Comprehensive psychoneuroendocrinology最新文献

{"title":"Oxytocin: Not “just a female hormone”: A very special issue and a very special molecule","authors":"C. Sue Carter,&nbsp;Rose-Marie Bluthé,&nbsp;Jessica J. Connelly,&nbsp;Marcy A. Kingsbury","doi":"10.1016/j.cpnec.2024.100273","DOIUrl":"10.1016/j.cpnec.2024.100273","url":null,"abstract":"<div><div>For decades it was believed that oxytocin was “just a female hormone.” This was a mistake. In the 21st century it has become clear that oxytocin arose from ancient roots, and acquired dozens of diverse functions throughout the mammalian body. This Special Issue of <em>Comprehensive Psychoneuroendocrinology</em> brings together a series of fifteen papers describing different facets and functions of oxytocin. Each author was invited to describe her perspectives on oxytocin, as well as to share experiences that led them to study this remarkable molecule. Many of these stories are highly personal and set in the context of what it means to be a female and to be an academic scientist. Oxytocin is not “just” a female hormone and these articles are not “just” routine descriptions of scientific facts. The readers are invited to join us in a celebration of the molecule that made us human.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100273"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of participating in cortisol awakening response research: “I was more conscious than usual, I wanted to get it right”","authors":"Natasha Ramachandran,&nbsp;Nina Smyth,&nbsp;Sanjay Joban,&nbsp;Maria Flynn,&nbsp;Angela Clow,&nbsp;Lisa Thorn","doi":"10.1016/j.cpnec.2024.100276","DOIUrl":"10.1016/j.cpnec.2024.100276","url":null,"abstract":"<div><div>Cortisol awakening response (CAR) research relies upon self-collected saliva sampling during the post-awakening period. It is unknown how the CAR protocol is perceived and how they may affect typical routines relevant to CAR methodology. CAR assessment is sensitive to state variables, suggesting that CAR measurement may be affected by research participation. This is the first qualitative study to explore motivation and experiences of participation in CAR research.</div><div>Interviews were conducted with a sample of 20 participants (males/females: 4/16) aged 46-82 years following their participation in CAR research in the domestic setting. Responses were transcribed verbatim and thematically analysed.</div><div>Participants were motivated to take part in CAR research for altruistic reasons and the apparent convenience of undertaking the study at home. Participants experienced the study as arduous describing apprehension and the cognitive burden it placed on them leading to disruptions to sleep and morning routines. Participants also struggled to identify the moment of awakening and there was uncertainty surrounding the timing of the first awakening sample. Disruptions were lessened with habituation to sampling on repeated study days.</div><div>There was apprehension about taking part in CAR research, affecting mood, cognition, and sleep; state variables known to influence the CAR. Findings inform ways to optimise CAR ‘ecological validity’ and obtain typical CAR characteristics. The ‘moment of awakening’, was not universally understood, leading to hesitancy in deciding when to collect saliva samples. Researchers need to include a specific discussion of the commonly experienced ambiguity surrounding awakening to increase awareness, lessen anxiety and highlight its importance.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100276"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142655637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding psychological symptoms among Chinese college students during the COVID-19 Omicron pandemic: Findings from a national cross-sectional survey in 2023","authors":"You Xin,&nbsp;Tianrui Ren,&nbsp;Xu Chen,&nbsp;Xin Liu,&nbsp;Yijin Wu,&nbsp;Shu Jing,&nbsp;Ling Zhang,&nbsp;Zhenwei Dai,&nbsp;Ye Wang,&nbsp;Xiaoyou Su","doi":"10.1016/j.cpnec.2024.100278","DOIUrl":"10.1016/j.cpnec.2024.100278","url":null,"abstract":"<div><div>During the Omicron pandemic in late 2022, this study surveyed Chinese students via an online questionnaire to assess their mental health status, prevalence of psychological symptoms, and associated factors. A nationwide cross-sectional survey of 4254 participants was conducted in seven regions of China from January 5 to February 9, 2023. Scales were utilized respectively to measure depressive symptoms, anxiety symptoms, post-traumatic stress disorder (PTSD) symptoms, and perceived social support. Descriptive, univariate, and multivariable analyses were performed to identify associated factors. Protective factors against depressive symptoms include regular exercise and robust social support networks, while risk factors involve excessive alcohol consumption, comorbidities, Omicron infection, and irregular sleep patterns. Risk factors for anxiety symptoms include comorbidities, Omicron infection, living alone, and irregular sleep patterns, while social support emerges as a protective factor. For PTSD symptoms, regular exercise and strong social support systems are identified as protective measures, with risks associated with comorbidities, Omicron infection, and poor sleep quality. Students are particularly vulnerable during the pandemic due to their lifestyle and academic pressures. It's essential to bolster their social support and promote healthier habits.