Advanced pharmaceutical bulletin最新文献_第8页

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers 转运蛋白18kda (TSPO):一个有前途的分子靶标，用于图像引导的实体癌手术

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.015

Hendris Wongso, Ahmad Kurniawan, Yanuar Setiadi, Crhisterra E. Kusumaningrum, Eva M. Widyasari, Teguh H.A. Wibawa, Isa Mahendra, Muhamad B. Febrian, Maula E. Sriyani, Iim Halimah, Isti Daruwati, Rudi Gunawan, Arifudin Achmad, Dwianto H. Nugraha, Ronny Lesmana, Ari S. Nugraha

{"title":"Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers","authors":"Hendris Wongso, Ahmad Kurniawan, Yanuar Setiadi, Crhisterra E. Kusumaningrum, Eva M. Widyasari, Teguh H.A. Wibawa, Isa Mahendra, Muhamad B. Febrian, Maula E. Sriyani, Iim Halimah, Isti Daruwati, Rudi Gunawan, Arifudin Achmad, Dwianto H. Nugraha, Ronny Lesmana, Ari S. Nugraha","doi":"10.34172/apb.2024.015","DOIUrl":"https://doi.org/10.34172/apb.2024.015","url":null,"abstract":"Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified as the peripheral benzodiazepine receptor (PBR). TSPO involves in a broad number of biochemical events, such as steroidogenesis, mitochondrial cholesterol transport, cell survival and death, cell proliferation, and carcinogenesis. Several investigations have reported the roles of TSPO in various types of cancers, including colorectal cancer, brain cancer, melanoma, breast cancer, prostate cancer, and lung cancer. It was found that TSPO is upregulated in cancer cells, and it appears that its expression is parallel with an aggressive phenotype and/or poor prognosis. As a consequence, there is great potential for developing diagnostic and prognostic tools targeting the TSPO. In this regard, several radioligands targeting the TSPO have been identified, and some of the candidates have advanced to clinical trials. In recent years, image-guided surgery using hybrid probes bearing radioactive and fluorescence molecules has demonstrated promising outcomes in animal and human studies, and thus might serve as a valuable surgical navigator during cancer surgery. In general, current hybrid probes are built from various molecular platforms, including small molecules, nanoparticles, and antibodies. Although several TSPO-targeted imaging probes have been developed, their development for image-guided surgery of cancers is scarce. This review highlights recent findings of the involvement of TSPO in carcinogenesis, and provides a new perspective on the potential application of TSPO-targeted hybrid probes for image-guided surgery.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis Reliability of ChatGPT for Journal Evaluation ChatGPT在期刊评估中的诊断可靠性

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.020

Mehdi Dadkhah, Marilyn H Oermann, Mihály Hegedüs, Raghu Raman, Lóránt Dénes Dávid

引用次数: 0

Lipid-based nanoparticles as oral drug delivery systems: overcoming poor gastrointestinal absorption and enhancing bioavailability of peptide/protein-based drugs 脂质纳米颗粒作为口服给药系统:克服胃肠道吸收不良和提高肽/蛋白基药物的生物利用度

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.016

Soheil Mehrdadi

{"title":"Lipid-based nanoparticles as oral drug delivery systems: overcoming poor gastrointestinal absorption and enhancing bioavailability of peptide/protein-based drugs","authors":"Soheil Mehrdadi","doi":"10.34172/apb.2024.016","DOIUrl":"https://doi.org/10.34172/apb.2024.016","url":null,"abstract":"Delivery and formulation of oral therapeutic peptide/protein-based biotechnological drugs have always been a challenge for the pharmaceutical industry. The bioavailability of oral biopharmaceuticals mainly relies on their gastrointestinal solubility and permeability which are affected by their poor membrane penetration, high molecular weight and proteolytic (chemical and enzymatic) degradation resulting in limited delivery and therapeutic efficacy. The present review article highlights the challenges and limitations of oral delivery of therapeutic peptide/protein-based drugs focusing on the application, potential and importance of solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) as lipid-based drug delivery systems (LBDDSs) and their advantages and drawbacks. LBDDSs, due to their lipid-based matrix can encapsulate both lipophilic and hydrophilic drugs, and by reducing the first-pass effect and avoiding proteolytic degradation offer improved drug stability, dissolution rate, absorption, bioavailability and controlled drug release. Furthermore, their small size, high surface area and surface modification increase their mucosal adhesion, tissue-targeted distribution, physiological function and half-life. Properties such as simple preparation, high-scale manufacturing, biodegradability, biocompatibility, prolonged half-life, lower toxicity, lower adverse effects, lipid-based structure, higher drug encapsulation rate and various drug release profile compared to other similar carrier systems makes LBDDSs a promising drug delivery system. Nevertheless, undesired physicochemical features of peptide/protein drug development and discovery such as plasma stability, membrane permeability and circulation half-life remain a serious challenge which should be addressed in future.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135804136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Intranasal insulin and Cholinergic agonist improve PostCovid-19 Cognition Impairment? 鼻内胰岛素和胆碱能激动剂能改善covid -19后认知障碍吗?

