Acupuncture in Medicine最新文献

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Electroacupuncture of muscle and tendon attachments in an athlete with lateral epicondylitis of the humerus: a case report. 电针治疗肱骨外侧上髁炎运动员的肌肉和肌腱附着物:一例报告。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-06-01 DOI: 10.1177/09645284221131335
Toshihiro Maemichi, Shigeru Meguriya, Atsuya Furusho, Toshiharu Tsutsui, Tsukasa Kumai
{"title":"Electroacupuncture of muscle and tendon attachments in an athlete with lateral epicondylitis of the humerus: a case report.","authors":"Toshihiro Maemichi, Shigeru Meguriya, Atsuya Furusho, Toshiharu Tsutsui, Tsukasa Kumai","doi":"10.1177/09645284221131335","DOIUrl":"https://doi.org/10.1177/09645284221131335","url":null,"abstract":"Enthesopathy is a common overuse disorder in athletes who frequently perform the same movements. Continuous and frequent repetitive movements place excessive tension on tendons, resulting in microdamage, inflammation and pain in the tendon attachments.1 Conservative therapy helps reduce stress on the tendon attachment. However, athletes who continue to play experience severe inflammation and pain, and conservative treatment is often ineffective, leading to a need for surgery in some cases.2 Herein, we describe an apparently successful case of electroacupuncture (EA) treatment of a field hockey player with lateral epicondylitis of the humerus. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"186-188"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for trigger finger: a case report. 针刺治疗扳机指1例。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-06-01 DOI: 10.1177/09645284221146202
Kaiyong Zhang, Peng Liu, Zixiang Geng, Bimeng Zhang
{"title":"Acupuncture for trigger finger: a case report.","authors":"Kaiyong Zhang, Peng Liu, Zixiang Geng, Bimeng Zhang","doi":"10.1177/09645284221146202","DOIUrl":"https://doi.org/10.1177/09645284221146202","url":null,"abstract":"Trigger finger, also known as stenosing flexor tenosynovitis, is a frequent mechanical pathology characterized by painful popping or clicking during extension or flexion of the finger, which is due to a mismatch between the flexor tendons and the size of their surrounding sheath (pulleys).1 Currently, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to suppress excessive inflammation and pain in trigger finger patients, but their effectiveness appears limited.2 Here, we report the case of a patient with trigger finger who appeared to benefit from acupuncture treatment. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"195-196"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials. 针刺在雷诺综合征患者中的应用:随机对照试验的系统回顾和荟萃分析。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 Epub Date: 2022-05-24 DOI: 10.1177/09645284221076504
Fangwen Zhou, Emma Huang, Elena Zheng, Jiawen Deng
{"title":"The use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials.","authors":"Fangwen Zhou, Emma Huang, Elena Zheng, Jiawen Deng","doi":"10.1177/09645284221076504","DOIUrl":"10.1177/09645284221076504","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of acupuncture for the treatment of Raynaud's syndrome by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>Studies were identified from English and Chinese databases from their inception to September 2020. The outcomes of interest were remission incidence, number of daily attacks, incidence of positive cold stimulation tests and incidence of cold provocation tests. We conducted meta-analysis and network meta-analysis using meta and gemtc.</p><p><strong>Results: </strong>Six trials (n = 272 participants) were included in the meta-analysis. Pairwise meta-analyses show that acupuncture was associated with increased remission incidence (risk ratio (RR) = 1.21, 95% confidence interval (CI) = 1.10 to 1.34), decreased daily number of attacks (weighted mean difference (WMD) = -0.57, 95% CI = -1.14 to -0.01), and increased incidence of positive cold stimulation tests (RR = 1.64, 95% CI = 1.27 to 2.11). There was not enough evidence to associate acupuncture with decreased incidence of positive cold provocation tests. The network meta-analyses did not demonstrate significant results for the effectiveness of any acupuncture treatments (electroacupuncture or manual acupuncture ± moxibustion), compared with controls, in terms of remission incidence or daily number of attacks, possibly due to small sample sizes and a lack of statistical power.