Comprehensive psychoneuroendocrinology最新文献

{"title":"Weight-based discrimination and cortisol output: A systematic review","authors":"Maria A. Kalantzis ,&nbsp;Daniel M. Maitland ,&nbsp;Miranda Yannon ,&nbsp;Christina Gaggiano ,&nbsp;Jinbo He ,&nbsp;Aldo Barrita ,&nbsp;Lorelai Symmes ,&nbsp;William H. O'Brien","doi":"10.1016/j.cpnec.2025.100290","DOIUrl":"10.1016/j.cpnec.2025.100290","url":null,"abstract":"<div><div>Discrimination based on weight status (or weight-related discrimination/stigma) may be related to greater physical and mental health concerns via physiological and psychological phenotypes of stress. Cortisol output, a biomarker of stress, has been measured in relation to weight stigma and weight-related discrimination. This systematic review aims to synthesize existing research on the relationship between weight-related discrimination and cortisol output, evaluate methodological approaches for measuring these constructs, and identify research gaps regarding contextual factors influencing this relationship. A comprehensive search was conducted across multiple databases (PsycINFO, Scopus, ProQuest, and PubMed) from February 1 to July 1, 2024, resulting in 11 eligible studies that examined weight discrimination in relation to cortisol levels. Studies were assessed for quality using the NHLBI Study Quality Assessment Tool, and inter-rater reliability for coding was established at 90 %. The findings revealed a range of sample sizes (45–4341) and diverse participant characteristics, including variations in age, race, and body mass index (BMI). About half (N = 5) of the included studies reported a positive relation between weight stigma and cortisol output. The review also uncovered significant limitations in current methodologies, particularly concerning contextual factors and other marginalized identities, such as socioeconomic status and food insecurity, along with measuring other forms of discrimination in tandem with weight stigma, such as racial discrimination. These findings underscore the need for future research to adopt a more intersectional approach in examining the multifaceted nature of weight stigma and how it relates to a greater stress response in multiple marginalized identities, as well as including longitudinal modeling of weight stigma's impact on biomarkers for stress.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100290"},"PeriodicalIF":2.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical language lateralization in positive schizotypy and modulating effects of the menstrual cycle","authors":"Helene Hjelmervik ,&nbsp;Josef J. Bless ,&nbsp;Julien Laloyaux ,&nbsp;Kenneth Hugdahl ,&nbsp;Markus Hausmann","doi":"10.1016/j.cpnec.2025.100291","DOIUrl":"10.1016/j.cpnec.2025.100291","url":null,"abstract":"<div><div>Previous studies have shown atypical language asymmetry in male participants with high schizotypy traits, but in female participants the pattern is less clear. Such sex differences could suggest a role of sex hormones, especially since hemispheric asymmetries have been shown to change across the menstrual cycle. By modulating attention in a consonant-vowel dichotic listening test, the current study aimed to investigate language lateralization (ear advantage of non-forced condition) in high vs low positive-schizotypy and the role of the menstrual cycle. In addition, we aimed to replicate menstrual cycle effects on the left attention condition. Thirty-nine female participants were tested in the menstrual (low estradiol) or follicular (high estradiol) cycle phase. Women tested in the follicular phase were found to perform better on the left attention condition, indicating enhanced cognitive control. In the non-forced condition, the high positive-schizotypy group showed increased right hemispheric involvement during the follicular phase relative to the menstrual phase; whereas an increase in left hemispheric dominance was seen in the low positive-schizotypy group during this cycle phase. The results suggest an underlying difference in lateralization between low and high positive-schizotypy that is enhanced by gonadal hormones, perhaps through altered interhemispheric inhibition. Overall, the study suggests that the atypical language lateralization in high schizotypy individuals is highly flexible and dependent on the hormonal milieu, and could potentially be related to neuroprotective effects of estradiol.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100291"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workers’ well-being during viral pandemics and epidemics: A scoping review","authors":"Tyler Pacheco ,&nbsp;Simon Coulombe ,&nbsp;Nancy L. Kocovski ,&nbsp;Julia Carbone","doi":"10.1016/j.cpnec.2025.100286","DOIUrl":"10.1016/j.cpnec.2025.100286","url":null,"abstract":"<div><div>Studies have documented workers' well-being during individual pandemics and epidemics. However, there lies a need to summarize worker well-being <em>across</em> crises. Moreover, there is a scarcity of reviews exploring precarious workers' well-being during these crises. Adopting a multidisciplinary perspective via positive psychology's third wave, this scoping review examines positive and negative well-being across diverse occupational groups and situations (e.g., precarious employment) and across crises. Inspired by Ecological Systems Theory, factors at different ecological levels (self, social, workplace, pandemic) relevant to workers' well-being are reviewed. The following questions are addressed: 1) How are virus-related public health crises (i.e., epidemics, pandemics) related to workers' well-being? 