Advanced pharmaceutical bulletin最新文献

{"title":"<i>In Vivo</i>, Evaluation of Wound Healing Activity of Nanoliposomes Loaded <i>Withania somnifera</i> Extract.","authors":"Mohadese Mirshekari, Azar Bagheri Ghomi, Hamed Hamishehkar, Mohammad Reza Farahpour","doi":"10.34172/apb.42403","DOIUrl":"10.34172/apb.42403","url":null,"abstract":"<p><strong>Purpose: </strong>Medicinal plants and their derivatives have been used to treat wounds, and loading the plants into nanoliposomes (NLPs) helps to increase their efficacy. This study investigated the efficacy of NLPs loaded with <i>Withania somnifera</i> (WHSE) extract in mouse models for excisional wound healing.</p><p><strong>Methods: </strong>In the present study, we thoroughly evaluated WHSE's antibacterial, antioxidant, and safety profiles. Additionally, we assessed wound contraction, pathological evaluations, and the expression of basic fibroblast growth factor (bFGF) and CD31.</p><p><strong>Results: </strong>The results showed that the extract and its NLPs had biocompatibility and exhibited antibacterial and antioxidant properties. Furthermore, our in vivo wound healing assay results showed that ointments containing 0.50% and 1.00% of the WHSE-NLPs accelerated wound healing and increased collagen and epithelialization. Furthermore, the results of the immunofluorescence and immunochemical tests indicated more expression of CD31 and bFGF in the mice that have been treated with WHSE-NLPs compared to those who were treated with WHSE and control groups. (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>We demonstrated that the administration of 1.00% of the WHSE-NLPs could compete with the commercial ointment (Nitrofurazone®). Therefore, balms prepared from WHSE-NLPs expedited the wound healing process by increasing collagen, epithelialization, and the expression of CD31 and bFGF.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"846-857"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade in Hijacked Journals: What Will be the Future Trend?","authors":"Mihály Hegedűs, Mehdi Dadkhah, Lóránt Dénes Dávid","doi":"10.34172/apb.44002","DOIUrl":"10.34172/apb.44002","url":null,"abstract":"<p><strong>Purpose: </strong>Hijacked journals are fraudulent websites that mimic legitimate journals and, by charging authors, publish manuscripts. The current editorial endeavors to provide a close view of current literature. This editorial piece analyzes 10 years of research on hijacked journals and endeavors to shed light on future trends.</p><p><strong>Methods: </strong>Current research uses a bibliometric approach to analyze data and discuss results. The OpenAlex has been used for data collection. Some of the data analysis was conducted using OpenAlex. The other study was done using Bibliometrix, and the date is limited to publication between 2014 and 2024.</p><p><strong>Results: </strong>The findings provide a close view of the published literature in terms of access type, growth, topics, most frequent words, country contribution, top publishers, and alignment of literature with sustainable development goals.</p><p><strong>Conclusion: </strong>The gap in current literature is the limitation in easily usable methods to be accessible by all researchers for hijacked journal detection and data analysis. The use of artificial intelligence can be promising.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"722-728"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Estrogen in Brain MicroRNAs Regulation.","authors":"Peyvand Bahramiazar, Naseh Abdollahzade, Bakhtyar Tartibian, Naser Ahmadiasl, Fakhreddin Yaghoob Nezhad","doi":"10.34172/apb.39216","DOIUrl":"10.34172/apb.39216","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to elucidate the role of estrogen-sensitive microRNAs (miRNAs) in modulating brain functions and disorders, highlighting the protective effects of estrogen on the central nervous system.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted, examining the relationship between estrogen, miRNAs, and cognitive health. The study focused on experimental data comparing cognitive impairments between genders and the mechanisms of estrogen's effects on brain function.</p><p><strong>Results: </strong>Cognitive impairments are less prevalent in women of reproductive age compared to men, indicating estrogen's neuroprotective role. Estrogen modulates gene expression through specific receptors, while miRNAs regulate approximately 30% of protein-coding genes in mammals. These miRNAs play critical roles in synaptic plasticity and neuronal survival. The review identifies several estrogen-sensitive miRNAs and their potential involvement in brain disorders.</p><p><strong>Conclusion: </strong>The interplay between estrogen and miRNAs offers valuable insights into the molecular mechanisms underlying cognitive health and disease. Understanding these relationships may lead to novel therapeutic strategies for addressing various brain disorders, particularly those associated with hormonal changes and aging.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"819-835"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Characterization, and Leishmanicidal Assessment of Silver- and Dapsone-Loaded Niosomes Co-administration: <i>In Silico</i> and <i>In Vitro</i> Study.","authors":"Anna Etemadifar, Sina Bahraminejad, Abbas Pardakhty, Iraj Sharifi, Alireza Keyhani, Mehdi Ranjbar","doi":"10.34172/apb.42740","DOIUrl":"10.34172/apb.42740","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, there is a crucial need for alternative strategies to control leishmaniasis, which threatens more than 1 billion people worldwide. The simultaneous use of combination therapy and nanostructured lipid carriers aimed to assess the leishmanicidal activity of silver and dapsone niosomes co-administration <i>in vitro</i> and <i>in silico</i>.