</p><p><strong>Conclusion: </strong>The use of acupuncture may be effective for the treatment of Raynaud's syndrome in terms of increasing remission incidence, decreasing daily number of attacks and increasing incidences of positive cold stimulation tests. However, our findings should be interpreted with caution due to small sample sizes, very low quality of evidence and high risk of bias. Future large-scale RCTs are warranted.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"63-72"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9337607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for neurodermatitis: a case report. 针灸治疗神经性皮炎1例。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221146201
Kai-Huan Zeng, Dong-Nan Chen, Gai-Qin Yang, Yong-Gang Yu, Ting-Ting Li
{"title":"Acupuncture for neurodermatitis: a case report.","authors":"Kai-Huan Zeng,&nbsp;Dong-Nan Chen,&nbsp;Gai-Qin Yang,&nbsp;Yong-Gang Yu,&nbsp;Ting-Ting Li","doi":"10.1177/09645284221146201","DOIUrl":"https://doi.org/10.1177/09645284221146201","url":null,"abstract":"Neurodermatitis (also known as lichen simplex chronicus) is a common chronic inflammatory skin disease, which is characterized by paroxysmal pruritus and a mossy skin surface with a long, recurrent and often incurable course. According to surveys,1 the prevalence of neurodermatitis is around 12%. Currently, neurodermatitis is mostly treated with glucocorticoids, immunomodulators, antipruritic agents and antihistamines, but these management options are often accompanied by side effects and do not always prevent recurrence.2 Although neurodermatitis is not harmful, it can have a significant psychosocial impact on patients, causing depression, anxiety and sleep disruption.3 As a result, it would be helpful to find a complementary or alternative therapy that is both safe and effective. Although acupuncture has the advantage of being simple and having few side effects, there is limited evidence to support its use in the treatment of neurodermatitis. Here, we describe a case in which a patient with neurodermatitis who appeared to have been successfully treated with acupuncture without any early signs of recurrence.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"114-115"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Motor function and fALFF modulation in convalescent-period ischemic stroke patients after scalp acupuncture therapy: a multi-centre randomized controlled trial. 头皮针刺治疗恢复期缺血性脑卒中患者的运动功能和fALFF调节:一项多中心随机对照试验。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221086289
Yijun Zhan, Jian Pei, Jun Wang, Qinhui Fu, Jia Xu, Minghang Yan, Yiwen Cai, Xiao Cui, Wencheng Ye, Mingxia Fan, Qiurong Yu, Jie Jia
{"title":"Motor function and fALFF modulation in convalescent-period ischemic stroke patients after scalp acupuncture therapy: a multi-centre randomized controlled trial.","authors":"Yijun Zhan,&nbsp;Jian Pei,&nbsp;Jun Wang,&nbsp;Qinhui Fu,&nbsp;Jia Xu,&nbsp;Minghang Yan,&nbsp;Yiwen Cai,&nbsp;Xiao Cui,&nbsp;Wencheng Ye,&nbsp;Mingxia Fan,&nbsp;Qiurong Yu,&nbsp;Jie Jia","doi":"10.1177/09645284221086289","DOIUrl":"https://doi.org/10.1177/09645284221086289","url":null,"abstract":"<p><strong>Background: </strong>Scalp acupuncture has been found to be effective at improving motor function after ischemic stroke, but few studies examining its central mechanisms of action have been carried out. The aim of this study was to investigate the clinical effects of scalp acupuncture on motor dysfunction and changes in spontaneous brain activity in patients with ischemic stroke.