Advanced pharmaceutical bulletin最新文献_第8页

Monoclonal Antibodies-Anchored Quantum Dots-Based Delivery Strategies for Glioblastoma Treatment: Challenges and Applications. 基于单克隆抗体锚定量子点的胶质母细胞瘤治疗递送策略：挑战和应用。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-06-02 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.44026

Dipak B Bari, Chandrakantsing V Pardeshi

{"title":"Monoclonal Antibodies-Anchored Quantum Dots-Based Delivery Strategies for Glioblastoma Treatment: Challenges and Applications.","authors":"Dipak B Bari, Chandrakantsing V Pardeshi","doi":"10.34172/apb.025.44026","DOIUrl":"10.34172/apb.025.44026","url":null,"abstract":"Treatment of glioblastoma multiforme (GBM) has been a great challenge before medical fraternity since last century owing to a median survival of less than 15 months, despite of intensive therapy. Neurosurgeries, intense chemotherapy, advanced radiotherapy, and targeted therapies have bought some extension to the life of GBM patients. Combination and targeted therapies could bring a concrete approach to tackle the complexities of GBM treatment. Monoclonal antibodies (mAbs) have already proved their potential, owing to their high affinity and target-specificity, as a promising cancer immunotherapy. In addition, the unique optical properties of quantum dots (QDs) make them an ideal choice of nanocarrier for delivering the chemotherapeutic agents across the blood-brain barrier (BBB) and blood-tumor barrier (BTB). Present review is a concise compilation of the investigations on mAbs conjugation on the QDs surface and their anticancer efficacy against GBM. The core purpose of this review is to discuss the major challenges in the current treatment of GBM and how the mAbs-conjugated QDs have enhanced the therapeutic efficacy in the targeted immunotherapy of GBM tumor. At the end of the article, authors have briefed about the current clinical status of mAbs in GBM treatment, which would urge the researchers to explore them in conjugation with the QDs-based delivery systems. Advancements in this strategy could further open the potential avenues in the future treatments of GBM.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"341-358"},"PeriodicalIF":4.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung Cancer Immunotherapy Approaches: From Clinical Testing to Future Advances. 肺癌免疫治疗方法：从临床试验到未来进展。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-06-02 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.45104

Mayuri Bhattacharyya, Suktilang Majaw

{"title":"Lung Cancer Immunotherapy Approaches: From Clinical Testing to Future Advances.","authors":"Mayuri Bhattacharyya, Suktilang Majaw","doi":"10.34172/apb.025.45104","DOIUrl":"10.34172/apb.025.45104","url":null,"abstract":"One of the major reason of deaths due to cancer globally is caused by lung cancer of which the two main types include non-small cell and small cell lung cancer. The onset of treatment-resistance in cancer cells offers a serious obstacle to the therapeutic effect despite that primary conventional treatments have provided significant benefits and cures. Cancer immunotherapy offers a compelling alternative in patients by utilizing their immune system to enhance its ability to fight against tumors. Cancer immunotherapy includes treatment with cytokines, hormones, bacterial products, monoclonal antibodies, vaccines, etc. Many of these immunotherapies are clinically tested in lung cancer patients. Tumor-associated antigens specific for lung cancer are being targeted using monoclonal antibodies and vaccines. Genetically engineered T-cells that are cultured outside the body are reinfused into the patients. In this review, we describe the different immunotherapeutic approaches that have been clinically tested and used to treat lung cancer globally. The data presented are collected from published studies through electronic databases like Google Scholar and Pubmed using keywords like immunotherapy, adoptive cell therapy, cancer, vaccines, lung cancer and immunological checkpoint inhibitors. The clinical trial results were acquired from ClinicalTrials.gov.in, a database of clinical research studies and their result updates. The review examines the current immunotherapies available for lung cancer treatment globally. While these therapies offer significant benefits to the community, several challenges have hindered their widespread adoption. Key issues such as adverse effects, high costs and varying patient responses to lung cancer immunotherapy require careful consideration. The integration of advanced technologies, including artificial intelligence and bioinformatics tools, along with combinatorial strategies and thorough monitoring, has the potential to increase widely use of lung cancer immunotherapy.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"326-340"},"PeriodicalIF":4.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

