Acupuncture in Medicine最新文献

{"title":"Electroacupuncture improves follicular development and metabolism and regulates the expression of adiponectin, AMPK and ACC in an obese rat model of polycystic ovary syndrome.","authors":"Jing Zhou,&nbsp;Ping Yin,&nbsp;Qingyi Zhao,&nbsp;Zhihai Hu,&nbsp;Yi Wang,&nbsp;Guizhi Ma,&nbsp;Xinyi Wu,&nbsp;Lu Lu,&nbsp;Yin Shi","doi":"10.1177/09645284221107690","DOIUrl":"https://doi.org/10.1177/09645284221107690","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and follicular arrest. Electroacupuncture (EA) has been shown to be effective at improving hyperandrogenism and follicular arrest in PCOS; however, its mechanism of action remains to be deciphered.</p><p><strong>Objective: </strong>In this study, we investigated whether EA improved follicular development in an obese rat model of PCOS and regulated the expression of adiponectin, AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC).</p><p><strong>Methods: </strong>EA was administered at CV3, CV4 and ST40. Changes in body weight, paraovarian fat, estrus cycle, ovarian morphology, levels of related hormones, and glucose and lipid metabolism were evaluated. In addition, protein and mRNA expression of adiponectin, AMPK and ACC was measured.</p><p><strong>Results: </strong>The body weight and paraovarian fat of rats in the EA group were reduced, while estrus cyclicity and ovarian morphology improved. Levels of free fatty acids, triglycerides, total cholesterol and low-density lipoprotein cholesterol were significantly reduced in the EA group, as well as blood glucose levels. Furthermore, levels of testosterone and luteinizing hormone were reduced in the EA group, while estradiol levels were increased. Protein and mRNA expression of adiponectin, AMPKα1 and liver kinase B1 (LKB1) was found to be increased in the EA group, while protein and mRNA expression of ACC were significantly reduced.Conclusion: Our findings suggest that EA improved follicular development and metabolism and regulated expression levels of adiponectin, AMPKα1, LKB1 and ACC in our obese rat model of PCOS.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"151-162"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for persistent post-prostatectomy urinary incontinence: a case series.","authors":"Chaoran Wang,&nbsp;Wentao Li,&nbsp;Xiaojiang Li,&nbsp;Haojian Zhang,&nbsp;Huichuan Tian,&nbsp;Yingjie Jia","doi":"10.1177/09645284221131332","DOIUrl":"https://doi.org/10.1177/09645284221131332","url":null,"abstract":"Radical prostatectomy is considered to be the best treatment for patients with localized and locally advanced prostate cancer. Unfortunately, post-prostatectomy urinary incontinence (PPUI) is a common complication, with an incidence ranging from 4% to 31%.1 PPUI can adversely affect quality of life and cause emotional and financial distress. For most patients, PPUI improves to near baseline levels within 12 months of surgery. However, only a minority of patients with residual PPUI at 12 months experience sustained improvement. Implantation of an artificial urinary sphincter (AUS) represents the gold standard of treatment, although its widespread adoption is limited due to high costs and a significant risk of requiring surgical revision. Hence, early intervention to facilitate patient recovery within 12 months is desirable. For persistent PPUI patients, especially the elderly, we hope to find a safe and non-invasive treatment option that can improve symptoms. Acupuncture is widely used in the treatment of various types of urinary incontinence due to evidence of its effectiveness, the simple nature of the procedure, and its minimal side effects. Electroacupuncture can reduce urine leakage in women with stress urinary incontinence (SUI),2 but relatively little is known about its efficacy and safety for men with PPUI, in whom the quality of evidence is considered to be low. Herein, we report on the use of acupuncture in five patients with persistent PPUI who received routine clinical care at our center.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"183-185"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease.","authors":"Xuemei Liu,&nbsp;Tao Fan,&nbsp;Jinshuai Guan,&nbsp;Ai Luo,&nbsp;Yan Yu,&nbsp;Daohong Chen,&nbsp;Bing Mao,&nbsp;Hongli Jiang,&nbsp;Wei Liu","doi":"10.1177/09645284221107684","DOIUrl":"https://doi.org/10.1177/09645284221107684","url":null,"abstract":"<p><strong>Objective: </strong>To detect the role of dopamine in the anti-inflammatory effect of electroacupuncture (EA) at ST36 in a mouse model of chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>Twenty-eight male BALB/c mice were randomly divided into the control group, model group, sham EA (sham) group or ST36 EA (ST36) group in a 1:1:1:1 ratio (<i>n</i> = 7 each). The COPD mouse model was established through cigarette smoke (CS) exposure for 12 weeks. During the last 2 weeks, EA was applied at a sham point location or ST36 before CS exposure. Lung function, histopathological changes, inflammatory cell counts in bronchoalveolar lavage fluid (BALF), inflammatory cytokines in BALF, plasma, lung tissue homogenate (LTH), and plasma dopamine levels were detected in the different groups. Furthermore, the role of different dopamine receptors was explored through intraperitoneal injections of non-specific dopamine receptor antagonist chlorpromazine, specific dopamine D1 receptor antagonist SCH 23390 and specific dopamine D2 receptor antagonist eticlopride hydrochloride prior to ST36 EA and CS exposure.