Comprehensive psychoneuroendocrinology最新文献

{"title":"Moxie begets MOXI: The journey to a novel hypothesis about Mu-opioid and OXytocin system Interactions","authors":"Khalin E. Nisbett","doi":"10.1016/j.cpnec.2024.100244","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100244","url":null,"abstract":"<div><p>This narrative review summarizes the early life of the author, Khalin E. Nisbett, and highlights the factors that led to her career in research and her development of two novel research hypotheses: the <strong>M</strong>u-opioid and <strong>OX</strong>ytocin system <strong>I</strong>nteraction (MOXI) hypothesis and <strong>M</strong>u-Opioid receptor antagonist and <strong>OX</strong>ytocin receptor <strong>A</strong>gonist <strong>I</strong>n <strong>C</strong>ombination (MOXAIC) treatment hypothesis. Notably, Nisbett's career began in the era after countless studies demonstrated that oxytocin is not just a female neurotransmitter and not just a female reproductive hormone, an era in which researchers are exploring the role of oxytocin in emotion regulation, social interaction, and cognitive processing across both sexes. As such, the previously held perspective that oxytocin is “just a female hormone” did not impede Nisbett's ideas. Intrigued by science, emotion regulation, and social interaction, she began to explore the role of oxytocin and opioids in emotion regulation. On the heels of earlier theories, such as the Tend-and-Befriend theory and Opioid Theory of Social Attachment, she began to develop the MOXI hypothesis, which postulates that the μ-opioid receptor and oxytocin systems interact to mediate social interaction and emotion regulation. In this narrative review, Nisbett summarizes two studies that explored (i) the role of oxytocin in anxiety- and depression-like behavior and (ii) the effect of opioid receptor blockade on the anxiolytic-like effect of oxytocin, which led to a revision of the MOXI hypothesis and postulation of the Mu−Opioid receptor antagonist and OXytocin receptor Agonist In Combination (MOXAIC) treatment hypothesis. Nisbett also discusses several limitations of these hypotheses and her current research interests and aspirations.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100244"},"PeriodicalIF":2.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000201/pdfft?md5=f17d3a14ed9bc656f0c03b40af2a532b&pid=1-s2.0-S2666497624000201-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpersonal relationships, PNI, and health: Seeds in the 1980s, fruiting trees today","authors":"Theodore F. Robles","doi":"10.1016/j.cpnec.2024.100247","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100247","url":null,"abstract":"<div><p>In this contribution to the Special Issue, I highlight how Janice Kiecolt-Glaser's research in the 1980s planted the seeds for two areas of social relationships and health research: loneliness and intimate/marital relationships. I review the foundational “seed” studies from the mid-to late-1980s, the research “saplings” that sprouted and grew during the subsequent twenty years, and the “mature trees” that have gone on to fruit and grow their respective areas of inquiry over the past twenty years. In addition to highlighting the mature trees that have borne rich empirical fruit, my other goal for this contribution is to draw attention to ideas and concepts from Kiecolt-Glaser's work and writing that merit further conceptual and empirical examination in the next generation of research on social relationships, psychoneuroendocrinology, psychoneuroimmunology, and health.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100247"},"PeriodicalIF":2.1,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000237/pdfft?md5=5a4fe2e6717c88593c55c285276eb5f0&pid=1-s2.0-S2666497624000237-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair collection protocol in 12-month-old infants","authors":"Renata Pereira Defelipe ,&nbsp;Júlia Terra ,&nbsp;Isabella Francischelli ,&nbsp;Beatriz Pacheco ,&nbsp;Patrícia Pereira Araújo ,&nbsp;Ana Raquel Mesquita ,&nbsp;Miriam Oliveira Ribeiro ,&nbsp;Murilo Correa ,&nbsp;Ana Osório","doi":"10.1016/j.cpnec.2024.100243","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100243","url":null,"abstract":"<div><h3>Purpose</h3><p>Most studies assessing hair cortisol were conducted with adults. As specific guidelines for infant hair collection are lacking, we developed a hair collection protocol for 12-month-old infants and assessed its acceptability and feasibility.</p></div><div><h3>Results</h3><p>Out of the total (<em>N</em> = 45), 95.6 % (<em>n</em> = 43) of caregivers consented to the procedure, while one caregiver did not consent (2.2 %), and another requested the procedure to be halted before required amount of hair had been reached (2.2 %). Furthermore, two (4.4 %) infants did not have enough hair for collection. There was no attrition due to infant fussiness/crying.</p></div><div><h3>Discussion</h3><p>We learned five lessons which can help to enhance reproducibility, mother's consent, and mother-infant comfort and acceptance of the procedure. The first lesson is to have the infant sit on the caregiver's lap to ensure the infant feels safe and remains relatively still. The second is to reassure caregivers by showing hair samples representing the amount to be cut as well as by clarifying no unaesthetic gaps would be visible. The third is to caress the infant's head to habituate them to the hair manipulation and to make soap bubbles as distractors. The fourth is to take extra care when securing the lock of hair for cutting because the infant scalp is thin and malleable. The fifth is to place a precision scale in the collection room to ensure the necessary weight is reached.