Comprehensive psychoneuroendocrinology最新文献

{"title":"Oxytocin: Not “just a female hormone”: A very special issue and a very special molecule","authors":"C. Sue Carter,&nbsp;Rose-Marie Bluthé,&nbsp;Jessica J. Connelly,&nbsp;Marcy A. Kingsbury","doi":"10.1016/j.cpnec.2024.100273","DOIUrl":"10.1016/j.cpnec.2024.100273","url":null,"abstract":"<div><div>For decades it was believed that oxytocin was “just a female hormone.” This was a mistake. In the 21st century it has become clear that oxytocin arose from ancient roots, and acquired dozens of diverse functions throughout the mammalian body. This Special Issue of <em>Comprehensive Psychoneuroendocrinology</em> brings together a series of fifteen papers describing different facets and functions of oxytocin. Each author was invited to describe her perspectives on oxytocin, as well as to share experiences that led them to study this remarkable molecule. Many of these stories are highly personal and set in the context of what it means to be a female and to be an academic scientist. Oxytocin is not “just” a female hormone and these articles are not “just” routine descriptions of scientific facts. The readers are invited to join us in a celebration of the molecule that made us human.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100273"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The post-Cartesian dilemma: Reuniting the mind and body through psychoneuroimmunology","authors":"Jeanette M. Bennett","doi":"10.1016/j.cpnec.2024.100265","DOIUrl":"10.1016/j.cpnec.2024.100265","url":null,"abstract":"<div><div>While today, it might seem absurd to hear anyone claim that stress does not alter all aspects of the human experience, including behavioral, cognitive, affective, and physiological processes. Dr. Janice Kiecolt-Glaser started her career at a time when stress was primarily considered a neuroendocrine response with cardiovascular repercussions. She was part of a small group of innovative scientists who began to push the boundaries of stress research – many contemporary immunologists and virologist disputed their early results in 1980s and 90s – and, yet, they persevered by connecting psychological stress to altered immune function via stress-related neuroendocrine changes. As a clinical psychologist, she focused mainly on human research studies to advance the field of psychoneuroimmunology throughout her career. Her research demonstrates how adversity and psychosocial aspects of human experience alter physiological functioning, primarily immune, and health or, in other words, the embodiment of our lived experiences. This short review is a contextualized synthesis of Dr. Kiecolt-Glaser's key contributions to the fields of psychoneuroimmunology and health psychology and her influence on my present day thinking and research approaches, as well as potential steps forward in our post-pandemic world.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100265"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distress and inflammation are independently associated with cancer-related symptom severity","authors":"Tamara E. Lacourt ,&nbsp;D. Tripathy ,&nbsp;Maria C. Swartz ,&nbsp;Emily C. LaVoy ,&nbsp;Cobi J. Heijnen","doi":"10.1016/j.cpnec.2024.100269","DOIUrl":"10.1016/j.cpnec.2024.100269","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate longitudinal associations of distress and inflammation with somatic and depressive symptom severity in breast cancer patients, from before to six months after neoadjuvant chemotherapy. We also explored feasibility and effects of an early mindfulness-based intervention for preventing or reducing somatic and depressive symptoms.</div></div><div><h3>Methods</h3><div>Longitudinal pilot study with a randomized waitlist-controlled intervention design. Women with breast cancer were randomized to receive access to a smartphone application offering meditation exercises, either immediately after baseline testing (intervention group) or after study completion (control group) in a 1:1 ratio. Assessments (self-report questionnaires and a blood draw when feasible) were completed before, halfway through, immediately after, and 6 months after completing neoadjuvant chemotherapy.</div></div><div><h3>Results</h3><div>Fifty evaluable women were enrolled. Somatic symptom severity increased during chemotherapy, whereas depressive symptom severity was at its peak before treatment and declined gradually thereafter. Distress was positively associated with depressive symptom severity. Only Distress Thermometer-results were positively associated with somatic symptom severity. Inflammation was positively associated with both types of symptoms, and distress did not moderate the associations between inflammation and symptom severity. Intervention adherence was low and no intervention effect on symptom experience was observed.</div></div><div><h3>Conclusion</h3><div>Inflammation and distress are independently associated with somatic and depressive symptoms experienced during breast cancer treatment.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100269"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of participating in cortisol awakening response research: “I was more conscious than usual, I wanted to get it right”","authors":"Natasha Ramachandran,&nbsp;Nina Smyth,&nbsp;Sanjay Joban,&nbsp;Maria Flynn,&nbsp;Angela Clow,&nbsp;Lisa Thorn","doi":"10.1016/j.cpnec.2024.100276","DOIUrl":"10.1016/j.cpnec.2024.100276","url":null,"abstract":"<div><div>Cortisol awakening response (CAR) research relies upon self-collected saliva sampling during the post-awakening period. It is unknown how the CAR protocol is perceived and how they may affect typical routines relevant to CAR methodology. CAR assessment is sensitive to state variables, suggesting that CAR measurement may be affected by research participation. This is the first qualitative study to explore motivation and experiences of participation in CAR research.