Comparative biochemistry and physiology. C: Comparative pharmacology最新文献_第10页

Stereoselective response of tribolium castaneum herbst and Musca domestica L. against optically active 2-methoxy-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide 肉桂和家蝇对旋光性2-甲氧基-5-苯基-1,3,2-恶氮膦2-硫化物的立体选择性反应

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90007-8

Akinori Hirashima , Takeshi Nagano , Rou Oishi , Morifusa Eto

{"title":"Stereoselective response of tribolium castaneum herbst and Musca domestica L. against optically active 2-methoxy-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide","authors":"Akinori Hirashima , Takeshi Nagano , Rou Oishi , Morifusa Eto","doi":"10.1016/0742-8413(93)90007-8","DOIUrl":"10.1016/0742-8413(93)90007-8","url":null,"abstract":"<div>1. The optical isomers of 2-methoxy-5-phenyl-l,3,2-oxazaphospholidine 2-sulfide (5-PMOS) were synthesized by a chiral two-step phosphorylating method, and their absolute configurations and optical purities were determined by 1H-NMR.2. (S)c(R)p-trans-5-PMOS showed the highest activity and the activity decreased in the order of (S)c(R)p-trans->(R)c(R)p-cis->(R)c(S)p-trans->(S)c(S)p-cis-5-PMOS in reducing larval growth and inhibiting acetylcholinesterase (AChE) of the red flour beetle Tribolium castaneum Herbst.3. (R)c(R)p-cis-5-PMOS showed the highest anti-AChE activity followed by (R)c(S)p-trans- >(S)c(R)p-trans->(S)c(S)p-cis-5-PMOS, corresponding with insecticidal activity against Musca domestica L.4. Optical isomers of 5-PMOS were not effective in stimulating adenylate cyclase prepared from ventral nerve cords of Periplaneta americana L.5. The reversed stereospecificity between the T. castaneum larval growth-inhibitory and M. domestica insecticidal activities of 5-PMOS optical isomers is due to a stereospecific difference in the intrinsic potency of active form of 5-PMOS isomers as AChE inhibitors with the two insects.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"104 3","pages":"Pages 395-399"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90007-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54004661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is lead toxicosis a reflection of altered fatty acid composition of membranes? 铅中毒是细胞膜脂肪酸组成改变的反映吗?

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90003-4

W.E. Donaldson, Scott O. Knowles

引用次数: 98

The effect of time, concentration and temperature on bioaccumulation in the gill of crayfish procambarus clarkii induced by organochlorine pesticides, lindane and endosulfan 时间、浓度和温度对有机氯农药、林丹和硫丹诱导的克氏原螯虾鳃内生物积累的影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90016-E

C. Cebrian , E. Andreu-Moliner , M. Gamon

引用次数: 2

Combined effects of cadmium and nickel on hepatic glutathione S-transferases in raTS 镉和镍对大鼠肝脏谷胱甘肽s -转移酶的联合影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90017-F

M. İşcan, B.C. Eke, T. Çoban

{"title":"Combined effects of cadmium and nickel on hepatic glutathione S-transferases in raTS","authors":"M. İşcan, B.C. Eke, T. Çoban","doi":"10.1016/0742-8413(93)90017-F","DOIUrl":"10.1016/0742-8413(93)90017-F","url":null,"abstract":"<div>1. The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), l,2-dichloro-4nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone.2. Male adult rats (225–275 g) were administered either a single dose of Cd (3.58 mg CdCl2 · <math><mtext>H</mtext><msub><mi></mi><mn>2</mn></msub><mtext>O</mtext><mtext>kg</mtext></math>, i.p.) 72 hr prior to sacrifice or a single dose of Ni (59.5 mg NiCl2 · <math><mtext>6H</mtext><msub><mi></mi><mn>2</mn></msub><mtext>O</mtext><mtext>kg</mtext></math>, s.c.) 16 hr prior to sacrifice. For the combined treatment, animals received the single dose of Ni 56 hr after the single dose of Cd and they were killed 16hr later.3. Cd treatment alone did not produce any changes in the hepatic GST activities toward the substrates studied.4. Ni treatment alone, however, significantly increased hepatic GST activity toward EAA whereas it was ineffective on GST activities for CDNB and DCNB.5. Combined treatment of metals did not alter hepatic GST activities toward the substrates CDNB and DCNB. Hepatic GST activity for EAA, however, was significantly increased by the combined treatment. Nevertheless, the combined treatment did not augment the increase in GST activity for EAA noted by Ni treatment alone.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"104 3","pages":"Pages 453-456"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90017-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19096414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Species difference in plasma antioxidant activity 血浆抗氧化活性的物种差异