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.017

Amr kamel Ahmed, Mahmoud Elkazzaz, Aml M Brakat

引用次数: 0

The apoptotic, oxidative and histological changes induced by different diameters of sphere gold nanoparticles (GNPs) with special emphasis on the hepatoprotective role of Quercetin 不同直径球形金纳米颗粒(GNPs)诱导的细胞凋亡、氧化和组织学改变，特别强调槲皮素的肝保护作用

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.014

Wael Ghonimi

{"title":"The apoptotic, oxidative and histological changes induced by different diameters of sphere gold nanoparticles (GNPs) with special emphasis on the hepatoprotective role of Quercetin","authors":"Wael Ghonimi","doi":"10.34172/apb.2024.014","DOIUrl":"https://doi.org/10.34172/apb.2024.014","url":null,"abstract":"Purpose: Gold nanoparticles (GNPs) as pharmaceutical and drug delivery tools exhibited harmful effects on human health and other living species. Quercetin reveals various pharmacological effects specially antioxidant, anti-inflammatory and antiapoptotic. This study is directed to investigate hepatotoxicity of GNPs, in addition, to assess the impact of quercetin in mitigating the toxicological effects of GNPs. Methods: Groups of rats were treated with or without sphere GNPs (10, 20 and 50 nm) and quercetin (200 mg/kg b.wt.). Blood and liver samples from euthanized rats were subjected to biochemical, hematological, histopathological, and immunohistochemical investigations. Results: In comparison with 20 and 50 nm treated groups, the 10 nm GNPs significantly increased serum hepatic enzymes; AST, ALT, ALP and bilirubin. These 10 nm GNPs were associated with oxidative stress and markedly decreased antioxidant enzymes: GPX, CAT and SOD. Immunohistochemically, 10 nm GNPs expressed intense positive signals in nuclei of hepatocytes when stained with anti-caspase-3 antibody confirming extensive apoptosis. Pre-cotreatment with quercetin decreased all tested hepatic enzymes and increased serum level of antioxidant enzymes compared to 10 nm GNPs. Quercetin treatment strongly exhibited anti-Ki67 antibody (proliferative marker) indicating high proliferation of hepatic parenchyma. Histopathologically, 10 nm GNPs revealed diffuse hydropic degenerations, severe sinusoidal congestion, coagulative necrosis, sever steatosis and diffuse hemosiderosis within the hepatic parenchyma. Quercetin treatment ameliorated most of these pathological effects. Conclusion: The smaller diameters of GNPs induce potential oxidative stress, cytotoxic, and apoptotic effects in hepatic tissues rather than larger ones. In addition, quercetin demonstrated a significant prophylactic role against hepatotoxicity of GNPs.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement 透皮给药系统:渗透增强物理方法的重点综述

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.018

Rifath Sheikh Vaseem, Alison D’cruz, Srishti Shetty, Hafsa -, Aditya Vardhan, Shreya Shenoy R, Shirleen Miriam Marques, Lalit Kumar, Ruchi Verma

{"title":"Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement","authors":"Rifath Sheikh Vaseem, Alison D’cruz, Srishti Shetty, Hafsa -, Aditya Vardhan, Shreya Shenoy R, Shirleen Miriam Marques, Lalit Kumar, Ruchi Verma","doi":"10.34172/apb.2024.018","DOIUrl":"https://doi.org/10.34172/apb.2024.018","url":null,"abstract":"The skin is the body's largest organ and serves as a site of administration for various medications. Transdermal drug delivery systems have several advantages over traditional delivery systems. It has both local and systemic therapeutic properties. Controlled plasma drug levels, reduced dosing frequency, and avoidance of hepatic first-pass metabolism are just a few of these systems' advantages. To achieve maximum efficacy, it is critical to understand the kinetics, physiochemical properties of the drug moiety, and drug transport route. This manuscript focused on the principles of various physical means to facilitate transdermal drug delivery. Some examples are iontophoresis, electrophoresis, photomechanical waves, ultrasound, needleless injections, and microneedles. Mechanical, chemical, magnetic, and electrical energy are all used in physical methods. A major advantage of physical methods is their capability to abbreviate pain, which can be used for effective disease management. Further investigation should be carried out at the clinical level to understand these methods for effective drug delivery.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on Novel Lipid- Based nano drug delivery 新型脂质纳米给药技术综述

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.012

Sonam Suresh Godase, Nilesh Shrikant Kulkarni, Shashikant Nivrutti Dhole

引用次数: 0

AMPK signaling pathway as a potential therapeutic target for Parkinson's disease AMPK信号通路作为帕金森病的潜在治疗靶点

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.013

Seyed Zanyar Athari, Fereshteh Farajdokht, Rana Keyhanmanesh, Gisou Mohaddes

引用次数: 0

Green formulation of spironolactone loaded chitosan coated nano lipid carrier for treatment of acne vulgaris: a randomized double-blind clinical trial 绿色配方载螺内酯壳聚糖包被纳米脂质载体治疗寻常性痤疮:随机双盲临床试验

