ChemSystemsChem最新文献_第3页

Higher-Order Behaviours in Bio-Inspired Materials 生物启发材料的高阶行为

IF 3.1

ChemSystemsChem Pub Date : 2024-04-16 DOI: 10.1002/syst.202400014

Dr. Aina Rebasa-Vallverdu, Dr. Manuel Antuch, Beatrice Rosetti, Dr. Nicoletta Braidotti, Prof. Pierangelo Gobbo

{"title":"Higher-Order Behaviours in Bio-Inspired Materials","authors":"Dr. Aina Rebasa-Vallverdu, Dr. Manuel Antuch, Beatrice Rosetti, Dr. Nicoletta Braidotti, Prof. Pierangelo Gobbo","doi":"10.1002/syst.202400014","DOIUrl":"10.1002/syst.202400014","url":null,"abstract":"Bio-inspired approaches in materials science and systems chemistry are yielding a variety of stimuli-responsive and dynamic materials that are gradually changing our everyday life. However, the ability to chemically program these materials to exhibit macroscopic higher-order behaviours such as self-assembly, contractility, swarming, taxis, chemical communication, or predator-prey dynamics remains an ongoing challenge. While still in its infancy, the successful fabrication of bio-inspired materials displaying higher-order behaviours not only will help bridging the gap between living and non-living matter, but it will also contribute to the development of advanced materials for potential applications ranging from tissue engineering and biotechnology, to soft robotics and regenerative medicine. Our Mini-Review will systematically discuss the higher-order behaviours developed thus far in bio-inspired systems, namely (i) polymer networks (ii) microbots, (iii) protocells, and (iv) prototissues. For each system it will provide key examples and highlight how the emergent behaviour could be chemically programmed.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cysteine-Based Dynamic Self-Assembly and Their Importance in the Origins of Life 基于半胱氨酸的动态自组装及其在生命起源中的重要性

IF 3.1

ChemSystemsChem Pub Date : 2024-04-12 DOI: 10.1002/syst.202400022

Soumen Kuila, Jayanta Nanda

{"title":"Cysteine-Based Dynamic Self-Assembly and Their Importance in the Origins of Life","authors":"Soumen Kuila, Jayanta Nanda","doi":"10.1002/syst.202400022","DOIUrl":"10.1002/syst.202400022","url":null,"abstract":"The knowledge regarding the origins of life from inanimate materials is still elusive. It was proposed that biological building blocks evolved from the inorganic substances present in the early earth conditions. However, the process by which chemistry can be converted into biology has not yet been achieved in the laboratory. The artificial system in the out-of-equilibrium state must maintain a few critical features of life, like compartmentalization, metabolism, and replication, to be considered alive. In this direction, working with cysteine (Cys)-based molecules is strategic to understand the life evolution process. The presence of the sulphydryl (−SH) group in the Cys-residue can build a dynamic equilibrium state through disulfide redox chemistry under the proper guidance of oxidizing and reducing agents. In this review article, our primary focus is to discuss the Cys-containing short-peptide-based self-assembly and disassembly processes. The formation of disulfide bonds sometimes helps in the self-assembly process and gelation, but the reverse is also true in some cases. In the later part of this article, we cover the fact that these sulphydryl-based systems have shown their adaptability to mimic different life-essential criteria to participate in Darwinian evolution.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Selection in Mineral Mediated Polymerization Reactions Executed in a Robotic Chemputer System 在机器人化学计算机系统中执行的矿物介导聚合反应中的选择证据

ChemSystemsChem Pub Date : 2024-03-07 DOI: 10.1002/syst.202400006

Silke Asche, Robert W. Pow, Hessam M. Mehr, Geoffrey J. T. Cooper, Abhishek Sharma, Prof. Leroy Cronin

{"title":"Evidence of Selection in Mineral Mediated Polymerization Reactions Executed in a Robotic Chemputer System","authors":"Silke Asche, Robert W. Pow, Hessam M. Mehr, Geoffrey J. T. Cooper, Abhishek Sharma, Prof. Leroy Cronin","doi":"10.1002/syst.202400006","DOIUrl":"https://doi.org/10.1002/syst.202400006","url":null,"abstract":"It has long been thought that abiogenesis requires a process of selection and evolution at the molecular level, but this process is hard to explore experimentally. One solution could be the use of automation in experiments which could allow for traceability and the ability to explore a larger reaction space. We report a fully programmable and automated platform to explore the reactions of amino acids in the presence of mineral environments. The robotic system is based upon the Chemputer system which has well defined modules, software, and a chemical programming language to orchestrate the chemical processes, including analysis. The reaction mixtures were analysed with tandem mass spectrometry and a peptide sequencing algorithm. Each experiment was screened for 1,398,100 possible unique sequences, and more than 550 specifically defined sequences were confirmed experimentally. This work aimed to develop a new understanding of selection in repeated cycles of polymerisation reactions to explore the emergence of well-defined amino acid sequences. We found that the outcome of oligomerisation was significantly influenced by the presence of different minerals, and that a serpentine environment selects glycine and phenylalanine rich fragments that enable the formation of longer oligomers with well-defined sequences as a function of cycle number.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards Autonomous Materials–Challenges in Chemical Communication 迈向自主材料--化学交流中的挑战