</p><p><strong>Results: </strong>EA at ST36 improved lung function, alleviated lung and systemic inflammatory responses by reducing inflammatory cells and cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-8 and IL-1β in BALF, plasma and lung tissue in this COPD mouse model. Plasma dopamine was greatly increased after EA at ST36, negatively correlated with lung histological lesions and inflammatory cytokine levels, and positively correlated with mice body weight and lung function indicators. Chlorpromazine and eticlopride hydrochloride inhibited the anti-inflammatory effect of EA at ST36, while SCH 23390 showed no neutralizing effect.</p><p><strong>Conclusion: </strong>EA at ST36 could alleviate inflammation in this mouse model of COPD through the dopamine D2 receptor pathway.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"163-174"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9987742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture of muscle and tendon attachments in an athlete with lateral epicondylitis of the humerus: a case report.","authors":"Toshihiro Maemichi,&nbsp;Shigeru Meguriya,&nbsp;Atsuya Furusho,&nbsp;Toshiharu Tsutsui,&nbsp;Tsukasa Kumai","doi":"10.1177/09645284221131335","DOIUrl":"https://doi.org/10.1177/09645284221131335","url":null,"abstract":"Enthesopathy is a common overuse disorder in athletes who frequently perform the same movements. Continuous and frequent repetitive movements place excessive tension on tendons, resulting in microdamage, inflammation and pain in the tendon attachments.1 Conservative therapy helps reduce stress on the tendon attachment. However, athletes who continue to play experience severe inflammation and pain, and conservative treatment is often ineffective, leading to a need for surgery in some cases.2 Herein, we describe an apparently successful case of electroacupuncture (EA) treatment of a field hockey player with lateral epicondylitis of the humerus. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"186-188"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for trigger finger: a case report.","authors":"Kaiyong Zhang,&nbsp;Peng Liu,&nbsp;Zixiang Geng,&nbsp;Bimeng Zhang","doi":"10.1177/09645284221146202","DOIUrl":"https://doi.org/10.1177/09645284221146202","url":null,"abstract":"Trigger finger, also known as stenosing flexor tenosynovitis, is a frequent mechanical pathology characterized by painful popping or clicking during extension or flexion of the finger, which is due to a mismatch between the flexor tendons and the size of their surrounding sheath (pulleys).1 Currently, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to suppress excessive inflammation and pain in trigger finger patients, but their effectiveness appears limited.2 Here, we report the case of a patient with trigger finger who appeared to benefit from acupuncture treatment. Case report","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 3","pages":"195-196"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials.","authors":"Fangwen Zhou, Emma Huang, Elena Zheng, Jiawen Deng","doi":"10.1177/09645284221076504","DOIUrl":"10.1177/09645284221076504","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of acupuncture for the treatment of Raynaud's syndrome by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>Studies were identified from English and Chinese databases from their inception to September 2020. The outcomes of interest were remission incidence, number of daily attacks, incidence of positive cold stimulation tests and incidence of cold provocation tests. We conducted meta-analysis and network meta-analysis using meta and gemtc.</p><p><strong>Results: </strong>Six trials (n = 272 participants) were included in the meta-analysis. Pairwise meta-analyses show that acupuncture was associated with increased remission incidence (risk ratio (RR) = 1.21, 95% confidence interval (CI) = 1.10 to 1.34), decreased daily number of attacks (weighted mean difference (WMD) = -0.57, 95% CI = -1.14 to -0.01), and increased incidence of positive cold stimulation tests (RR = 1.64, 95% CI = 1.27 to 2.11). There was not enough evidence to associate acupuncture with decreased incidence of positive cold provocation tests. The network meta-analyses did not demonstrate significant results for the effectiveness of any acupuncture treatments (electroacupuncture or manual acupuncture ± moxibustion), compared with controls, in terms of remission incidence or daily number of attacks, possibly due to small sample sizes and a lack of statistical power.