Tomasz Mikolajczyk , Claudine Weil , Bernard Breton
{"title":"尼古丁刺激鲤鱼(Cyprinus carpio L.)垂体细胞释放成熟促性腺激素(GtH2)","authors":"Tomasz Mikolajczyk , Claudine Weil , Bernard Breton","doi":"10.1016/0742-8413(93)90062-P","DOIUrl":null,"url":null,"abstract":"<div><p>1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH<sub>2</sub>) in carp.</p><p>2. Nicotine strongly, and in a dose dependent manner, stimulated GtH<sub>2</sub> release in male and in female carp (from 10<sup>−8</sup>M in the Perifusion and 10<sup>−10</sup>M in the cells cultures).</p><p>3. Nicotine is 10 times more active in females than in males.</p><p>4. The results suggest that in carp, nicotine stimulates GtH<sub>2</sub> release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH<sub>2</sub> secretion in teleost fish.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 1","pages":"Pages 83-88"},"PeriodicalIF":0.0000,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90062-P","citationCount":"5","resultStr":"{\"title\":\"Nicotine stimulates maturational gonadotropin (GtH2) release from carp (Cyprinus carpio L.) pituitary cells\",\"authors\":\"Tomasz Mikolajczyk , Claudine Weil , Bernard Breton\",\"doi\":\"10.1016/0742-8413(93)90062-P\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH<sub>2</sub>) in carp.</p><p>2. Nicotine strongly, and in a dose dependent manner, stimulated GtH<sub>2</sub> release in male and in female carp (from 10<sup>−8</sup>M in the Perifusion and 10<sup>−10</sup>M in the cells cultures).</p><p>3. Nicotine is 10 times more active in females than in males.</p><p>4. The results suggest that in carp, nicotine stimulates GtH<sub>2</sub> release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH<sub>2</sub> secretion in teleost fish.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"105 1\",\"pages\":\"Pages 83-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90062-P\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/074284139390062P\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390062P","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Nicotine stimulates maturational gonadotropin (GtH2) release from carp (Cyprinus carpio L.) pituitary cells
1. Perifusion of dispersed pituitary cells and pituitary cell culture was used to investigate the effects of cholinergic drugs on the secretion of maturational gonadotropin (GtH2) in carp.
2. Nicotine strongly, and in a dose dependent manner, stimulated GtH2 release in male and in female carp (from 10−8M in the Perifusion and 10−10M in the cells cultures).
3. Nicotine is 10 times more active in females than in males.
4. The results suggest that in carp, nicotine stimulates GtH2 release directly from the pituitary cells, indicating a possible involvement of a cholinergic system in the regulation of GtH2 secretion in teleost fish.
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