M2 Macrophages-Based Immunotherapy: A New Therapeutic Approach in Liver Fibrosis. 基于M2巨噬细胞的免疫疗法：治疗肝纤维化的新途径。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-06-02 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.43855

Wahyu Widowati, Adilah Hafizha Nur Sabrina, Annisa Firdaus Sutendi, Fadhilah Haifa Zahiroh, Teresa Liliana Wargasetia, Ita Margaretha Nainggolan, Elham Rismani, Massoud Vosough

{"title":"M2 Macrophages-Based Immunotherapy: A New Therapeutic Approach in Liver Fibrosis.","authors":"Wahyu Widowati, Adilah Hafizha Nur Sabrina, Annisa Firdaus Sutendi, Fadhilah Haifa Zahiroh, Teresa Liliana Wargasetia, Ita Margaretha Nainggolan, Elham Rismani, Massoud Vosough","doi":"10.34172/apb.025.43855","DOIUrl":"10.34172/apb.025.43855","url":null,"abstract":"Liver fibrosis (LF) is a pathological condition resulting from a chronic inflammatory response to multiple etiological factors, including viral infections, excessive alcohol consumption, and metabolic disorders. The important role of macrophages in this process, especially the M2 subtype, has attracted attention as a potential target for macrophage-based immunotherapy. M2 macrophages have anti-inflammatory and reparative properties that enable them to modulate the immune response and facilitate repairing damaged tissues. They participate in reducing fibrogenic features in term of gene expression and histological markers associated with LF. These cells phagocytose apoptotic cells and matrix components. M2 macrophage-based immunotherapy has shown great potential in ameliorating LF through mechanisms involving the IL-10/STAT3 and TGF-β/SMAD signaling pathways, which are essential in suppressing the pro-inflammatory response and supporting tissue regeneration. However, significant challenges such as individual resistance to therapy and the potential for promoting fibrosis suggest that further development and research are needed to optimize the safety and efficacy of this therapy in clinical applications. This study provides comprehensive insights into the role of M2 macrophages in LF and explores their potential as an innovative therapeutic approach in treating LF.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"314-325"},"PeriodicalIF":4.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview on Lipid Nanocapsules: Exploring the Role in Precision Cancer Treatment and Lymphatic Drug Distribution. 脂质纳米胶囊在肿瘤精准治疗和淋巴药物分布中的作用

IF 4.1

Advanced pharmaceutical bulletin Pub Date : 2025-06-01 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.45109

Mahesha Keerikkadu, Pragathi Devanand Bangera, Vamshi Krishna Tippavajhala, Mahalaxmi Rathnanand

{"title":"An Overview on Lipid Nanocapsules: Exploring the Role in Precision Cancer Treatment and Lymphatic Drug Distribution.","authors":"Mahesha Keerikkadu, Pragathi Devanand Bangera, Vamshi Krishna Tippavajhala, Mahalaxmi Rathnanand","doi":"10.34172/apb.025.45109","DOIUrl":"10.34172/apb.025.45109","url":null,"abstract":"Lipid nanocapsules (LNCs) are an emerging nanocarrier platform for cancer therapy as they can co-deliver multiple drugs, promote synergistic action, and provide targeted drug delivery. The phase inversion temperature (PIT) process is most used for LNC formulation, which has the advantage of process simplicity, thermodynamic stability, and the employment of non-toxic solvents without requiring high energy input. Surface functionalization with targeting ligands like folic acid and peptides increases tumor specificity and reduces off-target toxicity. The nanoscale dimensions and stealth properties of LNCs also take advantage of the enhanced permeability and retention (EPR) effect for enhanced tumor accumulation. LNCs provide precise cancer therapy through the ability to deliver drugs selectively, improve bioavailability, and reduce systemic toxicity. Their nanometer dimensions and surface characteristics allow for effective lymphatic uptake and passive tumor targeting. LNCs offer a potential platform for site-specific treatment, particularly in metastatic cancer with lymphatic involvement. LNCs have become multifunctional platforms with accurate, effective, and patient-friendly delivery systems for cancer treatments. This review critically examines new developments in LNC-based cancer therapies, focusing on optimization of physicochemical properties, improved targeting efficiency, and facilitation of combination therapy. In addition, it draws attention to the translational advantages of LNCs in alleviating systemic toxicity, enhancing pharmacokinetics, and overcoming multidrug resistance in cancer treatment.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"248-267"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomedical Applications of Carbon-Based Nanomaterials: Exploring Recent Advances in Therapeutics, Diagnostics, and Tissue Engineering. 碳基纳米材料的生物医学应用：探索治疗学、诊断学和组织工程的最新进展。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-05-31 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.44083