</div><div>Interviews were conducted with a sample of 20 participants (males/females: 4/16) aged 46-82 years following their participation in CAR research in the domestic setting. Responses were transcribed verbatim and thematically analysed.</div><div>Participants were motivated to take part in CAR research for altruistic reasons and the apparent convenience of undertaking the study at home. Participants experienced the study as arduous describing apprehension and the cognitive burden it placed on them leading to disruptions to sleep and morning routines. Participants also struggled to identify the moment of awakening and there was uncertainty surrounding the timing of the first awakening sample. Disruptions were lessened with habituation to sampling on repeated study days.</div><div>There was apprehension about taking part in CAR research, affecting mood, cognition, and sleep; state variables known to influence the CAR. Findings inform ways to optimise CAR ‘ecological validity’ and obtain typical CAR characteristics. The ‘moment of awakening’, was not universally understood, leading to hesitancy in deciding when to collect saliva samples. Researchers need to include a specific discussion of the commonly experienced ambiguity surrounding awakening to increase awareness, lessen anxiety and highlight its importance.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100276"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142655637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous oxytocin administered to induce or augment labour is positively associated with quality of observed mother-infant bonding","authors":"Hannah Edwards ,&nbsp;Femke TA. Buisman-Pijlman ,&nbsp;Adrian Esterman ,&nbsp;Craig Phillips ,&nbsp;Sandra Orgeig ,&nbsp;Andrea Gordon","doi":"10.1016/j.cpnec.2024.100262","DOIUrl":"10.1016/j.cpnec.2024.100262","url":null,"abstract":"<div><p>Oxytocin is a key hormone in the transition to motherhood. The maternal endogenous oxytocin system facilitates many physiological and biological adaptations, including breastfeeding, maternal wellbeing, and brain plasticity. Additionally, maternal endogenous oxytocin works as a finetuned orchestrator prior to, during, and after the birth of a child to support birth progression and mother-infant bonding. Exogenous oxytocin may be administered to induce or augment labour when this is not progressing naturally and is a common obstetric intervention worldwide. However, the lasting impact of these widely varying levels of systemic exogenous oxytocin on mother-infant bonding is currently unknown. This study aimed to investigate the association between exogenous oxytocin administered to induce or augment labour and quality of observed mother-infant bonding.</p><p>Thirty-eight mother and infant dyads participated (mothers aged 24–48 years; infants aged 2–5 months). Mother-infant bonding quality was assessed via the Recorded Interaction Task and hospital birth records were consulted to obtain exogenous oxytocin administration data. Demographic information and possible confounding factors were collected from dyads, and salivary oxytocin concentration was measured for both mother and infant.</p><p>Mother's perception of infant sleep difficulty was identified as a confounding factor for quality of mother-infant bonding. After controlling for the confounding factor, receiving exogenous oxytocin to induce or augment labour, as opposed to not, was found to be significantly positively associated with higher quality of observed mother-infant bonding (p = 0.029). These novel findings highlight the need for further exploration, both of the impact of the treatment and of the mechanisms of action of intrapartum exogenous oxytocin on the endogenous oxytocin system. It is argued that particular focus be given to investigate action on the central oxytocin receptors, and if this may play a role in subsequent mother-infant bonding outcomes. It is vital to understand the full breadth and the clinical implications of this commonplace procedure.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100262"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000389/pdfft?md5=6489786dd5815ff9e6c46ec865d7a201&pid=1-s2.0-S2666497624000389-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding psychological symptoms among Chinese college students during the COVID-19 Omicron pandemic: Findings from a national cross-sectional survey in 2023","authors":"You Xin,&nbsp;Tianrui Ren,&nbsp;Xu Chen,&nbsp;Xin Liu,&nbsp;Yijin Wu,&nbsp;Shu Jing,&nbsp;Ling Zhang,&nbsp;Zhenwei Dai,&nbsp;Ye Wang,&nbsp;Xiaoyou Su","doi":"10.1016/j.cpnec.2024.100278","DOIUrl":"10.1016/j.cpnec.2024.100278","url":null,"abstract":"<div><div>During the Omicron pandemic in late 2022, this study surveyed Chinese students via an online questionnaire to assess their mental health status, prevalence of psychological symptoms, and associated factors. A nationwide cross-sectional survey of 4254 participants was conducted in seven regions of China from January 5 to February 9, 2023. Scales were utilized respectively to measure depressive symptoms, anxiety symptoms, post-traumatic stress disorder (PTSD) symptoms, and perceived social support. Descriptive, univariate, and multivariable analyses were performed to identify associated factors. Protective factors against depressive symptoms include regular exercise and robust social support networks, while risk factors involve excessive alcohol consumption, comorbidities, Omicron infection, and irregular sleep patterns. Risk factors for anxiety symptoms include comorbidities, Omicron infection, living alone, and irregular sleep patterns, while social support emerges as a protective factor. For PTSD symptoms, regular exercise and strong social support systems are identified as protective measures, with risks associated with comorbidities, Omicron infection, and poor sleep quality. Students are particularly vulnerable during the pandemic due to their lifestyle and academic pressures. It's essential to bolster their social support and promote healthier habits.