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90005-6

N. Koçak-Toker, D. Ayribaş, M. Uysal

引用次数: 4

Changes in mitochondrial calmitine and calcium in rat denervated skeletal muscle after injection of a myotoxic drug, chlorpromazine 注射肌毒性药物氯丙嗪后大鼠去神经骨骼肌线粒体钙和钙的变化

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90006-7

Nelly Schmitt, Brigitte Lucas-Heron, Béatrice Ollivier

引用次数: 1

Effects of dietary clenbuterol on net flux across the portal-drained viscera, liver and hindquarters of steers (Bos taurus) 饲粮中添加瘦肉精对牛门静脉引流脏器、肝脏和后腿净通量的影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90008-9

Joan H. Eisemann , Gerald B. Huntington

引用次数: 6

Effects of dexamethasone on the hepatic cytochrome P450IIIA subfamily in two hamster strains Mesocricetus auratus and Cricetus griseus 地塞米松对两种仓鼠中裂腹鼠和灰鼠肝细胞色素P450IIIA亚家族的影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90014-C

Eric Antignac , Morio Fukuhara , Masanobu Kimura

引用次数: 8

Stizolobic acid on frog spinal cord; possible species dependent activation of excitatory amino acid receptors 蛙脊髓上的刺绿酸;可能的物种依赖性兴奋性氨基酸受体激活

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90015-D

M. Maruyama, K. Takeda

{"title":"Stizolobic acid on frog spinal cord; possible species dependent activation of excitatory amino acid receptors","authors":"M. Maruyama, K. Takeda","doi":"10.1016/0742-8413(93)90015-D","DOIUrl":"10.1016/0742-8413(93)90015-D","url":null,"abstract":"<div>1. We examined the effects of stizolobic acid, an amino acid isolated from a plant, Stizolobium hassjoo, on the binding of [3H]glutamic acid and [3H]kainic acid to synaptosomes from frog spinal cords and on the depolarization at the ventral roots of frog spinal cords.2. Stizolobic acid inhibited the binding of [3H]kainic acid more potently than that of [3H]glutamic acid.3. Among Stizolobic acid derivatives, 3-Br-stizolobic acid was the most potent inhibitor of the binding of [3H]kainic acid, but the inhibitory potency was 100 times weaker than that of kainic acid.4. Stizolobic acid and its derivatives could cause depolarization of the ventral root of frog spinal cord in a dose dependent manner, and 3-Br-stizolobic acid was a more potent inducer of depolarization than kainic acid, but the dose dependency of 3-Br-stizolobic acid was a little different from that of kainic acid.5. The results suggest that Stizolobic acid and its analogues act as a kainic acid agonist in frog spinal cord.6. The present results and others indicate that Stizolobic acid may interact with the different types of excitatory amino acid receptors dependent on the species of animals.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"104 3","pages":"Pages 439-444"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90015-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19096472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mechanisms of heavy metal cation homeostasis in marine invertebrates 海洋无脊椎动物体内重金属阳离子稳态机制研究

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-03-01 DOI: 10.1016/0742-8413(93)90001-2

A. Viarengo , J.A. Nott

引用次数: 500