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100278"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled clinical trial of a Wim Hof Method intervention in women with high depressive symptoms","authors":"Robin Blades ,&nbsp;Wendy Berry Mendes ,&nbsp;Brian P. Don ,&nbsp;Stefanie E. Mayer ,&nbsp;Rebecca Dileo ,&nbsp;Julia O'Bryan ,&nbsp;Elena Fromer ,&nbsp;Joanna Y. Guan ,&nbsp;Sylvia S. Cheng ,&nbsp;Ashley E. Mason ,&nbsp;Aric A. Prather ,&nbsp;Elissa S. Epel","doi":"10.1016/j.cpnec.2024.100272","DOIUrl":"10.1016/j.cpnec.2024.100272","url":null,"abstract":"<div><h3>Objective</h3><div>Stress is a driver of depression, and people with depression often struggle to cope with stress and anxiety. This study directly compares the mental health effects of a Wim Hof Method intervention to an active control condition (slow breathing) in women with high stress and high depressive symptoms.</div></div><div><h3>Methods</h3><div>We randomized 84 healthy midlife women with high stress and high depressive symptoms to either: 1) the hormetic stress condition based on the Wim Hof Method (WHM) involving a breathing technique designed to induce intermittent hypoxia and cold showers (n = 41) or 2) an active comparison condition involving slow-paced breathing and warm showers (n = 43). We provided participants with daily audio instructions (15 min) for three weeks during the COVID-19 pandemic (2020–2021). Our primary outcomes were depressive symptoms, anxiety symptoms, and perceived stress collected at pre-intervention, post-intervention, and 3 months later. We also assessed daily stress rumination and affect with daily diary during the intervention, and participants completed a laboratory stressor, the Trier Social Stress Test, before and after the intervention, and provided samples for salivary cortisol reactivity.</div></div><div><h3>Results</h3><div>Participants in the active control condition perceived the intervention to be more credible and expected greater mental wellbeing benefits compared to those in the Wim Hof Method condition. Differential attrition was observed with six participants (7 %) dropping out -- all from WHM condition. Among the participants who completed the intervention, both groups improved on mental health outcomes immediately after the intervention with a 24 % reduction in depressive symptoms, a 27 % reduction in anxiety symptoms, and 20 % reduction in perceived stress. Improvements were maintained at the 3-month follow-up with 46 % of the sample reporting mild or no depressive symptoms. Participants in the WHM condition had significant reductions in rumination after daily stressful events compared to those in the active control group. Both conditions had reduced daily negative affect across the intervention and lower peak cortisol reactivity to the lab stressor post-intervention.</div></div><div><h3>Conclusions</h3><div>Counter to the preregistered predictions, and despite participants’ differing expectations, the interventions led to equivalent reductions in depressive symptoms, anxiety symptoms, and perceived stress, which were sustained at three months. They also produced comparable reductions in cortisol reactivity and daily negative affect. However, the WHM condition was associated with greater reduction in reported rumination after daily stressful events than the active control, a finding that needs replication with larger and more diverse samples.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100272"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142655638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Mannheim Multicomponent Stress Test a viable alternative to the Trier Social Stress Test?","authors":"Daniel S. Kashi,&nbsp;Marianne Hunter,&nbsp;Jason P. Edwards,&nbsp;Harry Bell,&nbsp;Megan Robinson,&nbsp;Neil P. Walsh","doi":"10.1016/j.cpnec.2024.100275","DOIUrl":"10.1016/j.cpnec.2024.100275","url":null,"abstract":"<div><h3>Background</h3><div>The Trier Social Stress Test (TSST) is a widely used laboratory protocol to study acute stress reactivity, a hallmark of which is a meaningful increase in saliva cortisol (&gt;2.5 nmol/L) in most individuals, reflecting hypothalamic-pituitary-adrenal (HPA) axis activation. The Mannheim Multicomponent Stress Test (MMST) has potential as a low staff burden alternative to the TSST, with one study showing statistically significant increases in subjective stress, heart rate and saliva cortisol; however, uncertainty remains about the meaningfulness of these psychobiological responses.</div></div><div><h3>Objective</h3><div>To assess whether the MMST is a viable alternative to the TSST.</div></div><div><h3>Methods</h3><div>Using a between subjects design, 31 healthy adults were randomised to the standard TSST or the MMST using stratified block randomisation accounting for sex and trait anxiety. The standard TSST consisted of an anticipation phase, followed by a free speech and mental arithmetic task performed in front of a panel of trained actors. The MMST consisted of a computer based Paced Auditory Serial Addition Task (cognitive stressor) with additional motivational, emotional and acoustic stressors in the presence of one unresponsive observer.