</p></div><div><h3>Conclusion</h3><p>Our hair collection protocol developed for 12-month-old infants was deemed feasible and acceptable, filled an important literature gap concerning the absence of published protocols for infants, and will contribute to increase the replicability and collection efficiency for other research teams.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100243"},"PeriodicalIF":2.1,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000195/pdfft?md5=4f85a6b4d4ab39feaee2644b77ebeb64&pid=1-s2.0-S2666497624000195-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving toward affective immunology: Legacy and future directions","authors":"Jennifer E. Graham-Engeland","doi":"10.1016/j.cpnec.2024.100241","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100241","url":null,"abstract":"<div><p>The term “affective immunology” has recently been used to denote a field focused on the interplay between affective processes (including mood states, specific emotions, and regulatory processes) and various aspects of immune function. The overarching goals of this commentary are <strong>a)</strong> to provide historical underpinnings of this field with a focus on the profound impact of the work of Janice Kiecolt-Glaser, who is further honored in this special issue, <strong>b)</strong> to review important off-shoots of her legacy work in this domain, and <strong>c)</strong> to highlight important future directions for the field. Kiecolt-Glaser's work laid much of the foundation for affective immunology, with groundbreaking research related to depression, hostility and dyadic interactions, loneliness, and other affective patterns, often in the context of holistic models, novel experimental designs, and interventions. Her former mentees (and many of their mentees) have carried on her legacy in these domains, in ways that continue to advance appreciation of how affective processes relate to immune function. There are numerous remaining questions for the field to pursue, including better understanding of the role of emotion regulation, emotional reactivity and recovery, restorative processes, affective variability, and developmental and dynamic social processes. Such work will require greater use of longitudinal and within-person approaches and/or examination of processes in daily life, as well as models that account for interactive and reciprocal processes and which integrate behavior, social context, sociocultural factors, individual differences, and other aspects of health. As more work in these domains continues, building on Kiecolt-Glaser's rich legacy, we move toward the emergence of affective immunology as an important subfield in the domain of psychoneuroimmunology, one which will offer more nuanced understanding of the role of affective processes in immune health.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000171/pdfft?md5=68f6591c26d97af9bdea97d65430df0e&pid=1-s2.0-S2666497624000171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics","authors":"Elizabeth A. Lawson","doi":"10.1016/j.cpnec.2024.100242","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100242","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000183/pdfft?md5=e5e7819e17fae76dc147870fc3b466f9&pid=1-s2.0-S2666497624000183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intertwining of oxytocin's effects on social affiliation and inflammation","authors":"Marcy A. Kingsbury","doi":"10.1016/j.cpnec.2024.100239","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100239","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000158/pdfft?md5=888163b2175a2e0ec1679a79912a7329&pid=1-s2.0-S2666497624000158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You can't spell distress without stress: Expanding our perspective of the intersection between mental and physical health in cancer survivors","authors":"Megan E. Renna ,&nbsp;M. Rosie Shrout","doi":"10.1016/j.cpnec.2024.100240","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100240","url":null,"abstract":"<div><p>Although many breast cancer survivors adjust to cancer treatment and survivorship, a sizable subgroup of women do not do so, resulting in psychological distress. Over time, this psychological distress can contribute to immune dysfunction and accompanying worsened physical symptoms as women navigate survivorship. Dr. Kiecolt-Glaser's work and mentorship has been integral to our understanding of breast cancer survivors' immune risks, and how behavioral factors may enhance these risks. As a postdoctoral fellow in the Stress and Health Lab, under Dr. Kiecolt-Glaser's mentorship, my research focused on understanding how distress is associated with immune functioning and physical health in breast cancer survivors. In this paper, we highlight Dr. Kiecolt-Glaser's influence on our careers as a strong female research and mentor, the work completed under her mentorship, and how the field of psychoneuroimmunology can continue to expand her research to better understand how distress in the cancer context confers long-term health risks.