Comprehensive psychoneuroendocrinology最新文献

{"title":"Reviewer Acknowledgement","authors":"","doi":"10.1016/j.cpnec.2023.100222","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100222","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000565/pdfft?md5=3c249bca3627df46f8f507402edb8ada&pid=1-s2.0-S2666497623000565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140042616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin 4 receptor brain binding and oxytocin-promoted affective and social cognition in healthy women – A randomized controlled trial","authors":"Vibeke Høyrup Dam ,&nbsp;Sidsel Høgsgaard Andersen ,&nbsp;Sofie Trolle Pedersen ,&nbsp;Dea Siggaard Stenbæk ,&nbsp;Vibe Gedsoe Frokjaer","doi":"10.1016/j.cpnec.2023.100224","DOIUrl":"10.1016/j.cpnec.2023.100224","url":null,"abstract":"<div><h3>Background</h3><p>Oxytocin is a neuropeptide known for its prosocial properties and role in social bonding, and intervention with intranasal oxytocin is posited to modulate affective and social cognition (i.e., hot cognition). Serotonin (5-HT) neurotransmission is also involved in emotional and social behaviors and appear to work in concert with oxytocin. However, this interaction so far remains elusive in humans. Therefore, we here investigate the relation between brain 5-HT 4 receptor (5-HT₄R) levels and oxytocin-modulated hot cognition.</p></div><div><h3>Methods</h3><p>Using a double blind, placebo-controlled, randomized crossover design, 35 healthy women received a dose of 24 IU intranasal oxytocin or placebo one month apart. The women were naturally cycling and to control for hormonal fluctuations across the menstrual cycle, intervention days were placed during the early follicular phase. Following intervention cognitive domains including affective memory, affective bias in emotion processing, moral emotions and social information preference were assessed. In a subgroup (n = 25), Positron Emission Tomography (PET) was used to image 5-HT₄R brain binding at baseline with the [¹¹C]SB207145 radiotracer.</p></div><div><h3>Results</h3><p>No effect of oxytocin intervention relative to placebo was observed for any of the cognitive outcomes. Likewise, regional brain 5-HT₄R binding at baseline was not associated with cognitive responses to oxytocin intervention.</p></div><div><h3>Conclusion</h3><p>Our data suggest that intervention with intranasal oxytocin does not have an overall effect on hot cognition in healthy women and further that 5-HT₄R brain architecture does not mediate cognitive effects of oxytocin in the healthy state.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000589/pdfft?md5=9c4499ce94441191083837e300eccab3&pid=1-s2.0-S2666497623000589-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between telomere length, glucocorticoid receptor gene DNA methylation, volume of stress-related brain structures, and academic performance in middle-school-age children","authors":"Olga V. Burenkova ,&nbsp;Oksana Yu. Naumova ,&nbsp;Jessica A. Church ,&nbsp;Jenifer Juranek ,&nbsp;Jack M. Fletcher ,&nbsp;Elena L. Grigorenko","doi":"10.1016/j.cpnec.2023.100223","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100223","url":null,"abstract":"<div><h3>Background</h3><p>The biological embedding theory posits that early life experiences can lead to enduring physiological and molecular changes impacting various life outcomes, notably academic performance. Studying previously revealed and objective biomarkers of early life stress exposure, such as telomere length (TL), glucocorticoid receptor gene DNA methylation (DNAme), and the volume of brain structures involved in the regulation of HPA axis functioning (the hippocampus, the amygdala, and the medial prefrontal cortex), in relation to academic performance is crucial. This approach provides an objective measure that surpasses the limitations of self-reported early life adversity and reveals potential molecular and neurological targets for interventions to enhance academic outcomes.</p></div><div><h3>Methods</h3><p>The participants were 52 children of Mexican or Central American origin aged 11.6–15.6 years. DNA methylation levels and TL were analyzed in three cell sources: saliva, whole blood, and T cells derived from whole blood.</p></div><div><h3>Results</h3><p>Overall, the concordance across three systems of stress-related biomarkers (TL, DNAme, and the brain) was observed to some extent, although it was less pronounced than we expected; no consistency in different cell sources was revealed. Each of the academic domains that we studied was characterized by a unique and distinct complex of associations with biomarkers, both in terms of the type of biomarker, the directionality of the observed effects, and the cell source of biomarkers. Furthermore, there were biomarker-by-sex interaction effects in predicting academic performance measures.