</div></div><div><h3>Results</h3><div>Group × time interactions showed that the MMST induced smaller psychobiological responses compared with the TSST (mixed model ANCOVA, <em>P</em> &lt; 0.05). Post-hoc analyses revealed that the MMST induced a significant yet smaller state anxiety response (score range 20–80, MMST: 47 ± 12 <em>vs.</em> TSST: 57 ± 9; <em>P</em> &lt; 0.01, Cohens <em>d</em> = 0.9) and peak heart rate response (MMST: 98 ± 17 <em>vs.</em> TSST: 110 ± 21 bpm; <em>P</em> &lt; 0.05, Cohens <em>d</em> = 0.6) compared with the TSST. Despite observing stereotypical neuroendocrine responses to the TSST, the MMST did not increase saliva α-amylase or cortisol (Δ saliva cortisol, 0.1 ± 1.1 <em>vs.</em> TSST: 10.3 ± 12.8 nmol/L; between group difference <em>P</em> &lt; 0.01, Cohens <em>d</em> = 1.1). Moreover, meaningful increases in saliva cortisol (&gt;2.5 nmol/L) were observed in 80% of participants after the TSST but in no participant after the MMST.</div></div><div><h3>Conclusion</h3><div>The Mannheim Multicomponent Stress Test increased state anxiety and heart rate but not saliva cortisol. As such, the present results do not support the utility of the Mannheim Multicomponent Stress Test as a viable alternative to The Trier Social Stress Test.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100275"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to the special issue: A festschrift for Janice Kiecolt-Glaser – At the origin of stress and immunity","authors":"Christopher Fagundes","doi":"10.1016/j.cpnec.2024.100274","DOIUrl":"10.1016/j.cpnec.2024.100274","url":null,"abstract":"<div><div>This special issue of <em>Comprehensive Psychoneuroendocrinology</em> pays tribute to Janice Kiecolt-Glaser's groundbreaking career and marks her well-earned retirement. As a leader in human psychoneuroimmunology (PNI), Kiecolt-Glaser transformed the domain by showing that everyday stressors, along with significant life events, can significantly affect the immune system. Her groundbreaking research on informal dementia caregivers revealed the detrimental effects of chronic psychological stress, including delayed wound healing, virus reactivation, heightened proinflammatory cytokine levels, and weakened vaccine responses. This issue features contributions from her former mentees and collaborators, reflecting the enduring influence of her mentorship and research. Few psychologists in PNI have matched her mentorship legacy, and the included works showcase the ways her guidance has shaped their scientific careers. These articles explore new frameworks for integrating affective science with immune health, interventions designed for couples managing chronic illness, and studies examining the immune consequences of relational dynamics. Personal reflections from her trainees and collaborators highlight Kiecolt-Glaser's unique ability to balance rigorous expectations with unwavering support, fostering their professional growth. Collectively, this special issue illustrates how Kiecolt-Glaser's scholarship continues to advance the field, pushing the boundaries of interdisciplinary inquiry. Her influence on the next generation of scientists ensures that her legacy will remain central to PNI, reinforcing the critical role of relationships in health and disease.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100274"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depression and anxiety disorders with euthyroid Hashimoto's thyroiditis: A systematic review and meta-analysis","authors":"Bo Wang ,&nbsp;Jie Huang ,&nbsp;Li Chen","doi":"10.1016/j.cpnec.2024.100279","DOIUrl":"10.1016/j.cpnec.2024.100279","url":null,"abstract":"<div><h3>Background</h3><div>Hashimoto's thyroiditis (HT) affects up to 10 % of the population and is a common cause of hypothyroidism, which can lead to depression and anxiety. However, it remains unclear whether HT directly causes these conditions or if they arise due to HT-induced hypothyroidism. The present review aims to offer meta-analytic insights into the relationship between depression and anxiety in patients with euthyroid HT.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Data, SinoMed, and VIP from their inception through May 2024. Case-control or cross-sectional studies examining the association between euthyroid HT and either depression, anxiety disorders, or both were included.</div></div><div><h3>Results</h3><div>For depression, 1365 patients (694 HT vs. 671 controls) from 11 articles were analyzed; for anxiety, 1009 patients (516 HT vs. 493 controls) from 8 articles were included. HT patients had 2.5 times higher odds of anxiety disorders (OR = 2.52, 95 % CI: 1.66–3.82). The Beck Depression Inventory showed a WMD of 4.26 (95 % CI: 1.28–7.24) and the Beck Anxiety Inventory a WMD of 5.10 (95 % CI: 1.55–8.66).</div></div><div><h3>Limitation</h3><div>The findings should be interpreted cautiously due to heterogeneity, potential publication bias, and variability in assessment tools, which may limit generalizability.</div></div><div><h3>Conclusions</h3><div>Euthyroid HT patients exhibit a higher prevalence of anxiety disorders compared to healthy control groups, and more susceptible to anxiety and depression symptoms based on the Beck Inventory. Thyroid antibodies themselves are also associated with depression and anxiety disorder.