Comprehensive psychoneuroendocrinology最新文献

{"title":"Longitudinal trajectories of cancer-related cognitive impairment and influential factors among patients with lung cancer","authors":"Xiaoju Zhu ,&nbsp;Yalan Huang ,&nbsp;Haiwei Fu ,&nbsp;Sixiong Luo ,&nbsp;Yuanjing Jiang ,&nbsp;Zonghua Wang","doi":"10.1016/j.cpnec.2025.100330","DOIUrl":"10.1016/j.cpnec.2025.100330","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate longitudinal cognitive changes and identify factors associated with cancer-related cognitive impairment (CRCI) among lung cancer survivors.</div></div><div><h3>Methods</h3><div>Cognitive function was assessed using the FACT-Cog (subjective) and TICS-M (objective). The baseline assessment was completed before the use of chemotherapy drugs and recorded as T0. After completing the first cycle of chemotherapy, it was recorded as T1; after the second cycle, as T2; after the third cycle, as T3; after the fourth cycle, as T4; and after the fifth cycle, as T5. Linear mixed-effect models evaluated associations between clinical/sociodemographic factors and cognitive outcomes.</div></div><div><h3>Results</h3><div>Higher education level and later treatment progression were correlated with increased TICS-M scores. In contrast, Rural residence (β = −1.89, p = 0.021) and more comorbidities (β = −2.15, p = 0.033) were associated with reduced FACT-Cog scores. Treatment progression correlated with improved TICS-M scores (β = 0.716, p = 0.001). No significant differences were observed between the chemotherapy and chemoimmunotherapy groups (p &gt; 0.05). A key finding was the observed discordance between stable subjective reports and modestly improving objective scores over time. There was a discrepancy between subjective and objective cognitive evaluations, as FACT-Cog scores remained consistent over time (mean 129.8 ± 20.2), while TICS-M scores showed a slight improvement (from 23.4 ± 4.9 to 24.4 ± 3.7).</div></div><div><h3>Discussion</h3><div>The influence of education, residence, and comorbidities on CRCI trajectories in lung cancer patients highlights the need for integrated evaluation tools. This longitudinal analysis not only identifies distinct risk profiles for CRCI but also underscores the critical need for proactive screening and tailored supportive care programs. These priorities provide a guide for improving cognitive health outcomes in lung cancer survivorship care.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"25 ","pages":"Article 100330"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal thyroid function in the first half of pregnancy and neurodevelopmental outcomes in early adolescence in the Amsterdam Born Children and their Development (ABCD) cohort","authors":"Sarai M. Keestra ,&nbsp;Susanne R. de Rooij ,&nbsp;Tessa J. Roseboom ,&nbsp;Marsh Königs ,&nbsp;Tanja GM. Vrijkotte ,&nbsp;Martijn J.J. Finken","doi":"10.1016/j.cpnec.2025.100333","DOIUrl":"10.1016/j.cpnec.2025.100333","url":null,"abstract":"<div><div>Maternal thyroid hormone levels in pregnancy have been implicated to play a role in brain development, but few observational studies have examined their relationship with neurodevelopmental outcomes beyond early childhood. We investigated associations between maternal thyroid function during the first 20 weeks of pregnancy and neurodevelopmental outcomes in 1824 children aged 10–13 years from the Amsterdam Born Children and their Development (ABCD) cohort. Outcomes included neurocognition (non-verbal intelligence [Raven's Progressive Matrices], executive working memory [SOPT]), behavioural organisation (behaviour regulation and metacognition [BRIEF], and internalizing behaviour and risk-seeking [SURPS]), and emotional, social, and behavioural problems (mother-, teacher-, and self-reported SDQ internalizing and externalizing problems). We fitted linear and quadratic multivariable regression models, as well as restricted cubic splines with three knots for the 10th, 50th and 90th percentiles, choosing the best model to assess associations across the continuous range of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) on the outcomes, both in pregnancies without overt thyroid disease and in the full cohort. Secondary analyses examined potential threshold effects (10th and 90th percentiles of TSH and FT4), and