</p><p><strong>Methods: </strong>After preparing the niosomal formulations of dapsone and silver using the film hydration method, Span 40 and Tween 40/cholesterol with a 7/3 molar ratio was selected as the optimal formulation. Consequently, the arrays of experimental approaches were conducted to compare the anti-leishmaniasis efficacy of ready niosomes with amphotericin B and obtain a deeper understanding of their possible mechanisms of action.</p><p><strong>Results: </strong>Our findings showed higher potency of silver-loaded and dapsone-loaded niosomes co-administration compared to amphotericin B as a positive control group. The results of isobologram and combination index (CI) analyses confirmed the synergic potential of this mixture. This combination triggered anti-leishmanial pathways of macrophages, which promoted the expression level of Th1 cell-related genes, and the downregulated expression of the phenotypes related to Th2 cells. Furthermore, a high level of antioxidant and apoptotic profiles against the parasite provides a rational basis and potential drug combination for cutaneous leishmaniasis. Moreover, the outcomes of the molecular docking showed a high binding affinity between dapsone and iNOS, stimulating the immune response in Th1 direction.</p><p><strong>Conclusion: </strong>In general, the multifunctional leishmanicidal activity of dapsone and silver-niosomes co-administration should be considered for further <i>in vivo</i> and clinical studies.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"892-907"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Indian Pharmacopoeia Commission: Challenge, Compliance of Pharmaceutical Industries.","authors":"Ritu Tiwari, Gaurav Sanjay Mahalpure, Poornima Gulati","doi":"10.34172/apb.43313","DOIUrl":"https://doi.org/10.34172/apb.43313","url":null,"abstract":"","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"720-721"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges of Serum Creatinine Level in GFR Assessment and Drug Dosing Decisions in Kidney Injury.","authors":"Xinyi Wang, Jing Mu, Kexin Ma, Yanrong Ma","doi":"10.34172/apb.42345","DOIUrl":"10.34172/apb.42345","url":null,"abstract":"<p><p>Serum creatinine (SCr) is widely regarded as a standard biomarker for assessing glomerular filtration rate (GFR) and is commonly used to guide dose adjustments for renally eliminated drugs. However, the application of SCr as a marker for evaluating GFR and drug dosing in kidney injury has significant limitations that are often overlooked in clinical practice. This oversight can result in subtherapeutic drug concentrations or adverse drug reactions due to inappropriate dosing adjustments based on SCr levels alone. This review aimed to highlight the factors affecting serum creatinine (SCr) and the challenges associated with using SCr as a biomarker for assessing GFR and adjusting drug doses with regard to its limitations and variability. The findings of this review underscore the complexity of SCr regulation, which is affected by its synthesis, metabolism, and excretion processes (glomerular filtration, tubular secretion, tubular reabsorption and extra-renal elimination), and disease states (such as trauma-induced hyperfiltration and HIV) and the use of medications (drug-creatinine interactions) lead to altered renal excretion of creatinine, either increasing or decreasing its levels. Additionally, the renal excretion pathways for drugs and creatinine are not entirely the same, making it difficult to use creatinine to evaluate drug renal excretion. In conclusion, SCr is an imperfect index of GFR and adjusting drug dosing, and the development of multi-biomarker panels, incorporating biomarkers from different excretory pathways-particularly those involving tubular transport-holds promise for improving the evaluation of renal excretory function and ensuring safer and more effective drug dosing.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"745-758"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Metformin Administration During the Pre-Gestation Period Improves Transient Cerebral Ischemia Injury in Male Offspring Rats.","authors":"Reyhaneh Vaali, Iraj Ahmadi, Fradin Sehati, Mina Ranjbaran, Marjan Nikbakhtzadeh, Fatemeh Nabavizadeh, Abbas Zareei, Ghorbangol Ashabi","doi":"10.34172/apb.43049","DOIUrl":"10.34172/apb.43049","url":null,"abstract":"<p><strong>Purpose: </strong>It seems that maternal intervention, which may involve epigenetic mechanisms, can affect cerebral ischemia in offspring. Metformin consumption by the mother activates the AMP-activated protein kinase (AMPK) pathway. Metformin has also induced the AMPK and protected neurons in cerebral ischemia. This study investigates the effect of maternal metformin administration, which activates the AMPK pathway, on cerebral ischemia in offspring.</p><p><strong>Methods: </strong>Animals were separated into four groups: sham, 2-vessels occlusion (2VO), Met+2VO, Met+compound c (<i>CC</i>)+2VO. Female rats were administrated with metformin at a dose of 200 mg.kg^-1 body weight for 2 weeks prior to mating. After the final metformin injection, each female rat was paired with an intact adult male to allow for mating. Sixty-days old offspring underwent cerebral ischemia and then memory-related tests were done.