Afsona Parveen, Arnab Chatterjee, Prithviraj Karak

{"title":"Biomedical Applications of Carbon-Based Nanomaterials: Exploring Recent Advances in Therapeutics, Diagnostics, and Tissue Engineering.","authors":"Afsona Parveen, Arnab Chatterjee, Prithviraj Karak","doi":"10.34172/apb.025.44083","DOIUrl":"10.34172/apb.025.44083","url":null,"abstract":"Carbon-based nanoparticles possess distinctive chemical, physical, and biological characteristics that render them suitable for biomedical uses. This paper reviews recent advancements in carbon-based nanomaterial (CBs) synthesis methods, emphasizing the importance of careful modification for biomedical uses, particularly in the passivation of drugs and chemicals on their surfaces. This review article examines information from 2021-2024 regarding carbon-based nanoparticles and the biomedical uses of graphene, fullerene, carbon nanotubes, nano horns, nanodiamonds, quantum dots, and graphene oxide. Initially, a total of 5,612 relevant data points from various databases such as PubMed, ScienceDirect, and Web of Science were analyzed. After eliminating duplicates, nearly 3,905 data points were found to meet the inclusion criteria for this study, with the latest research indicating that 1,791 (45.8%) of these databases pertained to graphene. Carbon nanotubes accounted for approximately 928 (25.14%) databases, while graphene oxide represented around 837 (21.43%) databases, placing them in second and third positions, respectively. Nanohorns and fullerene were found in very minor quantities, specifically 34 (0.87%) and 06 (0.15%) in the database. CBNs, have the capacity to revolutionize biological medicine by improving regenerative treatments, personalized healthcare, and therapeutic outcomes. They are utilized in scaffolding, drug delivery, tissue engineering, bioimaging, and additional fields. Nonetheless, successful integration necessitates tackling scale and regulatory limitations.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"232-247"},"PeriodicalIF":4.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responsive Nano-structured Cubosomes: Advancements and Therapeutic Applications. 反应性纳米结构立方体：进展和治疗应用。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-05-31 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.43330

Ishal Miranda, Biyas Misra, Manasa Chikballapur Manjunath, Geetha Nayak, Ullal Likhitha, Usha Yogendra Nayak

引用次数: 0

Hypoxic exosomes alleviated the spinal cord injury after ischemic/reperfusion in a rat model. 低氧外泌体减轻大鼠缺血/再灌注后的脊髓损伤。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-05-30 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.43118

Mahdiyeh Asadzadeh Bavil, Gollam Hossein Farjah, Bagher Pourheydar, Reza Rahbarghazi

{"title":"Hypoxic exosomes alleviated the spinal cord injury after ischemic/reperfusion in a rat model.","authors":"Mahdiyeh Asadzadeh Bavil, Gollam Hossein Farjah, Bagher Pourheydar, Reza Rahbarghazi","doi":"10.34172/apb.025.43118","DOIUrl":"10.34172/apb.025.43118","url":null,"abstract":"Purpose: Spinal cord ischemia-reperfusion injury (SCII) is initiated following the occlusion of supporting blood vessels, leading to the loss of neurological function. Here, we aimed to study the regenerative properties of tourniquet-induced hindlimb ischemia exosomes (Exos) in SCII Wistar rats.Methods: Exos were isolated from rats following tourniquet-induced hindlimb ischemia. CellTrackerTM CM-DiI-labeled Exos were injected systematically into SCII rats subjected to 60 min of abdominal aorta occlusion. The distribution of Exos was monitored using an immunofluorescence assay. Using histological examination and real-time PCR analysis, glial cell number, pyknotic and swollen neurons, and expression of apoptosis genes were studied. Oxidative stress was examined by measuring the SOD, GPx activity, MDA, and TAC levels. The neurological assessments were also performed 72 hours after the Exo injection.Results: Data revealed cup-shaped spherical Exos with average size and zeta potential of 279.3 nm and 15.6 mV, respectively. The isolated particles were CD9+, CD63+, and CD81+, indicating the existence of typical Exo biomarkers. Histological analysis showed reduced gliosis, pyknotic, and swollen neurons compared to SCII rats after Exos injection (P<0.05). Data indicated the existence of Exos at the site of injury 24 hours after systemic injection. The injection of hypoxic Exos led to inhibition of apoptosis [Bax (~0.6-fold↓), and Bcl-2 (~3.97-fold↑)] and reduction of oxidative stress [MDA (~58%↓), SOD (~310%↑), GPx (~260%↑), and TAC (~300%↑)] compared to SCII rats (P<0.05). Neurological assessments revealed the reduction of withdrawal response and motor deficit index in SCII rats after injection of hypoxic Exos.Conclusion: Hypoxic Exos are valid regenerative tools for the alleviation of spinal cord injury (SCI) following ischemic/reperfusion.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"406-415"},"PeriodicalIF":4.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PI3K Signaling Pathway Inhibitor Affects Myeloma Cells in a Culture-Dependent Manner. PI3K信号通路抑制剂以培养依赖的方式影响骨髓瘤细胞。