</p><p><strong>Methods: </strong>This was an evaluator- and analyst-blinded, multi-center randomized controlled trial. A total of 108 convalescent-stage ischemic stroke patients with motor dysfunction were allocated to receive either scalp acupuncture combined with rehabilitation treatment (SR group) or rehabilitation treatment alone (RE group). Patients in both groups received treatment 5 times per week for 8 weeks. The primary outcome measure was the Fugl-Meyer assessment (FMA). Secondary outcome measures included the modified Barthel index (mBI), modified Rankin scale (mRS) and values of fractional amplitude of low frequency fluctuation (fALFF) acquired using a resting-state functional magnetic resonance imaging (rs-fMRI) technique.</p><p><strong>Results: </strong>Both groups showed significant improvements in motor function, daily life ability and degree of disability, as measured by FMA, mRS and mBI (<i>p</i> < 0.05), and the SR group showed a significantly greater improvement (<i>p</i> < 0.05). Compared with the RE group, the areas where the fALFF values increased in the SR group were located in the cerebellum, praecuneus, precentral gyrus, superior frontal gyrus and parietal lobe. The improvement in FMA scores had the strongest correlation with the baseline fALFF values of the ipsilateral precentral gyrus.</p><p><strong>Conclusion: </strong>Scalp acupuncture improved motor function in convalescent-period ischemic stroke patients, and effects were correlated with regulation of motor-relevant brain regions. The fALFF value of the ipsilateral precentral and postcentral gyri could be potential clinical indices for prognostication of motor dysfunction.</p><p><strong>Trial registration number: </strong>NCT03120650 (http://www.clinicaltrials.gov).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"86-95"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Acupuncture for the treatment of constipation in Parkinson's disease: a case report. 针刺治疗帕金森病便秘1例。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221146200
Wujun Wang, Lianyan Jiang, Xianrong Feng, Mao Li
{"title":"Acupuncture for the treatment of constipation in Parkinson's disease: a case report.","authors":"Wujun Wang,&nbsp;Lianyan Jiang,&nbsp;Xianrong Feng,&nbsp;Mao Li","doi":"10.1177/09645284221146200","DOIUrl":"https://doi.org/10.1177/09645284221146200","url":null,"abstract":"Constipation is a common and bothersome non-motor symptom across all stages of Parkinson’s disease (PD), and can occur in up to 80% of patients.1 It has a negative impact on the overall quality of life of PD patients. Fiber, laxatives and prokinetic agents are common medications used to treat constipation. However, due to short-term effects and adverse events such as diarrhea and abdominal pain, approximately half of PD patients are dissatisfied with current treatments. Therefore, an increasing number of PD patients who suffer from constipation are looking for complementary and alternative therapies with potentially fewer side effects and/or superior clinical efficacy to improve their quality of life. Acupuncture, a traditional Chinese medical technique that dates back more than 2500 years, is widely used to treat a growing range of diseases worldwide.2,3 Here, we present the case of a PD patient who had constipation and was treated with acupuncture. Publication of this case report is in accordance with the guidelines of the Ethics Committee of Chengdu University of Traditional Chinese Medicine (no. 2020KL-72; approval date 12 December 2020), and permission was given by the patient.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"112-113"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The effectiveness and safety of acupuncture/electroacupuncture for chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. 针刺/电针治疗化疗引起的周围神经病变的有效性和安全性:一项系统综述和荟萃分析。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221076512
Li-Xia Pei, Yue Yi, Jing Guo, Lu Chen, Jin-Yong Zhou, Xiao-Liang Wu, Jian-Hua Sun, Hao Chen
