Comparative biochemistry and physiology. C: Comparative pharmacology最新文献_第8页

Inhibitors of the Na+ K+-atpase Na+ K+-atp酶抑制剂

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90049-Q

Seona E. MacGregor, John M. Walker

引用次数: 24

Sulfide and cyanide induced mortality and anaerobic metabolism in the arcid blood clam Scapharca inaequiv alvis 硫化物和氰化物引起的酸性血蛤的死亡和无氧代谢

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90056-Q

A. de Zwaan , O. Cattan , V.M. Putzer

引用次数: 21

Vicilin variants and the resistance of cowpea (Vigna unguiculata) seeds to the cowpea weevil (Callosobruchus maculatus) 豇豆(Vigna unguiculata)种子对豇豆象甲(Callosobruchus maculatus)抗性的研究

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90063-Q

Maria Lígia R. Macedo, Lúcia Betânia Da S. Andrade, Rosana A. Moraes, Jose Xavier-Filho

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引用次数: 111

Microsomal oxidation of bromo-, chloro- and fluorobiphenyls 溴、氯和氟联苯微粒体氧化

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90067-U

J.T. Borlakoglu , J.P.G. Wilkins

引用次数: 5

Pharmacological sensitivity of the articular capsule of the primary spines of Eucidaris tribuloides 三叶草初级棘关节囊的药理学敏感性

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90052-M

M. Morales , C. Sierra , A. Vidal , J. Del Castillo , D.S. Smith

{"title":"Pharmacological sensitivity of the articular capsule of the primary spines of Eucidaris tribuloides","authors":"M. Morales , C. Sierra , A. Vidal , J. Del Castillo , D.S. Smith","doi":"10.1016/0742-8413(93)90052-M","DOIUrl":"10.1016/0742-8413(93)90052-M","url":null,"abstract":"<div>1. This paper describes the effects of several cholinergic agonists and antagonists, and of β-phenylethylamine (PEA) and some of its derivatives, on the articular capsule, or ligament, of the primary spines of Eucidaris tribuloides.2. Carbamylcholine (CCh), methacholine (MeACh), nicotine, and muscarine exert a stiffening effect similar to that of acetylcholine (ACh), although the time course of their actions varies widely.3. Atropine induced stiffening and blocked and responses to muscarine and MeACh. The responses to MeACh were blocked also by 4-diphenylacetoxy-N-methylpiperidine, suggesting the presence in the ligament of type M3 muscarinic receptors, in addition to nicotinic ones. d-Tubocurarine induced stiffness of the ligament and failed to block the responses to ACh and nicotine.4. While ACh induced only a slight desensitization, CCh caused a long-lasting blockade of the stiffening effects of the cholinergic agonists. This shows that the receptors for ACh have a site or sites that recognize the ester moieties of these molecules.5. Eserine and neostigmine potentiate the responses to acetylcholine, indicating the presence of aeetyl-cholinesterase in the ligament.6. β-Phenylethy lamine, epinephrine, norepinephrine, and dopamine induce diphasic responses; usually a brief softening followed by a slow and irreversible stiffening of the ligament.7. In contrast to the above, tyramine and octopamine elicit a simple softening of ligaments which are stiff as a result of handling or by exposure to cholinergic agonists. However, tyramine and octopamine do not soften ligaments which become stiff as a result of exposure to adrenergic agonists.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 25-30"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90052-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19094868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Butyrylcholinesterase in the visual ganglia of the squid todarodes sagittatus I. (cephalopoda). isolation, molecular forms, interaction with substrates and inhibitors 矢尾乌贼视神经节中的丁酰胆碱酯酶。分离，分子形式，与底物和抑制剂的相互作用

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90068-V

G.M. Grigorjeva, N.V. Konitcheva

{"title":"Butyrylcholinesterase in the visual ganglia of the squid todarodes sagittatus I. (cephalopoda). isolation, molecular forms, interaction with substrates and inhibitors","authors":"G.M. Grigorjeva, N.V. Konitcheva","doi":"10.1016/0742-8413(93)90068-V","DOIUrl":"10.1016/0742-8413(93)90068-V","url":null,"abstract":"<div>1. Soluble butyrylcholinesterase (BuChE) was isolated from the visual ganglia of the squid Todarodes sagittatus L. Gel-chromatography on Sephadex G-200 columns resulted in its separation into three molecular forms.2. The major component with a molecular mass of 180kDa was used for kinetic study.3. The substrate analysis revealed squid enzyme to be BuChE of unusual type.4. Unlike typical BuChE (EC 3.1.1.8), squid enzyme splits acetyl-β-methylcholine (AMCh) with a relatively high rate, alongside with common BuChE substrates—butyrylcholine (BCh), propionylcholine (PCh), acetylcholine (ACh), butyrylthiocholine (BTCh) and acetylthiocholine (ATCh), the enzymic hydrolysis being suppressed by excess of all these substrates.5. Among them, the highest values of kcat andkcat/Km were found for BCh and BTCh. Maximal activity of the enzyme was noticed at low BCh and BTCh concentrations (1–2 mM).6. Tetraalkylammonium ions exhibit a mixed type of inhibition and suppress the substrate inhibition of squid BuChE.7. Among organophosphorus inhibitors (OPI), the methylthiophosphonates are most potent for squid BuChE, and for some phosphates, selective OPI of typical BuChE, are potent as well.8. By the pattern of selectivity to OPI, squid enzyme differs from both typical BuChE of horse serum and acetylcholinesterase (EC 3.1.1.7) from bovine erythrocytes.9. Some details of the active center structure of squid BuChE compared to that of typical enzymes are discussed.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 127-140"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90068-V","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54006203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hematological and enzymatic results of aluminum intoxication in rats 铝中毒大鼠血液学和酶学结果

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90060-X

K. Zaman , W. Zaman, H. Siddique

引用次数: 40

Effects of diltiazem on the calcium accumulation and atp synthesis simultaneously sustained by isolated rat heart mitochondria 地尔硫卓对离体大鼠心脏线粒体钙积累和atp合成的影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90055-P

Donata Branca, Michela S. Roberti, Antonella Venudo, Patrizia Arsie, Barbara Simonato, Guido Scutari

引用次数: 1

Metabolism of di-, tri-, tetra-, penta- and hexachlorobiphenyls by hepatic microsomes isolated from control animals and animals treated with aroclor 1254, a commercial mixture of polychlorinated biphenyls (pcbs) 对照动物和经aroclor 1254(一种多氯联苯的商业混合物)处理的动物肝脏微粒体对二、三、四、五和六氯联苯的代谢

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90064-R

J.T. Borlakoglu , J.P.G. Wilkins

引用次数: 2

Nicotine stimulates maturational gonadotropin (GtH2) release from carp (Cyprinus carpio L.) pituitary cells 尼古丁刺激鲤鱼(Cyprinus carpio L.)垂体细胞释放成熟促性腺激素(GtH2)

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-05-01 DOI: 10.1016/0742-8413(93)90062-P

Tomasz Mikolajczyk , Claudine Weil , Bernard Breton

引用次数: 5