</p></div><div><h3>Conclusions</h3><p>Assessed in an understudied youth sample, these preliminary data present new essential evidence for a deepened understanding of the biological mechanisms behind associations between exposure to early life stress and academic performance.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000577/pdfft?md5=4259f51ea9f865c923b6cddb7dcea3ac&pid=1-s2.0-S2666497623000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety","authors":"Orna Zagoory-Sharon ,&nbsp;Karen Yirmiya ,&nbsp;Itai Peleg,&nbsp;Ortal Shimon-Raz,&nbsp;Rachel Sanderlin,&nbsp;Ruth Feldman","doi":"10.1016/j.cpnec.2023.100219","DOIUrl":"10.1016/j.cpnec.2023.100219","url":null,"abstract":"<div><p>Breastfeeding has long been known to improve infants' health and mental development and to enhance the mother-infant bond, but much less research focused on the biological composition of breast milk and its associations with the infant's biomarkers and social development. In this exploratory study, we measured oxytocin (OT) and secretory immunoglobulin-A (s-IgA), the most abundant antibody in breast milk, and evaluated their associations with the same biomarkers in infant saliva and, consequently, with infant social engagement behavior. Fifty-five mother-infant dyads were home-visit and OT and s-IgA were assessed from breast milk and from infant saliva before and after a free-play interaction. Infant social behavior was coded offline using the Coding Interactive Behavior (CIB) and maternal anxiety self-reported. A path model revealed that mother's breast milk s-IgA impacted child social engagement via its links with child OT. In parallel, maternal breast milk OT was linked with infant social behavior through its association with the infant's immunity. This path was moderated by maternal anxiety; only in cases of high anxiety breast milk OT was positively connected to infant s-IgA. Our study, the first to measure OT and s-IgA in both breast milk and infant saliva in relation to observed social behavior, underscores the need for much further research on the dynamic interplay between breast milk composition, infant biomarkers, maternal mental health, and infant social outcomes. Results may suggest that biological systems in breast milk integrate to prepare infants to function in their social ecology through bio-behavioral feedback loops that signal the degree of stress in the environment.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266649762300053X/pdfft?md5=4fb158456df9468c46085f3cf4e072a0&pid=1-s2.0-S266649762300053X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fantastic voyage: Chasing oxytocin from the bedside to the bench and back again","authors":"Martha G. Welch","doi":"10.1016/j.cpnec.2023.100213","DOIUrl":"10.1016/j.cpnec.2023.100213","url":null,"abstract":"<div><p>This is the story of my 50-year career in medicine and research, and the people who influenced and helped me most along the way. I recount the way in which I became interested in oxytocin early in my career as a child psychiatrist, and how it led me back to Columbia University, my alma mater, to study oxytocin's role in mother-child innate behaviors. I recount how oxytocin/oxytocin receptor signaling was central to my basic and clinical research and present a new theory on mother-infant emotional behaviors that challenges 400 years of brain-centric science. My history underscores the important and unique perspective women bring to science and why women are especially needed in the sciences. I hope to inspire young women (and young men) who are beginning their careers in research.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"17 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000474/pdfft?md5=74e3c9412d08bc7e9e4a10ff01edcfde&pid=1-s2.0-S2666497623000474-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Are steroid hormones and autistic traits affected by metformin? First insights from a pilot” [Compr. Psychneuroendocrinology 16C 100196]","authors":"Benedikt Gasser ,&nbsp;Genevieve Escher ,&nbsp;Anca-Elena Calin ,&nbsp;Michael Deppeler ,&nbsp;Miriam Marchon ,&nbsp;Clarissa Vögel ,&nbsp;Johann Kurz ,&nbsp;Markus Mohaupt","doi":"10.1016/j.cpnec.2023.100208","DOIUrl":"10.1016/j.cpnec.2023.100208","url":null,"abstract":"","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"16 