Acupuncture in Medicine最新文献

{"title":"Changes in stiffness at active myofascial trigger points of the upper trapezius after dry needling in patients with chronic neck pain: a randomized controlled trial.","authors":"Juan Antonio Valera-Calero,&nbsp;Sandra Sánchez-Jorge,&nbsp;Jorge Buffet-García,&nbsp;Umut Varol,&nbsp;César Fernández-de-Las-Peñas,&nbsp;Javier Álvarez-González","doi":"10.1177/09645284221104831","DOIUrl":"https://doi.org/10.1177/09645284221104831","url":null,"abstract":"<p><strong>Background/objective: </strong>Since, to our knowledge, the effects of dry needling (DN) on active myofascial trigger point (MTrP) stiffness have not been analyzed previously with shear wave elastography (SWE), our aim was to compare the effects of a single session of DN and sham DN applied to the most active MTrP located in the upper trapezius muscle on clinical outcomes.</p><p><strong>Methods: </strong>A randomized, double-blinded sham-controlled trial was conducted; 60 patients were randomized into an experimental (DN) or sham (sham DN) group. Baseline data including sociodemographic and clinical characteristics were collected. SWE and pain pressure thresholds (PPTs) at the MTrP and a control point located 3 cm laterally were the main outcomes assessed before and 10 min after the interventions.</p><p><strong>Results: </strong>Patients receiving DN interventions experienced greater increases in the control point PPTs immediately after receiving the intervention compared with sham DN (<i>p</i> < 0.05), but no differences were found for the MTrP (<i>p</i> > 0.05). Post-intervention PPT improvements were found at both locations for both groups (<i>p</i> < 0.01). No significant changes for either MTrP or control locations were found for SWE outcomes in either group (all <i>p</i>s > 0.05). No significant within-group SWE differences were found in the DN or sham DN groups (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>A single session of DN or sham DN applied to active MTrPs located in the upper trapezius muscle produced no detectable changes in stiffness at the MTrP or control locations. Real DN induced an immediate analgesic response at both MTrP and control locations, while sham DN induced an immediate MTrP response.</p><p><strong>Trial registration number: </strong>NCT04832074 (ClinicalTrials.gov).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"121-129"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9614864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture pretreatment protects septic rats from acute lung injury by relieving inflammation and regulating macrophage polarization.","authors":"Jun Zhou,&nbsp;Lan Li,&nbsp;Mengjian Qu,&nbsp;Jinqu Tan,&nbsp;Guanghua Sun,&nbsp;Fu Luo,&nbsp;Peirui Zhong,&nbsp;Chengqi He","doi":"10.1177/09645284221118588","DOIUrl":"https://doi.org/10.1177/09645284221118588","url":null,"abstract":"<p><strong>Background: </strong>Macrophage polarization toward the M2 phenotype may attenuate inflammation and have a therapeutic effect in acute lung injury (ALI).</p><p><strong>Objective: </strong>To investigate the role of electroacupuncture (EA) pretreatment on the inflammatory response and macrophage polarization in a septic rat model of lipopolysaccharide (LPS)-induced ALI.</p><p><strong>Methods: </strong>Male Sprague Dawley rats (n = 24) were randomly divided into three groups (n = 8 each): control (Ctrl), ALI (LPS) and pre-EA (LPS + EA pretreatment). ALI and pre-EA rats were injected with LPS via the caudal vein. Pulmonary edema was assessed by left upper pulmonary lobe wet-to-dry (W/D) ratios. Lung injury scores were obtained from paraffin-embedded and hematoxylin and eosin-stained sections of the left lower pulmonary lobe. Inflammatory activation was quantified using serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β, transforming growth factor (TGF)-β and IL-10 levels measured by enzyme linked immunosorbent assay (ELISA). Macrophage phenotype was determined by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting.</p><p><strong>Results: </strong>Mean lung W/D ratio was significantly lower and serum IL-1β levels were decreased in pre-EA rats compared to ALI rats (P < 0.05). TNF-α mRNA expression was decreased and mannose receptor (MR) and Arg1 mRNA expression was increased in the lung tissues of pre-EA rats compared to ALI rats (P < 0.01). Arg1 protein expression was similarly increased in the lung tissues of pre-EA rats compared to ALI rats (P < 0.05).</p><p><strong>Conclusion: </strong>EA pretreatment may play a protective role by promoting macrophage polarization to the M2 phenotype in a septic rat model of LPS-induced ALI.