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100278"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled clinical trial of a Wim Hof Method intervention in women with high depressive symptoms","authors":"Robin Blades ,&nbsp;Wendy Berry Mendes ,&nbsp;Brian P. Don ,&nbsp;Stefanie E. Mayer ,&nbsp;Rebecca Dileo ,&nbsp;Julia O'Bryan ,&nbsp;Elena Fromer ,&nbsp;Joanna Y. Guan ,&nbsp;Sylvia S. Cheng ,&nbsp;Ashley E. Mason ,&nbsp;Aric A. Prather ,&nbsp;Elissa S. Epel","doi":"10.1016/j.cpnec.2024.100272","DOIUrl":"10.1016/j.cpnec.2024.100272","url":null,"abstract":"<div><h3>Objective</h3><div>Stress is a driver of depression, and people with depression often struggle to cope with stress and anxiety. This study directly compares the mental health effects of a Wim Hof Method intervention to an active control condition (slow breathing) in women with high stress and high depressive symptoms.</div></div><div><h3>Methods</h3><div>We randomized 84 healthy midlife women with high stress and high depressive symptoms to either: 1) the hormetic stress condition based on the Wim Hof Method (WHM) involving a breathing technique designed to induce intermittent hypoxia and cold showers (n = 41) or 2) an active comparison condition involving slow-paced breathing and warm showers (n = 43). We provided participants with daily audio instructions (15 min) for three weeks during the COVID-19 pandemic (2020–2021). Our primary outcomes were depressive symptoms, anxiety symptoms, and perceived stress collected at pre-intervention, post-intervention, and 3 months later. We also assessed daily stress rumination and affect with daily diary during the intervention, and participants completed a laboratory stressor, the Trier Social Stress Test, before and after the intervention, and provided samples for salivary cortisol reactivity.</div></div><div><h3>Results</h3><div>Participants in the active control condition perceived the intervention to be more credible and expected greater mental wellbeing benefits compared to those in the Wim Hof Method condition. Differential attrition was observed with six participants (7 %) dropping out -- all from WHM condition. Among the participants who completed the intervention, both groups improved on mental health outcomes immediately after the intervention with a 24 % reduction in depressive symptoms, a 27 % reduction in anxiety symptoms, and 20 % reduction in perceived stress. Improvements were maintained at the 3-month follow-up with 46 % of the sample reporting mild or no depressive symptoms. Participants in the WHM condition had significant reductions in rumination after daily stressful events compared to those in the active control group. Both conditions had reduced daily negative affect across the intervention and lower peak cortisol reactivity to the lab stressor post-intervention.</div></div><div><h3>Conclusions</h3><div>Counter to the preregistered predictions, and despite participants’ differing expectations, the interventions led to equivalent reductions in depressive symptoms, anxiety symptoms, and perceived stress, which were sustained at three months. They also produced comparable reductions in cortisol reactivity and daily negative affect. However, the WHM condition was associated with greater reduction in reported rumination after daily stressful events than the active control, a finding that needs replication with larger and more diverse samples.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100272"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142655638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is age more than a number? Accounting for adult development and aging in the study of psychoneuroimmunology, stress, and health","authors":"Stephanie J. Wilson","doi":"10.1016/j.cpnec.2024.100266","DOIUrl":"10.1016/j.cpnec.2024.100266","url":null,"abstract":"<div><div>Traditional stress-and-health models link stressors to their health consequences through a well-characterized cascade. Most of the research assumes that the stress-health sequence unfolds in the same way across adulthood, whether a person is 25 years old or 80. Taking a “developmental” or “lifespan” approach has been synonymous with studying the lasting health impacts of early life experiences. However, theories and evidence from adult development and geroscience suggest that stress-health dynamics evolve in important ways over the adult lifespan—from the stressors that we encounter, to the emotion regulation strategies that we use to confront challenges, to the psychosocial resources at our disposal, to the cellular milieu, and thus to the magnitude of stressors' biological and functional consequences. This critical review synthesizes theoretical perspectives and selected empirical literature on the social-emotional and biological dimensions of aging to promote an Integrative Model of Aging, Stress, and Health. Through this integration, the model illustrates how an interdisciplinary, developmental perspective can enrich our understanding of stress's consequences for health across adulthood. It also seeks to guide a new generation of research questions that confront aging with a multidimensional approach. The piece concludes with personal reflections on the foundational legacy of the author's mentor, Dr. Janice Kiecolt-Glaser.