</p><p><strong>Results: </strong>Current data revealed that the neurological deficits score was reduced Met+2VO group (<i>P</i><0.001), and the memory increased (<i>P</i><0.001) in comparison to the 2VO. The Bcl-2/Bax ratio declined in the metformin group (<i>P</i><0.001) while the brain-derived neurotropic factor (BDNF), c-fos, p-AMPK/AMPK ratio and Histone H3K9 acetylation in the hippocampus augmented significantly compared to the 2VO group (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>These findings indicated that the metformin intervention via AMPK activation could improve the movement disability, enhance spatial memory, increase neural plasticity, and augment the bioenergetics state and histone acetylation in the hippocampus of the offspring.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"927-937"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Impact of India's Recent Ban on Fixed-Dose Combinations: A Call for Evidence-Based Regulation.","authors":"Muhammed Favas Kt, Guru Datt Sharma, Sanjit Sah","doi":"10.34172/apb.43741","DOIUrl":"10.34172/apb.43741","url":null,"abstract":"","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"716-717"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Formulation of Menadione-Loaded Niosome as a Skin-Lightening Preparation: <i>In Vitro</i> /<i>In Vivo</i> Safety Evaluation on Wistar Rat.","authors":"Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Mohammad Reza Mojaveri, Saghar Ahmadipour, Seyyed Mohammad Hassan Hashemi","doi":"10.34172/apb.42731","DOIUrl":"10.34172/apb.42731","url":null,"abstract":"<p><strong>Purpose: </strong>In the present research, a green technique (an ultrasonic method) was used to synthesize menadione sodium bisulfite (MSB) niosome (Menasome) which is used to improve dermal delivery and increase anti-melanogenesis activities.</p><p><strong>Methods: </strong>Various cholesterol: surfactant (Chol: Sur) ratios were investigated to optimize the Menasomes. Photon correlation spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) were employed to characterize the solid state of MSB in nanoparticle form. Additionally, the optimized formulation was used to investigate <i>ex-vivo</i> skin absorption, <i>in vivo</i> skin irritation, <i>in vitro</i> cell survival, and anti-melanogenesis activity.</p><p><strong>Results: </strong>The results exhibited that increasing cholesterol declined the average size of the Menasomes from 653.766±25.171 nm to 298.133±8.823 nm and increased entrapment efficiency 30.237±3.4204% to 83.616±2.550 %. The rat skin permeation study indicated that Menasome gel administered more MSB in dermal layers (439.000±36.190 μg/cm² or 23.827±1.964%) than MSB plain gel (286.200±22.6 μg/cm² or 15.53±1.227%). In both the <i>in vivo</i> skin irritation test and the <i>in vitro</i> cytotoxicity experiment, the extended-release behavior of the enhanced Menasome demonstrated a minimal side effect profile. Furthermore, optimum Menasome inhibited melanin formation (37.426±1.644% at 15μM) greater than free MSB (57.383±1.654%) considerably (<i>P</i><0.05). Furthermore, Menasome 7 prevented L-dopa auto-oxidation in higher levels (95.140±2.439%) than pure MSB solution (83.953±1.629%).</p><p><strong>Conclusion: </strong>According to the study's findings, the prepared Menasome could be employed as a viable nanovehicle for MSB dermal delivery, a promising solution for the management of human hyperpigmentation disorders.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"858-869"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Silica Administration as a New Strategy in the Management of Warfarin Toxicity: An In-Vitro and In-Vivo Study.","authors":"Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi","doi":"10.34172/apb.42665","DOIUrl":"10.34172/apb.42665","url":null,"abstract":"<p><strong>Purpose: </strong>Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.</p><p><strong>Methods: </strong>Amino-functionalized mesoporous silica (MS-NH₂) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The capacity of MS-NH₂ in the adsorption of warfarin was evaluated in vitro, at pH=7.4 and pH=1.2. In vivo evaluations were performed in control and warfarin-overdosed animal models. Overdosed animals were treated with MS-NH₂ by oral gavage. Biomarkers of organ injury were assessed in animal serum.</p><p><strong>Results: </strong>The MS-NH₂ was relatively uniform, spherical with defined diameters (400 nm) and porous structure. Synthesized particles had a large surface area (1015 m₂ g^-1) and mean pore diameter of 2.4 nm which led to considerable adsorption capacity for warfarin 1666 mg/g. In vivo studies revealed that oral administration of MS-NH₂ in mice poisoned with warfarin caused a significant difference (<i>P</i><0.05) in the International Normalized Ratio (INR) and prothrombin time (PT). Moreover, the warfarin with MS-NH₂ group demonstrated a notable decrease in biomarkers associated with tissue damage, such as bilirubin, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST).</p><p><strong>Conclusion: </strong>The results confirm that MS-NH₂ administration can be an effective treatment for warfarin toxicity and could potentially mitigate the adverse effects of warfarin poisoning.</p>","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"14 4","pages":"883-891"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}