</p><p><strong>Conclusion: </strong>The use of acupuncture may be effective for the treatment of Raynaud's syndrome in terms of increasing remission incidence, decreasing daily number of attacks and increasing incidences of positive cold stimulation tests. However, our findings should be interpreted with caution due to small sample sizes, very low quality of evidence and high risk of bias. Future large-scale RCTs are warranted.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"63-72"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9337607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for neurodermatitis: a case report.","authors":"Kai-Huan Zeng,&nbsp;Dong-Nan Chen,&nbsp;Gai-Qin Yang,&nbsp;Yong-Gang Yu,&nbsp;Ting-Ting Li","doi":"10.1177/09645284221146201","DOIUrl":"https://doi.org/10.1177/09645284221146201","url":null,"abstract":"Neurodermatitis (also known as lichen simplex chronicus) is a common chronic inflammatory skin disease, which is characterized by paroxysmal pruritus and a mossy skin surface with a long, recurrent and often incurable course. According to surveys,1 the prevalence of neurodermatitis is around 12%. Currently, neurodermatitis is mostly treated with glucocorticoids, immunomodulators, antipruritic agents and antihistamines, but these management options are often accompanied by side effects and do not always prevent recurrence.2 Although neurodermatitis is not harmful, it can have a significant psychosocial impact on patients, causing depression, anxiety and sleep disruption.3 As a result, it would be helpful to find a complementary or alternative therapy that is both safe and effective. Although acupuncture has the advantage of being simple and having few side effects, there is limited evidence to support its use in the treatment of neurodermatitis. Here, we describe a case in which a patient with neurodermatitis who appeared to have been successfully treated with acupuncture without any early signs of recurrence.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"114-115"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor function and fALFF modulation in convalescent-period ischemic stroke patients after scalp acupuncture therapy: a multi-centre randomized controlled trial.","authors":"Yijun Zhan,&nbsp;Jian Pei,&nbsp;Jun Wang,&nbsp;Qinhui Fu,&nbsp;Jia Xu,&nbsp;Minghang Yan,&nbsp;Yiwen Cai,&nbsp;Xiao Cui,&nbsp;Wencheng Ye,&nbsp;Mingxia Fan,&nbsp;Qiurong Yu,&nbsp;Jie Jia","doi":"10.1177/09645284221086289","DOIUrl":"https://doi.org/10.1177/09645284221086289","url":null,"abstract":"<p><strong>Background: </strong>Scalp acupuncture has been found to be effective at improving motor function after ischemic stroke, but few studies examining its central mechanisms of action have been carried out. The aim of this study was to investigate the clinical effects of scalp acupuncture on motor dysfunction and changes in spontaneous brain activity in patients with ischemic stroke.</p><p><strong>Methods: </strong>This was an evaluator- and analyst-blinded, multi-center randomized controlled trial. A total of 108 convalescent-stage ischemic stroke patients with motor dysfunction were allocated to receive either scalp acupuncture combined with rehabilitation treatment (SR group) or rehabilitation treatment alone (RE group). Patients in both groups received treatment 5 times per week for 8 weeks. The primary outcome measure was the Fugl-Meyer assessment (FMA). Secondary outcome measures included the modified Barthel index (mBI), modified Rankin scale (mRS) and values of fractional amplitude of low frequency fluctuation (fALFF) acquired using a resting-state functional magnetic resonance imaging (rs-fMRI) technique.</p><p><strong>Results: </strong>Both groups showed significant improvements in motor function, daily life ability and degree of disability, as measured by FMA, mRS and mBI (<i>p</i> < 0.05), and the SR group showed a significantly greater improvement (<i>p</i> < 0.05). Compared with the RE group, the areas where the fALFF values increased in the SR group were located in the cerebellum, praecuneus, precentral gyrus, superior frontal gyrus and parietal lobe. The improvement in FMA scores had the strongest correlation with the baseline fALFF values of the ipsilateral precentral gyrus.