{"title":"The effectiveness and safety of acupuncture/electroacupuncture for chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis.","authors":"Li-Xia Pei,&nbsp;Yue Yi,&nbsp;Jing Guo,&nbsp;Lu Chen,&nbsp;Jin-Yong Zhou,&nbsp;Xiao-Liang Wu,&nbsp;Jian-Hua Sun,&nbsp;Hao Chen","doi":"10.1177/09645284221076512","DOIUrl":"https://doi.org/10.1177/09645284221076512","url":null,"abstract":"<p><strong>Objective: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse effect of anticancer agents with virtually no effective treatment. Safe and effective therapies are needed urgently. Acupuncture shows therapeutic possibilities in this regard but needs to be further evaluated.</p><p><strong>Methods: </strong>A systematic search was conducted in seven databases from their inception to April 2020. Randomized controlled trials (RCTs) focused on acupuncture/electroacupuncture (EA) for the treatment of CIPN were included. Revman 5.3 software was used for meta-analysis if there was no significant heterogeneity. Otherwise, qualitative analysis was utilized.</p><p><strong>Results: </strong>Nine studies involving 582 patients were included in this review. Most of the studies exhibited unclear risk of bias because some details were not mentioned. As the clinical heterogeneity was significant, qualitative analysis was performed to describe nerve conduction velocity, effective rate for motor neuropathy, pain scores, quality of life and adverse events. Meta-analysis was performed on four studies to analyze the effective rate for sensory neuropathy due to inconspicuous heterogeneity. The results indicated that acupuncture may generate a better effect on sensory neuropathy than vitamin B (risk ratio = 1.60, 95% confidence interval = 1.31-1.95, I<sup>2</sup> = 0%, p < 0.00001). The efficacy of EA plus glutathione (GSH) appeared to be better than that of GSH alone in alleviating sensory neurotoxicity and in improving nerve conduction velocity. Acupuncture plus methylcobalamin showed more favorable effects than methylcobalamin alone in relieving neuralgia, restoring nerve conduction velocity and improving quality of life. In terms of pain relief and improved CIPN-specific quality of life, acupuncture plus standard care was better than standard care alone. In terms of pain relief, EA was more effective than usual care.</p><p><strong>Conclusion: </strong>Acupuncture may be effective and safe in the treatment of CIPN according to the analyzed studies. However, more studies with higher methodological quality are warranted in order to be able to draw firmer conclusions. Future rigorous RCTs will be necessary to confirm the effectiveness and safety of acupuncture for CIPN.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"73-85"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Billing for perioperative acupuncture: current practices and future directions. 围手术期针灸计费:目前的做法和未来的方向。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221146203
Alexander B Stone, Roberta J Stack, Stephanie I Cheng
{"title":"Billing for perioperative acupuncture: current practices and future directions.","authors":"Alexander B Stone,&nbsp;Roberta J Stack,&nbsp;Stephanie I Cheng","doi":"10.1177/09645284221146203","DOIUrl":"https://doi.org/10.1177/09645284221146203","url":null,"abstract":"Perioperative acupuncture has been shown to reduce anxiety, as well as mitigate perioperative nausea.1 The addition of intra-operative acupuncture has been shown to help with post-operative pain control in total knee and anterior cruciate ligament replacements.2,3 One barrier to increasing access to perioperative acupuncture services is the lack of clear, widely applicable billing practices and guidelines. Establishing the ability to show an additional revenue stream could increase institutional support for perioperative integrative medicine programs. In this letter, we will review current billing practices for perioperative acupuncture and explore existing economic barriers to increased access for perioperative acupuncture services. Current billing practices (outpatient acupuncture)","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"116-118"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-oral acupuncture treatment for chronic aspiration after esophageal cancer surgery: a case report. 口针治疗食管癌术后慢性误吸1例。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221125249
SunKyung Jin, WooJeong Lee, Hae Jeong Nam, Kyuseok Kim