IF 4.7

Advanced pharmaceutical bulletin Pub Date : 2025-04-24 eCollection Date: 2025-07-01 DOI: 10.34172/apb.025.42774

Mehrnaz Janfada, Sadaf Vahdat, Saeid Kaviani

{"title":"PI3K Signaling Pathway Inhibitor Affects Myeloma Cells in a Culture-Dependent Manner.","authors":"Mehrnaz Janfada, Sadaf Vahdat, Saeid Kaviani","doi":"10.34172/apb.025.42774","DOIUrl":"10.34172/apb.025.42774","url":null,"abstract":"Purpose: The survival and progression of multiple myeloma (MM) cells rely heavily on supportive factors and cells within the MM microenvironment, notably macrophages. The PI3K signaling pathway plays a crucial role in both myeloma cells survival and macrophage polarity, making it a potential target for altering the MM microenvironment dynamics.Methods: In this study, the impact of LY294002, a PI3K signaling pathway inhibitor, on the viability of U266 myeloma cells in mono-culture and MM patient-derived bone marrow mononuclear cells (BM-MNCs) in co-culture was investigated. Additionally, the effect of treatments on the M1/M2 macrophage ratio was assessed. Cultures were conducted in both two-dimensional (2D) matrix-free and fibrin gel-based three-dimensional (3D) environments.Results: The treatment significantly increased U266 cell death in 2D cultures, dose-dependently compared to control. However, this effect was not replicated in 3D cultures. In both 2D and 3D cultures, the percentages of cells in G0/G1 phase were dose-dependently increased, compared to the untreated control. However, the percentages of cells in S and G2/M phases in both 2D and 3D cultures were dose-dependently decreased, compared to control. Treatment of BM-MNCs with LY294002 showed patient- and culture-dependent patterns of CD138+ myeloma cell death and M1/M2 macrophage ratio, contrasting the observed consistent responses in U266 mono-culture.Conclusion: LY294002 affected U266 cell viability and cell cycle in a dose-dependent manner in 2D mono-cultures. However, its impact varied in 3D cultures. Treatment of MNCs showed varied responses based on individuals and culture conditions, underscoring the need for more similar tumor microenvironment (TME) recapitulation for drug screening.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 2","pages":"440-452"},"PeriodicalIF":4.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Elateriospermum tapos Supplementation on Leptin and Hypothalamic Signaling in Female Offspring of High-Fat Diet-Induced Obese. 高脂饮食诱导肥胖雌性后代瘦素和下丘脑信号传导的影响

IF 3.1

Advanced pharmaceutical bulletin Pub Date : 2025-04-04 eCollection Date: 2025-04-01 DOI: 10.34172/apb.43919

Santhra Segaran Balan, Hasnah Bahari, Azrina Zainal Abidin, Nurul Husna Shafie, Maizaton Atmadini Abdullah, Azmiza Syawani Jasni