impact of clinical thyroid dysfunction based on cohort-specific reference ranges, anti-TPO positivity, and sex differences. We found a small but significant positive linear association between maternal log-transformed TSH in pregnancies free of overt thyroid disease and non-verbal intelligence in girls (estimate: 0.05, 95 % CI: 0.01 to 0.09, p = 0.02; SMD: 0.015), but not in boys, after correction for multiple testing. No other neurodevelopmental outcomes were associated with maternal thyroid function. These findings suggest that maternal thyroid function in early pregnancy, in the absence of overt thyroid disease, shows no consistent associations with child neurodevelopmental outcomes in adolescence, apart from a small association with non-verbal intelligence in girls that may not be clinically relevant.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"25 ","pages":"Article 100333"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing change: Navigating menopause with the help of mobile health apps in Germany","authors":"Klara Greffin ,&nbsp;Marlene Muehlmann ,&nbsp;Anna Pauleikhoff ,&nbsp;Bita Stelling ,&nbsp;Holger Muehlan ,&nbsp;Michael Stach ,&nbsp;Silke Schmidt ,&nbsp;Samuel Tomczyk","doi":"10.1016/j.cpnec.2025.100320","DOIUrl":"10.1016/j.cpnec.2025.100320","url":null,"abstract":"<div><h3>Background</h3><div>Mobile health applications (mHealth apps) have shown promise as potential solutions for mitigating the negative health impacts of menopause. However, there is a lack of standardized expert and user ratings regarding the quality of these apps, making it difficult to provide evidence-based recommendations. Therefore, this app review aimed to summarize the currently available mHealth apps for menopause in Germany. Subsequently, the identified apps were evaluated, and their quality was assessed.</div></div><div><h3>Methods</h3><div>A web crawler was used to search for mHealth apps related to the predefined search criteria, and information for all included apps was extracted (year of search: 2021). In the second step, healthcare providers and individuals experiencing menopause tested and evaluated the apps using the German version of the Mobile Application Rating Scale (MARS-G).</div></div><div><h3>Results</h3><div>The initial search yielded 6917 apps. Of these, 6879 were excluded, 32 duplicates were removed, three were available only in English, and one was designed for a specific drug treatment. The two remaining apps, Femilog and Mimeno, received low expert ratings (<em>n</em> = 2) for engagement, therapeutic gain, and subjective quality. In the user ratings (<em>n</em> = 4), both apps received average scores across all MARS-G scales.</div></div><div><h3>Conclusion</h3><div>This app review identified two mHealth apps for menopause in German that met the inclusion criteria. Both apps were found to have poor perceived therapeutic gain and received mixed ratings and recommendations from experts and users. Further studies on user experience and efficacy are necessary to make evidence-based recommendations regarding mHealth apps for individuals experiencing menopause.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100320"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder","authors":"Sebastian Laufer ,&nbsp;Johannes Bohn ,&nbsp;Sinha Engel ,&nbsp;Hannah Klusmann ,&nbsp;Nadine Skoluda ,&nbsp;Urs M. Nater ,&nbsp;Christine Knaevelsrud ,&nbsp;Sarah Schumacher","doi":"10.1016/j.cpnec.2025.100314","DOIUrl":"10.1016/j.cpnec.2025.100314","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Poor sleep quality is a persistent and debilitating symptom of major depressive disorder (MDD), with dysregulations in the biological stress system constituting a potential underlying physiological mechanism. Accordingly, a psychotherapeutic intervention may affect the interplay between sleep quality, MDD and the biological stress system.We examined how basal cortisol, and alpha-amylase levels correspond to perceived sleep quality during an internet-based intervention for MDD. Furthermore, we investigated how changes in sleep quality during the intervention relate to changes in these biological stress system markers. We hypothesized that: 1) short-term and long-term sleep quality would improve during the intervention, 2a) across assessment time points, poor sleep quality would be associated with higher cortisol and alpha-amylase concentrations, and 2b) pre-to-post intervention improvements in sleep quality (treatment response) would be associated with pre-to-post decreases in both biological markers, compared to non-response.