</p><p><strong>Conclusion: </strong>Scalp acupuncture improved motor function in convalescent-period ischemic stroke patients, and effects were correlated with regulation of motor-relevant brain regions. The fALFF value of the ipsilateral precentral and postcentral gyri could be potential clinical indices for prognostication of motor dysfunction.</p><p><strong>Trial registration number: </strong>NCT03120650 (http://www.clinicaltrials.gov).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"86-95"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for the treatment of constipation in Parkinson's disease: a case report.","authors":"Wujun Wang,&nbsp;Lianyan Jiang,&nbsp;Xianrong Feng,&nbsp;Mao Li","doi":"10.1177/09645284221146200","DOIUrl":"https://doi.org/10.1177/09645284221146200","url":null,"abstract":"Constipation is a common and bothersome non-motor symptom across all stages of Parkinson’s disease (PD), and can occur in up to 80% of patients.1 It has a negative impact on the overall quality of life of PD patients. Fiber, laxatives and prokinetic agents are common medications used to treat constipation. However, due to short-term effects and adverse events such as diarrhea and abdominal pain, approximately half of PD patients are dissatisfied with current treatments. Therefore, an increasing number of PD patients who suffer from constipation are looking for complementary and alternative therapies with potentially fewer side effects and/or superior clinical efficacy to improve their quality of life. Acupuncture, a traditional Chinese medical technique that dates back more than 2500 years, is widely used to treat a growing range of diseases worldwide.2,3 Here, we present the case of a PD patient who had constipation and was treated with acupuncture. Publication of this case report is in accordance with the guidelines of the Ethics Committee of Chengdu University of Traditional Chinese Medicine (no. 2020KL-72; approval date 12 December 2020), and permission was given by the patient.","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"112-113"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness and safety of acupuncture/electroacupuncture for chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis.","authors":"Li-Xia Pei,&nbsp;Yue Yi,&nbsp;Jing Guo,&nbsp;Lu Chen,&nbsp;Jin-Yong Zhou,&nbsp;Xiao-Liang Wu,&nbsp;Jian-Hua Sun,&nbsp;Hao Chen","doi":"10.1177/09645284221076512","DOIUrl":"https://doi.org/10.1177/09645284221076512","url":null,"abstract":"<p><strong>Objective: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse effect of anticancer agents with virtually no effective treatment. Safe and effective therapies are needed urgently. Acupuncture shows therapeutic possibilities in this regard but needs to be further evaluated.</p><p><strong>Methods: </strong>A systematic search was conducted in seven databases from their inception to April 2020. Randomized controlled trials (RCTs) focused on acupuncture/electroacupuncture (EA) for the treatment of CIPN were included. Revman 5.3 software was used for meta-analysis if there was no significant heterogeneity. Otherwise, qualitative analysis was utilized.</p><p><strong>Results: </strong>Nine studies involving 582 patients were included in this review. Most of the studies exhibited unclear risk of bias because some details were not mentioned. As the clinical heterogeneity was significant, qualitative analysis was performed to describe nerve conduction velocity, effective rate for motor neuropathy, pain scores, quality of life and adverse events. Meta-analysis was performed on four studies to analyze the effective rate for sensory neuropathy due to inconspicuous heterogeneity. The results indicated that acupuncture may generate a better effect on sensory neuropathy than vitamin B (risk ratio = 1.60, 95% confidence interval = 1.31-1.95, I² = 0%, p < 0.00001). The efficacy of EA plus glutathione (GSH) appeared to be better than that of GSH alone in alleviating sensory neurotoxicity and in improving nerve conduction velocity. Acupuncture plus methylcobalamin showed more favorable effects than methylcobalamin alone in relieving neuralgia, restoring nerve conduction velocity and improving quality of life. In terms of pain relief and improved CIPN-specific quality of life, acupuncture plus standard care was better than standard care alone. In terms of pain relief, EA was more effective than usual care.</p><p><strong>Conclusion: </strong>Acupuncture may be effective and safe in the treatment of CIPN according to the analyzed studies. However, more studies with higher methodological quality are warranted in order to be able to draw firmer conclusions. Future rigorous RCTs will be necessary to confirm the effectiveness and safety of acupuncture for CIPN.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"41 2","pages":"73-85"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}