2) What resilience and risk factors are associated with workers' well-being in these crises? And 2a) How is the well-being of precarious workers impacted during virus-related public health crises? Of the 2,395 potentially relevant articles published before October 23rd, 2020, 187 were retained. Overall, more research has been conducted on negative than positive well-being. Workers experienced: 1) positive well-being frequently or at moderately high levels overall during pandemics and epidemics, 2) mild to moderate negative well-being during SARS and COVID-19's beginning and high negative well-being during other crises, and 3) high work-related well-being during such crises. Factors at self- (age, gender), social- (social support), workplace- (occupation, frontline status), and pandemic-related (risk/exposure, knowing someone infected/killed by the virus, PPE access) levels were associated with workers' well-being. Although explored infrequently, precarious employment was typically associated with greater negative well-being. Practice- and policy-related recommendations are discussed.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100286"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using hair biomarkers to examine social-emotional resilience in adolescence: A feasibility study","authors":"Cynthia R. Rovnaghi ,&nbsp;Anjali Gupta ,&nbsp;Susan Ramsundarsingh ,&nbsp;Ronnie I. Newman ,&nbsp;Sa Shen ,&nbsp;Jordan K.H. Vedelli ,&nbsp;Elizabeth L. Reichert ,&nbsp;Kanwaljeet J.S. Anand","doi":"10.1016/j.cpnec.2025.100287","DOIUrl":"10.1016/j.cpnec.2025.100287","url":null,"abstract":"<div><h3>Background</h3><div>The SKY Schools Program combines breath-based techniques and a social-emotional learning curriculum. We examined its effects on objective physiological biomarkers, including hair cortisol (HCC, chronic stress measure) and hair oxytocin (HOC, social affiliation measure), as well as behavioral (youth risk behaviors) and mental health outcomes (anxiety, depression).</div></div><div><h3>Methods</h3><div>The SKY Schools program was adapted for post-pandemic restrictions (i.e., staff shortages, no lessons requiring writing, limited weekly follow-ups) and implemented among 7th grade students (daily in-person 40-min sessions for three weeks during physical education classes). Longitudinal assessments were obtained at baseline (T1, February 2022, N = 21), post-intervention (T2, June 2022, N = 20), and follow-up (T3, December 2022, N = 18).</div></div><div><h3>Results</h3><div>Most of our sample was male (67 %), Hispanic (62 %), and lived in low-income (&lt;$100K) households (75 %). Students reported fewer poor mental health days at follow-up (Friedman test p &lt; 0.01). Log-normal (Ln)-HCC (p &lt; 0.01) were higher post-intervention vs. baseline (median 1.81 (IQR 1.63–2.46) vs. 1.60 (0.91–1.85)) and lower at follow-up (1.23; IQR: 0.64–1.50), with HCC in more students moving into the adaptive range (25th-75th percentile). Ln-HOC (p = 0.04) were higher post-intervention vs. baseline (1.78 (1.54–2.26) vs. 1.50 (0.81–1.70)).</div></div><div><h3>Conclusions</h3><div>This study uniquely evaluated the impact of the SKY intervention on hair cortisol (HCC) and hair oxytocin concentrations (HOC), which are objective, physiological measures of chronic stress and social affiliation. Results suggest that SKY may improve social affiliation and possibly HPA-axis regulation.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100287"},"PeriodicalIF":2.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and the prefrontal-hippocampal pathway - A multimodal neuroimaging study in transgender women","authors":"Setthanan Jarukasemkit ,&nbsp;Karen M. Tam ,&nbsp;Seksan Yoadsanit ,&nbsp;Ty Easley ,&nbsp;Hailey Modi ,&nbsp;Lyn Stahl ,&nbsp;Adun Kampaengtip ,&nbsp;Thanissara Chansakul ,&nbsp;Rena Janamnuaysook ,&nbsp;Akarin Hiransuthikul ,&nbsp;Chaipat Chunharas ,&nbsp;Janine D. Bijsterbosch","doi":"10.1016/j.cpnec.2025.100288","DOIUrl":"10.1016/j.cpnec.2025.100288","url":null,"abstract":"<div><div>This study aims to investigate functional and neurotransmitter signaling in the prefrontal-hippocampal pathway in relation to depression in a cohort of Thai transgender women. Twenty participants completed mental health surveys and imaging between January and March 2024. Depression severity was measured by Patient Health Questionnaire-9 (PHQ-9) scores. Higher PHQ-9 scores were associated with lower GABA levels in the hippocampus, and with lower fractional amplitude of low-frequency fluctuations (fALFF) in the dorsolateral prefrontal cortex. However, removal of the hippocampal GABA outlier resulted in a non-significant relationship with PHQ-9. Therefore, future studies with larger datasets should further investigate the association between GABA and depression in a transgender cohort. These findings revealed interactions between neurotransmitter signaling and functional brain activity of the hippocampal-prefrontal circuit in depression.