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000425/pdfft?md5=509ce22e4a4bf7fa976ab887e3cdbf1a&pid=1-s2.0-S2666497623000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical approaches to conducting biopsychosocial research with refugee and internally displaced communities","authors":"Liza M.E. Hinchey,&nbsp;Dalia Khalil,&nbsp;Arash Javanbakht","doi":"10.1016/j.cpnec.2023.100217","DOIUrl":"10.1016/j.cpnec.2023.100217","url":null,"abstract":"<div><p>Refugees and internally displaced people comprise one percent of the world population. Forced migration involves a multitude of ongoing stressful and traumatic experiences, often resulting in lasting psychological symptoms for people resettling as refugees. Despite these risks, the underrepresentation of refugee populations in research—particularly in biological sciences—has impeded the allocation of effective resources and the development of novel interventions for these groups. This paper identifies and addresses key methodological challenges to successfully and appropriately conducting research with refugee and internally displaced communities, many of which have served as barriers to improving research representation for these populations. Methodological challenges discussed include language and literacy barriers; political fears; differing cultural dynamics between participants and researchers; and others. We provide practical recommendations for overcoming each challenge, often sourced from our experience conducting multi-year studies and interventions in refugee mental health. Several key strategies include the recruitment of researchers and research assistants from similar cultural and linguistic backgrounds as participants; providing detailed, ongoing communication about informed consent; avoiding assumptions regarding participants' understanding of concepts that may vary based on culture or experience (e.g., “voluntary” research; confidentiality); and adopting flexible data collection procedures compatible with participants’ needs and restrictions. Finally, we discuss the role of the researcher in regard to cultural competencies and partnering with the refugee community. Given the increasing global population of refugees, the strategies discussed in this paper are suggested in order to encourage future research in this underrepresented population and empower investigators to logistically carry out studies with refugees.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"16 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000516/pdfft?md5=b2d8827b246878973e421e0829483d55&pid=1-s2.0-S2666497623000516-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135510207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of sociopolitical stress during the 2020 United States presidential election season: Associations with psychological well-being, civic action, and social identities","authors":"Sara Suzuki ,&nbsp;Lindsay Till Hoyt ,&nbsp;Neshat Yazdani ,&nbsp;Mariah Kornbluh ,&nbsp;Elan C. Hope ,&nbsp;Melissa J. Hagan ,&nbsp;Alison K. Cohen ,&nbsp;Parissa J. Ballard","doi":"10.1016/j.cpnec.2023.100218","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100218","url":null,"abstract":"<div><p>Sociopolitical stress arises in reaction to awareness of, exposure to, and/or involvement in political events. Among a longitudinal cohort of 628 college students from 10 universities across the U.S., we explored trajectories of sociopolitical stress during the 2020 United States presidential election season and examined relationships to psychological well-being. Growth mixture modeling classified our sample into four subgroups each with distinct trajectories of sociopolitical stress: <em>High and Decreasing</em>, <em>Moderate and Increasing</em>, <em>Consistently Low</em>, and <em>High-to-Low</em>. Participants with lower levels of sociopolitical stress expressed higher psychological well-being (high flourishing, high optimism, low anxiety symptoms, low depressive symptoms). The <em>High and Decreasing</em> subgroup was associated with the highest levels of civic action. Participants in the <em>High and Decreasing</em> trajectory were 20 times more likely to identify as LGBQ+, and 4 times more likely to be a woman or a transgender/gender diverse student, compared to participants in the <em>Consistently Low</em> subgroup.