Advanced pharmaceutical bulletin Pub Date : 2023-09-23 DOI: 10.34172/apb.2024.011

Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Zohreh Hajheydari, Amin Goodarzi, Seyyed Sohrab Rostamkalaei, Seyyed Mohammad Hassan Hashemi, Seyyed Mobin Rahimnia

{"title":"Green formulation of spironolactone loaded chitosan coated nano lipid carrier for treatment of acne vulgaris: a randomized double-blind clinical trial","authors":"Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Zohreh Hajheydari, Amin Goodarzi, Seyyed Sohrab Rostamkalaei, Seyyed Mohammad Hassan Hashemi, Seyyed Mobin Rahimnia","doi":"10.34172/apb.2024.011","DOIUrl":"https://doi.org/10.34172/apb.2024.011","url":null,"abstract":"Purpose: Spironolactone (SPN), which is classified as an anti-androgen, has demonstrated efficacy in treating acne. This study aimed to utilize ultrasonication to create a chitosan-coated nano lipid carrier (NLC) for enhancing the delivery of SPN to the skin and treating acne. Methods: Various Hydrophilic-Lipophilic Balance (HLB) values were investigated to optimize the SPN-NLCs. Photon correlation spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) were employed to characterize the solid state of SPN in nanoparticle form. Additionally, the optimized formulation was used in a double-blind, randomized clinical trial. Results: Reducing the HLB of the surfactant mixtures resulted in a reduction in the size of SPN-NLCs. The formula with the smallest particle diameter (238.4±0.74 nm) and the lowest HLB value (9.65) exhibited the highest encapsulation efficiency of 79.88 ± 1.807%. Coating the optimized SPN-NLC with chitosan increased the diameter, PDI, zeta potential, and encapsulation efficiency. In vitro skin absorption studies demonstrated sustained release profiles for chitosan-coated SPN-NLC. In the double-blind trial, a gel containing chitosan-coated SPN-NLC effectively treated mild to moderate acne vulgaris, leading to improved healing and reduced lesion count after 8 weeks of therapy compared to the placebo. It successfully addressed both non-inflammatory and inflammatory lesions without adverse effects on the skin. Conclusion: The findings indicate that chitosan-coated SPN-NLCs have the potential as nanoparticles for targeted SPN delivery to the skin, offering novel options for the treatment of acne vulgaris.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136010485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing hyperlipidemia treatment: Nanoencapsulated CoQ10 and selenium combat simvastatin-induced myopathy and insulin resistance in rats 革命性的高脂血症治疗:纳米胶囊化辅酶q10和硒对抗辛伐他汀诱导的大鼠肌病和胰岛素抵抗

Advanced pharmaceutical bulletin Pub Date : 2023-09-23 DOI: 10.34172/apb.2024.010

Hager A Zalam, Ezz ElDeen Saeed El Denshary, Rania Mohsen, Islam Khlail, Mahmoud Khattab, Mohamed Hamzawy

{"title":"Revolutionizing hyperlipidemia treatment: Nanoencapsulated CoQ10 and selenium combat simvastatin-induced myopathy and insulin resistance in rats","authors":"Hager A Zalam, Ezz ElDeen Saeed El Denshary, Rania Mohsen, Islam Khlail, Mahmoud Khattab, Mohamed Hamzawy","doi":"10.34172/apb.2024.010","DOIUrl":"https://doi.org/10.34172/apb.2024.010","url":null,"abstract":"Purpose: The objective of this study was to develop a nanoencapsulated platform for Coenzyme Q10 (coQNPs) or selenium (SeNPs) and explore their potential therapeutic benefits in treating hyperlipidemia and combating simvastatin-induced myopathy and adverse reactions in hyperlipidemic rats. Methods: The physical and chemical properties of the solid nanoparticles (SLNPs), coQNPs, and SeNPs were characterized, including zeta potential studies. Male Wistar albino rats were treated with various interventions for 112 days, including a nano-vehicle only, high-fat diet (HFD), HFD with simvastatin alone, or with coQNPs or/ and SeNPs for the last 30 days. Results: The coQNPs and SeNPs exhibited uniform spherical shapes with high encapsulation efficiency (EE% 91.20 ±2.14 and 94.89 ±1.54, respectively). The results demonstrated that coQNPs and SeNPs effectively reduced hyperlipidemia, insulin resistance, simvastatin-induced myopathy, and hepatotoxicity. However, combining simvastatin with coQNPs and SeNPs resulted in severe liver and muscle damage. Treatment with simvastatin and SeNPs or simvastatin and coQNPs alone showed significant improvements compared to simvastatin treatment alone. Conclusion: These findings suggest that the CoQNPs or SeNPs platforms offer advanced relief for hyperlipidemia and insulin resistance while limiting adverse effects such as myopathy and hepatotoxicity.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136010357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0