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"175-182"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Core outcomes were rarely reported overall in systematic reviews on acupuncture for osteoarthritis: a cross-sectional meta-epidemiological study.","authors":"Tengyue Hu,&nbsp;Youlin Long,&nbsp;Rui Chen,&nbsp;Zixin Yang,&nbsp;Liqin Liu,&nbsp;Litao Huang,&nbsp;Jin Huang,&nbsp;Ga Liao,&nbsp;Liang Du","doi":"10.1177/09645284221108215","DOIUrl":"https://doi.org/10.1177/09645284221108215","url":null,"abstract":"<p><strong>Objective: </strong>To identify a comprehensive list of outcomes and explore the reporting rate of core outcome sets (COS) and related factors in systematic reviews (SRs) of acupuncture for osteoarthritis (OA).</p><p><strong>Study design and setting: </strong>Databases were searched for the relative SRs. Descriptive statistics were calculated as frequencies and percentages. Binary logistic regression was used to explore the factors affecting the reporting rate of COS.</p><p><strong>Results: </strong>We included 59 SRs. Outcome measures reported in the SRs were classified into 11 domains and 67 unique outcomes. No SR completely reported COS. In COS released in 2016, 75% of outcomes (6/8) were only reported by ⩽5% SRs. In COS released in 2019, the reporting rate was very low (from 0% to 17%) for 73.3% of outcomes (11/15). SRs published in the most recent 5 years had a significantly greater possibility of reporting COS (odds ratio (OR) = 4.74, 95% confidence interval (CI) = 1.33 to 16.88, <i>p</i> = 0.016).</p><p><strong>Conclusion: </strong>Core outcomes were rarely reported in systematic reviews of acupuncture for OA, with considerable heterogeneity in the use of outcomes. The publication of COS in the COMET (Core Outcome Measures in Effectiveness Trials) database may help promote the reporting of COS. We encourage systematic reviewers to use relevant COS.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"142-150"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perforating globe injury after acupuncture treatment: two cases.","authors":"Qimiao Wang,&nbsp;Yuanlong Zhang,&nbsp;Xin Wang,&nbsp;Yaju Pang","doi":"10.1177/09645284221131338","DOIUrl":"https://doi.org/10.1177/09645284221131338","url":null,"abstract":"Acupuncture has a long history of use in the treatment of various eye diseases, such as acquired paralytic strabismus, dry eye and optic atrophy, for which good results have been reported. However, there is an abundance of blood vessels in the eye, and needle penetration into the orbit may potentially puncture these blood vessels. Therefore, acupuncture treatment poses certain risks. Adverse events of acupuncture in ophthalmology have ranged from subcutaneous petechiae to ocular hematoma and even blindness. Ruolin et al.1 observed that the incidence of hematoma in suborbital acupuncture was 0.2%. Zhang and Zhang2 described two cases of anterior chamber hemorrhage and conjunctival hyperemia caused by acupuncture. Some researchers have mentioned puncture of the cornea or lens, resulting in traumatic cataract associated with acupuncture needles.3 Herein, we report two cases of perforating injury of the globe by acupuncture needles resulting in retinal injury.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"189-191"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture improves follicular development and metabolism and regulates the expression of adiponectin, AMPK and ACC in an obese rat model of polycystic ovary syndrome.","authors":"Jing Zhou,&nbsp;Ping Yin,&nbsp;Qingyi Zhao,&nbsp;Zhihai Hu,&nbsp;Yi Wang,&nbsp;Guizhi Ma,&nbsp;Xinyi Wu,&nbsp;Lu Lu,&nbsp;Yin Shi","doi":"10.1177/09645284221107690","DOIUrl":"https://doi.org/10.1177/09645284221107690","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and follicular arrest. Electroacupuncture (EA) has been shown to be effective at improving hyperandrogenism and follicular arrest in PCOS; however, its mechanism of action remains to be deciphered.</p><p><strong>Objective: </strong>In this study, we investigated whether EA improved follicular development in an obese rat model of PCOS and regulated the expression of adiponectin, AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).</p><p><strong>Methods: </strong>EA was administered at CV3, CV4 and ST40. Changes in body weight, paraovarian fat, estrus cycle, ovarian morphology, levels of related hormones, and glucose and lipid metabolism were evaluated. In addition, protein and mRNA expression of adiponectin, AMPK and ACC was measured.