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We analyzed forty-one participants (age: 35 ± 12y; females: 82.6 %) suffering from mild to moderate MDD. The cognitive behavioral internet-based intervention consisted of seven weekly writing-based modules with individualized feedback. Participants collected 12 saliva samples at home over two consecutive weekdays at pre-, mid-, and post-intervention. Outcome parameters of the cortisol and alpha-amylase diurnal profiles were the awakening responses, the total diurnal output, and the diurnal slopes. Self-reported sleep quality was retrospectively assessed for the night before (short-term) and for the two-week period preceding saliva collection (long-term). Treatment response was determined using the reliable change index of the pre-to-post, two-week sleep quality difference scores. Hypotheses 1 and 2a were tested using random intercept hierarchical linear models, Hypothesis 2b was tested using linear regressions with age, biological sex, BMI and medication use on the day of sampling as covariates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Long-term sleep quality increased significantly from pre-to post-intervention (d = 0.78; p &lt; 0.001), partially confirming Hypothesis 1. Contrary to the expected effect of Hypothesis 2a, poor long-term sleep quality at pre-intervention was associated with a blunted cortisol awakening response (CAR; p &lt; 0.05). Post-hoc analyses showed an association of pre-to-post CAR changes and pre-intervention sleep quality (p &lt; 0.01) indicating that individuals with higher pre-intervention sleep problems, on average, exhibited a pre-to-post increase in the CAR. The responder analyses showed that individuals with a marked pre-to-post sleep quality increase (i.e., responders) showed a higher increase in the CAR, compared to non-responders (p &lt; 0.05), which again ran contrary to the effect proposed in Hypothesis 2b.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100314"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using machine learning models to predict the risk of mild cognitive impairment for COPD patients: A multi-cohort study","authors":"Xiang Tang ,&nbsp;Shuyuan Li ,&nbsp;Hongjiang Liu ,&nbsp;Yong Ge ,&nbsp;Deju Zhou ,&nbsp;Teng Sun ,&nbsp;Cheng Zhang ,&nbsp;Shoujie Feng ,&nbsp;Hao Zhang","doi":"10.1016/j.cpnec.2025.100323","DOIUrl":"10.1016/j.cpnec.2025.100323","url":null,"abstract":"<div><h3>Purpose</h3><div>The evaluation of cognitive function in patients with chronic obstructive pulmonary disease (COPD) is critical. This study aimed to construct a risk prediction model capable of predicting the rsik of mild cognitive impairment (MCI) in COPD patients using machine learning methods.</div></div><div><h3>Methods</h3><div>This study enrolled 2142 COPD patients from the China Health and Retirement Longitudinal Study (CHARLS), analyzing 16 sociodemographic, health, and psychological indicators. The predictors screened by LASSO regression were integrated with five machine learning models—Logistic Regression, Neural Network, XGBoost, LightGBM, and Random Forest —to identify the optimal model for predicting MCI risk in COPD patients. External validation was conducted using the Health and Retirement Study dataset (HRS). Model performance underwent comprehensive evaluation across three critical dimensions: discrimination capacity (AUC-ROC), calibration accuracy (Brier score and calibration curves), and clinical applicability (decision curve analysis). Additionally, the SHAP method was employed to elucidate the feature contributions to the final model.</div></div><div><h3>Results</h3><div>The analysis included 2142 COPD patients, of whom 420 were diagnosed with MCI. 11 predictive variables were selected to construct five machine learning algorithms. Among these, the LightGBM model demonstrated superior performance across all evaluation dimensions - including discrimination capacity, calibration accuracy, and clinical utility - achieving AUROC values ranging from 0.722 to 0.782.The eight most significant features for predicting MCI in COPD patients were sex, residence, instrumental activities of daily living (IADL) score, educational level, social activity engagement, marital status, Internet use and depression.