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"16 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000528/pdfft?md5=697acd7db453823ea358030b65377c0c&pid=1-s2.0-S2666497623000528-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92135621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between balance and urinary cortisol and neopterin in autistic children","authors":"Siobhan de Lange ,&nbsp;Dee Muller ,&nbsp;Chloe Dafkin","doi":"10.1016/j.cpnec.2023.100216","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100216","url":null,"abstract":"<div><p>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by stereotyped behavior, restricted interests and social/communicative deficits. The physiological etiology of ASD is not currently understood, however recent research has implicated dysregulation of the immune system as a central feature. The interplay between the stress systems, the immune system and the brain has been well-documented and implicated in other psychiatric and neurological disorders. This interplay suggests a role for the hypothalamic-pituitary-adrenal (HPA) axis in the etiology of ASD. We assessed levels of urinary cortisol and neopterin as markers of immune function and HPA activation in a cohort of 50 children from the central Johannesburg region. Additionally, we used the Autism Treatment Evaluation Checklist to assess autistic symptomatology and the Bruininks-Oseretsky Motor Proficiency Test (Second Edition) (BOT-2) to assess motor skills. No relationships were found between cortisol and autistic symptomatology. No relationships were found between neopterin and any of the other measures. However, a relationship was observed between urinary cortisol and performance on balance-related tasks from the BOT-2 (P &lt; 0.05). Our findings support a theory of neurological interconnectedness between postural modulation and activation of the stress system, which has not previously been documented in children with ASD.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"16 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000504/pdfft?md5=59404e7aa2812228388c80ada85ab411&pid=1-s2.0-S2666497623000504-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92013653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between stress, depression or anxiety and cancer: Rapid review of reviews","authors":"Katy Cooper ,&nbsp;Fiona Campbell ,&nbsp;Sue Harnan ,&nbsp;Anthea Sutton","doi":"10.1016/j.cpnec.2023.100215","DOIUrl":"https://doi.org/10.1016/j.cpnec.2023.100215","url":null,"abstract":"<div><h3>Background</h3><p>Several studies have suggested links between psychological stress, depression or anxiety, and cancer incidence or outcomes. Existing systematic reviews have addressed this question, with differing results.</p></div><div><h3>Aims</h3><p>This rapid systematic umbrella review summarises existing reviews assessing the association between psychological stress, depression or anxiety and cancer incidence or cancer outcomes.</p></div><div><h3>Methods</h3><p>Systematic reviews assessing stress, depression or anxiety and cancer were identified via searches of MEDLINE, PsycInfo and Cochrane Database of Systematic Reviews from 2010 to November 2020.</p></div><div><h3>Results</h3><p>Twelve systematic reviews were included, summarising cohort and case-control studies, most of which adjusted for confounders. Regarding cancer incidence, one large meta-analysis reported a significant association between depression/anxiety and cancer incidence, while another showed a non-significant trend. Two further meta-analyses reported significant associations between stressful life events and cancer incidence. Conversely, two meta-analyses of work stress showed no significant association with cancer incidence. Regarding outcomes among cancer patients, three meta-analyses reported significant associations between depression/anxiety and cancer mortality, while another reported a non-significant trend for depression and cancer recurrence. One meta-analysis reported a significant association between partner bereavement and cancer mortality, while another showed no significant association between work stress and cancer mortality.</p></div><div><h3>Conclusions</h3><p>There is consistent evidence for an association between psychological stress, depression or anxiety and cancer incidence in general populations, and some evidence for an association with mortality in cancer populations. Future research may focus on confirmation of these findings, as well as the role of social support and stress-reducing interventions in buffering against these effects.</p></div>","PeriodicalId":72656,"journal":{"name":"Comprehensive psychoneuroendocrinology","volume":"16 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666497623000498/pdfft?md5=66873ebfc80905b556df2057fc9c71a6&pid=1-s2.0-S2666497623000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92099224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}