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100279"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Festschrift for Janice Kiecolt-Glaser: At the origin of stress and immunity","authors":"Robert Dantzer (Editor-in-Chief of Comprehensive Psychoneuroendocrinology)","doi":"10.1016/j.cpnec.2024.100277","DOIUrl":"10.1016/j.cpnec.2024.100277","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100277"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived partner responsiveness alters the association between marital distress and well-being in dementia spousal caregivers","authors":"Vincent D. Lai ,&nbsp;Jensine Paoletti-Hatcher ,&nbsp;E. Lydia Wu-Chung ,&nbsp;Itee Mahant ,&nbsp;Daniel L. Argueta ,&nbsp;Kelly N. Brice ,&nbsp;Bryan T. Denny ,&nbsp;Charles Green ,&nbsp;Luis D. Medina ,&nbsp;Paul E. Schulz ,&nbsp;Jennifer M. Stinson ,&nbsp;Cobi J. Heijnen ,&nbsp;Christopher P. Fagundes","doi":"10.1016/j.cpnec.2024.100271","DOIUrl":"10.1016/j.cpnec.2024.100271","url":null,"abstract":"<div><div>Caregivers for spouses with Alzheimer's disease and related dementias (ADRD) experience drastic changes in the marital relationship that may put them at risk for worsening well-being. Perceived partner responsiveness, or feeling cared for, understood, and appreciated by one's spouse, may help mitigate these effects. In this study, we investigated the associations between marital distress, perceived partner responsiveness, and psychological and physiological well-being indicators among ADRD spousal caregivers.</div></div><div><h3>Method</h3><div>A sample of 161 caregivers provided blood samples and completed self-report measures of marital distress, perceived partner responsiveness, and depressive symptoms. We tested hypotheses in our sample cross-sectionally based on two theoretical frameworks.</div></div><div><h3>Results</h3><div>Testing the marital discord model of depression, caregivers who reported greater marital distress also reported more depressive symptoms, and this association was stronger as participants reported lower perceived partner responsiveness. Caregivers who reported greater marital distress exhibited elevated proinflammatory cytokine production by in vitro lipopolysaccharide (LPS)-stimulated peripheral blood leukocytes at low levels of perceived partner responsiveness, but not mean or high levels. Testing the vulnerability-stress-adaptation model, caregivers who reported more depressive symptoms also reported greater marital distress. Further, caregivers who exhibited elevated LPS-stimulated proinflammatory cytokine production reported greater marital distress at mean and high levels of perceived partner responsiveness, but not low levels. These patterns of results held even when accounting for the dementia stage and reported hours of caregiving per day.</div></div><div><h3>Discussion</h3><div>This study's findings contribute to the body of research examining interpersonal factors that shape health and well-being among the caregiver population.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100271"},"PeriodicalIF":2.1,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distress and inflammation are independently associated with cancer-related symptom severity","authors":"Tamara E. Lacourt ,&nbsp;D. Tripathy ,&nbsp;Maria C. Swartz ,&nbsp;Emily C. LaVoy ,&nbsp;Cobi J. Heijnen","doi":"10.1016/j.cpnec.2024.100269","DOIUrl":"10.1016/j.cpnec.2024.100269","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate longitudinal associations of distress and inflammation with somatic and depressive symptom severity in breast cancer patients, from before to six months after neoadjuvant chemotherapy. We also explored feasibility and effects of an early mindfulness-based intervention for preventing or reducing somatic and depressive symptoms.</div></div><div><h3>Methods</h3><div>Longitudinal pilot study with a randomized waitlist-controlled intervention design. Women with breast cancer were randomized to receive access to a smartphone application offering meditation exercises, either immediately after baseline testing (intervention group) or after study completion (control group) in a 1:1 ratio. Assessments (self-report questionnaires and a blood draw when feasible) were completed before, halfway through, immediately after, and 6 months after completing neoadjuvant chemotherapy.</div></div><div><h3>Results</h3><div>Fifty evaluable women were enrolled. Somatic symptom severity increased during chemotherapy, whereas depressive symptom severity was at its peak before treatment and declined gradually thereafter. Distress was positively associated with depressive symptom severity. Only Distress Thermometer-results were positively associated with somatic symptom severity. Inflammation was positively associated with both types of symptoms, and distress did not moderate the associations between inflammation and symptom severity. Intervention adherence was low and no intervention effect on symptom experience was observed.</div></div><div><h3>Conclusion</h3><div>Inflammation and distress are independently associated with somatic and depressive symptoms experienced during breast cancer treatment.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100269"},"PeriodicalIF":2.1,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}