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266649762400016X/pdfft?md5=f56ad6a92c6fe9e98a1caf294ea457af&pid=1-s2.0-S266649762400016X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019 and its impact on the cognition of older adults: Unraveling the role of inflammation","authors":"Shahrzad Mortazavi ,&nbsp;Vahid Rashedi ,&nbsp;Bahman Cheraghian ,&nbsp;Fatemeh Pourshams ,&nbsp;Saeid Saeidimehr ,&nbsp;Bahram Dehghan ,&nbsp;Maryam Pourshams","doi":"10.1016/j.cpnec.2024.100238","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100238","url":null,"abstract":"<div><h3>Background</h3><p>The Coronavirus Disease 2019 (COVID-19) pandemic significantly impacted the older adult population globally. This study aimed to investigate cognitive function and its relationship with inflammation in older COVID-19 survivors over a three-month follow-up to address concerns about cognitive impairment and its risk factors.</p></div><div><h3>Methods</h3><p>In this descriptive-analytical study, 177 hospitalized COVID-19 patients aged &gt;60 were assessed from July 2021 to February 2022. Psychiatric, global cognitive assessments and activities of daily living were conducted at discharge, 1 month, and 3 months post-discharge. Statistical analyses were conducted using SPSS Version 24. The evolution of cognitive status over time was evaluated using the Repeated Measures Test. The study probed into the association between inflammatory markers and cognitive function through the Pearson correlation test and the Mann–Whitney <em>U</em> test. Additionally, the link between anxiety/depression and cognitive performance was examined using the Pearson correlation.</p></div><div><h3>Results</h3><p>Results indicated that higher levels of C-reactive protein (CRP), D-dimer, and Lactate Dehydrogenase (LDH) were correlated to reduced cognitive performance. Conversely, Erythrocyte Sedimentation Rate (ESR) and Creatine Phosphokinase (CPK) did not exhibit a significant relationship with cognitive scores. A positive correlation was observed between improved cognitive function (reflected by higher GPCOG scores) and lower levels of anxiety and depression (indicated by lower scores on the Hospital Anxiety and Depression Scale). Over the study period, cognitive function and anxiety scores showed an upward trend, whereas symptoms of depression and challenges in daily activities remained consistent.</p></div><div><h3>Conclusions</h3><p>The study highlights the enduring effects and detrimental role of inflammation on overall cognitive abilities among older survivors of COVID-19. It underscores the urgent need for specialized interventions and rehabilitative strategies to facilitate sustained cognitive recuperation among these individuals.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000146/pdfft?md5=2dc2c05daeb93885d05caf7089fcb087&pid=1-s2.0-S2666497624000146-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to’ The vagal paradox: A polyvagal solution’ [Compr. Psychoneuroendocrinology 16C (2023) 100200]","authors":"Stephen W. Porges","doi":"10.1016/j.cpnec.2024.100233","DOIUrl":"10.1016/j.cpnec.2024.100233","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"18 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000092/pdfft?md5=23e648f26c86d003638debb16c08dd55&pid=1-s2.0-S2666497624000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140773098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe PTSD is marked by reduced oxytocin and elevated vasopressin","authors":"Alexander J. Horn ,&nbsp;Steve Cole ,&nbsp;Hans P. Nazarloo ,&nbsp;Nazarloo Parmida ,&nbsp;John M. Davis ,&nbsp;David Carrier ,&nbsp;Craig Bryan ,&nbsp;C. Sue Carter","doi":"10.1016/j.cpnec.2024.100236","DOIUrl":"https://doi.org/10.1016/j.cpnec.2024.100236","url":null,"abstract":"<div><p>Neuroendocrine analyses of posttraumatic stress disorder (PTSD) have generally focused on hypothalamic-pituitary-adrenal (HPA) axis alterations. In the present analyses, we examine two additional neuroendocrine factors that have been previously implicated in biological stress responses: oxytocin (OT) and arginine vasopressin (AVP). Here we examined basal neuropeptide status in military veterans clinically diagnosed with PTSD (n = 29) and in two non-traumatized comparison groups with previous stress exposure (n = 11 SWAT trainees and n = 21 ultramarathon runners). PTSD patients showed low levels of plasma OT and high levels of AVP. The ratio of AVP/OT robustly related to PTSD status, and emerged as a statistically plausible mediator of relationships between the number of personal traumatic experiences and subsequent PTSD symptom burden. Over the course of behavioral therapy for PTSD, measures of OT showed a significant but modest normalization. Plasma cortisol levels were not statistically different among the three groups. This study suggests that AVP/OT ratios may represent a neuroendocrine predictor of severe PTSD, as well as a potential treatment response biomarker.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"19 ","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497624000122/pdfft?md5=65ed3dbc67c6f898c0b215d5473888a2&pid=1-s2.0-S2666497624000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}