ChemSystemsChem Pub Date : 2024-03-07 DOI: 10.1002/syst.202400005

P. Jarne de Jong, Foteini Trigka, Dr. Michael M. Lerch

{"title":"Towards Autonomous Materials–Challenges in Chemical Communication","authors":"P. Jarne de Jong, Foteini Trigka, Dr. Michael M. Lerch","doi":"10.1002/syst.202400005","DOIUrl":"10.1002/syst.202400005","url":null,"abstract":"Coordination of functions in multi-body or multi-component systems requires communication among its parts and is a prerequisite for achieving complex tasks. While electromagnetic (network) communication provides a key ingredient for modern robotics, its molecular equivalent is largely missing for soft robots. With advancements in programmed cargo release, DNA strand-displacement reactions, enzymatic cascades, and genetic circuits, budding solutions to such chemical network communication have emerged with the potential to drive function in soft machines. In order for such chemical communication to be useful, however, new control concepts, (orthogonal) communication protocols, and molecular solutions should be found. Herein, we provide a critical perspective on the current state-of-the-art chemical communication and identify key challenges towards autonomous soft materials, including signal processing, dealing with noise, switching signaling modalities, and limitations in time and length scales that determine material design. Building on an emerging body of examples, we illustrate gaps, synergies, and new concepts that may provide possible solutions to achieve standardized and reliable molecular information exchange for regulating (soft) robotic function.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Crown Ether Active Template Synthesis of Rotaxanes (ChemSystemsChem 2/2024) 封面：冠醚活性模板合成轮烷（ChemSystemsChem 2/2024）

ChemSystemsChem Pub Date : 2024-02-26 DOI: 10.1002/syst.202400018

Dr. Stephen D. P. Fielden

引用次数: 0

Membrane Transport, Molecular Machines, and Maxwell's Demon 膜传输、分子机器和麦克斯韦恶魔

ChemSystemsChem Pub Date : 2024-02-09 DOI: 10.1002/syst.202400004

Stefan Borsley

引用次数: 0

Membrane Transport, Molecular Machines, and Maxwell's Demon 膜传输、分子机器和麦克斯韦恶魔

ChemSystemsChem Pub Date : 2024-02-09 DOI: 10.1002/syst.202400004

Dr. Stefan Borsley

引用次数: 0

Nucleotide-Protocell Interactions: A Reciprocal Relationship in Prebiotically Pertinent Environments 核苷酸与原细胞的相互作用：前生物相关环境中的互惠关系

ChemSystemsChem Pub Date : 2024-02-07 DOI: 10.1002/syst.202300031

Kshitij Deshpande, Nishant Nitinidhi Kulshreshtha, Sahil Sunil Mulewar, Dr. Sudha Rajamani

{"title":"Nucleotide-Protocell Interactions: A Reciprocal Relationship in Prebiotically Pertinent Environments","authors":"Kshitij Deshpande, Nishant Nitinidhi Kulshreshtha, Sahil Sunil Mulewar, Dr. Sudha Rajamani","doi":"10.1002/syst.202300031","DOIUrl":"https://doi.org/10.1002/syst.202300031","url":null,"abstract":"Spontaneous interactions between nucleotides and lipid membranes are likely to have played a prominent role in the emergence of life on Earth. However, the effect of nucleotides on the physicochemical properties of model protocellular membranes is relatively less understood. To this end, we aimed to discern the effect of canonical nucleotides on the properties of single-chain amphiphile membranes under prebiotically relevant conditions of multiple wet-dry cycles. Furthermore, the change in the critical aggregation concentration of the membranes and their stability in the presence of nucleotides was also investigated in astrobiologically relevant analogue environments. We report that different nucleotides, lipid headgroups, and the ionic makeup of the system affect lipid-nucleotide interactions, and these, in turn, modulate the effect of nucleotides on the membrane properties. Specifically, the presence of AMP, UMP, and CMP promoted self-assembly of oleic acid membranes and increased their stability against certain prebiotically relevant selection pressures. This study takes us a step towards an appreciable understanding of how nucleotides might have shaped the protocellular landscape of the prebiotic Earth.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to Celebrate: 5 Years of ChemSystemsChem 是时候庆祝了：ChemSystemsChem成立5周年

ChemSystemsChem Pub Date : 2024-01-12 DOI: 10.1002/syst.202300051

Dr. Deanne Nolan, Dr. Leana Travaglini

引用次数: 0

Polylysine-Coated Surfaces Drive Competition in Chemical Reaction Networks to Enable Molecular Information Processing 聚赖氨酸涂层表面推动化学反应网络竞争，实现分子信息处理

ChemSystemsChem Pub Date : 2023-12-28 DOI: 10.1002/syst.202300052

A. Hazal Koyuncu, Dr. Jacopo Movilli, Dr. Sevil Sahin, Dmitrii V. Kriukov, Prof. Jurriaan Huskens, Dr. Albert S. Y. Wong

引用次数: 0