</p><p><strong>Results: </strong>The body weight and paraovarian fat of rats in the EA group were reduced, while estrus cyclicity and ovarian morphology improved. Levels of free fatty acids, triglycerides, total cholesterol and low-density lipoprotein cholesterol were significantly reduced in the EA group, as well as blood glucose levels. Furthermore, levels of testosterone and luteinizing hormone were reduced in the EA group, while estradiol levels were increased. Protein and mRNA expression of adiponectin, AMPKα1 and liver kinase B1 (LKB1) was found to be increased in the EA group, while protein and mRNA expression of ACC were significantly reduced.Conclusion: Our findings suggest that EA improved follicular development and metabolism and regulated expression levels of adiponectin, AMPKα1, LKB1 and ACC in our obese rat model of PCOS.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"151-162"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for persistent post-prostatectomy urinary incontinence: a case series.","authors":"Chaoran Wang,&nbsp;Wentao Li,&nbsp;Xiaojiang Li,&nbsp;Haojian Zhang,&nbsp;Huichuan Tian,&nbsp;Yingjie Jia","doi":"10.1177/09645284221131332","DOIUrl":"https://doi.org/10.1177/09645284221131332","url":null,"abstract":"Radical prostatectomy is considered to be the best treatment for patients with localized and locally advanced prostate cancer. Unfortunately, post-prostatectomy urinary incontinence (PPUI) is a common complication, with an incidence ranging from 4% to 31%.1 PPUI can adversely affect quality of life and cause emotional and financial distress. For most patients, PPUI improves to near baseline levels within 12 months of surgery. However, only a minority of patients with residual PPUI at 12 months experience sustained improvement. Implantation of an artificial urinary sphincter (AUS) represents the gold standard of treatment, although its widespread adoption is limited due to high costs and a significant risk of requiring surgical revision. Hence, early intervention to facilitate patient recovery within 12 months is desirable. For persistent PPUI patients, especially the elderly, we hope to find a safe and non-invasive treatment option that can improve symptoms. Acupuncture is widely used in the treatment of various types of urinary incontinence due to evidence of its effectiveness, the simple nature of the procedure, and its minimal side effects. Electroacupuncture can reduce urine leakage in women with stress urinary incontinence (SUI),2 but relatively little is known about its efficacy and safety for men with PPUI, in whom the quality of evidence is considered to be low. Herein, we report on the use of acupuncture in five patients with persistent PPUI who received routine clinical care at our center.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"183-185"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease.","authors":"Xuemei Liu,&nbsp;Tao Fan,&nbsp;Jinshuai Guan,&nbsp;Ai Luo,&nbsp;Yan Yu,&nbsp;Daohong Chen,&nbsp;Bing Mao,&nbsp;Hongli Jiang,&nbsp;Wei Liu","doi":"10.1177/09645284221107684","DOIUrl":"https://doi.org/10.1177/09645284221107684","url":null,"abstract":"<p><strong>Objective: </strong>To detect the role of dopamine in the anti-inflammatory effect of electroacupuncture (EA) at ST36 in a mouse model of chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>Twenty-eight male BALB/c mice were randomly divided into the control group, model group, sham EA (sham) group or ST36 EA (ST36) group in a 1:1:1:1 ratio (<i>n</i> = 7 each). The COPD mouse model was established through cigarette smoke (CS) exposure for 12 weeks. During the last 2 weeks, EA was applied at a sham point location or ST36 before CS exposure. Lung function, histopathological changes, inflammatory cell counts in bronchoalveolar lavage fluid (BALF), inflammatory cytokines in BALF, plasma, lung tissue homogenate (LTH), and plasma dopamine levels were detected in the different groups. Furthermore, the role of different dopamine receptors was explored through intraperitoneal injections of non-specific dopamine receptor antagonist chlorpromazine, specific dopamine D1 receptor antagonist SCH 23390 and specific dopamine D2 receptor antagonist eticlopride hydrochloride prior to ST36 EA and CS exposure.</p><p><strong>Results: </strong>EA at ST36 improved lung function, alleviated lung and systemic inflammatory responses by reducing inflammatory cells and cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-8 and IL-1β in BALF, plasma and lung tissue in this COPD mouse model. Plasma dopamine was greatly increased after EA at ST36, negatively correlated with lung histological lesions and inflammatory cytokine levels, and positively correlated with mice body weight and lung function indicators. Chlorpromazine and eticlopride hydrochloride inhibited the anti-inflammatory effect of EA at ST36, while SCH 23390 showed no neutralizing effect.