{"title":"Intra-oral acupuncture treatment for chronic aspiration after esophageal cancer surgery: a case report.","authors":"SunKyung Jin,&nbsp;WooJeong Lee,&nbsp;Hae Jeong Nam,&nbsp;Kyuseok Kim","doi":"10.1177/09645284221125249","DOIUrl":"https://doi.org/10.1177/09645284221125249","url":null,"abstract":"1 Department of Clinical Korean Medicine, Graduate School of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea 2Cosoom Korean Medical Clinic, Seoul, Republic of Korea 3 Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea 4 Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine, Kyung Hee University College of Korean Medicine, Kyung Hee University Medical Center, Seoul, Republic of Korea","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"110-111"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 macrophage polarization and enhancing Treg cell populations in adjuvant-induced arthritic rats. 手针刺ST36部位通过抑制M1巨噬细胞极化和增加佐剂诱导的关节炎大鼠Treg细胞群来减轻类风湿关节炎。
IF 2.5 3区 医学
Acupuncture in Medicine Pub Date : 2023-04-01 DOI: 10.1177/09645284221085278
Nannan Yu, Fuming Yang, Xue Zhao, Yongming Guo, Yuan Xu, Guangchang Pang, Yinan Gong, Shenjun Wang, Yangyang Liu, Yuxin Fang, Kun Yu, Lin Yao, Hui Wang, Kuo Zhang, Baohu Liu, Zhenguo Wang, Yi Guo, Zhifang Xu
{"title":"Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 macrophage polarization and enhancing Treg cell populations in adjuvant-induced arthritic rats.","authors":"Nannan Yu,&nbsp;Fuming Yang,&nbsp;Xue Zhao,&nbsp;Yongming Guo,&nbsp;Yuan Xu,&nbsp;Guangchang Pang,&nbsp;Yinan Gong,&nbsp;Shenjun Wang,&nbsp;Yangyang Liu,&nbsp;Yuxin Fang,&nbsp;Kun Yu,&nbsp;Lin Yao,&nbsp;Hui Wang,&nbsp;Kuo Zhang,&nbsp;Baohu Liu,&nbsp;Zhenguo Wang,&nbsp;Yi Guo,&nbsp;Zhifang Xu","doi":"10.1177/09645284221085278","DOIUrl":"https://doi.org/10.1177/09645284221085278","url":null,"abstract":"<p><strong>Objectives: </strong>Acupuncture has been found to be effective at relieving many inflammatory pain conditions, including rheumatoid arthritis (RA). We aimed to assess the anti-inflammatory potential of manual acupuncture (MA) treatment of RA using adjuvant-induced arthritic (AIA) rats and to explore the underlying mechanisms.</p><p><strong>Methods: </strong>The anti-inflammatory and analgesic actions of MA at ST36 (<i>Zusanli</i>) in AIA rats were assessed using paw withdrawal latency and swelling, histological examination and cytokine detection by enzyme-linked immunoassay (ELISA). The cell-cell communication (CCC) network was analyzed with a multiplex immunoassay of 24 immune factors expressed in the inflamed joints, and the macrophage and Treg populations and associated cytokines regulated by MA were investigated using reverse-transcription quantitative polymerase chain reaction (RT-qPCR), ELISA and flow cytometry.</p><p><strong>Results: </strong>MA markedly decreased heat hyperalgesia and paw swelling in AIA rats. MA-treated rats also exhibited decreased levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β) coupled with increased anti-inflammatory cytokines (IL-10, transforming growth factor (TGF)-β1) in the ankle joints at protein and mRNA levels. CCC network analysis confirmed that macrophages are of critical importance and are potential therapeutic targets in RA. Repeated treatment with MA triggered a macrophage phenotypic switch in the paws, with fewer M1 macrophages. Prominent increases in the Treg cell population and TGF-β1 in the popliteal lymph nodes demonstrated the immunomodulatory effects of MA. Furthermore, a selective TGF-β1-receptor inhibitor, SB431542, attenuated the anti-inflammatory effects of MA and MA-induced suppression of the levels of M1-released cytokines.</p><p><strong>Conclusion: </strong>These findings provide novel evidence that the anti-inflammatory and analgesic effects of MA on RA act through phenotypic modulation involving the inhibition of M1 macrophage polarization and an increase in the Treg cell population, highlighting the potential therapeutic advantages of acupuncture in controlling pain and ameliorating inflammatory conditions.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"96-109"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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