</div></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100266"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin in growth, reproduction, restoration and health","authors":"Kerstin Uvnäs Moberg","doi":"10.1016/j.cpnec.2024.100268","DOIUrl":"10.1016/j.cpnec.2024.100268","url":null,"abstract":"&lt;div&gt;&lt;div&gt;This article summarizes my scientific work and describes some personal experiences during this period. After my basal medical training (MD) (1971), I obtained a PhD in pharmacology (1976) and ended up as a professor of Physiology.&lt;/div&gt;&lt;div&gt;My initial studies were within the field of gastroenterology. I showed that the gastrointestinal hormone gastrin, which stimulates HCL secretion in the stomach, was released in response to stimulation of the vagal nerve. Later I showed that the entire endocrine system of the gastrointestinal (GI) tract that promotes digestion and anabolic metabolism and growth was under vagal nerve control. I also showed that activation of the vagal nerve inhibits the function of the inhibitory substance somatostatin.&lt;/div&gt;&lt;div&gt;10 years later, after some big changes in my personal life, my research focus changed. I became interested in female physiology, particularly the role of oxytocin. In addition, I became aware of the situation of female scientists and started to work with questions regarding equality between women and men.&lt;/div&gt;&lt;div&gt;I gathered a group of interested female medical students and midwives around me. We demonstrated that breastfeeding and touch (e.g., between mother and baby), via stimulation of sensory nerves in the skin, activated the endocrine system of the GI tract and, thereby, anabolic processes and growth. The effects were exerted via a vagal mechanism and involved activation of parvocellular oxytocinergic neurons from the paraventricular nucleus (PVN). We also showed that the gastrointestinal hormone cholecystokinin stimulated the release of oxytocin in a calorie-dependent way via an afferent vagal mechanism.&lt;/div&gt;&lt;div&gt;In summary, there is a bidirectional, vagally mediated connection between the endocrine system of the GI tract and the oxytocin producing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus.1. Oxytocinergic neurons from the PVN enhances the activity of the endocrine system of the GI tract and thereby growth and regeneration. The effect is exerted via efferent vagal fibers which inhibit the release of somatostatin. 2. Food in the duodenum triggers a release of cholecystokinin (CCK), which via a vagal afferent mechanism stimulates the release and function of oxytocin. This mechanism is not activated in the absence of food intake.&lt;/div&gt;&lt;div&gt;Administration of oxytocin induces a multitude of actions, i.e., anxiolytic and sedative effects, increased pain threshold, lowering of cortisol and blood pressure and an increased activity of the endocrine system of the GI tract. Repeated administration of oxytocin may induce long-term effects and “secondary” mechanisms such as an increased activity of alpha-2- adrenoceptors are involved.&lt;/div&gt;&lt;div&gt;Oxytocin released by suckling during breastfeeding or by touch during social interaction will induce a similar effect spectrum. Activation of the parvocellular neurons will stimulate some aspects of social behavior,","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100268"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Writing tips for psychoneuroimmunology trainees: Lessons learned from Dr. Kiecolt-Glaser","authors":"Heather Derry-Vick","doi":"10.1016/j.cpnec.2024.100258","DOIUrl":"10.1016/j.cpnec.2024.100258","url":null,"abstract":"<div><p>Psychoneuroimmunology (PNI) researchers can advance their careers and increase their scientific impact by prioritizing their writing skills. In addition to Dr. Kiecolt-Glaser's landmark research that inspired this special issue, her legacy is reflected in her prolific writing. Dr. Kiecolt-Glaser has the unique ability to convey her innovative research clearly and to diverse audiences. She also made writing mentorship a critical part of the training experience in her lab. In these ways, Dr. Kiecolt-Glaser's writing skills and mentorship have shaped both the PNI field and her trainees' careers. In this paper, I distill lessons learned about writing from Dr. Kiecolt-Glaser during my time as a graduate student in her Stress and Health Lab in the 2010s. I reflect on Dr. Kiecolt-Glaser's influence on her trainees' writing habits, summarize “writing pearls” inspired by her feedback/revisions, and provide observations on her writing mentorship habits. These tips are intended to help PNI trainees to clearly communicate their work and to help mentors reflect on ways they can prioritize and advance their trainees' writing skills. Finally, I reflect on how Dr. Kiecolt-Glaser's mentorship and scientific accomplishments had a tremendous impact on my own career development.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"20 ","pages":"Article 100258"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000341/pdfft?md5=a3b35af8e1479f1262b80fcc6154c259&pid=1-s2.0-S2666497624000341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}