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"22 ","pages":"Article 100288"},"PeriodicalIF":2.1,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring stress and depressive symptoms in pregnancy and the IL-1β, IL-6, and C-reactive protein pathway: Looking for possible biomarker targets","authors":"Danielle Abukhalaf ,&nbsp;Rebecca Koerner ,&nbsp;Sapna Patel ,&nbsp;Allyson Duffy ,&nbsp;Stephanie Prescott","doi":"10.1016/j.cpnec.2024.100280","DOIUrl":"10.1016/j.cpnec.2024.100280","url":null,"abstract":"<div><h3>Background</h3><div>Individuals undergo significant stress throughout pregnancy and are at high risk for depressive symptoms. Elevated stress and depressive symptoms are associated with inflammatory processes and adverse maternal-infant outcomes. However, the biological processes associated with psychosocial outcomes and the maternal immune system remain unclear. As such, we aimed to examine associations among perceived stress, depressive symptoms, salivary IL-1β, IL-6, and CRP levels, and hair and salivary cortisol levels during the second and third trimesters of pregnancy.</div></div><div><h3>Methods</h3><div>We conducted an ancillary study consisting of 37 pregnant individuals. Participants collected salivary samples and measures of perceived stress and depression at 17–19 weeks, 25–27 weeks, and 32–34 weeks gestation. We collected a one-time hair sample between 36 and 40 weeks. Provided salivary samples were used to detect changes in cortisol, IL-1β, IL-6, and CRP levels. Hair was used to detect changes in cortisol levels throughout pregnancy.</div></div><div><h3>Results</h3><div>Elevated levels of perceived stress and depressive symptoms are associated with increased salivary CRP levels, respectively (p = 0.0142, p = 0.0008). Salivary and hair cortisol increased significantly throughout the second and third trimesters of pregnancy (p = 0.0004 and p &lt; 0.0001). We also observed variations in IL-6 during pregnancy (p = 0.029) and significant increases between 25 and 27 weeks (p = 0.016).</div></div><div><h3>Conclusion</h3><div>Salivary samples may provide a non-invasive measurement of alterations in cytokine and cortisol levels in pregnant individuals reporting elevated stress and depressive symptoms. These may be candidate biomarkers for mechanistic study possibly aiding providers in early detection of deleterious immunological processes which could result in adverse maternal-infant outcomes.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"21 ","pages":"Article 100280"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression","authors":"Aditya Singh ,&nbsp;Mandakh Bekhbat ,&nbsp;David R. Goldsmith ,&nbsp;Ngoc-Anh Le ,&nbsp;Evanthia C. Wommack ,&nbsp;Zhihao Li ,&nbsp;Ebrahim Haroon ,&nbsp;Jennifer C. Felger","doi":"10.1016/j.cpnec.2025.100284","DOIUrl":"10.1016/j.cpnec.2025.100284","url":null,"abstract":"<div><div>Increased inflammation and associated metabolic disturbances have been shown to affect neurotransmitters and brain circuits, contributing to an immunometabolic phenotype of anhedonic depression. To extend our previous findings on relationships between plasma lipids and antidepressant response to anti-cytokine therapy, we explored in secondary analyses whether lipid-related biomarkers similarly predicted change in anhedonia or functional connectivity (FC) in dopamine-rich corticostriatal reward circuitry in medically-stable, depressed patients with a range of inflammation levels (indexed by plasma C-reactive protein [CRP]) who were administered inflammation-targeted therapies. Relationships were examined between baseline lipids (plasma cholesterols, triglycerides and non-esterified fatty acids) and reduction of anhedonia symptoms in Study 1 (n = 60) after three infusions of infliximab or placebo and change in resting-state FC in Study 2 (n = 31) after acute, within-subject challenge with levodopa (L-DOPA) and placebo. A treatment by inflammation interaction revealed lower anhedonia after infliximab versus placebo (F[1,49] = 5.5, p &lt; 0.05) in patients with, but not without, CRP&gt;3 mg/L (n = 27). A composite score of lipid-related biomarkers (with increasing values reflecting higher concentrations) also precited anhedonia response (post-treatment minus baseline) to infliximab (r = −0.46, p &lt; 0.05) but not placebo (r = 0.14, p = 0.56). Lipid scores similarly predicted CRP-related increases in reward circuit FC after L-DOPA (r = 0.53, p &lt; 0.01) but not placebo (r = 0.20, p = 0.34). Responses to infliximab and L-DOPA were strongest in patients with versus without clinically elevated CRP (&gt;3 mg/L) and/or cholesterol (&gt;150 mg/dL)(p &lt; 0.05). Results highlight a role for dyslipidemia in immunometabolic depression, biomarkers of which, together with CRP, have potential to classify patients indicated for therapies that block inflammation or its effects on neurotransmitters like dopamine.