</div></div><div><h3>Conclusion</h3><div>The machine learning model accurately predicts MCI risk in COPD patients, enabling timely clinical interventions and improved care through early identification of high-risk individuals.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100323"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenomenon of hypocortisolism in individuals with obesity","authors":"Benedict Herhaus,&nbsp;Liza Mekschrat,&nbsp;Katja Petrowski","doi":"10.1016/j.cpnec.2025.100316","DOIUrl":"10.1016/j.cpnec.2025.100316","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity has been associated with abnormalities of the hypothalamic-pituitary-adrenocortical (HPA)-axis. The aim of this study was to investigate patterns of cortisol stress reactivity and basal resting levels in individuals with obesity and healthy weight controls.</div></div><div><h3>Methods</h3><div>Forty-seven individuals with obesity (BMI: 33.60 ± 4.09 kg/m²) and 47 age- and gender-matched healthy weight controls (BMI: 22.58 ± 1.89 kg/m²) underwent the Trier Social Stress Test (TSST) and a resting condition. Based on the salivary cortisol measurement during the TSST, individuals with obesity and the healthy weight controls were categorized into high/low cortisol reactivity group.</div></div><div><h3>Results</h3><div>Obese low cortisol reactors demonstrated significantly lower basal cortisol resting levels compared to obese high cortisol reactors and healthy weight high/low cortisol reactors (<em>F</em>_(1,90) = 7.780, <em>p</em> ≤ .001, <em>η2</em> = .21). In individuals with obesity, we found an overlap between the high cortisol reactivity group and the high basal cortisol level group in the resting condition as well as between the low cortisol reactivity group and the low basal cortisol level group during the resting condition (<em>x</em>^<em>2</em> = 7.671, <em>df</em> = 1, <em>p</em> ≤ .01, Cramér's V = .40). This overlap could not be observed in the healthy weight controls.</div></div><div><h3>Conclusions</h3><div>In conclusion, patterns of cortisol stress reactivity and basal resting levels were observed in the individuals with obesity but not in the healthy weight controls. The present data suggest that obesity may lead to the phenomenon of basal hypocortisolism.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100316"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Before pregnancy trauma primes oxytocin receptor expression in placenta during superstorm sandy","authors":"Patricia M. Pehme ,&nbsp;Wai M. Wong ,&nbsp;Corina Lesseur ,&nbsp;Joshua C. Brumberg ,&nbsp;Yoko Nomura","doi":"10.1016/j.cpnec.2025.100328","DOIUrl":"10.1016/j.cpnec.2025.100328","url":null,"abstract":"<div><h3>Objective</h3><div>Given the role of sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis in trauma transmission and oxytocin's stress buffering effects, this study examined whether placental oxytocin receptor (<em>OXTR</em>) gene expression differs by maternal trauma exposure status.</div></div><div><h3>Methods</h3><div>A sample (N = 152) was drawn from a longitudinal birth cohort. <em>OXTR</em> was quantified using nCounter platform as expressed or unexpressed. Maternal trauma exposure was assessed via validated questionnaire and categorized into four groups: before pregnancy trauma, Superstorm Sandy exposure during pregnancy, both, or neither (reference). Logistic regression and synergy index (SI) were calculated to examine individual and additive interaction effects.</div></div><div><h3>Results</h3><div>In the proportion of samples with detectable <em>OXTR,</em> neither individual exposure significantly altered placental <em>OXTR</em> expression. However, both traumas exposure group had an over a 6-fold increase (OR = 6.13, <em>p</em> = .01) compared to the reference. The SI was 2.17 suggesting that the combined effect of both traumas exceeded the sum of their individual effects on placental <em>OXTR</em> expression.