</p><p><strong>Conclusion: </strong>EA at ST36 could alleviate inflammation in this mouse model of COPD through the dopamine D2 receptor pathway.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"163-174"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9987742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture of muscle and tendon attachments in an athlete with lateral epicondylitis of the humerus: a case report.","authors":"Toshihiro Maemichi,&nbsp;Shigeru Meguriya,&nbsp;Atsuya Furusho,&nbsp;Toshiharu Tsutsui,&nbsp;Tsukasa Kumai","doi":"10.1177/09645284221131335","DOIUrl":"https://doi.org/10.1177/09645284221131335","url":null,"abstract":"Enthesopathy is a common overuse disorder in athletes who frequently perform the same movements. Continuous and frequent repetitive movements place excessive tension on tendons, resulting in microdamage, inflammation and pain in the tendon attachments.1 Conservative therapy helps reduce stress on the tendon attachment. However, athletes who continue to play experience severe inflammation and pain, and conservative treatment is often ineffective, leading to a need for surgery in some cases.2 Herein, we describe an apparently successful case of electroacupuncture (EA) treatment of a field hockey player with lateral epicondylitis of the humerus. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"186-188"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for trigger finger: a case report.","authors":"Kaiyong Zhang,&nbsp;Peng Liu,&nbsp;Zixiang Geng,&nbsp;Bimeng Zhang","doi":"10.1177/09645284221146202","DOIUrl":"https://doi.org/10.1177/09645284221146202","url":null,"abstract":"Trigger finger, also known as stenosing flexor tenosynovitis, is a frequent mechanical pathology characterized by painful popping or clicking during extension or flexion of the finger, which is due to a mismatch between the flexor tendons and the size of their surrounding sheath (pulleys).1 Currently, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to suppress excessive inflammation and pain in trigger finger patients, but their effectiveness appears limited.2 Here, we report the case of a patient with trigger finger who appeared to benefit from acupuncture treatment. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"195-196"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials.","authors":"Fangwen Zhou, Emma Huang, Elena Zheng, Jiawen Deng","doi":"10.1177/09645284221076504","DOIUrl":"10.1177/09645284221076504","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of acupuncture for the treatment of Raynaud's syndrome by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>Studies were identified from English and Chinese databases from their inception to September 2020. The outcomes of interest were remission incidence, number of daily attacks, incidence of positive cold stimulation tests and incidence of cold provocation tests. We conducted meta-analysis and network meta-analysis using meta and gemtc.</p><p><strong>Results: </strong>Six trials (n = 272 participants) were included in the meta-analysis. Pairwise meta-analyses show that acupuncture was associated with increased remission incidence (risk ratio (RR) = 1.21, 95% confidence interval (CI) = 1.10 to 1.34), decreased daily number of attacks (weighted mean difference (WMD) = -0.57, 95% CI = -1.14 to -0.01), and increased incidence of positive cold stimulation tests (RR = 1.64, 95% CI = 1.27 to 2.11). There was not enough evidence to associate acupuncture with decreased incidence of positive cold provocation tests. The network meta-analyses did not demonstrate significant results for the effectiveness of any acupuncture treatments (electroacupuncture or manual acupuncture ± moxibustion), compared with controls, in terms of remission incidence or daily number of attacks, possibly due to small sample sizes and a lack of statistical power.</p><p><strong>Conclusion: </strong>The use of acupuncture may be effective for the treatment of Raynaud's syndrome in terms of increasing remission incidence, decreasing daily number of attacks and increasing incidences of positive cold stimulation tests. However, our findings should be interpreted with caution due to small sample sizes, very low quality of evidence and high risk of bias. Future large-scale RCTs are warranted.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"63-72"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9337607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}