to clarify this association. This meta-analysis aimed to discover the association between antipsychotic use and the risk of breast cancer in females.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across major online databases from inception to May 2025 to identify relevant studies. Data were extracted from eligible publications, and meta-analyses were performed to estimate the pooled effect sizes. Relative risks (RRs) were used for cohort studies, while odds ratios (ORs) were used for case-control studies.</div></div><div><h3>Results</h3><div>A pooled analysis of 13 observational studies (14 effect sizes from seven cohort and seven case-control studies) demonstrated a significant association between antipsychotic use and increased breast cancer risk (OR: 1.23; 95 % CI: 1.12–1.35; <em>p</em> &lt; 0.01). Subgroup analyses showed elevated risk in both cohort studies (OR: 1.25; 95 % CI: 1.00–1.56; <em>p</em> = 0.046) and case-control studies (OR: 1.21; 95 % CI: 1.11–1.32; <em>p</em> &lt; 0.001). First-generation antipsychotics were associated with a higher risk (OR: 1.22; 95 % CI: 1.03–1.45; <em>p</em> = 0.023) compared to second-generation agents (OR: 1.08; 95 % CI: 1.04–1.13; <em>p</em> &lt; 0.001). Geographically, the highest risk was observed in Asian populations (OR: 1.42; 95 % CI: 1.08–1.88; <em>p</em> = 0.011), followed by European (OR: 1.21; 95 % CI: 1.14–1.28; <em>p</em> &lt; 0.001) and North American populations (OR: 1.17; 95 % CI: 1.06–1.31; <em>p</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>This meta-analysis found that antipsychotic use is associated with a 23 % increased risk of breast cancer in females, with a higher risk observed for first-generation compared to second-generation antipsychotics, and particularly elevated in Asian populations. These findings emphasize the need for further research into the underlying mechanisms and regional disparities. Clinicians should carefully evaluate the risks when prescribing antipsychotics and consider regular breast health monitoring for patients undergoing long-term treatment.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100313"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma writing reduces conserved transcriptional response to adversity (CTRA) gene expression: A culturally adapted pilot study","authors":"Gail Ironson ,&nbsp;Roger McIntosh ,&nbsp;Maria Di Bello ,&nbsp;Yasmin Shemali ,&nbsp;Salman Ahmad ,&nbsp;Hannah Hoogerwoerd ,&nbsp;Steve Cole","doi":"10.1016/j.cpnec.2025.100310","DOIUrl":"10.1016/j.cpnec.2025.100310","url":null,"abstract":"<div><h3>Introduction</h3><div>Psychosocial interventions to reduce posttraumatic stress disorder (PTSD)-associated distress can improve health of people with PTSD. To identify potential biological mechanisms, we tested whether a PTSD-focused written emotional disclosure (WED) intervention can reduce a stress-associated gene expression profile known as the Conserved Transcriptional Response to Adversity (CTRA).</div></div><div><h3>Methods</h3><div>This pilot RCT compared 4 sessions of WED to a control group writing about daily events among thirteen Hispanic women who were living with or at risk for HIV, and had pre-post intervention gene expression data available (9 WED, 3 control). The PTSD checklist for the DSM-5 (PCL-5) was used to measure trauma symptom severity and CTRA gene expression was assessed by whole blood RNA sequencing.</div></div><div><h3>Results</h3><div>Primary analyses showed a significant Time x Intervention interaction (F_[1,11] = 16.01; p = 0.002), with the Intervention group showing a significant decrease in CTRA gene expression whereas the Control group revealed a significant increase. Effects on trauma symptoms were also significant.</div></div><div><h3>Conclusion</h3><div>PTSD-focused WED can reduce CTRA gene expression and PTSD symptoms in Hispanic women living with or at risk for HIV infection. We believe this is the first study to show that trauma treatment impacts CTRA gene expression in the context of PTSD.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100310"},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, functional and salivary cortisol level changes in individuals with schizophrenia undergoing cognitive behavioral therapy for psychosis in addition to their usual antipsychotic medication","authors":"Felicia Iftene,&nbsp;Adriana Farcas,&nbsp;Simon O'Brien","doi":"10.1016/j.cpnec.2025.100312","DOIUrl":"10.1016/j.cpnec.2025.100312","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"23 ","pages":"Article 100312"},"PeriodicalIF":2.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}