</div></div><div><h3>Conclusion</h3><div>Given oxytocin linked placental adaptations to cope with consequences of stress, this greater-than-additive modification, as evidenced by the synergy index, suggests trauma exposure before pregnancy fundamentally changes how the placenta responds to disaster exposure during pregnancy in anticipation of harsh external conditions.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100328"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep deprivation, sleep irregularity, depressive symptoms, and obesity using the KNHANES 2020","authors":"Jayeun Kim ,&nbsp;Kyuhyun Yoon ,&nbsp;Ji-Eun Park","doi":"10.1016/j.cpnec.2025.100318","DOIUrl":"10.1016/j.cpnec.2025.100318","url":null,"abstract":"<div><div>This study aimed to examine the associations between insufficient sleep and health outcomes, specifically depressive symptoms and obesity, using data from the 2020 Korea National Health and Nutrition Examination Survey (KNHANES) with a cross-sectional study design. A total of 5912 participants (2648 men and 3264 women) were included. Among them, 823 individuals (13.9 %) experienced difficulty with weekday sleep deprivation, and 442 individuals (7.5 %) exhibited weekday-weekend sleep mismatch. The mean sleep duration varied according to age group, underlying disease, and physical activity level. Individuals with sleep deprivation were more likely to have depressive symptoms (OR 3.21, 95 % CI 2.65–3.90) and obesity (OR 1.29, 95 % CI 1.07–1.754). On the basis of these findings, both the duration and regularity of sleep are associated with depressive symptoms and obesity, suggesting that sleep patterns may play important roles in these health outcomes.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100318"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in hair cortisol during retirement transition: the Finnish retirement and aging study","authors":"Konsta Kuusento ,&nbsp;Susanna Kortesluoma ,&nbsp;Saana Myllyntausta ,&nbsp;Jussi Vahtera ,&nbsp;Linnea Karlsson ,&nbsp;Sari Stenholm","doi":"10.1016/j.cpnec.2025.100325","DOIUrl":"10.1016/j.cpnec.2025.100325","url":null,"abstract":"<div><h3>Objectives</h3><div>Retirement is a significant life event involving removal of work stress and changes in other psychological factors. These changes may induce physiological responses in the body, such as changes in levels of the stress hormone cortisol, but no previous studies exist on the topic. The aim of this study was to examine changes in hair cortisol concentration and the associated work-related factors during the retirement transition.</div></div><div><h3>Methods</h3><div>One hundred and ninety-nine workers from the Finnish Retirement and Aging study participated in annual hair sampling before and after the retirement transition. Hair cortisol concentration was measured using mass spectrometry. Work-related factors were examined through survey measures. Latent trajectory analysis was used to investigate the heterogeneity of the changes in hair cortisol concentration during the retirement transition.</div></div><div><h3>Results</h3><div>The study population had a mean age of 63.1 (SD 1.1) years and 92 % were women. Three trajectory groups for hair cortisol changes were identified: ”stable low” (79 %), “fluctuating” (6 %) and “post-retirement increase” (15 %). ”Post-retirement increase” group consisted of older participants compared to the “stable low” and “fluctuating” groups. No significant differences in exposure to work-related stressors were found between the groups.</div></div><div><h3>Conclusion</h3><div>For the majority of the participants, the levels of hair cortisol remained relatively low and stable during the retirement transition, but for subgroups of individuals annual fluctuation and post-retirement increase in levels of hair cortisol were observed. Work-related stressors were not found to explain the variability, thus further research on changes in hair cortisol changes during retirement is warranted.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100325"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-three years of editorial work. A lifetime adventure","authors":"Rose-Marie Bluthe","doi":"10.1016/j.cpnec.2025.100331","DOIUrl":"10.1016/j.cpnec.2025.100331","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"24 ","pages":"Article 100331"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}