{"title":"Impact of Elateriospermum tapos Supplementation on Leptin and Hypothalamic Signaling in Female Offspring of High-Fat Diet-Induced Obese.","authors":"Santhra Segaran Balan, Hasnah Bahari, Azrina Zainal Abidin, Nurul Husna Shafie, Maizaton Atmadini Abdullah, Azmiza Syawani Jasni","doi":"10.34172/apb.43919","DOIUrl":"10.34172/apb.43919","url":null,"abstract":"Purpose: The central nervous system plays a crucial role in regulating food intake and energy expenditure to maintain energy homeostasis in the body. With rising obesity rates, alternative therapeutic strategies, including herbal-based interventions, are gaining attention. Elateriospermum tapos a plant that rich in flavonoids, has shown potential supporting weight reduction. This study aimed to evaluate the effects of E. tapos seed and shell supplementation on the hypothalamic feeding pathway in obese female rats and their offspring.Methods: Thirty adult female Sprague-Dawley rats were used in this study. Obesity was induced in 24 rats via high-fat diet (HFD) for five weeks. Six rats were maintained on a normal diet as the control group (DCG). The obese rats were then divided into four groups: negative control (DNG, HFD only), positive control (DPG, HFD+orlistat 200 mg/kg), treatment 1 (DTX1, HFD+E. tapos seed 200 mg/kg), and treatment 2 (DTX2, HFD+E. tapos shell 200 mg/kg). Treatments were administered daily for six weeks before mating. On postnatal day 21 (PND21), blood and hypothalamus samples were collected from female rats and their female offspring. Plasma leptin levels were measured using ELISA, and expression of leptin receptor (Obr), proopiomelanocortin (POMC), and neuropeptide Y (NPY) in the hypothalamus was assessed by western blotting.Results: DTX2 and offspring (OTX2) groups showed significantly (P<0.05) lower levels of leptin. Western blot results indicate Obr, POMC and NPY protein significantly (P<0.05) higher expression in DNG and ONG compared to the other groups.Conclusion: In conclusion, the E. tapos shell significantly reduced maternal obesity in female offspring at PND21 compared to its seed.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 1","pages":"186-193"},"PeriodicalIF":3.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gouty Arthritis Treatment: Advancements in Topical Lipid-Based Nanocarrier Delivery Systems. 痛风性关节炎治疗：局部脂基纳米载体递送系统的进展。

IF 4.1

Advanced pharmaceutical bulletin Pub Date : 2025-04-04 eCollection Date: 2025-04-01 DOI: 10.34172/apb.44012

Shubham Kumar, Shreya Kaul, Neha Jain, Chirag Jain, Manisha Pandey

{"title":"Gouty Arthritis Treatment: Advancements in Topical Lipid-Based Nanocarrier Delivery Systems.","authors":"Shubham Kumar, Shreya Kaul, Neha Jain, Chirag Jain, Manisha Pandey","doi":"10.34172/apb.44012","DOIUrl":"10.34172/apb.44012","url":null,"abstract":"The formation of urate crystals in the joints causes severe, erratic flare-ups of joint pain, swelling, and erythema in gout, one kind of inflammatory arthritis. The standard treatment currently available involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, allopurinol, febuxostat, and corticosteroids which require lifelong management via oral or parenteral route. The challenge is the therapy adherence as the symptoms become better, patients may quit taking them, which could result in more episodes. In addition, conventional therapy regimes demonstrate insufficient effectiveness and minimal safety owing to these drug molecule's biopharmaceutical limitations, including inadequate chemical stability and an insufficient capacity to target the pathophysiological pathways. Therefore, developing an alternative drug carrier system that can meet the challenge is necessary. In recent years, the use of lipid-based nanocarriers has increased due to their properties of enhancing solubility and bioavailability of poor-soluble drugs, site-specific targeting, and sustained release. In this review, an attempt has been made to highlight the challenges of available therapies for gout along with its pathophysiology, the mechanism of lipoidal nanocarriers permeation via topical route, and recent advancements in gout therapy using lipid nanocarriers based on preclinical experiments. In addition, patents and clinical trials of lipid-based nanocarriers have also been discussed. Lipid-based nanocarriers present a potential strategy specifically for topical gout therapy as this can offer localized therapy with minimal systemic exposure. Even though lipid-based nanocarriers show promise for gout topical therapy, several issues that need to be looked after, including economically viable scalability and regulatory approvals.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"15 1","pages":"11-26"},"PeriodicalIF":4.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0