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"21 ","pages":"Article 100284"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer Acknowledgement","authors":"","doi":"10.1016/j.cpnec.2025.100285","DOIUrl":"10.1016/j.cpnec.2025.100285","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"21 ","pages":"Article 100285"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation during pregnancy disrupts maternal behavior and hippocampal neurochemistry in rats: A role for BDNF, corticosterone, and GABAARα1","authors":"Samira Khayat ,&nbsp;Hamed Fanaei ,&nbsp;Kiarash Anaraki Haji Bagheri","doi":"10.1016/j.cpnec.2025.100282","DOIUrl":"10.1016/j.cpnec.2025.100282","url":null,"abstract":"<div><div>This study aimed to investigate the effects of social isolation stress during pregnancy on maternal behavior and associated neurochemical changes in the hippocampus of rats.</div><div>Twenty female Sprague-Dawley rats were randomly assigned to either a group housing (two rats per cage: control group) or a social isolation stress group (one rat per cage: SI group) during pregnancy. At the end of the study, we assessed the levels of BDNF, corticosterone, and GABAARα1 in the hippocampus of the maternal brain, along with evaluating the endurance, integration, and emotional aspects of maternal behavior. Results indicated that social isolation stress significantly decreased maternal endurance, integration, and emotionality (self-calming) of maternal behavior. Concurrently, blood and the hippocampal corticosterone concentration significantly increased, while BDNF concentration significantly decreased in the SI stress group compared to controls. Moreover, GABAARα1 mRNA expression was significantly decreased in the hippocampus of socially isolated rats. These findings demonstrate that social isolation stress during pregnancy profoundly impacts maternal behaviors in rats, including endurance, integration, and self-soothing. The altered concentration of corticosterone and BDNF, and GABAARα1 mRNA expression in the hippocampus of social isolation group suggests disruptions in stress response regulation and synaptic plasticity during pregnancy to form normal maternal behavior.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"21 ","pages":"Article 100282"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between fluid intake, hydration status and cortisol dynamics in healthy, young adult males","authors":"Mitchell E. Zaplatosch ,&nbsp;Laurie Wideman ,&nbsp;Jessica McNeil ,&nbsp;Jesse N.L. Sims ,&nbsp;William M. Adams","doi":"10.1016/j.cpnec.2024.100281","DOIUrl":"10.1016/j.cpnec.2024.100281","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have identified links between fluid intake, hydration related hormones and cortisol measured at one timepoint but have not considered how hydration may influence cortisol dynamics throughout the day. This study assessed associations between hydration status (copeptin, urinary osmolality, urine volume) and habitual fluid intake with cortisol dynamics.</div></div><div><h3>Methods</h3><div>The day before (DB) a 6-h laboratory visit, 29 male participants (age, 23±4y; BMI, 25.5 ± 4.3 kg/m²; body fat, 17.3 ± 9.3 %) provided 24-h urine samples and a fasted blood sample for hydration status assessment, recorded their 24-h fluid intake for three days prior, and provided 10 saliva samples to assess cortisol dynamics from DB into the evening of the laboratory visit. Calculated indices of cortisol dynamics included: nocturnal cortisol rise (NCR – salivary cortisol rise from bed to awakening), peak salivary cortisol (peak S_CORT – highest cortisol of all samples), cortisol awakening response (ΔCAR – difference between high morning sample and awakening sample), area under the curve with respect to ground (AUCG) and increase (AUCI), and diurnal cortisol slope (DCS – rate of change in cortisol from awakening to bed). The relationships between fluid intake or hydration status and cortisol dynamics were analyzed by separating participants into fluid intake tertile groups and by regressing cortisol dynamics on the continuous variables of total fluid intake (TFI) or hydration biomarkers.</div></div><div><h3>Results</h3><div>There were no between-group differences for ΔCAR (p = 0.89), AUCG (p = 0.57), AUCI (p = 0.48), peak S_CORT (p = 0.14), NCR (p = 0.95), DCS (p = 0.22), or serum cortisol (p = 0.61). TFI was not associated with log (peak S_CORT) (p = 0.49), ΔCAR (p = 0.61), AUCG (p = 0.76), or AUCI (p = 0.56). Copeptin was not associated with log (peak S_CORT) (p = 0.99), ΔCAR (p = 0.22), AUCG (p = 0.69) or AUCI (p = 0.18). Urinary hydration markers were not associated with any measures of cortisol dynamics (p &gt; 0.05). These null effects were consistent when controlling for physical activity, sleep, and body fat percentage.</div></div><div><h3>Conclusion</h3><div>In the absence of dehydrating stimuli, measures of fluid intake or hydration status may not be associated with cortisol dynamics in young healthy males.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"21 ","pages":"Article 100281"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}